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Founded in 1947, Charles River Laboratories International, Inc. (symbol: CRL) is a global leader in providing essential products and services to pharmaceutical and biotechnology companies, government agencies, and academic institutions. The company's mission is to accelerate research and drug development efforts, significantly contributing to the healthcare industry.
Charles River operates through three main segments:
- Research Models & Services: This segment is renowned for being the leading provider of laboratory animal models. Charles River breeds and supplies animals with specific genetic traits for preclinical studies worldwide, supporting the critical early stages of drug discovery.
- Discovery & Safety Assessment: This segment offers a comprehensive range of services necessary for the early development of new drugs. From discovery services to safety assessments, Charles River helps clients navigate the complex process of taking a drug from concept to early-stage development.
- Manufacturing Support: This includes microbial solutions for in vitro testing, biologics testing services, and avian vaccine services. These services are integral to ensuring the safe manufacture and quality control of new therapies.
The company's workforce is dedicated to providing clients with the expertise and services they need to improve and expedite the discovery and development of new therapies. Charles River's collaborative approach and commitment to excellence have established it as a trusted partner in the life sciences industry.
Charles River continues to innovate and expand its services, making significant strides in the fields of drug discovery, biotechnology, and pharmaceuticals. With a strong financial footing and strategic partnerships, the company is well-positioned to support the future of healthcare advancements globally.
Charles River Laboratories (NYSE: CRL) has launched the Charles River Incubator Program (CIP), aimed at supporting early-stage biotechnology companies in the discovery, development, and manufacturing of advanced therapies. Through its Global Innovation Center of Excellence, CIP offers knowledge, connectivity, and priority access to Charles River's extensive portfolio. This initiative builds on the success of the Cell and Gene Therapy Accelerator Program (CAP), designed to assist companies 18-24 months from Investigational New Drug (IND) or Clinical Trial Application (CTA) submission. CIP targets companies 24+ months from IND or CTA submission, providing regulatory and quality expertise, personnel training, and access to laboratory space and equipment. The Global Innovation Center of Excellence integrates a team of scientific, regulatory, and manufacturing experts to foster innovation and support thousands of IND and CTA submissions. The next cohort will be shortlisted at the Cell and Gene Therapy Summit on March 4, 2025, in San Francisco, CA.
Charles River Laboratories (NYSE: CRL) announced its participation in the 7th Annual Evercore ISI HealthCONx Conference on Wednesday, December 4th, at 10:00 a.m. ET. During the event, the management will discuss strategic focus, business developments, and recent trends. A live webcast of the presentation will be accessible via the Investor Relations section of the Charles River website at ir.criver.com. The webcast replay will be available on the same site for at least two weeks post-presentation.
Charles River Laboratories (NYSE: CRL) has announced its upcoming presentations at two major healthcare conferences. The company will present at the UBS Global Healthcare Conference on November 12th at 10:15 a.m. PT and the Jefferies London Healthcare Conference on November 20th at 2:00 p.m. GMT.
Management will discuss the company's strategic focus, business developments, and recent trends. Both presentations will be available via live webcast through the Investor Relations section of Charles River's website, with replays accessible for at least two weeks afterward.
Charles River Laboratories (NYSE: CRL) reported Q3 2024 revenue of $1.01 billion, down 1.6% from $1.03 billion in Q3 2023, with a 2.7% organic decline. The company's GAAP operating margin decreased to 11.6% from 14.8%, while non-GAAP operating margin fell to 19.9% from 20.5%. GAAP earnings per share dropped 21.3% to $1.33, and non-GAAP EPS decreased 4.8% to $2.59. The decline was primarily driven by lower revenue and higher restructuring costs, despite improvements in all three business segments' operating margins.
