Can-Fite: Scientific Article Published by KOL Presents Namodenoson as a Promising Drug Candidate to Treat Advanced Liver Cancer and MASH
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Insights
The publication of a scientific article delineating the efficacy of Namodenoson for treating advanced liver cancer and MASH underscores the potential of this drug in addressing two serious health conditions with overlapping etiologies. Liver cancer, particularly hepatocellular carcinoma (HCC), is the sixth most common cancer worldwide and the third-leading cause of cancer death. Concurrently, metabolic dysfunction-associated steatohepatitis (MASH), is an emerging public health concern. The dual mechanism of action of Namodenoson, as highlighted, targets both the oncogenic and inflammatory pathways, which could represent a significant therapeutic advancement.
Investors may be intrigued by the FDA and EMA's nod to the Phase III trial as a gauge of regulatory confidence in the drug's profile. Phase III trials are critical in determining a drug's market viability and the transition from this stage to market approval can dramatically alter the valuation of a biotech firm. Considering the high unmet need in HCC and MASH, a positive outcome could lead to substantial revenue streams. However, potential setbacks include trial failures or delays, which could adversely affect investor sentiment. The involvement of a key opinion leader such as Dr. Ohad Etzion in the drug's development could lend credibility to the clinical process and potentially catalyze investor interest.
Namodenoson's reported ability to modulate inflammatory cytokines while stimulating beneficial ones indicates a strategic intervention in the tumor microenvironment. This could differentiate it from other treatments that solely focus on tumor cell cytotoxicity. The anti-cancer activity combined with liver protective effects in the context of advanced liver cancer exemplifies an integrative approach to managing a malignancy that often coincides with underlying liver pathologies such as cirrhosis or chronic hepatitis.
From a medical perspective, the scope of Namodenoson's impact is promising, but it's essential to remain cautiously optimistic until the Phase III results confirm efficacy and safety in a broader population. For healthcare providers, a successful new treatment option would be highly welcomed, but the long-term implications for patient management and treatment algorithm adjustments will require careful consideration. Furthermore, the cost-effectiveness of the drug, once approved, could dictate its adoption rate in various healthcare systems.
Advanced liver cancer and MASH represent markets with significant potential due to the high incidence and the lack of effective treatments. Namodenoson's progression through the clinical trial phases could disrupt these markets if the drug demonstrates a substantial benefit over existing therapies. The market impact could extend well beyond immediate revenue generation for Can-Fite BioPharma, as success might incentivize competitors to accelerate similar integrative therapeutic approaches.
Investors should monitor enrollment progress and interim data releases for the Phase III trial. Such data will provide insights into Namodenoson's efficacy and safety, potentially influencing stock performance ahead of final trial results. Market dynamics following the introduction of a successful drug could lead to increased merger and acquisition activities within the sector, as larger pharmaceutical companies may seek to capitalize on innovative treatments emerging from smaller biotech firms.
A pivotal Phase III trial for advanced liver cancer, approved by FDA & EMA and a MASH Phase IIb are enrolling patients
PETACH TIKVA,
Namodenoson mechanism of action (Graphic: Business Wire)
The article’s first author, Dr. Ohad Etzion, is a renowned key opinion leader (KOL) in the Hepatology field and is the engine for some of the novel drugs under development for the treatment of MASH and additional liver diseases. Dr. Etzion is the Head, Department of Gastroenterology and Liver Diseases, at Soroka University Medical Center,
The Biomedicines article presents the pre-clinical and clinical activity of Namodenoson and the mechanism of action through which the drug induces the anti-cancer activity and at the same time the liver protective effects. This dual activity enables the drug to have positive effects in both liver cancer and MASH.
Currently, Namodenoson is being evaluated in LiverationTM, a pivotal Phase III study for advanced liver cancer that has been approved by both the
“We are very much encouraged by the clinical data from the Phase II study in HCC and the Phase IIa study in MASH. The drug mechanism of action which is presented in the manuscript and entails inflammatory cytokine inhibition together with the stimulation of positive cytokines, position Namodenoson as a promising safe drug,” stated Dr. Etzion.
About Namodenoson
Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson was evaluated in Phase II trials for two indications, as a second line treatment for hepatocellular carcinoma, and as a treatment for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential effect accounts for the excellent safety profile of the drug.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion dollar markets in the treatment of cancer, liver, and inflammatory disease. The Company's lead drug candidate, Piclidenoson recently reported topline results in a Phase III trial for psoriasis and is expected to commence a pivotal Phase III. Can-Fite's cancer and liver drug, Namodenoson, is being evaluated in a Phase IIb trial for the treatment metabolic dysfunction-associated steatohepatitis (MASH), a Phase III pivotal trial for hepatocellular carcinoma (HCC), and the Company is planning a Phase IIa study in pancreatic cancer. Namodenoson has been granted Orphan Drug Designation in the
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View source version on businesswire.com: https://www.businesswire.com/news/home/20240415044511/en/
Can-Fite BioPharma
Motti Farbstein
info@canfite.com
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Source: Can-Fite BioPharma Ltd.
FAQ
What is the focus of the scientific article published by Biomedicines regarding Can-Fite's drug Namodenoson?
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What positive effects does Namodenoson exhibit according to Dr. Etzion?
