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Aptose Biosciences, Inc. (NASDAQ: APTO, TSX: APS) is a clinical-stage biotechnology company dedicated to developing precision medicines for the treatment of life-threatening cancers. This science-driven organization is focused on advancing first-in-class agents targeting acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS), and other hematologic malignancies. Based on a deep understanding of the genetic and epigenetic profiles of specific cancers and patient demographics, Aptose is building a robust pipeline of novel oncology therapies aimed at dysregulated processes and signaling pathways.
One of Aptose's pioneering agents, tuspetinib (TUS), is a highly potent, first-in-class pan-FLT3/BTK inhibitor. Developed as a small molecule therapeutic, tuspetinib targets various key kinases such as SYK, FLT3, JAK1/2, and mutant forms of KIT, RSK2, and TAK1-TAB1. This mechanism of action not only combats the proliferation of AML cells but also minimizes the typical cytotoxic side effects associated with conventional cancer treatments, thus enhancing the quality of life for patients.
Tuspetinib has shown significant promise in ongoing clinical trials. In the APTIVATE Phase 1/2 study, tuspetinib, both as a monotherapy and in combination with venetoclax (VEN), has demonstrated favorable safety profiles and robust efficacy in relapsed/refractory AML patients. This includes patients with various genetic mutations and those who have failed prior therapies. Notably, tuspetinib has demonstrated a 48% overall response rate when used in combination with venetoclax, making it a potential candidate for accelerated approval in difficult-to-treat VEN-resistant AML cases.
Aptose is also developing luxeptinib (CG-806), an oral, dual lymphoid and myeloid kinase inhibitor currently in Phase 1 a/b development. Luxeptinib targets relapsed or refractory hematologic malignancies and is being positioned for future clinical trials using its new generation 3 (G3) formulation, which has shown improved pharmacokinetics and tolerability.
Recently, Aptose has entered strategic financial transactions, including a public offering and private placement, to support the further development of tuspetinib and general corporate activities. With strong clinical data and robust financial backing, Aptose continues to make strides in the oncology field, aiming to bring life-saving treatments to patients in need.
Aptose Biosciences Inc. has appointed Dr. Bernd R. Seizinger to its Board of Directors. With over 25 years of experience in biotechnology and pharmaceuticals, including senior positions at Bristol-Myers Squibb, Dr. Seizinger strengthens Aptose's leadership. The board now consists of seven members with diverse expertise. Dr. Seizinger expressed excitement to contribute to Aptose's advancement in developing oral hematology drugs, which include HM43239 and luxeptinib, currently in clinical trials.
Aptose Biosciences Inc. (NASDAQ: APTO) announced a significant advancement in its G3 formulation of luxeptinib, which shows an 18-fold improvement in oral bioavailability compared to the previous G1 formulation. This enhancement supports Aptose's plans for continuous dosing trials in relapsed/refractory acute myeloid leukemia (AML) patients. The original G1 formulation led to limited effectiveness, whereas the new G3 formulation aims to provide better absorption and clinical outcomes. Aptose's lead compound, HM43239, continues to progress through clinical trials.
Aptose Biosciences announced participation in the H.C. Wainwright 24th Annual Global Investment Conference in New York City from September 12-14, 2022. Dr. William G. Rice, Chairman and CEO, will present on September 13 at 11:30 a.m. ET. Additionally, one-on-one meetings with management will be available. Aptose focuses on developing oral kinase inhibitors for hematologic malignancies, with two key investigational drugs in clinical trials. For more details, visit www.aptose.com.
Aptose Biosciences Inc. (NASDAQ: APTO) reported a net loss of $10.6 million for Q2 2022, down from $13.5 million in Q2 2021. Total cash and equivalents reached $62.4 million, sufficient to fund operations through Q1 2024. The company highlighted a promising 43% response rate for HM43239 in relapsed/refractory AML patients with FLT3 mutations, despite the challenges of achieving complete remissions. Aptose is also advancing its dual inhibitor, Luxeptinib, and aims for accelerated approval in high-need AML subpopulations.
Aptose Biosciences Inc. (NASDAQ: APTO) announced that Dr. William G. Rice and CFO Mr. Fletcher Payne will attend the Canaccord Genuity 42nd Annual Growth Conference on August 10, 2022, at 3:30 p.m. ET. Dr. Rice will present at the conference, and the management team will also hold one-on-one meetings. Aptose is focused on developing innovative oral kinase inhibitors for treating hematologic malignancies, with investigational products HM43239 and luxeptinib in clinical trials for conditions such as acute myeloid leukemia and B-cell malignancies.
Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS) announced it will release its Q2 2022 financial results on August 2, 2022, after market close, alongside a corporate update. A conference call is scheduled for the same day at 5:00 PM ET. Participants must preregister for dial-in details. The company focuses on developing oral kinase inhibitors for hematologic malignancies, currently advancing two candidates in clinical trials. More details will be available on SEDAR and EDGAR.
Aptose Biosciences has appointed Fletcher Payne as the new Senior Vice President and Chief Financial Officer (CFO). With over two decades of finance experience in the biotech sector, Payne previously held CFO roles at notable companies including Syapse and Catalyst Bioscience. His expertise will be pivotal as Aptose advances its clinical-stage products, HM43239 and luxeptinib, which target hematologic malignancies. Aptose aims to leverage his strategic insights to enhance its financial operations and strengthen its executive management team.
Aptose Biosciences (NASDAQ: APTO) announced significant developments during a recent KOL update event on June 2, 2022. Findings from clinical trials of HM43239, a promising oral myeloid kinome inhibitor, showed eight responses, including seven complete remissions (CRs) at three dose levels (80 mg, 120 mg, 160 mg). Additionally, the G3 formulation of luxeptinib displayed favorable pharmacokinetics, indicating improved absorption. Expansion trials for HM43239 and luxeptinib are set to commence in 2022 and 2023, respectively. These advancements enhance Aptose's potential in treating acute myeloid leukemia (AML).
Aptose Biosciences announced significant updates at a recent event, highlighting clinical data for two investigational products: HM43239 for AML and luxeptinib. HM43239 demonstrated new complete remission (CRi) at 160 mg in AML patients with wildtype FLT3. The drug has shown up to eight complete remissions across various doses. The G3 formulation of luxeptinib also showed promising pharmacokinetics, with rapid absorption and sustained exposure. Expansion trials for both drugs are expected to begin in late 2022 and 2023, respectively.
Aptose Biosciences Inc. (NASDAQ: APTO), a clinical-stage oncology company, held its annual and special meeting of shareholders on May 31, 2022. During the meeting, 53.46% of common shares were represented. All nominees from the April 19, 2022 proxy statement were elected as Directors, with votes for nominees ranging from 93.22% to 97.99%. Shareholders also approved the re-appointment of KPMG LLP as the public accounting firm, an amendment to the 2021 Stock Incentive Plan allowing an increase of 3 million shares, and a resolution on executive compensation.
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