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Zentalis Pharmaceuticals, Inc. (NASDAQ: ZNTL) is a clinical-stage biopharmaceutical company dedicated to discovering and developing innovative small molecule therapeutics that target fundamental biological pathways in cancer. Utilizing its proprietary Integrated Discovery Engine, Zentalis aims to identify unique targets and develop novel, potentially best-in-class new chemical entities (NCEs) with differentiated product profiles.
The company's robust pipeline is highlighted by two lead product candidates: ZN-c5 and ZN-c3. ZN-c5 is being developed for the treatment of advanced estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer, while ZN-c3 targets advanced solid tumors and ovarian cancer. Zentalis is also developing azenosertib (ZN-c3), a WEE1 inhibitor, as a monotherapy and in combination with other agents to address multiple tumor types.
Recently, Zentalis announced plans to use the net proceeds from its latest offering to fund ongoing and planned clinical trials, as well as for working capital and other general corporate purposes. The company’s financial strategy is designed to support its operational expenses and capital expenditure requirements through 2026.
The company’s latest financial disclosures highlighted strong clinical data for azenosertib, showing an objective response rate of 36.8% in ovarian cancer and uterine serous carcinoma patients. Azenosertib, currently in multiple clinical trials, demonstrated encouraging efficacy both as a monotherapy and in combination with chemotherapy.
Headquartered in New York and San Diego, Zentalis is collaborating with top financial institutions like Morgan Stanley, Jefferies, and Guggenheim Securities to drive its growth. The company's strong cash position is bolstered by its recent offerings and ongoing support from financial advisors.
Continuing to advance its clinical strategies, Zentalis is focused on its fast-to-market approach for azenosertib, aiming to submit its first NDA in gynecologic malignancies by 2026. Furthermore, Zentalis is leveraging its expertise in cancer biology and medicinal chemistry to explore the potential of protein degraders and other innovative treatment modalities.
Stay updated on Zentalis Pharmaceuticals’ latest developments by visiting their official website or following them on social media platforms such as Twitter and LinkedIn.
Zentalis Pharmaceuticals, a clinical-stage biopharmaceutical firm, will participate in the Jefferies Global Healthcare Conference on June 5, 2024, at 4:00 p.m. ET. The company will host a fireside chat, with a live webcast and an archived recording accessible via their website. Zentalis specializes in developing small molecule therapeutics targeting cancer's fundamental biological pathways.
Zentalis Pharmaceuticals has appointed Dr. Luke Walker to its Board of Directors. Dr. Walker, currently the Chief Medical Officer at Harpoon Therapeutics, brings nearly 30 years of oncology and drug development experience, including successful product approvals. CEO Kimberly Blackwell highlighted his extensive expertise as pivotal for the advancement of Zentalis' pipeline, specifically azenosertib. Expected data readouts for azenosertib are anticipated throughout the remainder of 2024 and 2025, with regulatory submission planned for 2026. Dr. Walker's previous roles include VP of Clinical Development at Seagen and senior clinical roles at Cascadian Therapeutics.
Zentalis Pharmaceuticals announced the final results of its Phase 1 trial for azenosertib and gemcitabine in relapsed or refractory osteosarcoma patients, revealing a substantial improvement in event-free survival (EFS). The trial demonstrated a tripling of EFS at 18 weeks compared to historical data. Azenosertib was well tolerated, with thrombocytopenia and lymphopenia being the most common severe adverse events. The maximum tolerated dose was identified as 150 mg of azenosertib daily on a 5:2 schedule plus 800 mg/m2 of gemcitabine. The results support further investigation in a Phase 2 trial. The full data will be presented at the 2024 ASCO Annual Meeting.
Zentalis Pharmaceuticals, a clinical-stage biopharmaceutical company focused on developing small molecule therapeutics for cancer, will participate in the TD Cowen 5th Annual Oncology Innovation Summit on May 28, 2024, at 10:30 a.m. ET.
The event will be virtual, featuring a fireside chat with the management team. A live webcast and archived recording will be available on the company's website.
Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL) reported its financial results for Q1 2024, showcasing progress in azenosertib clinical development plans and a strong cash position. The company highlighted upcoming milestones, corporate updates, and the projected cash runway into mid-2026. Azenosertib shows promise in various tumor types, with multiple data readouts expected in late 2024 and 2025, including results in gynecological cancers.
Zentalis Pharmaceuticals, Inc. announced inducement grants under Nasdaq Listing Rule 5635(c)(4), granting non-qualified stock options to three new employees. The options have an exercise price of $11.31 per share, a 10-year term, and will vest over four years.
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