Exscientia Business Update for Second Quarter and First Half 2024
Exscientia plc (Nasdaq: EXAI) announced key business updates and financial results for Q2 and H1 2024. Highlights include:
1. Definitive agreement to combine with Recursion Pharmaceuticals, creating a global technology-enabled drug discovery leader.
2. Acquisition of full rights to GTAEXS617 (CDK7 inhibitor), with Phase I data expected in 2H24.
3. Launch of AWS AI-powered platform to advance drug discovery.
4. Progress in LSD1 and MALT1 inhibitor programmes, on track for 2H24 IND/CTA submissions.
5. Expansion of collaborations with Sanofi, Merck KGaA, and READDI.
6. Revenue for H1 2024 was $12.3 million, up from $11.1 million in H1 2023.
7. Cash balance of $370.1 million as of June 30, 2024.
Exscientia plc (Nasdaq: EXAI) ha annunciato importanti aggiornamenti aziendali e risultati finanziari per il secondo trimestre e il primo semestre 2024. Punti salienti includono:
1. Accordo definitivo per la fusione con Recursion Pharmaceuticals, creando un leader globale nella scoperta di farmaci abilitata dalla tecnologia.
2. Acquisizione dei diritti completi su GTAEXS617 (inibitore CDK7), con dati della Fase I attesi nella seconda metà del 2024.
3. Lancio di una piattaforma alimentata dall'IA di AWS per avanzare nella scoperta di farmaci.
4. Progressi nei programmi di inibitori LSD1 e MALT1, in linea per le sottomissioni IND/CTA nella seconda metà del 2024.
5. Espansione delle collaborazioni con Sanofi, Merck KGaA e READDI.
6. I ricavi per il primo semestre del 2024 sono stati di 12,3 milioni di dollari, rispetto agli 11,1 milioni di dollari nel primo semestre del 2023.
7. Saldo di cassa di 370,1 milioni di dollari al 30 giugno 2024.
Exscientia plc (Nasdaq: EXAI) anunció actualizaciones clave sobre la empresa y resultados financieros para el segundo trimestre y el primer semestre de 2024. Los aspectos destacados incluyen:
1. Acuerdo definitivo para combinarse con Recursion Pharmaceuticals, creando un líder global en la descubrimiento de medicamentos habilitado por tecnología.
2. Adquisición de derechos completos sobre GTAEXS617 (inhibidor de CDK7), con datos de la Fase I esperados para la segunda mitad de 2024.
3. Lanzamiento de una plataforma impulsada por inteligencia artificial de AWS para avanzar en la descubrimiento de medicamentos.
4. Progreso en los programas de inhibidores LSD1 y MALT1, a tiempo para las presentaciones IND/CTA en la segunda mitad de 2024.
5. Expansión de colaboraciones con Sanofi, Merck KGaA y READDI.
6. Los ingresos del primer semestre de 2024 fueron de 12,3 millones de dólares, en comparación con 11,1 millones de dólares en el primer semestre de 2023.
7. Saldo de efectivo de 370,1 millones de dólares a partir del 30 de junio de 2024.
Exscientia plc (Nasdaq: EXAI)가 2024년 2분기 및 상반기 주요 사업 업데이트와 재무 결과를 발표했습니다. 주요 내용은 다음과 같습니다:
1. Recursion Pharmaceuticals와의 합병을 위한 최종 계약 체결로, 기술 기반의 글로벌 의약품 발견 리더십을 창출합니다.
2. GTAEXS617 (CDK7 억제제)에 대한 전체 권리를 인수하였으며, 2024년 하반기에 1상 데이터가 기대됩니다.
3. 의약품 발견을 촉진하기 위해 AWS AI 기반 플랫폼을 런칭하였습니다.
4. LSD1 및 MALT1 억제제 프로그램이 진행 중이며, 2024년 하반기에 IND/CTA 제출을 목표로 하고 있습니다.
5. Sanofi, Merck KGaA, READDI와의 협력 확대.
6. 2024년 상반기 수익은 1,230만 달러로, 2023년 상반기 1,110만 달러에서 증가했습니다.
7. 2024년 6월 30일 기준 현금 잔액은 3억 7,010만 달러입니다.
Exscientia plc (Nasdaq: EXAI) a annoncé des mises à jour commerciales clés et des résultats financiers pour le deuxième trimestre et le premier semestre 2024. Les points forts incluent:
1. Accord définitif pour fusionner avec Recursion Pharmaceuticals, créant un leader mondial de la découverte de médicaments par la technologie.
