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Aptose Biosciences, Inc. (NASDAQ: APTO, TSX: APS) is a clinical-stage biotechnology company dedicated to developing precision medicines for the treatment of life-threatening cancers. This science-driven organization is focused on advancing first-in-class agents targeting acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS), and other hematologic malignancies. Based on a deep understanding of the genetic and epigenetic profiles of specific cancers and patient demographics, Aptose is building a robust pipeline of novel oncology therapies aimed at dysregulated processes and signaling pathways.
One of Aptose's pioneering agents, tuspetinib (TUS), is a highly potent, first-in-class pan-FLT3/BTK inhibitor. Developed as a small molecule therapeutic, tuspetinib targets various key kinases such as SYK, FLT3, JAK1/2, and mutant forms of KIT, RSK2, and TAK1-TAB1. This mechanism of action not only combats the proliferation of AML cells but also minimizes the typical cytotoxic side effects associated with conventional cancer treatments, thus enhancing the quality of life for patients.
Tuspetinib has shown significant promise in ongoing clinical trials. In the APTIVATE Phase 1/2 study, tuspetinib, both as a monotherapy and in combination with venetoclax (VEN), has demonstrated favorable safety profiles and robust efficacy in relapsed/refractory AML patients. This includes patients with various genetic mutations and those who have failed prior therapies. Notably, tuspetinib has demonstrated a 48% overall response rate when used in combination with venetoclax, making it a potential candidate for accelerated approval in difficult-to-treat VEN-resistant AML cases.
Aptose is also developing luxeptinib (CG-806), an oral, dual lymphoid and myeloid kinase inhibitor currently in Phase 1 a/b development. Luxeptinib targets relapsed or refractory hematologic malignancies and is being positioned for future clinical trials using its new generation 3 (G3) formulation, which has shown improved pharmacokinetics and tolerability.
Recently, Aptose has entered strategic financial transactions, including a public offering and private placement, to support the further development of tuspetinib and general corporate activities. With strong clinical data and robust financial backing, Aptose continues to make strides in the oncology field, aiming to bring life-saving treatments to patients in need.
Aptose Biosciences (Nasdaq: APTO; TSX: APS) announced its participation in the virtual Piper Sandler 33rd Annual Healthcare Conference, scheduled from November 23 to December 2, 2021. The company will present a pre-recorded fireside chat, which will be accessible on the conference website and through Aptose's official site. Additionally, management will engage in 1-on-1 investor meetings during the event. Aptose focuses on personalized oncology therapies, with a pipeline that includes three clinical-stage products targeting hematologic malignancies.
Aptose Biosciences reported a net loss of $11.3 million for Q3 2021, a decrease from $13.2 million in Q3 2020. Total cash as of September 30, 2021, was $95.1 million, projected to fund operations into early 2023. The company advanced its pipeline with HM43239, a myeloid kinome inhibitor, and increased the dose of Luxeptinib in ongoing clinical trials. Significant reductions in general and administrative expenses were observed. Aptose plans a conference call at 5 PM ET today to discuss these results.
Aptose Biosciences (NASDAQ: APTO) announced the acceptance of clinical data for its myeloid kinome inhibitor HM43239 for oral presentation at the 63rd ASH Annual Meeting in December 2021.
Additionally, data for Luxeptinib and APTO-253 have been accepted for poster presentations. The oral presentation is scheduled for December 13, 2021, while poster presentations will occur on December 11 and 13.
The presentations will feature new data and an investor event will provide further details.
Aptose Biosciences (Nasdaq: APTO) has secured an exclusive license for HM43239 from Hanmi Pharmaceutical, aimed at treating acute myeloid leukemia (AML). This highly potent oral myeloid kinome inhibitor has shown promising results, achieving multiple complete responses in ongoing clinical trials. The agreement includes a $12.5 million upfront payment, comprised of cash and shares, with potential milestone payments totaling $407.5 million. The CEO of Aptose expressed strong confidence in HM43239's commercial viability and strategic alignment with their focus on hematologic malignancies.
Aptose Biosciences Inc. (Nasdaq: APTO) will report its financial results for the quarter ended September 30, 2021, and provide a corporate update on November 11, 2021. The company is focused on developing personalized cancer therapies, particularly in hematology. Key investigational products include luxeptinib, a first-in-class kinase inhibitor for B cell malignancies and acute myeloid leukemia, and APTO-253, which targets the MYC oncogene. The conference call will occur at 5:00 PM ET, accessible via a toll-free number or online webcast.
Aptose Biosciences has appointed Janet Clennett as Vice President of Finance and Roger Davies as Vice President of Operations. Clennett, a CPA with over 15 years of experience in finance at biotech firms, has been with Aptose since 2017. Davies brings 25 years of senior project management experience, particularly in oncology. These additions aim to strengthen Aptose's financial and operational capabilities as the company pursues growth and clinical expansion in its oncology pipeline, which includes investigational products for hematologic malignancies.
Aptose Biosciences, a clinical-stage biotech firm (Nasdaq: APTO), is set to present at two upcoming virtual conferences in September 2021. The first, the H.C. Wainwright 23rd Annual Global Investment Conference, will take place on September 13 starting at 7:00 AM EDT, with a dedicated webcast. The second, the Cantor Global Healthcare Conference, is on September 28 at 11:20 AM EDT, also featuring a webcast. These events showcase Aptose's commitment to developing cancer therapies.
Aptose Biosciences reported a net loss of $13.5 million for Q2 2021, down from $15.8 million in Q2 2020. For the six-month period, the net loss rose to $29.7 million compared to $27.3 million in 2020. Total cash and equivalents stood at $103.3 million, sufficient to fund operations into H1 2023. Key highlights include full enrollment in the Luxeptinib Phase 1a/b studies for AML and B-cell malignancies, and continued dose escalation for APTO-253 in AML/MDS. The announcement was made on August 3, 2021, ahead of a conference call scheduled for the same day.
Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS) will release its financial results for Q2 2021 on August 3, 2021, after market close. The company is focused on developing innovative cancer therapies, with two clinical-stage products targeting hematologic malignancies: luxeptinib and APTO-253. A conference call to discuss the results will be held on the same day at 5:00 PM ET, accessible via phone or webcast. Financial statements will be available on SEDAR and EDGAR.
Aptose Biosciences presented an update on its oncology pipeline on June 11, 2021, during the EHA2021 Virtual Congress. The focus was on luxeptinib, an oral FLT3 and BTK inhibitor undergoing Phase 1a/b trials for relapsed acute myeloid leukemia (AML) and B-cell malignancies. Positive results include durable MRD-negative complete response in AML and anti-tumor activity in B-cell malignancies. The company is also developing APTO-253, a MYC inhibitor, which is in Phase 1a/b trials for AML and high-risk myelodysplastic syndrome (MDS). Future updates are expected as trials progress.
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