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ADC Therapeutics SA - ADCT STOCK NEWS

Welcome to our dedicated page for ADC Therapeutics SA news (Ticker: ADCT), a resource for investors and traders seeking the latest updates and insights on ADC Therapeutics SA stock.

ADC Therapeutics SA (NYSE: ADCT) is a commercial-stage biotechnology company headquartered in Lausanne, Vaud, Switzerland. The company specializes in the development of antibody-drug conjugates (ADCs) to treat hematological malignancies and solid tumors. ADC Therapeutics is particularly known for its product ZYNLONTA® (loncastuximab tesirine-lpyl), which received accelerated approval from the FDA and conditional approval from the European Commission for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. ZYNLONTA is also under development for use in combination with other agents and for earlier lines of therapy.

The company has a broad portfolio of ADCs in various stages of clinical and preclinical development, including camidanlumab tesirine, ADCT-602, ADCT-601, ADCT-901, ADCT-701, and ADCT-212. ADC Therapeutics leverages its proprietary technology to improve the treatment outcomes for cancer patients, focusing on both hematologic cancers and solid tumors.

In recent news, ADC Therapeutics announced several key updates, including the completion of dose escalation in their LOTIS-7 trial, which is evaluating ZYNLONTA in combination with bispecific antibodies for heavily pre-treated patients with relapsed/refractory B-cell non-Hodgkin lymphoma. The company also presented promising data from a Phase 2 trial evaluating ZYNLONTA in patients with relapsed/refractory marginal zone lymphoma, showing high response rates and a good safety profile.

Financially, ADC Therapeutics reported ZYNLONTA net sales of $17.8 million for the first quarter of 2024 and continues to advance its hematology and solid tumor pipelines. The company has operations in London, the San Francisco Bay Area, and New Jersey. For more information, visit adctherapeutics.com and follow the company on LinkedIn.

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ADC Therapeutics (NYSE: ADCT) announced positive initial data from the LOTIS-7 Phase 1b trial evaluating ZYNLONTA® in combination with glofitamab for relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The combination demonstrated a 94% best overall response rate and 72% complete response rate in evaluable patients.

The study included 29 B-NHL patients, with 18 evaluable 2L+ DLBCL patients receiving doses of 120 µg/kg or 150 µg/kg. At the 150µg/kg dose level, the combination achieved a 100% overall response rate and 78% complete response rate. Safety data showed no dose-limiting toxicities, with manageable Grade 3+ adverse events including neutropenia (24%), lymphopenia (7%), and hypokalemia (7%).

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ADC Therapeutics announced updated data from two clinical trials evaluating ZYNLONTA®. In the first trial, ZYNLONTA combined with rituximab for relapsed/refractory follicular lymphoma showed a 97.4% overall response rate and 76.9% complete response rate, with 12-month progression-free survival of 94.6%. The study enrolled 39 patients with a median age of 68 years.

In the second trial, ZYNLONTA as monotherapy for relapsed/refractory marginal zone lymphoma demonstrated a 91% overall response rate and 70% complete response rate in 23 patients. The median duration of complete response was 11.5 months, with the longest follow-up at 27 months.

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ADC Therapeutics (NYSE: ADCT) has announced a conference call and webcast scheduled for December 11, 2024, at 8:30 a.m. EST. The company will present preliminary data from the LOTIS-7 Phase 1b clinical trial, which evaluates ZYNLONTA® in combination with bispecific antibody glofitamab (COLUMVI™) for treating relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL).

The conference call will be accessible via toll-free dial-in for North America and Canada participants, and a webcast will be available on the company's investor relations website for 30 days following the presentation.

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ADC Therapeutics announced the granting of options to purchase 34,900 common shares to three new employees as employment inducement. The grants, approved by the Compensation Committee under the Company's Inducement Plan, will vest over four years, with 25% vesting on the first anniversary and 1/48th monthly thereafter until full vesting on the fourth anniversary, contingent on continued employment. The grants were made under NYSE's Listed Company Manual Rule 303A.08 employment inducement exemption.

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ADC Therapeutics reported Q3 2024 financial results with ZYNLONTA® net product revenues of $18.0 million, up from $14.3 million in Q3 2023. The company reported a net loss of $44.0 million ($0.42 per share) compared to $46.7 million in Q3 2023. Key operational updates include expected full enrollment in LOTIS-5 trial by year-end 2024, continued LOTIS-7 enrollment with interim data expected in December, and discontinuation of the ADCT-601 program. Cash position stands at $274.3 million, with runway extended into mid-2026 following a $97.4 million offering in May 2024.

