Xilio Therapeutics Announces Initial Clinical Trial Data from Phase 1C Dose Escalation for Vilastobart (XTX101), a Tumor-Activated Anti-CTLA-4, in Combination with Atezolizumab in Patients with Advanced Solid Tumors
Xilio Therapeutics announced initial clinical data from Phase 1C trial evaluating vilastobart combined with atezolizumab in advanced solid tumor patients. The combination showed promising anti-tumor activity, including two unconfirmed partial responses in patients with immunologically 'cold' tumors. A notable complete resolution of a metastatic liver lesion was observed in a patient with microsatellite stable colorectal cancer (MSS CRC). The treatment was generally well-tolerated, with no Grade 4 or 5 treatment-related adverse events reported. Initial Phase 2 data for the combination in metastatic MSS CRC patients is expected in Q4 2024.
Xilio Therapeutics ha annunciato i dati clinici iniziali del trial di Fase 1C che valuta vilastobart combinato con atezolizumab in pazienti con tumori solidi avanzati. La combinazione ha mostrato un'attività antitumorale promettente, compresi due risposte parziali non confermate in pazienti con tumori immunologicamente 'freddi'. È stata osservata una notevole risoluzione completa di una lesione epatica metastatica in un paziente con cancro colorettale microsatelliti stabili (MSS CRC). Il trattamento è stato generalmente ben tollerato, senza eventi avversi correlati al trattamento di Grado 4 o 5 segnalati. Si prevedono dati iniziali della Fase 2 per la combinazione in pazienti con MSS CRC metastatico nel quarto trimestre del 2024.
Xilio Therapeutics anunció datos clínicos iniciales del ensayo de Fase 1C que evalúa vilastobart combinado con atezolizumab en pacientes con tumores sólidos avanzados. La combinación mostró una actividad antitumoral prometedora, incluyendo dos respuestas parciales no confirmadas en pacientes con tumores inmunológicamente 'fríos'. Se observó una notable resolución completa de una lesión hepática metastásica en un paciente con cáncer colorrectal estable en microsatélites (MSS CRC). El tratamiento fue generalmente bien tolerado, sin eventos adversos relacionados con el tratamiento de Grado 4 o 5 reportados. Se esperan datos iniciales de la Fase 2 para la combinación en pacientes con MSS CRC metastásico en el cuarto trimestre de 2024.
Xilio Therapeutics는 진행성 고형종양 환자를 대상으로 vilastobart와 atezolizumab의 조합을 평가한 1C상 임상 시험의 초기 임상 데이터를 발표했습니다. 이 조합은 두 명의 면역학적으로 '차가운' 종양 환자에서 확인되지 않은 부분 반응을 포함하여 유망한 항종양 활성을 보였습니다. 미소위성 안정 대장암(MSS CRC)을 앓고 있는 환자에서 전이성 간 병변의 완전한 해결이 주목되었습니다. 치료는 일반적으로 잘 견뎌졌으며, 4등급 또는 5등급의 치료 관련 부작용은 보고되지 않았습니다. 전이성 MSS CRC 환자에 대한 조합의 초기 2상 데이터는 2024년 4분기에 발표될 예정입니다.
Xilio Therapeutics a annoncé des données cliniques initiales de l'essai en phase 1C évaluant vilastobart associé à l'atezolizumab chez des patients présentant des tumeurs solides avancées. La combinaison a montré une activité antitumorale prometteuse, y compris deux réponses partielles non confirmées chez des patients atteints de tumeurs immunologiquement 'froides'. Une résolution complète notable d'une lésion hépatique métastatique a été observée chez un patient atteint d'un cancer colorectal stable en microsatellites (MSS CRC). Le traitement a généralement bien été toléré, sans événements indésirables liés au traitement de grade 4 ou 5 signalés. Des données initiales de phase 2 pour la combinaison chez des patients atteints de MSS CRC métastatique sont attendues au quatrième trimestre 2024.
Xilio Therapeutics hat erste klinische Daten aus der Phase-1C-Studie veröffentlicht, die vilastobart in Kombination mit Atezolizumab bei Patienten mit fortgeschrittenen soliden Tumoren bewertet. Die Kombination zeigte vielversprechende antitumorale Aktivität, einschließlich zweier nicht bestätigter partieller Reaktionen bei Patienten mit immunologisch 'kalten' Tumoren. Bei einem Patienten mit mikrosatellitenstabilem kolorektalem Krebs (MSS CRC) wurde eine bemerkenswerte vollständige Auflösung einer metastatischen Leberläsion beobachtet. Die Behandlung wurde insgesamt gut vertragen, es wurden keine behandlungsbedingten Nebenwirkungen der Grade 4 oder 5 gemeldet. Erste Phase-2-Daten für die Kombination bei metastasierten MSS CRC-Patienten werden im vierten Quartal 2024 erwartet.
