Cellectis S.A. American Depositary Shares - CLLS STOCK NEWS

Cellectis has released its monthly share capital and voting rights information as of November 30, 2024. The company reported a total of 100,093,873 shares in the capital and 88,576,206 voting rights. This disclosure is made in accordance with Article 223-16 of the General Regulation of the French financial markets authority, with the company's shares listed on Euronext Growth under ISIN code FR0010425595.

Cellectis has reported its monthly share capital and voting rights information as of October 31, 2024. The company disclosed a total of 100,093,873 shares in the capital and 88,569,210 voting rights. This disclosure is made in compliance with Article 223-16 of the General Regulation of the French financial markets authority for its listing on Euronext Growth under ISIN code FR0010425595.

Cellectis announced pre-clinical data presentation at SITC's 39th Annual Meeting, showcasing strategies to enhance CAR T-cell efficacy against solid tumors. The research focuses on overcoming challenges in the tumor microenvironment (TME) using TALEN®-mediated gene editing to generate allogeneic CAR T-cells. The company developed two key approaches: a FAP-dependent expression system to limit cytotoxic activity to tumor areas, and integration of IL-12 into PD-1 regulatory elements while inactivating TGFBR2. These strategies showed enhanced T-cell proliferation and infiltration while reducing tumor burden and limiting side effects, potentially offering new therapeutic options for solid tumor patients.

Cellectis (CLLS) reported Q3 2024 business updates and financial results, highlighting ongoing enrollment in UCART22 and UCART20x22 clinical trials, with Phase 1 dataset expected in 2025. The company's cash position stands at $264 million as of September 30, 2024, projecting runway into 2027. Research and development activities have commenced on three programs under the AstraZeneca partnership. The company reported revenues of $34.1 million for the nine months ended September 30, 2024, compared to $7.2 million in the same period of 2023. Net loss was $42.7 million, an improvement from the $59.3 million loss in the previous year.

Cellectis (NASDAQ: CLLS), a clinical-stage biotechnology company focused on gene-editing and cell therapies, has announced it will release its third quarter 2024 financial results on November 4, 2024 after US market close. The company will host an investor conference call and webcast on November 5, 2024 at 8:00 AM ET / 2:00 PM CET to discuss the quarterly results and provide a business update.

Cellectis, a clinical-stage biotechnology company, will present pre-clinical data on TALE base editors (TALEB) and non-viral gene insertion at the European Society of Cell and Gene Therapy 31st annual congress in Roma, Italy, from October 22-25, 2024. Two posters will be showcased:

1. 'Controlling C-to-T editing with TALE base editors' by Alexandre Juillerat, Ph.D., on October 24. This study enhances understanding of TALEB and allows for the design of efficient and specific tools potentially compatible with therapeutic applications.

2. 'Circular Single-Stranded DNA Enables Efficient TALEN-Mediated Gene Insertion in Long Term HSC' by Julien Valton, Ph.D., also on October 24. This research demonstrates that circularizing ssDNA increases gene insertion rates in long-term HSCs and may enhance their engraftment capacity in preclinical murine models, advancing non-viral gene therapy.

Cellectis (CLLS) has released its monthly information on share capital and voting rights as of September 30, 2024. The company reported a total of 100,093,873 shares in the capital and 88,569,683 voting rights. This information is disclosed in compliance with Article 223-16 of the General Regulation of the French financial markets authority.

Cellectis is listed on the Euronext Growth market with the ISIN code FR0010425595. For additional information, investors and media can contact the company's designated representatives, including the Director of Communications and the Chief of Staff to the CEO. The Interim Chief Financial Officer is available for investor relations inquiries.

Cellectis (CLLS) has released its monthly update on share capital and voting rights as of August 31, 2024. The company reported a total of 100,093,635 shares in the capital and 88,029,440 voting rights. This information is disclosed in compliance with Article 223-16 of the General Regulation of the French financial markets authority. Cellectis is listed on the Euronext Growth market under the ISIN code FR0010425595.

For investors seeking further information, Cellectis has provided contact details for media and investor relations inquiries. This regular disclosure helps maintain transparency and keeps shareholders informed about the company's capital structure.

Cellectis, a clinical-stage biotechnology company, has published a scientific article in Science Advances showcasing promising pre-clinical results for treating triple-negative breast cancer (TNBC) using TALEN®-edited MUC1 CAR T-cells. The study demonstrates that multi-armored CAR T-cells, engineered with PD1KO, tumor-specific IL12 release, and TGFBR2KO attributes, showed enhanced cytotoxic activity against TNBC in mouse models.

Notably, intratumoral treatment effectively reduced both local and distant tumors using low doses of the engineered CAR T-cells, suggesting potential efficacy against metastasis. The research highlights the capabilities of multiplex editing in improving both efficacy and safety of CAR T-cell therapies for solid tumors, offering hope for advanced-stage TNBC patients with treatment options.