Aadi Bioscience Announces Multiple Presentations on nab-Sirolimus at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting

Rhea-AI Summary

Aadi Bioscience, a biopharmaceutical company, announced the acceptance of abstracts for the 2023 ASCO Annual Meeting from June 2-6 in Chicago. The presentations will highlight updates from the PRECISION 1 Phase 2 study and combination data from an ongoing trial involving nab-sirolimus and pazopanib. Key poster details include:

• Title: Phase 2 multicenter trial of nab-sirolimus for patients with TSC1 or TSC2 gene alterations. Date: June 3, 2023, 8:00 AM-11:00 AM.
• Title: Phase I study of nab-sirolimus with pazopanib in advanced soft tissue sarcoma. Date: June 3, 2023, 1:15 PM-4:15 PM.

Aadi's FDA-approved product, FYARRO, targets advanced PEComa. The company aims to advance precision therapies for cancers driven by mTOR pathway alterations.

Positive

• Acceptance of multiple abstracts at ASCO Annual Meeting may increase visibility and investor interest.
• Presentation of data from the ongoing PRECISION 1 Phase 2 study could indicate progress in clinical trials.

Negative

• No specific financial metrics or outcomes were reported, which may raise concerns about the company's performance.
• Forward-looking statements indicate potential risks, including clinical development uncertainties and regulatory approval delays.

LOS ANGELES, April 26, 2023 /PRNewswire/ -- Aadi Bioscience, Inc. (NASDAQ: AADI), a commercial-stage biopharmaceutical company focused on developing and commercializing precision therapies for genetically-defined cancers with alterations in mTOR pathway genes, today announced the acceptance of abstracts for poster presentation at the upcoming 2023 ASCO Annual Meeting taking place June 2-6, 2023, in Chicago, IL. 

The presentations will consist of a company-sponsored Trials-in-Progress (TIP) update from the PRECISION 1 Phase 2 study and combination data of nab-sirolimus and pazopanib (PAZO) from an ongoing Investigator Initiated Trial.   

The details of the poster presentations are below:

Title: "Phase 2, multicenter, open-label basket trial of nab-sirolimus for patients with malignant solid tumors harboring pathogenic inactivating alterations in TSC1 or TSC2 genes (PRECISION I)"
Date and Time: June 3, 2023, 8:00 AM-11:00 AM
Session Type/Title: Poster Session - Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Presenter: Dr. Gopa Iyer, MD, Memorial Sloan Kettering Cancer Center
Abstract Number: TPS3168

Title: "A phase I study of nanoparticle albumin-bound sirolimus (NAB-S) combined with pazopanib (PAZO) in patients with advanced soft tissue sarcoma (STS)"
Poster Session Display Date and Time: June 3, 2023, 1:15 PM-4:15 PM
Poster Board Number: 455
Poster Discussion Session Date and Time: June 3, 2023, 4:30 PM-6:00 PM
Session Category: Clinical Research Excluding Trials
Session Title: Poster Discussion Session - Sarcoma
Presenter: Lee Cranmer, M.D., Ph.D., F.A.C.P., Fred Hutch Cancer Center
Abstract Number: 11521

Meeting details are available through the ASCO Annual Meeting planner Program | ASCO Annual Meeting  Following Aadi's presentation at ASCO, the posters will be made available on the investor relations page of the Aadi website at www.aadibio.com 

About Aadi Bioscience, Inc.

Aadi is a commercial-stage biopharmaceutical company focused on precision therapies for genetically defined cancers to bring transformational therapies to cancer patients with mTOR pathway driver alterations.  Aadi received FDA approval and has commercialized FYARRO® for the treatment of adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa).

Aadi has also initiated PRECISION 1, a Phase 2 tumor-agnostic registration-intended trial in mTOR inhibitor-naïve malignant solid tumors harboring TSC1 or TSC2 inactivating alterations. More information on the Company's development pipeline is available on the Aadi website at www.aadibio.com and connect with us on Twitter and LinkedIn.

Cautionary Note Regarding Forward-Looking Statements

This press release contains certain forward-looking statements regarding the business of Aadi Biosciences that are not a description of historical facts within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding the Company's current beliefs and expectations; anticipated future growth; the potential commercialization of FYARRO in the tumor agnostic oncology market; expectations regarding management performance following the leadership transition; and the Company's potential as a commercial precision oncology company. Actual results could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, those associated with uncertainties associated with the clinical development and regulatory approval of FYARRO in additional indications, including potential delays in the commencement, enrollment and completion of clinical trials for additional indications; the risk that unforeseen adverse reactions or side effects may occur in the course of commercializing, developing and testing FYARRO; and risks related to collaborations with third-parties.

Additional risks and uncertainties that could cause actual outcomes and results to differ materially from those contemplated by the forward-looking statements are included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2022, including under the caption "Item 1A. Risk Factors," anticipated to be filed on or about the date hereof, and elsewhere in Aadi's reports and other documents that Aadi has filed, or will file, with the SEC from time to time and available at www.sec.gov.

All forward-looking statements in this press release are current only as of the date hereof and, except as required by applicable law, Aadi undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. All forward-looking statements are qualified in their entirety by this cautionary statement. This cautionary statement is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

Contact:
Marcy Graham
IR@aadibio.com 

 

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SOURCE Aadi Bioscience

FAQ

What presentations will Aadi Bioscience hold at the ASCO Annual Meeting 2023?

Aadi will present updates from the PRECISION 1 Phase 2 study and a trial on nab-sirolimus combined with pazopanib.

When is Aadi Bioscience's presentation at ASCO 2023?

The presentations are scheduled for June 3, 2023.

What is FYARRO and its significance for Aadi Bioscience?

FYARRO is Aadi's FDA-approved treatment for advanced PEComa, marking a significant step in their precision oncology portfolio.

What are the potential risks mentioned in Aadi Bioscience's press release?

The press release highlights risks related to clinical trials, including delays and unforeseen adverse reactions.

Where can I find more information about Aadi Bioscience's products?

More information is available on Aadi's website and their investor relations page.