- Two unconfirmed partial responses observed in difficult-to-treat tumors
- Complete resolution of liver metastasis in MSS CRC patient
- Generally well-tolerated safety profile with no Grade 4 or 5 treatment-related adverse events
- Only 6% of patients required dose reduction due to treatment-related adverse events
- Only 6% discontinued treatment due to adverse events
- Partial responses are still unconfirmed
- One patient withdrew consent before confirmatory scan
- Grade 3 treatment-related adverse events reported in three patients
- Two patients experienced dose-limiting toxicities at 150mg dose level
Insights
The Phase 1C trial data for vilastobart (XTX101) in combination with atezolizumab shows promising early results in treating difficult-to-treat solid tumors. Key findings include two unconfirmed partial responses, notably in MSS colorectal cancer with liver metastasis and ampullary carcinoma. The safety profile appears favorable, with no Grade 4 or 5 treatment-related adverse events and immune-related adverse events.
The complete resolution of a liver metastasis in an MSS CRC patient is particularly significant, as liver metastases typically resist immunotherapy. The selected Phase 2 dose of 100 mg Q6W demonstrates a balanced efficacy-safety profile. The upcoming Phase 2 data in Q4 2024 for approximately 20 patients will be important in validating these early positive signals.
For a small-cap biotech with a market cap of
The upcoming Q4 2024 and Q1 2025 data readouts are critical value inflection points. Positive Phase 2 results could attract partnership interest from larger pharmaceutical companies and potentially lead to accelerated development pathways given the unmet medical need in MSS CRC.
Combination of vilastobart and atezolizumab demonstrated encouraging early evidence of anti-tumor activity, including unconfirmed partial responses observed in two patients with difficult-to-treat, immunologically “cold” tumors
Complete resolution of a metastatic liver lesion observed in a patient with microsatellite stable colorectal cancer (MSS CRC)
Safety data indicated combination of vilastobart and atezolizumab was generally well-tolerated and support the potential of vilastobart to be a differentiated next-generation anti-CTLA-4 in combination with PD-(L)1 inhibitors
Continue to anticipate initial data from Phase 2 trial for combination of vilastobart and atezolizumab in metastatic MSS CRC patients with and without liver metastases in fourth quarter of 2024
Xilio Therapeutics to host investor conference call and webcast today at 4:30 pm EST
WALTHAM, Mass., Nov. 07, 2024 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology therapies for people living with cancer, today announced initial clinical data from its ongoing Phase 1C clinical trial evaluating vilastobart (XTX101), a tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4, in combination with atezolizumab (Tecentriq®) in patients with advanced solid tumors. The data will be presented in a late-breaker poster presentation (abstract #1455) on November 8, 2024, at the Society for Immunotherapy of Cancer (SITC) 39th Annual Meeting taking place in Houston, Texas.
“These Phase 1 combination data for vilastobart and atezolizumab provide promising initial clinical evidence of the potential for the combination in patients with traditionally immunotherapy-resistant tumors, or “cold” tumors, including MSS colorectal cancer,” said René Russo, Pharm.D., president and chief executive officer of Xilio. “In particular, we are encouraged by the potentially differentiated safety profile and two unconfirmed partial responses, including complete resolution of a metastatic liver lesion observed in a patient with MSS colorectal cancer. The majority of metastatic MSS colorectal cancer patients have liver metastases, which have proven to be resistant to existing immuno-oncology treatments, including combination treatments, and represent a significant unmet need. We look forward to sharing initial Phase 2 data for the combination of vilastobart and atezolizumab in patients with metastatic MSS colorectal cancer with and without liver metastases later this year.”
“With the increasing incidence of MSS colorectal cancer, particularly in younger adults, the lack of effective treatment options for these patients represents one of the most significant challenges in oncology today,” said Diwakar Davar, M.D., Associate Professor of Medicine, Clinical Director of the Melanoma Program and Medical Oncologist/Hematologist at the UPMC Hillman Cancer Center and the lead author of the study. “These initial combination data for vilastobart are encouraging as they show early evidence of meaningful anti-tumor activity in patients with traditionally immunotherapy-resistant tumors and highlight the potential for vilastobart to be a differentiated, next-generation anti-CTLA-4 in combination with PD-(L)1 inhibitors in MSS colorectal cancer and other tumors.”
