Welcome to our dedicated page for Aligos Therapeutics news (Ticker: ALGS), a resource for investors and traders seeking the latest updates and insights on Aligos Therapeutics stock.
Company Overview
Aligos Therapeutics, Inc. (NASDAQ: ALGS) is a clinical-stage biopharmaceutical company dedicated to developing novel therapeutics to address significant unmet medical needs in liver and viral diseases. Founded in 2018 and headquartered in South San Francisco, California, the company leverages decades of drug development expertise and a science‐driven approach to design therapies for conditions such as chronic hepatitis B (CHB) and metabolic dysfunction-associated steatohepatitis (MASH). The pipeline includes a range of investigational agents such as oral capsid assembly modulators, thyroid hormone receptor beta (THR-β) agonists, siRNA candidates, and other modalities that target multiple aspects of disease pathways.
Core Business and Therapeutic Focus
Aligos Therapeutics focuses on two primary disease areas:
- Viral Diseases (Chronic Hepatitis B): Utilizing innovative small molecule capsid assembly modulators, the company aims to disrupt the hepatitis B viral lifecycle by reducing key viral markers including HBV DNA, RNA, HBsAg, HBeAg, and HBcrAg. This approach is designed to not only provide chronic viral suppression but also to serve as the backbone for combination regimens aimed at achieving a functional cure.
- Liver Diseases (MASH): The company is developing a best-in-class THR-β agonist designed to address metabolic dysfunction-associated steatohepatitis. By reducing liver fat and affecting key non-invasive biomarkers, this candidate has demonstrated robust reductions in liver fat content as measured by MRI-PDFF, with potential implications in improving histological outcomes and mitigating fibrosis.
Aligos supports its innovative pipeline with a strong commitment to rigorous clinical trials and strategic partnerships. Its agents are under evaluation in multiple phases of clinical studies, with study designs that emphasize safety, pharmacokinetics, tolerability, and efficacy across different patient populations.
Pipeline and Scientific Rationale
The company’s pipeline showcases several advanced drug candidates:
- ALG-000184: A potent oral small molecule capsid assembly modulator (CAM-E) intended for CHB patients. It targets the hepatitis B virus lifecycle by interfering with the formation and function of covalently closed circular DNA (cccDNA), thereby reducing viral replication and antigen expression. Preclinical and early clinical data indicate strong antiviral activity and sustained viral suppression in both HBeAg-positive and HBeAg-negative subjects.
- ALG-010133, ALG-020572, and ALG-125097: Additional oligonucleotide-based drug candidates in the CHB portfolio that further underline the company’s multifaceted approach to viral inhibition through complementary mechanisms of action.
- ALG-055009: A THR-β agonist candidate aiming to treat MASH. Clinical studies have demonstrated its potential in reducing liver fat significantly and modulating lipid profiles, suggesting benefits for patients with metabolic dysfunction-associated liver disease. Its favorable pharmacokinetic profile and tolerability promise an improved treatment paradigm for patients requiring long-term therapy.
Strategic Collaborations and Clinical Development
Aligos Therapeutics has established multiple collaborations and trial partnerships to advance its clinical programs globally. The company collaborates with research institutions and partnering biotechs to sponsor and conduct pivotal clinical trials. Its recent clinical trial collaborations have featured innovative study designs including randomized, double-blind, placebo-controlled trials to evaluate both monotherapy and combinatory approaches with existing standard-of-care drugs. The creation of these collaborations supports robust clinical data generation and reinforces the company’s comprehensive strategy to address significant unmet needs across diverse patient populations.
Competitive Positioning and Industry Impact
Within the competitive landscape of liver and viral therapeutics, Aligos Therapeutics distinguishes itself by adopting a multi-pronged approach to drug development. By focusing on innovative mechanisms such as capsid assembly modulation and THR-β agonism, the company targets both viral suppression and metabolic modulation effectively. This contrasts with traditional monotherapy approaches which may not fully address the complexities of chronic hepatitis B or MASH. The company’s portfolio, underpinned by advanced science and strategic partnerships, positions it well within a highly competitive market that demands next-generation therapeutics capable of achieving both safety and durable efficacy.
