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Annovis Bio, Inc. (NYSE: ANVS) is a clinical-stage pharmaceutical company dedicated to developing novel therapies for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). Headquartered in Malvern, Pennsylvania, Annovis is pioneering innovative approaches to combat neurodegeneration by targeting multiple neurotoxic proteins simultaneously. The company’s lead compound, Buntanetap (formerly Posiphen or ANVS401), is designed to inhibit the formation of amyloid beta, tau, alpha-synuclein, and TDP43, aiming to improve synaptic transmission and axonal transport while reducing neuroinflammation.
Annovis Bio’s flagship product, Buntanetap, is in phase II/III clinical trials for the treatment of mild to moderate AD and early PD. The drug has shown promising results, demonstrating significant improvements in cognitive function and reducing neurotoxic biomarkers in patients. Alongside Buntanetap, the company is advancing ANVS405 for acute neurodegeneration post-traumatic brain injury and stroke, and ANVS301, currently in phase I trials, aimed at enhancing cognitive capabilities in advanced AD and dementia.
Founded in 2008 by Dr. Maria Maccecchini, Ph.D., Annovis Bio continues to focus on restoring brain function to alleviate symptoms and improve the quality of life for individuals affected by neurodegenerative diseases. The company has established itself as a leader in the field through partnerships, rigorous scientific research, and a commitment to transparency with all stakeholders.
Recent achievements include the completion of a Phase II/III study of Buntanetap in Alzheimer’s patients, demonstrating a statistically significant improvement in cognition and a favorable safety profile. Additionally, Annovis has filed a patent application for the use of Buntanetap in treating neuropsychiatric conditions such as autism and bipolar disorder, highlighting the drug’s versatile potential.
A financial overview reveals that Annovis ended the first quarter of 2024 with $3.1 million in cash, ensuring operational sustainability into the fourth quarter through strategic financial management. The company has actively engaged with the scientific and investment communities, participating in notable conferences like the International Conference on Alzheimer’s and Parkinson’s Diseases and hosting investor calls to discuss clinical milestones and future plans.
For more information about Annovis Bio, visit their website and follow them on LinkedIn and X (formerly Twitter).
On October 15, 2020, Annovis Bio Inc. (ANVS) reported significant advancements in its business operations for Q3 2020. The company announced the initiation of a Phase 2a clinical study for its lead compound, ANVS401, targeting Alzheimer’s and Parkinson’s diseases, with preliminary data expected in early 2021. Annovis Bio also restarted a previously halted Alzheimer's study, completed a chronic toxicology study with favorable safety results, and published three scientific papers corroborating its findings. Additionally, the company secured two patents and filed five more related to treatments for neurodegenerative diseases.
On October 12, 2020, Annovis Bio (NYSE American: ANVS) announced that its CEO, Maria Maccecchini, will present at the 2020 BIO Investor Forum, taking place October 13-15, 2020, in a digital format. The presentation will be available on demand for registered attendees. Annovis Bio focuses on developing treatments for Alzheimer’s disease (AD), Parkinson’s disease (PD), and Alzheimer’s in Down Syndrome (AD-DS), targeting neurotoxic proteins to enhance nerve cell function. For further information, visit www.annovisbio.com.
On September 3, 2020, Annovis Bio Inc. (NYSE American: ANVS) announced a televised interview with CEO Maria Maccecchini, airing on The RedChip Money Report on September 6 at 6 p.m. local time. The interview will discuss the Company's innovative approach to treating neurodegenerative diseases, including ongoing Phase 2a studies in Alzheimer’s and Parkinson’s diseases. Additionally, viewers can catch the program in the U.S. on the Action Channel. Annovis focuses on multi-target solutions for neurodegeneration, aiming to improve conditions like memory loss associated with Alzheimer's.
On September 1, 2020, Annovis Bio Inc. (ANVS) announced the dosing of the first three patients in its Phase 2a clinical trial for Alzheimer’s disease (AD) and Parkinson’s disease (PD). The trial, which has IRB approval, will enroll a total of 28 patients over four weeks, focusing on the drug ANVS401's ability to reverse toxic nerve cell death. Initial data is expected in early 2021, followed by a larger dose-response trial. This is a significant milestone for the company, which aims to offer a novel treatment for these neurodegenerative diseases.
Annovis Bio Inc. (NYSE American:ANVS) announced its participation in the LD 500 investor conference on September 1, 2020, at 9:20 AM EDT. CEO Maria Maccecchini will present the company’s innovative approach to treating Alzheimer’s, Parkinson’s, and other neurodegenerative diseases. The company is currently conducting two Phase 2 trials focused on these conditions. The LD 500, running from September 1-4, will be virtual, making it accessible to all interested parties. For more information, visit annovisbio.com.
Annovis Bio Inc. (NYSE American: ANVS) has resumed patient recruitment for its suspended Phase 2a clinical trial targeting Alzheimer’s disease (AD) and initiated a new Phase 2a trial for both AD and Parkinson’s disease (PD). The first trial involves 24 patients and is in collaboration with major institutions. Initial data is expected in early 2021. The second trial will also enroll patients across 15 US sites, with results anticipated in summer 2021. The company plans to report final data from long-term toxicology studies by fall 2020 to confirm the safety of its lead compound, ANVS401.
On July 23, 2020, Annovis Bio (NYSE American: ANVS) announced that CEO Maria Maccecchini will appear on Executive Leaders Radio on July 26, 2020. The show focuses on interviews with prominent CEOs, particularly within life sciences, discussing professional success and personal stories. Dr. Maccecchini expressed her enthusiasm for sharing the Annovis story and her personal commitment to neurodegeneration solutions. Annovis Bio, based in Berwyn, PA, is focused on developing drugs for Alzheimer’s and Parkinson’s diseases, with ongoing Phase 2a studies targeting these conditions.
Annovis Bio (NYSE American: ANVS) announces that CEO Maria Maccecchini, Ph.D., will present at the University of Pennsylvania on July 20, 2020. Her talk, titled “Rethinking Parkinson’s Disease”, addresses a novel treatment approach for Parkinson's disease at the Parkinson’s Disease and Movement Disorders Center, recognized as a global Center of Excellence.
Maccecchini will discuss the toxic cascade caused by neurotoxic proteins in neurodegenerative diseases, presenting data from clinical trials using ANVS401, Annovis Bio's lead compound.
Annovis Bio (ANVS) has received Central IRB approval to initiate a Phase 2 clinical study targeting early Parkinson's disease (PD) and Alzheimer's disease (AD) patients. The study will involve 68 patients over four weeks, assessing the lead compound, ANVS401, for its effects on nerve cell death and cognitive functions. The trial aims to understand safety, tolerability, and the potential reversal of toxic cascades affecting nerve cells. CEO Maria Maccecchini expressed optimism about staying on schedule to complete the study by Q1 2021, despite initial delays related to COVID-19.
Annovis Bio Inc. (NYSE American: ANVS) announced the successful completion of a chronic toxicology study for its lead compound, ANVS401, with no adverse side effects reported in rats. Funded by a $1.7 million NIH grant, this six-month study corroborates previous positive results from shorter studies. CEO Maria Maccecchini highlighted this milestone as critical for advancing long-term human studies. Ongoing safety studies on dogs are anticipated to yield results in Q3 2020, supporting Annovis's ongoing clinical trials for Alzheimer's and Parkinson's diseases.
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