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XORTX Files New PCT Patent to Treat and Protect Individuals Most at Risk to Severe Viral Infection

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XORTX Therapeutics has submitted a Patent Cooperation Treaty application for a patent titled “Compositions and Methods for Enhancing Anti-Viral Therapies”. This patent focuses on addressing purine metabolism and hyperuricemia, particularly in individuals at risk for severe COVID-19 outcomes, including those with obesity and chronic kidney disease. The submission is based on retrospective clinical data suggesting the potential for uric acid-lowering agents to inhibit SARS-CoV-2 replication. The company clarifies that it does not claim to cure or contain COVID-19.

Positive
  • Submitted a PCT patent application for innovative anti-viral therapies.
  • Focuses on a therapeutic opportunity for high-risk COVID-19 patients.
  • Potential for compositions to inhibit virus replication through uric acid reduction.
Negative
  • No express claims of capability to combat COVID-19.

Compositions and Methods for Enhancing Anti-Viral Therapies

CALGARY, Alberta, March 23, 2022 (GLOBE NEWSWIRE) -- XORTX Therapeutics Inc. ("XORTX" or the “Company”) (NASDAQ: XRTX | TSXV: XRTX | Frankfurt: ANU), a pharmaceutical therapeutics company focused on developing innovative therapies to treat progressive kidney disease, with late-stage clinical programs, announces the submission of a Patent Cooperation Treaty (PCT) patent application seeking international patent protection for the patent entitled “Compositions and Methods for Enhancing Anti-Viral Therapies”.

This patent is based on retrospective clinical data from XORTX scientific partners suggesting that an important therapeutic opportunity lies with addressing aberrant purine metabolism combined with hyperuricemia in patients most at risk to severe COVID-19 outcome. Since the advent of COVID-19 and during 2020, accumulating evidence suggests that individuals most at risk for more severe health consequences fall within a group that includes individuals with obesity, hypertension, metabolic syndrome, insulin resistance, pre-diabetes, diabetes or chronic kidney disease. These individuals have a higher incidence of hyperuricemia and endothelial dysfunction. Low grade systemic inflammation associated with these disease states and pre-existing vascular injury may suppress an individual’s ability to respond with a sufficiently robust response to fight infection and leaves the individual more prone to excessive pro-inflammatory and pro-coagulative state. This new patent filing proposes compositions of xanthine oxidase inhibitors, uric acid lowering agents and/or anti-viral agents alone or in combination, and methods for enhancing anti-viral therapies for the treatment of individuals most at risk.

Recent peer reviewed publications suggest that individuals with hyperuricemia appear to have an increased susceptibility to develop more severe sepsis associated with COVID-19 infection. Recent studies of Coronavirus infections show that SARS and MERS and specifically COVID-19 can be frequently accompanied by pneumonia, acute kidney injury, proteinuria and hematuria1,2. Viral load during infection has been reported to be associated with more severe symptoms.3 Acute kidney injury (“AKI”) has been identified as an independent risk factor for patients’ in-hospital mortality due to COVID-19 as well as other Coronavirus infections2. Associated with modest to severe COVID-19 infection is an increased risk of a hyper-inflammatory state, increased pro-coagulative state and bacterial infection - each can contribute to acute organ injury, and death. A higher incidence of bacterial or fungal infection is also associated with high mortality.4 Recent study results suggest that uric acid lowering can inhibit SARS-CoV-2 replication a finding that supports the clinical use of uric acid lowering agents to control SARS-CoV-2 infection in humans.5

The Company is not making any express or implied claims that it has the ability to eliminate, cure or contain the COVID-19 coronavirus at this time.

About XORTX Therapeutics Inc.

XORTX Therapeutics Inc. is a pharmaceutical therapeutics company with clinically advanced products in development – XRx-008 for Autosomal Dominant Polycystic Kidney Disease (ADPKD), XRx-101 for Coronavirus / COVID-19 infection and XRx-221 is a clinical stage program for Type 2 Diabetic Nephropathy (T2DN). The Company has strong intellectual property rights and established proof of concept through independent clinical studies. XORTX is working to advance its clinical development stage products that target xanthine oxidase to inhibit production of uric acid. At XORTX Therapeutics, we are dedicated to developing medications to improve the quality of life and future of patients. Additional information on XORTX Therapeutics is available at www.xortx.com.

For further information, please contact:

Allen Davidoff, CEONick Rigopulos, Director of Communications
adavidoff@xortx.com or +1 403 455 7727nick@alpineequityadv.com or +1 617 901 0785

The TSX Venture Exchange and Nasdaq have neither approved nor disapproved the contents of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

References:

  1. Saraladevi Naicker, Chih-Wei Yang, Shang-Jyh Hwang, Bi-Cheng Liu, Jiang-Hua Chen, Vivekan and Jha, The Novel Coronavirus 2019 Epidemics and Kidneys, Kidney International March 2, 2020. https://www.kidney-international.org/article/S0085-2538(20)30251-9/pdf.
  2. Cheng, Y, Luo R., Wang K., Zhang M., Wang Z., Dong L., Li J, Yao Y., Ge S., Xu g., Kidney Impairment is associated with in-hospital deal of COVID-19 patients, medRxiv, March 04, 2020 https://www.medrxiv.org/content/10.1101/2020.02.18.20023242v1.
  3. Stankiwicz HC et al Trajectory of Viral RNA Load Among Persons with SARS-CoV-G614 Infection in Association with COVID-19 Symptom Onset and Severity JAMA Jan 2022
  4. Zhou P et al Bacterial and fungal infections in COVID-19 patient_Infection Control & Hospital Epidemiology 1 2020
  5. Murray J et al Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro Nature (11) 18085 2021

Forward Looking Statements

This press release may contain express or implied forward-looking statements pursuant to Canadian and U.S. Federal securities laws. These forward-looking statements and their implications are based on the current reasonable expectations of the management of XORTX only, and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in such forward-looking statements. Except as otherwise required by law, XORTX undertakes no obligation to publicly release any revisions or updates to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. More detailed information about the risks and uncertainties affecting XORTX is contained in the Company’s most recently filed Annual Information Form and the Management Discussion and Analysis for its most recent financial reporting period filed on the Company’s SEDAR profile (www.sedar.com) and under the heading “Risk Factors” in XORTX’s Registration Statement on Form F-1 filed with the Securities and Exchange Commission (“SEC”) available on the SEC's website, www.sec.gov.


FAQ

What is the recent patent application by XORTX Therapeutics about?

XORTX Therapeutics submitted a PCT patent application for enhancing anti-viral therapies relating to purine metabolism and hyperuricemia.

How does XORTX's patent relate to COVID-19?

The patent aims to provide therapeutic measures for individuals at risk of severe COVID-19 outcomes, particularly those with high uric acid levels.

What therapeutic methods are proposed in XORTX's patent?

The patent proposes the use of xanthine oxidase inhibitors and uric acid-lowering agents to enhance anti-viral therapies.

Does XORTX claim to cure COVID-19?

No, XORTX is not making any claims to eliminate or cure COVID-19 at this time.

What are the clinical implications of XORTX's patent submission?

The submission suggests a potential therapeutic avenue for treating COVID-19 in high-risk patients through uric acid management.

XORTX Therapeutics Inc.

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Biotechnology
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United States of America
Alberta Beach