Charles River Laboratories International, Inc. (NYSE: CRL) has launched the Retrogenix® Non-Human Protein Library, a first-in-class in vitro library designed to assess off-target binding and de-risk in vivo studies. This innovative tool helps biopharmaceutical clients evaluate how therapeutics interact with non-human protein targets, providing early insights without the lead time and expense of ex vivo or in vivo studies.
The library builds on the established Retrogenix® platform, which offers the industry's largest library of human proteins for screening. By confirming whether potential off-targets are conserved across species, the new non-human library enhances the interpretability of in vivo results and aids in selecting appropriate models for safety studies. This approach aligns with the 3Rs principles (Reduction, Refinement, Replacement) in animal research and supports Charles River's Alternative Methods Advancement Project (AMAP).
Charles River Laboratories International, Inc. (NYSE: CRL) has announced the schedule for its third-quarter 2024 earnings release and conference call. The company will release its financial results on Wednesday, November 6th, before the market opens. A conference call to discuss the results has been scheduled for the same day at 9:30 a.m. ET.
Investors can access a live webcast of the conference call through the Investor Relations section of the Company's website at ir.criver.com. For those unable to attend the live event, a replay of the webcast will be made available on the same website.
Charles River Laboratories International, Inc. (NYSE: CRL) announced its participation in Neuroscience 2024, the annual Society for Neuroscience meeting from October 5-9 in Chicago. The company's neuroscience experts will present 18 scientific posters, showcasing their commitment to advancing neuroscience research. Key presentations include studies on in vitro co-culture models for myelination and neuroinflammation using iPSC-derived cells.
Charles River's team will also discuss advancements in ALS research and their impact on drug discovery. The company's global team of nearly 200 neuroscientists has supported 80% of new neuroscience drugs approved by the FDA since 2018. Recent initiatives include collaborations with CEBINA, integration of Insightec's ultrasound platform, and the AI-powered Logica® drug discovery solution in partnership with Lundbeck.
Charles River Laboratories International, Inc. (NYSE: CRL) has announced an agreement with H. Lundbeck A/S to utilize Logica®, an AI-powered drug discovery solution, to advance research into neurological diseases. Logica® integrates Valo Health's AI-powered Opal Computational Platform™ with Charles River's expertise in drug discovery and preclinical development.
The collaboration aims to create optimized small molecules for novel therapies in neurological research. Lundbeck will deploy Logica® to work on unprecedented molecular targets with causal biology, potentially overcoming drug design challenges that often slow down the translation of promising targets into drug candidates.
This partnership combines Lundbeck's industry-leading neurology expertise with Charles River's agile approach, leveraging AI-augmented processes to progress critical brain disease research.
Charles River Laboratories (NYSE: CRL) and CEBINA GmbH have announced a strategic collaboration within the DanubeNeuro acceleration program. This initiative aims to identify and advance pioneering academic research projects in the field of neurodegeneration. The collaboration will leverage CEBINA's experience in acceleration programs and Charles River's expertise in drug discovery and development for central nervous system (CNS) disorders.
The partnership seeks to address the growing global challenge of age-related neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. DanubeNeuro will focus on creating innovative drugs, diagnostic methods, disease biomarkers, and imaging techniques. The program is supported by a dedicated fund, Danube BioVentures, and features a rolling application process.
Charles River Laboratories (NYSE: CRL) and Insightec have announced a five-year strategic collaboration to advance drug discovery and preclinical development in neuroscience using focused ultrasound (FUS) technology. The partnership aims to provide Charles River's clients access to a comprehensive global service and technology platform for FUS applications.
Insightec's low-frequency ultrasound platform non-invasively disrupts the blood-brain barrier, enabling targeted drug delivery to brain areas. This technology has shown positive clinical evidence in various neurological diseases, including Parkinson's, Alzheimer's, and oncology indications. The collaboration is designed to meet the increasing demand for advancing therapeutic development and delivery of genetic medicines, biologics, and immunotherapies in multiple Good Laboratory Practice (GLP) preclinical models in neuroscience.
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