2. Acquisition des droits complets sur GTAEXS617 (inhibiteur de CDK7), avec des données de Phase I attendues pour la deuxième moitié de 2024.
3. Lancement d'une plateforme alimentée par l'IA d'AWS pour avancer dans la découverte de médicaments.
4. Progrès dans les programmes d'inhibiteurs LSD1 et MALT1, en bonne voie pour des soumissions IND/CTA dans la seconde moitié de 2024.
5. Expansion des collaborations avec Sanofi, Merck KGaA et READDI.
6. Le revenu pour le premier semestre 2024 était de 12,3 millions de dollars, contre 11,1 millions de dollars pour le premier semestre 2023.
7. Solde de trésorerie de 370,1 millions de dollars au 30 juin 2024.
Exscientia plc (Nasdaq: EXAI) hat wichtige Geschäftsupdates und finanzielle Ergebnisse für das 2. Quartal und das 1. Halbjahr 2024 bekannt gegeben. Höhepunkte sind:
1. Endgültige Vereinbarung zur Fusion mit Recursion Pharmaceuticals, was einen globalen Technologieführer in der Arzneimittelentdeckung schafft.
2. Erwerb der vollständigen Rechte an GTAEXS617 (CDK7-Inhibitor), mit Phase-I-Daten, die für die zweite Hälfte von 2024 erwartet werden.
3. Start einer von AWS KI unterstützten Plattform zur Förderung der Arzneimittelentdeckung.
4. Fortschritte bei den LSD1- und MALT1-Inhibitorprogrammen, auf dem richtigen Weg für die IND/CTA-Einreichungen in der zweiten Hälfte von 2024.
5. Erweiterung der Kooperationen mit Sanofi, Merck KGaA und READDI.
6. Der Umsatz für das 1. Halbjahr 2024 betrug 12,3 Millionen US-Dollar, im Vergleich zu 11,1 Millionen US-Dollar im 1. Halbjahr 2023.
7. Der Cash-Bestand betrug zum 30. Juni 2024 370,1 Millionen US-Dollar.
- Entered definitive agreement to combine with Recursion Pharmaceuticals, potentially creating a leading technology-first drug discovery platform
- Acquired full rights to GTAEXS617 (CDK7 inhibitor), with Phase I data expected in 2H24
- Launched AWS AI-powered platform to advance drug discovery
- LSD1 and MALT1 inhibitor programmes on track for 2H24 IND/CTA submissions
- Revenue increased to $12.3 million in H1 2024 from $11.1 million in H1 2023
- Expanded collaborations with Sanofi, Merck KGaA, and READDI
- Strong cash position of $370.1 million as of June 30, 2024
- Net loss of $72.4 million for H1 2024
- R&D expenses of $61.5 million in H1 2024
- G&A expenses of $25.6 million in H1 2024
- Net operating cash outflows of $84.8 million in H1 2024
- Cash balance decreased from $458.9 million at end of 2023 to $370.1 million as of June 30, 2024
Insights
Exscientia's Q2 and H1 2024 results reveal a mixed financial picture. Revenue increased to
Positively, R&D expenses decreased to
The pending merger with Recursion Pharmaceuticals could be transformative, potentially creating synergies and accelerating drug discovery. However, investors should closely monitor integration costs and the combined entity's cash burn rate post-merger.
Exscientia's pipeline progress and strategic moves are noteworthy. The acquisition of full rights to GTAEXS617, a CDK7 inhibitor, demonstrates confidence in their AI-driven drug design capabilities. With Phase I data expected in H2 2024, this could be a significant near-term catalyst.
The advancement of EXS74539 (LSD1 inhibitor) and EXS73565 (MALT1 inhibitor) towards clinical trials in early 2025 showcases a robust pipeline. These compounds, if successful, could address significant unmet needs in oncology.
The collaboration with READDI for antiviral compound development highlights Exscientia's versatility and potential in infectious diseases. The expansion of their AWS-powered AI platform for end-to-end drug discovery further solidifies their position as a technology leader in the space.
However, investors should note that clinical success is not guaranteed and the true value of Exscientia's AI approach will be proven through clinical outcomes.
Exscientia's expanded collaboration with AWS to power its end-to-end drug discovery platform is a significant technological advancement. By integrating generative AI for drug design with robotic lab automation, Exscientia aims to accelerate drug development while reducing costs.
The company's "Design-Make-Test-Learn" facility, now fully operational, represents a closed-loop AI-driven drug discovery system. This approach, combining proprietary synthesis-aware GenAI with automated manufacturing and testing, could potentially revolutionize the traditional drug discovery process.
