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About Defence Therapeutics Inc. (DTCFF)
Defence Therapeutics Inc. is a publicly traded, clinical-stage biopharmaceutical company headquartered in Canada, specializing in engineering next-generation vaccines, antibody-drug conjugates (ADCs), and radiopharmaceutical products. At the heart of Defence’s innovation is its proprietary ACCUM® technology platform, a groundbreaking solution designed to optimize intracellular drug delivery by overcoming endosomal entrapment. This enhancement enables precise delivery of therapeutic agents directly to target cells, significantly increasing their efficacy and potency. Defence’s technology is particularly impactful in the fields of oncology and infectious diseases, addressing critical unmet medical needs.
Core Technology: The ACCUM® Platform
The ACCUM® technology is a versatile platform that enhances the delivery and efficacy of biologics, including ADCs, radiopharmaceuticals, vaccines, and protein therapeutics. By addressing the common challenge of endosomal entrapment, ACCUM® ensures that therapeutic agents reach their intended intracellular targets intact, thereby amplifying their therapeutic potential. This innovation is especially valuable in oncology, where precision delivery can improve treatment outcomes while minimizing side effects.
Key Applications and Innovations
- Antibody-Drug Conjugates (ADCs): Defence’s ACCUM® technology enhances the potency of ADCs by ensuring efficient intracellular delivery of cytotoxic agents. This advancement has the potential to reduce dosing requirements and improve patient outcomes.
- Radiopharmaceuticals: The company is developing novel radio-immuno-conjugates that leverage ACCUM® to deliver radioactive isotopes directly to cancer cells. This targeted approach minimizes damage to healthy tissues and enhances therapeutic efficacy.
- Immune-Oncology Vaccines: Defence is pioneering vaccines that utilize ACCUM® to boost immunogenicity, making them more effective against cancers and infectious diseases.
- GLP-1 Analog Development: Defence is exploring the use of ACCUM® to improve the stability and half-life of GLP-1 analogs, addressing challenges in the treatment of obesity and type 2 diabetes.
Business Model and Revenue Streams
Defence Therapeutics operates on a dual business model. It licenses its ACCUM® technology to pharmaceutical and biotech companies, generating immediate revenue while establishing its platform as an industry standard. Concurrently, the company invests in proprietary drug development programs, focusing on oncology and infectious diseases. This balanced approach ensures both near-term profitability and long-term growth.
Market Position and Competitive Landscape
Defence Therapeutics is strategically positioned in the rapidly growing biopharmaceutical and radiopharmaceutical markets. The global cancer immunotherapy market, for instance, is projected to grow significantly, driven by advancements in targeted therapies. Defence’s focus on enhancing the delivery and efficacy of biologics sets it apart from competitors, which include established pharmaceutical companies and emerging biotech firms. Its robust intellectual property portfolio, with patents in multiple jurisdictions, further strengthens its competitive edge.
Commitment to Innovation and Collaboration
Defence is actively involved in collaborative projects with leading research institutions and industry partners. Notable initiatives include its work with Canadian Nuclear Laboratories on radio-immuno-conjugates and its partnership with Orano Support SAS for advanced radiopharmaceutical development. These collaborations underscore Defence’s commitment to leveraging external expertise to accelerate innovation.
Conclusion
With its cutting-edge ACCUM® technology, diversified business model, and strategic focus on oncology and infectious diseases, Defence Therapeutics Inc. is at the forefront of biopharmaceutical innovation. Its dedication to addressing critical medical challenges and its robust intellectual property portfolio position the company as a key player in the global healthcare landscape.
Defence Therapeutics (OTCQB: DTCFF) has completed the second tranche of its non-brokered private placement, raising $3.915 million through a fully subscribed financing totaling $4.2 million. The company offered units at $0.60 per unit, with each unit comprising one common share and one warrant exercisable at $0.75 for 24 months.
The company paid $217,680 in finder's fees and issued 372,000 finder's warrants exercisable at $0.75 per share. PowerOne Capital Markets acted as a finder for part of the offering. Additionally, Defence granted 250,000 stock options to board members at $1.02 per share for ten years and 100,000 options to a consultant for three years.
The proceeds will be used to advance preclinical and clinical programs and for general working capital. All securities are subject to a four-month statutory hold period.
Defence Therapeutics (DTCFF) has announced its participation in the Biotech Showcase™ conference during the J.P. Morgan Healthcare Conference in San Francisco from January 13-16, 2025. The company's CEO and CSO will meet with industry leaders, potential partners, and investors to showcase their proprietary Accum® technology platform, particularly its applications in improving ADCs and developing targeted radiopharmaceutical therapies.
Additionally, Defence has completed the first tranche of its non-brokered private placement, raising $300,000 through units priced at $0.60 each. Each unit includes one common share and one warrant exercisable at $0.75 per share for 24 months. The company paid $24,000 in finder's fees and issued 40,000 finder's warrants. The proceeds will support preclinical and clinical programs and working capital.