Data from Phase 1C Dose Escalation for Vilastobart (XTX101), a Tumor-Activated Anti-CTLA-4, in Combination with Atezolizumab
As of a data cutoff date of October 7, 2024, 17 patients had been treated with the combination of vilastobart at doses ranging from 75 mg to 150 mg once every six weeks (Q6W) and atezolizumab at 1200 mg once every three weeks (Q3W). Across all patients treated:
- Tumor types included MSS CRC (n=12) and microsatellite instability high (MSI-H) CRC, non-small cell lung cancer (NSCLC), esophageal cancer, ampullary carcinoma and cancer of the abdomen (n=1 each).
- The median age was 69 years (ranging from 39 to 77 years), and patients were generally heavily pre-treated.
83% of patients previously received three or more prior lines of anti-cancer therapy.
As of the data cutoff date, seven patients were continuing on treatment with the combination of vilastobart and atezolizumab, and 10 patients had discontinued treatment.
Initial Safety Data
Safety data support the potential for vilastobart to be a differentiated next-generation anti-CTLA-4 in combination with PD-(L)1 inhibitors—combination was generally well-tolerated with patients experiencing minimal immune-related adverse events
- Across all dose levels, no Grade 4 or Grade 5 treatment-related adverse events (AEs) were reported by investigators. In addition, no endocrine immune-related AEs (irAEs) and limited skin irAEs were reported by investigators. Only one patient (
6% ) experienced a dose reduction due to a treatment-related AE, and only one patient (6% ) discontinued treatment of both vilastobart and atezolizumab due to a treatment-related AE. - Across all dose levels, investigators reported Grade 3 treatment-related AEs in only three patients: alanine aminotransferase (ALT) increase (
12% ); diarrhea, colitis and blood alkaline phosphatase (ALP) increase (6% each). Of these Grade 3 treatment-related AEs, two patients at the 150 mg dose level for vilastobart had dose-limiting toxicities: one patient with Grade 3 colitis and diarrhea and one patient with Grade 3 ALT increase and blood ALP increase. - Across all dose levels, the most common treatment-related AEs (≥
10% incidence) of any grade reported by investigators were the following: infusion-related reactions (59% ); aspartate aminotransferase (AST) increase, ALT increase and lipase increase (18% each); diarrhea, fatigue and blood ALP increase (12% each). Of the 10 patients with infusion-related reactions, four patients experienced reactions related to vilastobart, three patients experienced reactions related to atezolizumab and three patients experienced reactions related to the combination.
Initial Anti-Tumor Activity Data
Encouraging early evidence of anti-tumor activity, including partial responses (unconfirmed) in two patients with difficult-to-treat, immunologically “cold” tumors, including one patient with MSS CRC and a metastatic liver lesion
- Patient with MSS CRC and a metastatic liver lesion: A patient with MSS CRC and a metastatic liver lesion achieved a partial response (pending confirmation) per Response Evaluation Criteria in Solid Tumors (RECIST) (
33% reduction in the sum of diameters of target lesions), including full resolution of the liver lesion. The patient previously progressed on five prior lines of therapy and was administered the combination of vilastobart at the 150 mg Q6W dose level and atezolizumab (1200 mg Q3W). - Patient with ampullary carcinoma: A patient with ampullary carcinoma achieved a partial response (unconfirmed) per RECIST (
32% reduction in the sum of diameters of target lesions) accompanied by a substantial decrease in the serum tumor marker CA 19-9 (from 700.2 at baseline to 40.8 after 6 weeks of treatment). CA 19-9 associated antigen levels are often significantly elevated in patients with pancreatic cancer. The patient previously progressed on two prior lines of therapy and was administered the combination of vilastobart at the 150 mg Q6W dose level and atezolizumab (1200 mg Q3W). The patient withdrew consent prior to undergoing a confirmatory scan.
Clinical Development Plans for Vilastobart
The initial Phase 1C data supported the selection of an initial recommended Phase 2 dose (RP2D) for vilastobart at 100 mg Q6W in combination with atezolizumab at 1200 mg Q3W. In addition, Xilio continues to enroll patients in Phase 1C dose escalation for the combination of vilastobart at the 150 mg Q6W dose level and atezolizumab at 1200 mg Q3W.
