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Aptose Biosciences, Inc. (NASDAQ: APTO, TSX: APS) is a clinical-stage biotechnology company dedicated to developing precision medicines for the treatment of life-threatening cancers. This science-driven organization is focused on advancing first-in-class agents targeting acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS), and other hematologic malignancies. Based on a deep understanding of the genetic and epigenetic profiles of specific cancers and patient demographics, Aptose is building a robust pipeline of novel oncology therapies aimed at dysregulated processes and signaling pathways.
One of Aptose's pioneering agents, tuspetinib (TUS), is a highly potent, first-in-class pan-FLT3/BTK inhibitor. Developed as a small molecule therapeutic, tuspetinib targets various key kinases such as SYK, FLT3, JAK1/2, and mutant forms of KIT, RSK2, and TAK1-TAB1. This mechanism of action not only combats the proliferation of AML cells but also minimizes the typical cytotoxic side effects associated with conventional cancer treatments, thus enhancing the quality of life for patients.
Tuspetinib has shown significant promise in ongoing clinical trials. In the APTIVATE Phase 1/2 study, tuspetinib, both as a monotherapy and in combination with venetoclax (VEN), has demonstrated favorable safety profiles and robust efficacy in relapsed/refractory AML patients. This includes patients with various genetic mutations and those who have failed prior therapies. Notably, tuspetinib has demonstrated a 48% overall response rate when used in combination with venetoclax, making it a potential candidate for accelerated approval in difficult-to-treat VEN-resistant AML cases.
Aptose is also developing luxeptinib (CG-806), an oral, dual lymphoid and myeloid kinase inhibitor currently in Phase 1 a/b development. Luxeptinib targets relapsed or refractory hematologic malignancies and is being positioned for future clinical trials using its new generation 3 (G3) formulation, which has shown improved pharmacokinetics and tolerability.
Recently, Aptose has entered strategic financial transactions, including a public offering and private placement, to support the further development of tuspetinib and general corporate activities. With strong clinical data and robust financial backing, Aptose continues to make strides in the oncology field, aiming to bring life-saving treatments to patients in need.
Aptose Biosciences (Nasdaq: APTO; TSX: APS) will report its financial results for the quarter ended March 31, 2022, on May 9, 2022, after market close. The company, focused on precision oncology, is developing oral kinase inhibitors for hematologic malignancies, including HM43239 and luxeptinib, which are currently in clinical trials. A conference call is scheduled for the same day at 5:00 PM ET, accessible via toll-free numbers or webcast. Financial statements and management discussions will be available on SEDAR and EDGAR.
Aptose Biosciences has appointed Philippe Ledru as the new Chief Commercial Officer, effective immediately. Ledru brings over 30 years of pharmaceutical experience, with prior roles at Merck and Novartis, focusing on oncology product development. His expertise will support the commercialization of Aptose's lead drug, HM43239, aimed at treating acute myeloid leukemia. Concurrently, CFO Jotin Marango has resigned to pursue another opportunity, and CEO William G. Rice will temporarily handle the financial responsibilities until a new CFO is appointed.
Aptose Biosciences (NASDAQ: APTO) announced its participation in Canaccord Genuity’s 2022 Horizons in Oncology Virtual Conference. William G. Rice, Ph.D., Chairman and CEO, will discuss innovative treatments for acute myeloid leukemia (AML) on April 14, 2022, from 1:30 to 2:30 PM ET. The event, moderated by John Newman, will feature a panel titled 'Attacking AML: New Approaches.' The audio webcast can be accessed via Aptose's website. The company focuses on developing precision therapies for hematologic malignancies, with ongoing Phase 1 trials for its investigational products.
Aptose Biosciences reported a net loss of $24.3 million for Q4 2021 and $65.4 million for the year, both increased compared to 2020. The company announced successful clinical results for HM43239, an oral kinase inhibitor, with expanding treatable acute myeloid leukemia (AML) populations following new complete remissions at the 120mg dose. Cash reserves stand at $79.1 million, supporting operations through Q4 2023. The company is advancing HM43239 into broader clinical trials in 2H2022. A conference call is scheduled for today to discuss these results and updates.
Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS) announced it will release financial results for the year and quarter ended December 31, 2021, on March 22, 2022, post-market close. The report will include a corporate update. A conference call is scheduled for the same day at 5:00 PM ET, accessible via dial-in and webcast. Key products in Aptose's pipeline include two oral kinase inhibitors aimed at treating hematologic malignancies, currently undergoing various clinical trials.
Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS) announced its participation in Oppenheimer’s 32nd Annual Healthcare Conference on March 15, 2022. William G. Rice, Ph.D., Chairman, President, and CEO, will present and host one-on-one meetings during the event. The virtual presentation is scheduled from 10:00 to 10:30 ET. Interested parties can access the webcast through Aptose's website or directly via a provided link. Aptose specializes in developing personalized oncology therapies, currently focusing on treatments for hematologic malignancies, including two investigational products in clinical trials.
Aptose Biosciences Inc. (NASDAQ: APTO, TSX: APS) will participate in two key biotech events in January 2022: the H.C. Wainwright BIOCONNECT Virtual Conference (January 10-13) and the 11th Annual LifeSci Partners Corporate Access Event (January 5-7). The management team will host investor meetings at both events. Aptose focuses on developing innovative cancer therapies, with products like HM43239 and luxeptinib aimed at treating hematologic malignancies. For more details, visit www.aptose.com.
Aptose Biosciences Inc. (NASDAQ: APTO) announced the discontinuation of clinical development for APTO-253, following an internal review and a clinical hold from the FDA. The focus will shift to advancing their kinome inhibitor pipeline, specifically HM43239 and luxeptinib, which have shown promising clinical activity in hematologic malignancies. The company is exploring strategic alternatives for APTO-253. This decision underlines Aptose's commitment to addressing unmet medical needs in oncology.
Aptose Biosciences has reported promising results for its oral myeloid kinome inhibitor HM43239, presented at the 2021 ASH Annual Meeting. The drug showed durable activity in patients with relapsed or refractory acute myeloid leukemia (AML). Key highlights include a 37.5% complete response rate among FLT3 mutant patients at the 80 mg dose. The Phase 1/2 trial enrolled 34 patients, showing a favorable safety profile. Additionally, data for luxeptinib and APTO-253 were shared, showcasing their potential in treating hematologic malignancies. Aptose aims to expand its clinical portfolio significantly.
Aptose Biosciences Inc. (NASDAQ: APTO) provided an update on its clinical developments on November 29, 2021, ahead of its corporate presentation on December 13, 2021. The presentation will highlight data from the oral Phase 1/2 trial of HM43239, an oral myeloid kinome inhibitor targeting relapsed or refractory acute myeloid leukemia (AML). Additionally, the status of luxeptinib, a dual lymphoid and myeloid kinome inhibitor, will be discussed. Both compounds are part of Aptose's continued commitment to advancing therapies for unmet needs in oncology.
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