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ADC Therapeutics (NYSE: ADCT) announced two investigator-initiated study abstracts on ZYNLONTA accepted for presentation at the 66th ASH Annual Meeting. The Phase 2 study combining ZYNLONTA with rituximab in relapsed/refractory follicular lymphoma showed a 97.1% overall response rate among 35 patients, with an 80% best complete metabolic response rate. In a separate study for relapsed/refractory marginal zone lymphoma, ZYNLONTA as a single agent achieved an 85% overall response rate with 75% complete response rate in 20 evaluable patients. Both studies demonstrated safety profiles consistent with known ZYNLONTA data.

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ADC Therapeutics (NYSE: ADCT), a commercial-stage leader in antibody drug conjugates, has announced its participation in two major investor conferences this November. The company will present at the Guggenheim Securities Healthcare Innovation Conference on November 11, 2024, at 11:00 a.m. ET, and the Jefferies London Healthcare Conference on November 19, 2024, at 11:00 a.m. GMT. Both presentations will feature CEO Ameet Mallik in fireside chat formats. Live webcasts will be available on the company's investor relations website, with replays accessible for approximately 30 days after each event.

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ADC Therapeutics announced the grant of options to purchase 42,000 common shares to two new employees as employment inducement. The grants, approved by the Compensation Committee under the Company's Inducement Plan, will vest over four years, with 25% vesting on the first anniversary and 1/48th monthly thereafter until full vesting on the fourth anniversary, subject to continued employment.

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ADC Therapeutics (NYSE: ADCT) announced it will host a conference call and live webcast on November 7, 2024, at 8:30 a.m. EST to discuss third quarter 2024 financial results and provide business updates. North American and Canadian participants can join via toll-free number 1-800-836-8184. The webcast will be available under 'Events and Presentations' on the company's investor relations website and archived for 30 days after the call.

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ADC Therapeutics SA (NYSE: ADCT), a commercial-stage global leader in antibody drug conjugates (ADCs), has announced the granting of options to purchase 113,700 common shares to six new employees on October 1, 2024. These grants were approved by the Compensation Committee of the Company's Board of Directors under the Company's Inducement Plan as a material inducement to employment.

The options will vest and become exercisable in stages: 25% on the first anniversary of the grant date, and 1/48th monthly thereafter, becoming fully vested after four years, subject to continued employment. This action aligns with NYSE's Listed Company Manual Rule 303A.08, emphasizing ADC Therapeutics' commitment to attracting and retaining top talent in the competitive field of ADCs.

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FAQ

What is the current stock price of ADC Therapeutics SA (ADCT)?

The current stock price of ADC Therapeutics SA (ADCT) is $1.96 as of December 20, 2024.

What is the market cap of ADC Therapeutics SA (ADCT)?

The market cap of ADC Therapeutics SA (ADCT) is approximately 207.9M.

What is the primary focus of ADC Therapeutics?

ADC Therapeutics focuses on developing antibody-drug conjugates (ADCs) to treat hematological malignancies and solid tumors.

What is ZYNLONTA?

ZYNLONTA® (loncastuximab tesirine-lpyl) is a CD19-directed antibody drug conjugate approved for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy.

Where is ADC Therapeutics headquartered?

ADC Therapeutics is headquartered in Lausanne, Vaud, Switzerland.

What recent developments has ADC Therapeutics announced?

Recent developments include the completion of dose escalation in the LOTIS-7 trial and promising Phase 2 data for ZYNLONTA in relapsed/refractory marginal zone lymphoma.

What are some of the product candidates in ADC Therapeutics' pipeline?

Some of the product candidates include camidanlumab tesirine, ADCT-602, ADCT-601, ADCT-901, ADCT-701, and ADCT-212.

How did ZYNLONTA perform financially in the first quarter of 2024?

ZYNLONTA generated net sales of $17.8 million in the first quarter of 2024.

Does ADC Therapeutics have international operations?

Yes, ADC Therapeutics has operations in London, the San Francisco Bay Area, and New Jersey.

What are the strategic goals of ADC Therapeutics?

The strategic goals include advancing their proprietary ADC technology to improve cancer treatment outcomes and expanding their product portfolio in both hematologic malignancies and solid tumors.

How can I learn more about ADC Therapeutics?

For more information, visit their website at https://adctherapeutics.com/ and follow them on LinkedIn.

Who is the current Chief Executive Officer of ADC Therapeutics?

Ameet Mallik is the current Chief Executive Officer of ADC Therapeutics.

ADC Therapeutics SA

NYSE:ADCT

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207.88M
72.20M
21.03%
63.14%
3.27%
Biotechnology
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