The appointment of Nicola Richmond as Chief Scientist, AI, brings valuable expertise to lead AI solution development. Her 20 years of experience at the intersection of drug discovery and technology could drive further innovation.
While these advancements are promising, the true test will be in translating AI-designed compounds into successful clinical candidates. Investors should monitor the progress of Exscientia's AI-designed drugs in clinical trials to validate the platform's effectiveness.
Entered into definitive agreement to combine with Recursion to create a global technology-enabled drug discovery leader with end-to-end capabilities
Acquired full rights to GTAEXS617 (CDK7 inhibitor), with initial Phase I monotherapy data expected in 2H24
Launched AWS AI-powered platform to advance drug discovery
LSD1 and MALT1 inhibitor programmes continue to progress towards the clinic, on track for 2H24 IND/CTA submissions
“Last week, we announced that Exscientia entered into a definitive agreement to combine with Recursion Pharmaceuticals,” said David Hallett, Ph.D., interim Chief Executive Officer and Chief Scientific Officer of Exscientia. “When we bring together our platforms at closing, our world class scientists and Exscientia’s best-in-class focused precision oncology internal pipeline with Recursion’s first-in-class focused pipeline, we believe we will be able to discover better drugs for patients faster and at a lower cost.”
“In the first half of 2024, we believe we have made important progress across our AI-powered pipeline and progress towards autonomous drug design as well as deepening our technology and pharma partnerships,” continued David Hallett, Ph.D. “We made the strategic decision to fully invest in our CDK7 inhibitor GTAEXS617 (‘617) by acquiring full rights to the programme, which we believe is highly differentiated and demonstrates the power of our design capabilities. We look forward to sharing topline data later this year.”
Key Business Updates
Transaction with Recursion
-
Earlier this month, Exscientia entered into a definitive agreement to combine with Recursion Pharmaceuticals in a transaction that will create a company positioned to leverage the latest life sciences and technology advances to deliver better, novel treatments to patients, faster and at a lower cost relative to traditional drug discovery and development methods
- This combination will bring together Recursion’s scaled biology exploration and translational capabilities with Exscientia’s precision chemistry design and small molecule automated synthesis capabilities to create, at closing, a leading technology-first, end-to-end drug discovery platform
Internal Precision Oncology Pipeline
-
The Company continues to enrol patients with advanced solid tumours in its Phase 1/2 ELUCIDATE trial evaluating ‘617, a potential best-in-class CDK7 inhibitor
- In July, the Company announced that it reached an agreement to acquire the full rights to ‘617 from its partner GT Apeiron - with GT Apeiron retaining an interest via an increased ownership stake in Exscientia
- The Company remains on track to announce topline pharmacokinetic, pharmacodynamic and safety data from the dose escalation phase of ELUCIDATE in the second half of this year
- Exscientia expects to transition to the dose expansion phase of ELUCIDATE in the second half of this year or early next year, starting with the evaluation of ‘617 in HR+/HER2- breast cancer in combination with a selective estrogen receptor degrader (SERD)
- EXS74539 (‘539), Exscientia’s highly differentiated, brain penetrant LSD1 inhibitor, continues to advance towards the clinic, with an IND expected to be submitted later this year. The Company expects to initiate a Phase 1/2 clinical trial in early 2025
- Exscientia remains on track to submit a CTA for EXS73565 (‘565), the Company’s potential best-in-class MALT1 inhibitor, in the second half of 2024. The Company expects to initiate a Phase 1/2 clinical trial of ‘565 in B-cell malignancies, including chronic lymphocytic leukaemia (CLL), in early 2025
Collaborations & Partnerships
- The Sanofi partnership, with a primary focus on immunology and inflammation, continues to advance with multiple potential near-term milestones
-
Exscientia continues to make progress in its collaboration with Merck KGaA, Darmstadt,
Germany with multiple programmes already in early discovery -
In July 2024 the Company announced a collaboration with READDI, a non-profit biotechnology initiative funded by the National Institute of Allergy and Infectious Disease (NIAID), to evaluate and improve a range of AI-designed antiviral compounds for pandemic preparedness
- Exscientia will use its generative AI capabilities to design novel compounds to fight coronaviruses with READDI providing antiviral expertise as well as funding testing and analyses
Drug Discovery Platform
-
Exscientia announced the expansion of its work with Amazon Web Services (AWS) to use the cloud provider’s artificial intelligence and machine learning services to power its platform for end-to-end drug discovery and automation
- Exscientia’s state-of-the-art platform, built using AWS technologies, integrates generative AI drug design and robotic lab automation to further accelerate drug development at a lower cost
- The Company’s closed loop “Design-Make-Test-Learn” facility is now fully online and the first compounds have rolled off the production line. These were designed using Exscientia’s proprietary synthesis aware GenAI and manufactured and tested using the Company’s in-house state-of-the-art automation facility
Leadership Updates
- Marie-Louise Fjallskog, M.D., Ph.D., was appointed interim Chief Medical Officer, bringing extensive oncology drug development expertise to execute robust clinical strategy on Exscientia’s internal oncology pipeline
-
Nicola Richmond, Ph.D., will be joining Exscientia in September as Chief Scientist, AI. Holding a Ph.D. in mathematics, she brings over 20 years’ experience operating at the intersection of drug discovery and technology. Dr.
