aTyr Pharma, Inc. - ATYR STOCK NEWS

aTyr Pharma (Nasdaq: ATYR) has appointed Eric Benevich to its Board of Directors, effective December 10, 2024. Benevich, who currently serves as Chief Commercial Officer at Neurocrine Biosciences, brings over 30 years of pharmaceutical industry experience. He has previously held positions at AstraZeneca, Amgen, Peninsula Pharmaceuticals, and Avanir Pharmaceuticals, where he was involved in the sales and marketing of notable drugs including Prilosec®, Epogen®, Enbrel®, and Neudexta®.

aTyr is a clinical-stage biotechnology company focused on developing first-in-class medicines from its tRNA synthetase platform. Their lead candidate, efzofitimod, is being developed for the treatment of interstitial lung disease.

aTyr Pharma announced positive results from the third pre-planned interim safety analysis of its Phase 3 EFZO-FIT™ study for efzofitimod in pulmonary sarcoidosis patients. The independent Data and Safety Monitoring Board (DSMB) reviewed data from all 268 enrolled patients and recommended continuing the study without modifications.

The EFZO-FIT™ study is a global Phase 3 randomized, double-blind, placebo-controlled trial evaluating efzofitimod's efficacy and safety. The 52-week study includes three parallel cohorts randomized to receive either 3.0 mg/kg, 5.0 mg/kg of efzofitimod, or placebo monthly for 12 doses. The trial's primary endpoint is steroid reduction, with secondary endpoints measuring lung function and sarcoidosis symptoms.

aTyr Pharma announced the presentation of two posters about their tRNA synthetase candidate ATYR0101 at the Keystone Symposia on Fibrosis. The research demonstrates that ATYR0101, a fusion protein derived from aspartyl-tRNA synthetase, binds to LTBP-1 to induce myofibroblast apoptosis, showing significant anti-fibrotic effects in lung and kidney fibrosis models.

The preclinical studies revealed that ATYR0101 reduced key fibrosis measures, including Ashcroft score and collagen content in the bleomycin model of lung fibrosis and the ureteral obstruction model of kidney fibrosis. The compound's mechanism of action differs from current standard treatments, suggesting potential as a novel therapeutic approach for advanced fibrotic conditions.

aTyr Pharma (Nasdaq: ATYR) announced it will present two posters about its tRNA synthetase candidate ATYR0101 at the Keystone Symposia on Fibrosis in Whistler, British Columbia, from December 8-11, 2024. The first poster explores how a newly evolved domain of Asp-tRNA Synthetase interacts with LTBP-1 to induce myofibroblast apoptosis. The second poster discusses anti-fibrotic activity observed in preclinical models of pulmonary and renal fibrosis. Both presentations are scheduled for Monday, December 9, 2024, at 7:30 p.m. PST during Poster Session #1.

aTyr Pharma announced completion of enrollment in its Phase 3 EFZO-FIT™ study for efzofitimod in pulmonary sarcoidosis, with topline data expected in Q3 2025. The study enrolled 268 patients across 85 centers in nine countries. A publication in the European Respiratory Journal showed significant improvements in corticosteroid relapse rates. The company reported $68.9 million in cash and investments as of September 30, 2024, and raised an additional $19.4 million through ATM offering. R&D expenses were $14.8 million and G&A expenses were $3.3 million for Q3 2024.

aTyr Pharma (Nasdaq: ATYR) has announced its participation in four major investor conferences during November and December 2024. The company will present at the Stifel Healthcare Conference (Nov 18), Jefferies London Healthcare Conference (Nov 20), Evercore HealthCONx Conference (Dec 3), and Piper Sandler Healthcare Conference (Dec 5). The presentations will include corporate presentations and fireside chats across locations in New York, London, and Coral Gables.

Management will be available for one-on-one meetings with registered attendees. Webcasts of the presentations will be accessible on the company's website and remain available for at least 90 days. aTyr is developing first-in-class medicines from its tRNA synthetase platform, with efzofitimod as its lead candidate for treating interstitial lung disease.

aTyr Pharma, a clinical stage biotech company developing medicines from its tRNA synthetase platform, has announced its participation in the 17th Annual LD Micro Main Event. The event is scheduled for October 28-30, 2024, in Los Angeles, CA.

Dr. Sanjay S. Shukla, President and CEO of aTyr Pharma, will present a corporate overview on Tuesday, October 29, 2024, at 9:00am PDT at the Luxe Sunset Boulevard Hotel. The three-day event will feature approximately 150 companies presenting in half-hour increments and attending private meetings with investors.

Interested parties can view aTyr's presentation online and request meetings with management by contacting registration@ldmicro.com. This event provides an opportunity for aTyr Pharma to showcase its progress in developing first-in-class medicines to potential investors and industry professionals.

aTyr Pharma announced that its lead therapeutic candidate, efzofitimod, will be featured in the Best of CHEST Journals session at the CHEST 2024 Annual Meeting in Boston, MA. The presentation, titled 'Efzofitimod for the Treatment of Pulmonary Sarcoidosis,' will be given by Dr. Daniel A. Culver on October 8, 2024. It will review data from a Phase 1b/2a study showing efzofitimod's ability to reduce steroid use while controlling symptoms in pulmonary sarcoidosis patients.

Efzofitimod is currently being investigated in the global Phase 3 EFZO-FIT™ study with 268 pulmonary sarcoidosis patients. Topline data is expected in Q3 2025. The drug is a first-in-class biologic immunomodulator designed to treat interstitial lung disease by modulating activated myeloid cells to resolve inflammation without immune suppression.

aTyr Pharma (Nasdaq: ATYR) announced the publication of a post hoc analysis of their Phase 1b/2a clinical trial for efzofitimod in pulmonary sarcoidosis patients in the European Respiratory Journal. The analysis showed a statistically significant difference in time-to-first-relapse for corticosteroid use between therapeutic (3.0 and 5.0 mg/kg efzofitimod) and subtherapeutic (1.0 mg/kg efzofitimod and placebo) groups.

Key findings include:

• 54.4% of patients in the subtherapeutic group relapsed following corticosteroid taper, compared to only 7.7% in the therapeutic group
• Median time-to-first-relapse in the subtherapeutic group was 126 days, while only one of 17 patients in the therapeutic group relapsed by the end of the study (p=0.017)

Efzofitimod is currently being investigated in the global pivotal Phase 3 EFZO-FIT™ study in 268 pulmonary sarcoidosis patients.