Defence Therapeutics (DTCFF) has strengthened its patent portfolio with multiple key patent issuances and allowances. The USPTO issued a Notice of Allowance for US patent application 18/318,384, filed in May 2023, covering Accum®-based dimers and multimers. This patent, expected in early 2025, will provide market exclusivity until 2043 for Defence's AccuTOX® and ARM® anti-cancer programs.
The company also secured US patent 12,150,989 on November 26, 2024, extending protection of Accum®-based immunogenicity-enhancing variants to steroid acid-based compounds. Additionally, a Singaporean patent application was recently allowed and is expected to be granted in early 2025.
These developments strengthen Defence's intellectual property position for licensing and strategic partnerships, particularly in improving vaccine potency. The company plans additional national patent filings in Q3 2025 through PCT application PCT/CA2023/051758.
Defence Therapeutics (CSE: DTC) (OTCQB: DTCFF) has announced a non-brokered private placement to raise up to $4.2 million through the issuance of up to 7 million units at $0.60 per unit. Each unit consists of one common share and one warrant, with each warrant allowing the purchase of an additional common share at $0.75 for 24 months after closing.
The proceeds will be used to advance preclinical and clinical programs and for general working capital. The company may pay finder's fees, and securities will be subject to a four-month and one-day hold period following closing.
Defence Therapeutics (DTCFF) has announced Dr. Elias Theodorou has joined its board of directors. Dr. Theodorou brings over 25 years of experience in cancer research, stem cell differentiation, and gene delivery. He currently serves as Chief Scientific Officer at Protos Biologics Inc. and previously held leadership positions at WBC Biosciences, ATUM Inc., and Metagenomix Inc. The company granted him 100,000 incentive stock options, exercisable at $0.60 per share for three years.
Additionally, Mr. Arnab De has been appointed as CFO and Corporate Secretary, replacing Mr. Joseph Meagher and Miss Carrie Cesarone. The board now consists of five members: Sébastien Plouffe, Dr. Sarkis Meterissian, Dr. Philippe Lefrançois, Dr. Svetlana Selivanova, and Dr. Elias Theodorou.
Defence Therapeutics announces its annual general and special meeting of shareholders scheduled for December 12th, 2024, at 10:00 a.m. (Pacific Time) in Vancouver. Shareholders of record as of November 4, 2024, are eligible to vote, with a proxy deadline of December 10th, 2024, at 10:00 a.m. Due to a Canada Post labour strike, shareholders may experience delays in receiving the Information Circular dated November 8, 2024. The company encourages shareholders to access materials electronically via SEDAR+ and vote according to the Circular's instructions.
Defence Therapeutics announces plans to license its proprietary Accum® technology to pharmaceutical companies developing Antibody Drug Conjugates (ADCs). The technology enhances the delivery and efficacy of biologics by overcoming endosomal entrapment, potentially increasing therapeutic potency and reducing dosing requirements. The company aims to generate revenue through licensing while establishing its technology as an industry standard. Additionally, Defence completed a private placement, issuing 50,000 units at $0.50 per unit for proceeds of $25,000, and amended terms for 1,497,780 warrants, reducing their exercise price from $1.75 to $0.75.
Defence Therapeutics has appointed Dr. Maxime Parisotto as Chief Scientific Officer, Director of Science and Business Development. Dr. Parisotto brings over 20 years of experience in biochemistry, drug development, and innovation, holding a PhD focused on breast cancer and metabolism. His background includes postdoctoral fellowships at IGBMC and Université de Montréal, and a senior analyst role at adMare Bioinnovations. He will complete his MBA from Sherbrooke University in April 2025. The company has granted him 100,000 incentive stock options, exercisable at 60 cents per share for three years. The announcement also notes that Dr. Moutih Rafei has left the company.
Defence Therapeutics has closed a non-brokered private placement of unsecured convertible debentures raising CAD$1,476,000. The new debentures bear an 8.0% annual interest rate, mature on November 16, 2025, and are convertible to common shares at $0.60 per share. This offering settles previous debentures from November 2022. The accrued interest of $251,200 from previous debentures was settled through conversion into 440,697 common shares at $0.57 per share. Additionally, 123,000 common shares were issued to a finder as compensation.
Defence Therapeutics announces a new convertible debenture financing offering for CAD$1,570,000 to settle outstanding debt. The new unsecured debentures will bear an 8.0% annual interest rate and mature on November 16, 2025. Debenture holders can convert their principal into common shares at $0.60 per share, potentially resulting in 2,616,666 new common shares. Additionally, approximately $251,200 in accrued interest from previous debentures will be converted into shares at market price. The securities will have a four-month statutory hold period, and the offering requires regulatory approvals.
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