Richmond will be leading efforts in developing AI solutions for the Company’s drug discovery efforts
Second Quarter and First Half 2024 Financial Results
For the convenience of the reader, the Company has translated pound sterling amounts to
Revenue: Revenue for the three and six months ended June 30, 2024 was
Research and development expenses (R&D): R&D expenses for the three and six months ended June 30, 2024 were
General and administrative expenses (G&A): G&A expenses for the three and six months ended June 30, 2024 were
Cash inflows: For the second quarter 2024, Exscientia received
Net operating cash flow and cash balance: For the three and six months ended June 30, 2024, net operating cash outflows were
SELECTED CONSOLIDATED STATEMENT OF OPERATIONS, CONSTANT CURRENCY CONVERSION (unaudited) | ||||||||
($ millions, except per share data, at the rate of |
||||||||
|
Three months ended
|
Six months ended
|
||||||
|
2024 |
2023 |
2024 |
2023 |
||||
Revenue |
5.6 |
3.8 |
12.3 |
11.1 |
||||
Cost of sales |
(9.8) |
(7.9) |
(19.2) |
(18.6) |
||||
Research and development expenses |
(31.7) |
(41.7) |
(61.5) |
(83.9) |
||||
General and administrative expenses |
(21.2) |
(14.7) |
(25.6) |
(28.5) |
||||
Operating expenses |
(62.7) |
(64.3) |
(106.3) |
(131.0) |
||||
Foreign exchange (losses)/gains |
0.1 |
(0.6) |
1.2 |
(2.1) |
||||
Other income |
7.6 |
2.3 |
9.1 |
5.6 |
||||
Operating loss |
(49.4) |
(58.8) |
(83.7) |
(116.4) |
||||
Net finance income |
4.5 |
5.0 |
9.0 |
9.1 |
||||
Share of loss on joint ventures |
(0.5) |
(0.2) |
(1.2) |
(0.8) |
||||
Loss before taxation |
(45.4) |
(54.0) |
(75.9) |
(108.1) |
||||
Income tax (charge)/benefit |
(0.3) |
8.5 |
3.5 |
15.0 |
||||
Loss for the period |
(45.7) |
(45.5) |
(72.4) |
(93.1) |
||||
Net loss per share |
(0.36) |
(0.37) |
(0.57) |
(0.75) |
||||
Weighted average shares outstanding (basic and diluted) |
126,594,358 |
123,748,524 |
126,285,033 |
123,504,575 |
SELECTED CONSOLIDATED BALANCE SHEET, CONSTANT CURRENCY CONVERSION (unaudited) |
||||
($ millions, except per share data, at the rate of |
||||
|
June 30, 2024 |
December 31, 2023 |
||
Cash, cash equivalents and short-term deposits |
370.1 |
458.9 |
||
Total assets |
553.4 |
645.6 |
||
Total equity |
374.2 |
449.7 |
||
Total liabilities |
179.2 |
195.9 |
||
Total equity and liabilities |
553.4 |
645.6 |
SELECTED CONSOLIDATED STATEMENT OF CASH FLOWS, CONSTANT CURRENCY CONVERSION (unaudited) |
||||
($ millions, except per share data, at the rate of |
||||
|
Six months ended
|
Six months ended
|
||
Net cash outflows from operating activities |
(84.8) |
(107.0) |
||
Net cash flows used in investing activities |
(65.1) |
(85.6) |
||
Net cash used in financing activities |
(2.3) |
(2.0) |
||
Net decrease in cash and cash equivalents |
(152.2) |
(194.6) |
||
Exchange gain/(loss) on cash and cash equivalents |
0.4 |
(3.1) |
||
Net decrease in cash, cash equivalents and short-term bank deposits* |
(88.8) |
(133.6) |
* |
Includes both increases in short-term bank deposits and foreign exchange gains/(losses) on cash and cash equivalents |
About Exscientia
Exscientia is a technology-driven drug design and development company, committed to creating more effective medicines for patients, faster. Exscientia combines precision design with integrated experimentation, aiming to invent and develop the best possible drugs in the most efficient manner. Operating at the interfaces of human ingenuity, artificial intelligence (AI), automation and physical engineering, we pioneered the use of AI in drug discovery as the first company to progress AI-designed small molecules into a clinical setting. We have developed an internal pipeline focused on oncology, while our partnered pipeline extends to many other therapeutic areas. By leading this new approach to drug creation, we believe we can change the underlying economics of drug discovery and rapidly advance the best scientific ideas into medicines for patients.