Xilio is currently enrolling patients in its ongoing Phase 2 clinical trial evaluating the combination of vilastobart and atezolizumab at the initial combination RP2D in patients with metastatic MSS CRC, including patients with and without liver metastases.
Xilio expects to report initial Phase 2 data for the combination in approximately 20 patients with metastatic MSS CRC in the fourth quarter of 2024 and additional Phase 2 data for the combination in a total of approximately 40 patients with metastatic MSS CRC in the first quarter of 2025.
Investor Conference Call Information
Xilio will host a conference call and webcast at 4:30 pm ET today (November 7, 2024) to discuss the Phase 1C dose escalation data for the combination of vilastobart and atezolizumab. Members of Xilio’s management team will be joined by Aparna Parikh, M.D., Director of Colorectal Medical Oncology Research and Director of the Young Adult Colorectal Cancer Program at The Massachusetts General Hospital Cancer Center. The conference call may be accessed by dialing (800) 715-9871 (domestic) or (646) 307-1963 (international) and referring to conference ID 7645770. A webcast of the call will also be available under “Events & Presentations” in the Investors & Media section of the Xilio Therapeutics website at https://ir.xiliotx.com. A replay of the webcast will be archived on the website for 30 days following the presentation.
About Vilastobart (XTX101) and the Phase 1/2 Combination Clinical Trial
Vilastobart is an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody designed to block CTLA-4 and deplete regulatory T cells when activated in the tumor microenvironment (TME). In 2023, Xilio entered into a co-funded clinical trial collaboration with Roche to evaluate vilastobart in combination with atezolizumab (Tecentriq®) in a multi-center, open-label Phase 1/2 clinical trial. Xilio is currently evaluating the safety of the combination in Phase 1C dose escalation in patients with advanced solid tumors and the safety and efficacy of the combination in Phase 2 in patients with metastatic microsatellite stable colorectal cancer with and without liver metastases. Please refer to NCT04896697 on www.clinicaltrials.gov for additional details.
About Xilio Therapeutics
Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize the therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines, antibodies, bispecifics and immune cell engagers. Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.).
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding plans, expectations and anticipated milestones for vilastobart (XTX101), including plans and timing for reporting Phase 2 clinical data for vilastobart in combination with atezolizumab in patients with MSS CRC; the potential benefits of vilastobart or any of Xilio’s other current or future product candidates in treating patients as a monotherapy or combination therapy; and Xilio’s strategy, goals and anticipated financial performance, milestones, business plans and focus. The words “aim,” “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “seek,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of important risks, uncertainties and other factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, general market conditions; risks and uncertainties related to ongoing and planned research and development activities, including initiating, conducting or completing preclinical studies and clinical trials and the timing and results of such preclinical studies or clinical trials; the delay of any current or planned preclinical studies or clinical trials or the development of Xilio’s current or future product candidates; Xilio’s ability to obtain and maintain sufficient preclinical and clinical supply of current or future product candidates; Xilio’s advancement of multiple early-stage immune cell engager programs, including tumor-activated immune cell engagers and tumor-activated effector-enhanced immune cell engagers; initial, preliminary or interim preclinical or clinical data or results (including without limitation, the Phase 1C data for vilastobart), which may not be replicated in or predictive of future preclinical or clinical data or results; Xilio’s ability to successfully demonstrate the safety and efficacy of its product candidates and gain approval of its product candidates on a timely basis, if at all; results from preclinical studies or clinical trials for Xilio’s product candidates, which may not support further development of such product candidates; actions of regulatory agencies, which may affect the initiation, timing and progress of current or future clinical trials; Xilio’s ability to obtain, maintain and enforce patent and other intellectual property protection for current or future product candidates; Xilio’s ability to obtain and maintain sufficient cash resources to fund its operations; the impact of international trade policies on Xilio’s business, including U.S. and China trade policies; Xilio’s ability to maintain its clinical trial collaboration with Roche to develop vilastobart in combination with atezolizumab; and Xilio’s ability to maintain its license agreement with Gilead to develop and commercialize XTX301. These and other risks and uncertainties are described in greater detail in the sections entitled “Risk Factor Summary” and “Risk Factors” in Xilio’s filings with the U.S. Securities and Exchange Commission (SEC), including Xilio’s most recent Quarterly Report on Form 10-Q and any other filings that Xilio has made or may make with the SEC in the future. Any forward-looking statements contained in this press release represent Xilio’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Except as required by law, Xilio explicitly disclaims any obligation to update any forward-looking statements.
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Investor and Media Contact
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Vice President, Investor Relations and Corporate Communications
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