Research and Development Excellence
Drawing upon a deep reservoir of R&D expertise, Aligos Therapeutics employs state-of-the-art technology and a rigorous scientific process to optimize its candidates. Detailed pharmacokinetic studies and dose-escalation clinical trials characterize their commitment to achieving linear pharmacokinetics, adequate target engagement, and potent antiviral effects without significant adverse events. This approach underscores the company’s dedication to building a robust scientific foundation for its product candidates while maintaining clear regulatory compliance and safety profiles.
Market Significance and Value Proposition
Aligos Therapeutics’ value proposition lies in its novel therapeutic approaches that address diseases with substantial unmet need. By focusing on critical endpoints such as viral biomarker suppression and liver fat reduction, the company establishes itself as an innovative force in the treatment of CHB and MASH. Its science-led, methodical approach to drug development communicates a clear message: the integration of advanced molecular mechanisms with stringent clinical evaluation provides a potentially transformative impact on patient outcomes. This positioning is critical for stakeholders and investors who seek comprehensive insights into the company’s strategic objectives and scientific rigor.
Conclusion
In summary, Aligos Therapeutics, Inc. represents a paradigm of innovation in the biopharmaceutical sector dedicated to improving patient care through best-in-class therapies. The company’s comprehensive pipeline, ranging from capsid assembly modulators for chronic hepatitis B to THR-β agonists for MASH, illustrates its broad commitment to tackling diseases that have long challenged conventional treatment paradigms. With extensive collaborations, robust clinical programs, and an unwavering commitment to research excellence, Aligos Therapeutics embodies the critical balance between scientific innovation and clinical pragmatism in a competitive and evolving therapeutic landscape.
Aligos Therapeutics (ALGS) announced positive data from three presentations at APASL 2025, highlighting significant progress in their liver disease treatments. ALG-000184 demonstrated strong antiviral activity in chronic hepatitis B patients, with 100% of HBeAg+ subjects (9/9) and 91% of HBeAg- subjects achieving sustained HBV DNA suppression, with no viral resistance observed up to 96 weeks.
The company's ALG-055009 showed promising results in MASH patients, with doses of 0.5-0.9mg achieving placebo-adjusted median relative reductions in liver fat up to 46.2%. Up to 70% of subjects achieved ≥30% reduction in liver fat. Notably, 11/14 subjects on stable GLP-1 agonists treated with ALG-055009 showed liver fat decreases, while all 4 placebo subjects on GLP-1 agonists experienced increases.
Aligos Therapeutics (Nasdaq: ALGS), a clinical stage biopharmaceutical company specializing in liver and viral diseases, has announced an inducement grant under Nasdaq Listing Rule 5635(c)(4). The company's Compensation Committee approved a non-qualified stock option to purchase 4,000 shares for a newly hired employee on March 11, 2025.
The grant, issued through Aligos' 2024 Inducement Plan, serves as an employment inducement and has an exercise price matching the closing price of Aligos' common stock on the grant date. The shares will vest over four years, with 25% vesting after the first year and the remaining portion vesting in equal monthly installments, contingent on continued employment.
Aligos Therapeutics (ALGS) reported its Q4 and full year 2024 financial results, highlighting significant progress in its pipeline. The company completed a $105 million private placement in February 2025. Their lead candidate ALG-000184, a CAM-E therapy for chronic hepatitis B virus infection, showed promising Phase 1 results with 100% HBV DNA suppression in tested subjects.
Financial results showed a net loss of $82.2 million for Q4 2024 ($13.08 per share), compared to $27.9 million loss in Q4 2023. Full-year 2024 net loss was $131.2 million. Cash position stood at $56.9 million as of December 31, 2024. The recent financing is expected to fund operations into second half of 2026.
R&D expenses decreased to $16.0 million in Q4 2024 from $22.3 million in Q4 2023. G&A expenses reduced to $5.2 million from $6.4 million in the same period. The company plans to begin Phase 2 studies for ALG-000184 in mid-2025.