For more information visit us on www.exscientia.com or follow us on LinkedIn @ex-scientia and X @exscientiaAI.
Forward-Looking Statements
This press release contains certain forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “expects,” “intends,” and “projects” or similar expressions are intended to identify forward-looking statements. These forward-looking statements, include statements with regard to Exscientia’s expectations regarding: the initiation, timing and progress of, and data collected during and reported from, the Company’s and its partners’ clinical trials, as well as expectations with respect to the outcome or benefit of such trials; the progress of Exscientia’s collaborations and partnered programmes; the onboarding of a new executive; and the closing of the transaction contemplated by the agreement between the Company and Recursion Pharmaceuticals, including the successful creation of a combined company and the ability of such combined company to provide patients with better novel medicines. Such statements are subject to a number of risks, uncertainties and assumptions, including those related to: the initiation, scope and progress of Exscientia’s and its partners’ planned and ongoing preclinical studies and clinical trials and ramifications for the cost thereof; clinical, scientific, regulatory and technical developments; the development and deployment of new technology and facilities; the process of discovering, developing and commercialising product candidates that are safe and effective for use as human therapeutics and the endeavour of building a business around such product candidates; and the process of creating a combined company with Recursion Pharmaceuticals and subsequent activities by any such combined company. In light of these risks and uncertainties, and other risks and uncertainties that are described in the Risk Factors section and other sections of Exscientia’s Annual Report on Form 20-F, filed with the Securities and Exchange Commission (SEC) on March 21, 2024, and other filings that Exscientia makes with the SEC from time to time (which are available at https://www.sec.gov/), the events and circumstances discussed in such forward-looking statements may not occur, and Exscientia’s actual results could differ materially and adversely from those anticipated or implied thereby. Although Exscientia’s forward-looking statements reflect the good faith judgement of its management, these statements are based only on facts and factors currently known by the Company. As a result, investors are cautioned not to rely on these forward-looking statements. Exscientia undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.
Additional Information and Where to Find It
The proposed transaction between Exscientia and Recursion will become the subject of a joint proxy statement to be filed by Exscientia and Recursion with the SEC. The joint proxy statement will provide full details of the proposed combination and the attendant benefits and risks, including the terms and conditions of the scheme of arrangement and the other information required to be provided to Exscientia’s shareholders under the applicable provisions of the
INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE PROXY STATEMENT (WHICH WILL INCLUDE AN EXPLANATORY STATEMENT IN RESPECT OF THE SCHEME OF ARRANGEMENT OF EXSCIENTIA, IN ACCORDANCE WITH THE REQUIREMENTS OF THE
Participants in the Solicitation
Exscientia, Recursion, and their respective directors and executive officers may be deemed to be participants in any solicitation of proxies in connection with the proposed combination of the two companies.
Information about Exscientia’s directors and executive officers is available in Exscientia’s Annual Report on Form 20-F dated March 21, 2024. Information about Recursion’s directors and executive officers is available in Recursion’s proxy statement dated April 23, 2024, for its 2024 Annual Meeting of Stockholders. Other information regarding the participants in the proxy solicitation and a description of their direct and indirect interests, by security holdings or otherwise, will be contained in the joint proxy statement and all other relevant materials to be filed with the SEC regarding the proposed combination when they become available. Investors should read the joint proxy statement carefully when it becomes available before making any voting or investment decisions.
View source version on businesswire.com: https://www.businesswire.com/news/home/20240815623767/en/
Investor Relations:
Sara Sherman / Chinedu Okeke
investors@exscientia.ai
Media:
David Keown
media@exscientia.ai
Source: Exscientia plc
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