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Eupraxia Pharmaceuticals Inc. (TSX: EPRX; NASDAQ: EPRX) is a clinical-stage biotechnology company using its proprietary Diffusphere™ technology to develop locally delivered, extended-release drug formulations. The company focuses on creating superior treatment options for conditions with significant unmet medical needs, striving for improved patient outcomes and fewer side effects.
Eupraxia's flagship product, EP-104, is targeted at treating osteoarthritis and eosinophilic esophagitis (EoE). The company recently completed a successful Phase 2b clinical trial (SPRINGBOARD) for EP-104IAR, aimed at alleviating knee pain due to osteoarthritis, meeting its primary endpoint and three out of four secondary endpoints. Eupraxia is also advancing EP-104GI through a Phase 1b/2a RESOLVE trial for EoE, with notable progress reported from its initial cohorts.
Recent achievements include the company's shares being approved for listing on the Nasdaq Capital Market, enhancing visibility and access to U.S. investors. Eupraxia’s financial stability is underpinned by a strong cash position, reported at $35.9 million as of March 31, 2024, which supports ongoing clinical trials and corporate activities.
The company’s innovative Diffusphere™ technology platform enables the creation of long-acting formulations for various therapeutic areas. This includes potential applications in other inflammatory joint conditions and oncology, each designed to enhance the efficacy and tolerability of current treatments.
Key partnerships, business development efforts, and strategic international expansions, such as the recent regulatory clearance in Australia and Canada to expand the RESOLVE trial, signify Eupraxia’s commitment to broadening its clinical reach and accelerating the development of its therapeutic pipeline.
For more detailed insights and updates, visit www.eupraxiapharma.com.
Eupraxia Pharmaceuticals (NASDAQ/TSX: EPRX) revealed new pharmacokinetic data from its Phase 2a Eosinophilic Esophagitis program, highlighting its DiffuSphere™ technology. The platform demonstrates targeted drug delivery maintaining therapeutic levels for over six months while minimizing systemic exposure. In clinical trials, DiffuSphere™ showed successful delivery of fluticasone propionate in both EoE and osteoarthritis patients. The technology's unique microsphere composition enables precise drug release into target tissues with a stable profile, achieving high local concentrations while minimizing systemic exposure. Clinical data showed steady drug levels of 1.5 pg/ml for six months in EoE patients at 4mg dose, and 10pg/ml at three months with 48mg dose.
Eupraxia Pharmaceuticals (TSX/NASDAQ: EPRX) announced its participation in the American College of Rheumatology (ACR) Convergence 2024 Annual Meeting in Washington, D.C., November 14-19, 2024. The company will present a poster (Number 2106) titled 'EP-104IAR Shows Sustained Improvement in Pain for Subjects with Moderate Baseline Pain and BMI Less Than 30 in SPRINGBOARD.' The presentation focuses on their long-acting intra-articular injection of fluticasone propionate for knee osteoarthritis. Philip G. Conaghan will present the findings on November 18, 2024, from 10:30 a.m. to 12:30 p.m. ET. The poster will be available on Eupraxia's website.
Eupraxia Pharmaceuticals (TSX: EPRX) (NASDAQ: EPRX) announced that CEO Dr. James A. Helliwell will present at a Tribe Public Webinar focused on Eosinophilic Esophagitis (EoE), a digestive disorder affecting over 450,000 people in the United States. The presentation, titled 'Eosinophilic Esophagitis: The Emerging Digestive Disorder Frequently Misdiagnosed,' is scheduled for November 15, 2024, at 8:30 am PT / 11:30 am ET.
The event is open to public registration at EPRXNOV1524.TribePublic.com. Participants can submit questions in advance via email or during the event through ZOOM chat. The webinar will be hosted by Tribe Public's Managing Member, John F. Heerdink, Jr.
Eupraxia Pharmaceuticals (TSX/NASDAQ: EPRX) announced positive data from the fifth cohort of its RESOLVE Phase 1b/2a trial for EP-104GI in treating Eosinophilic Esophagitis (EoE). Key highlights include: one patient achieving complete histological remission at 12 weeks, consistent improvement in patient-reported outcomes, and the largest average reduction in symptom scores observed in the fourth cohort at 24 weeks. The fifth cohort showed the greatest percentage change in histology scores to date, with clear dose response across Cohorts 3 to 5. No serious adverse events were reported, and Cohort 6 is fully enrolled with data expected in Q1 2025.