Aligos Therapeutics (Nasdaq: ALGS), a clinical stage biotech company specializing in liver and viral disease therapies, has scheduled its fourth quarter 2024 financial results announcement for Monday, March 10, 2025. The results will be released before U.S. financial markets open.
Aligos Therapeutics (NASDAQ: ALGS) has secured a $105 million private placement financing, led by a life sciences dedicated investment firm with participation from new and existing institutional investors. The company is selling 2,103,307 shares of common stock (1,427,000 voting and 676,307 non-voting), pre-funded warrants for up to 1,922,511 voting shares, and warrants for up to 2,012,909 voting shares.
The combined price is $26.0825 per share of common stock and accompanying warrant, with pre-funded warrants priced at $26.0824. The warrants will have an exercise price of $26.02 per share and will expire on February 13, 2032. The proceeds will fund the ALG-000184 Phase 2 clinical study in chronic hepatitis B virus infection and extend the company's cash runway into the second half of 2026.
Aligos Therapeutics (ALGS) has announced an inducement grant of non-qualified stock options to a newly hired employee. The grant, issued on December 10, 2024, allows for the purchase of 5,500 shares of company stock. The exercise price equals the closing price of Aligos' common stock on the grant date. The shares will vest over four years, with 25% vesting after the first year and the remainder vesting in equal monthly installments, contingent on continued employment. The grant was made under Aligos' 2024 Inducement Plan, exclusively used for equity awards to new hires, in compliance with Nasdaq Listing Rule 5635(c)(4).
Aligos Therapeutics (Nasdaq: ALGS), a clinical stage biopharmaceutical company specializing in liver and viral diseases, has announced its participation in two major investor conferences this December. The company will present at the Piper Sandler 36th Annual Healthcare Conference at 11:00am ET and the Evercore ISI 7th Annual HealthCONx Conference at 4:15pm ET, both on December 3, 2024.
Management will conduct fireside chats at both events and participate in one-on-one meetings. The presentations will be webcast live on the company's investor relations website, with replays available for at least 30 days afterward.
Aligos Therapeutics (ALGS) presented positive data at The Liver Meeting 2024, highlighting two key developments: First, ALG-000184 showed sustained antiviral activity in chronic hepatitis B patients, with 100% of HBeAg-positive subjects achieving HBV DNA suppression at 84 weeks, and 91% of HBeAg-negative subjects reaching below detection limits at 48 weeks. Second, their THR-β agonist ALG-055009 demonstrated significant liver fat reduction in MASH patients, with up to 46.2% placebo-adjusted median reductions at 12 weeks. Notably, 70% of subjects achieved ≥30% liver fat reduction, and the drug showed effectiveness in patients on GLP-1 agonists. Both compounds were well-tolerated with no significant safety concerns.
Aligos Therapeutics (Nasdaq: ALGS), a clinical-stage biopharmaceutical company, reported its Q3 2024 financial results and recent business progress. The company highlighted positive topline HERALD data for ALG-055009 in MASH subjects, showing placebo-adjusted median relative reductions in liver fat of up to 46.2%. Aligos is completing Phase 2b enabling studies and exploring funding options, including partnerships. For ALG-000184, a potential best-in-class small molecule CAM-E for CHB, the company received positive regulatory feedback and announced a collaboration with Xiamen Amoytop Biotech. Additionally, ALG-097558 is progressing towards externally funded clinical studies for COVID-19.
Financially, Aligos reported cash, cash equivalents, and investments of $74.9 million as of September 30, 2024, down from $135.7 million at the end of 2023. The net loss for Q3 2024 was $19.3 million, compared to $18.0 million in Q3 2023. R&D expenses increased to $16.8 million, while G&A expenses decreased to $4.6 million.
Aligos Therapeutics (Nasdaq: ALGS), a clinical-stage biopharmaceutical company dedicated to developing therapies for liver and viral diseases, announced it will release its third quarter 2024 financial results on November 6, 2024, after the U.S. markets close. The announcement will provide insights into the company's financial performance during this period.
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