Wave Life Sciences Ltd. Ordinary Shares - WVE STOCK NEWS

Wave Life Sciences Ltd. (Nasdaq: WVE) announced that CEO Paul Bolno will participate in a virtual fireside chat at the Stifel 2022 CNS Days event on March 28, 2022, at 9:15 a.m. EDT. This event highlights Wave's commitment to developing genetic medicines aimed at treating severe diseases. A live webcast of the presentation will be available on the Investor Relations page of Wave's website, with a replay available for a limited time after the event.

Wave Life Sciences Ltd. (Nasdaq: WVE) announced key presentations at the OPT Congress and RNA Editing Summit, showcasing advancements in their A-to-I(G) RNA base editing oligonucleotides (AIMers). Highlights include preclinical data on their AIMer program for Alpha-1 antitrypsin deficiency (AATD), demonstrating editing efficiency and protein restoration over 19 weeks. The AIMers leverage the body's natural ADAR enzymes for precise editing without permanent genomic changes. The company's IND-enabling studies are slated for Q3 2022, emphasizing Wave's commitment to innovative genetic therapies.

Wave Life Sciences (Nasdaq: WVE) announced preclinical proof-of-concept data demonstrating the efficacy of its AIMer technology for RNA base editing in non-human primates. Published in Nature Biotechnology, the study reported up to 50% editing of the ACTB transcript in the liver, with levels persisting at 40% for over a month. AIMers simplify delivery without the need for exogenous enzymes, potentially enhancing therapeutic applications, especially for genetic conditions like alpha-1 antitrypsin deficiency.

Wave Life Sciences (WVE) reported a net loss of $34.8 million for Q4 2021, compared to $28.8 million in Q4 2020. For the full year, the net loss was $122.2 million, down from $149.9 million in 2020. Revenue from the Takeda collaboration fell to $1.8 million in Q4 from $9.4 million in the previous year, while total revenue for 2021 reached $41.0 million, up from $20.1 million. Cash as of December 31, 2021, stood at $150.6 million, expected to fund operations into Q2 2023. Key developments include advancements in RNA therapies for ALS, DMD, and HD.

Wave Life Sciences (Nasdaq: WVE) will hold a live webcast and conference call on March 3, 2022, at 8:30 a.m. ET to discuss its Q4 and FY 2021 financial results and provide a business update. The webcast can be accessed via the Investor Relations section of the Wave Life Sciences website. The company's proprietary PRISM platform focuses on developing genetic medicines, targeting genetically defined diseases. Investors can dial in for the call using provided numbers and enter the conference ID: 7694386. An archived version will be available post-event.

Wave Life Sciences (Nasdaq: WVE) announced that CEO Paul Bolno will participate in an analyst-led fireside chat at the Virtual 11th Annual SVB Leerink Global Healthcare Conference on February 16, 2022, at 10:40 a.m. ET. The event underscores Wave's commitment to advancing genetic medicines for severe diseases. A live webcast will be accessible on their Investor Relations page, and a replay will be available for a limited time after the event. Wave Life Sciences focuses on creating innovative treatments using their proprietary PRISM platform.

Wave Life Sciences (Nasdaq: WVE) announced significant advancements in its research regarding PN chemistry for stereopure oligonucleotides, highlighted by two publications in Nucleic Acids Research. The studies demonstrate that PN chemistry enhances potency, distribution, and durability in preclinical models for CNS and neuromuscular diseases. Wave's ongoing clinical programs target ALS, DMD, and Huntington’s disease. The first clinical data from PN chemistry-containing oligonucleotides is expected in 2022. The research emphasizes the importance of stereochemistry in therapeutic design.

Wave Life Sciences has partnered with the Alzheimer's Drug Discovery Foundation (ADDF) and the Association for Frontotemporal Degeneration (AFTD) to advance the FOCUS-C9 Phase 1b/2a clinical trial for WVE-004, targeting C9orf72-associated frontotemporal degeneration (C9-FTD) and amyotrophic lateral sclerosis (C9-ALS). This collaboration aims to evaluate various biomarkers for effective treatment assessments. WVE-004's novel oligonucleotide chemistry could significantly impact treatment outcomes in these neurodegenerative diseases.

Vintage Wine Estates (NASDAQ: VWE) has reached a significant milestone with its Angels Share campaign, donating over one million meals to combat food insecurity in the U.S. Since its inception eight years ago, the initiative has partnered with the Redwood Empire Food Bank and various other organizations across states like Colorado and Maryland. In a recent event, the company packed 3,000 food boxes for local distribution, continuing its commitment to support communities during challenging times.