Eupraxia Pharmaceuticals (NASDAQ: EPRX) reported Q3 2024 financial results with a net loss of $6.0 million, compared to $4.9 million in Q3 2023. Cash position stood at $8.7 million as of September 30, 2024. The company announced positive clinical data from its RESOLVE Phase 1b/2a trial for EP-104GI in eosinophilic esophagitis treatment and published Phase 2b SPRINGBOARD trial data in The Lancet Rheumatology. Post-quarter, Eupraxia raised C$44.5 million through a private placement, appointed new executives, and expects funding through Q3 2026.
Eupraxia Pharmaceuticals (TSX/NASDAQ: EPRX) has completed a non-brokered private placement raising C$44.5 million through the issuance of 8,905,638 Series 1 Preferred shares at C$5.00 per share. The proceeds will fund clinical trials for EP104GI, research programs, and general corporate purposes. The company appointed Joseph Freedman, former Brookfield Asset Management executive, to its board. The Preferred Shares rank senior to common shares, are convertible to common shares on a one-to-one basis, and will earn dividends after three years. The company also terminated its C$12 million convertible debt facility.
Eupraxia Pharmaceuticals (TSX/NASDAQ: EPRX) announced its participation at the American College of Gastroenterology Annual Scientific Meeting 2024 in Philadelphia, presenting two significant posters. The first poster (P2209), which received a Presidential Award, focuses on EP-104GI's pharmacokinetics and tolerability in mini-pigs. The second poster (P3911), designated as an 'Abstract of Interest,' presents efficacy and pharmacokinetic results from the RESOLVE Phase 1b/2a study's first four cohorts. Both presentations, scheduled for October 28-29, 2024, showcase the company's work on their extended-release fluticasone formulation for treating Eosinophilic Esophagitis.
Eupraxia Pharmaceuticals Inc. (NASDAQ: EPRX) (TSX: EPRX) announced the publication of its Phase 2b SPRINGBOARD trial data for EP-104IAR in Lancet Rheumatology. The trial evaluated EP-104IAR for knee osteoarthritis treatment. Key findings include:
1. EP-104IAR demonstrated clinically significant and durable pain relief.
2. Minimal changes in glucose and cortisol were observed.
3. Stable fluticasone propionate concentrations in plasma were maintained.
The study involved 318 participants and met its primary endpoint, showing statistically significant improvement over placebo in WOMAC Pain at 12 weeks (p=0.004). Three of four secondary endpoints also showed significant improvement. The results suggest EP-104IAR's potential to become a best-in-class therapy for knee osteoarthritis, which affects over 30 million people in the U.S. alone.
Eupraxia Pharmaceuticals Inc. (TSX: EPRX) (NASDAQ: EPRX), a clinical-stage biotechnology company, has announced its participation in the United European Gastroenterology (UEG) Week 2024 in Vienna, Austria, from October 12-15, 2024. The company will present a poster featuring data from the RESOLVE trial, a Phase 1b/2a dose-escalation study of EP-104GI for Eosinophilic Esophagitis.
The presentation details include:
- Poster Number: PP0584
- Title: Results from Dose Escalation in RESOLVE, an Ongoing Phase 1b/2a Dose-Escalation Study of EP-104GI (Extended-Release Fluticasone Propionate Intra-Esophageal Injection) for Eosinophilic Esophagitis
- Topic: Oesophageal, gastric and duodenal
Eupraxia Pharmaceuticals (TSX: EPRX) (NASDAQ: EPRX) has announced key appointments to strengthen its senior management team. Dr. Amanda Malone, co-founder and former Chief Scientific Officer, has been promoted to Chief Operating and Scientific Officer. Dr. Rahul Sarugaser joins as Executive Vice President of Corporate Development.
Dr. Malone, who co-founded Eupraxia in 2012, has been instrumental in developing the company's DiffuSphere™ technology and leading successful clinical trials. Dr. Sarugaser brings 20 years of experience in capital markets and healthcare, most recently as Managing Director of Equity Research at Raymond James.
Eupraxia is advancing its DiffuSphere™ technology for targeted drug delivery in areas with high unmet medical need. The company's lead product, EP-104GI, is in a Phase 1b/2a trial for eosinophilic esophagitis. Eupraxia recently completed a successful Phase 2b trial of EP-104IAR for knee osteoarthritis pain.
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