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Wave Life Sciences Ltd. Ordinary Shares - WVE STOCK NEWS

Welcome to our dedicated page for Wave Life Sciences Ltd. Ordinary Shares news (Ticker: WVE), a resource for investors and traders seeking the latest updates and insights on Wave Life Sciences Ltd. Ordinary Shares stock.

Wave Life Sciences Ltd. (Nasdaq: WVE) is a clinical-stage biotechnology company harnessing its groundbreaking synthetic chemistry platform to create stereopure nucleic acid therapeutics. Focused on rare genetic diseases, Wave's pipeline addresses conditions such as alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy (DMD), and Huntington's disease. Wave's proprietary PRISMTM platform integrates various RNA modalities, including RNA editing, antisense, exon-skipping, and RNA interference, enabling scientific breakthroughs that address both rare and common disorders.

Recently, Wave has made significant progress with its Phase 2 FORWARD-53 trial for DMD, showing promising results with WVE-N531. This trial, which began dosing in December 2023, aims to evaluate dystrophin protein generation in boys amenable to exon 53 skipping, with critical data expected in 2024. The company also anticipates delivering first-of-its-kind RNA editing proof-of-mechanism data in 2024 for its WVE-006 program, targeting alpha-1 antitrypsin deficiency.

Financially, Wave is well-capitalized, with substantial cash inflows and strategic partnerships, including a notable collaboration with GSK. This partnership has led to significant milestone payments and the initiation of development programs utilizing Wave's advanced GalNAc-siRNA format.

Wave Life Sciences is at the forefront of RNA medicine, driven by a commitment to transform human health and provide life-changing treatments for devastating diseases.

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Wave Life Sciences (Nasdaq: WVE) announced an analyst and investor webcast on September 28, 2022, focusing on WVE-006, its first-in-class RNA editing candidate targeting alpha-1 antitrypsin deficiency (AATD). The event, titled 'Towards the Clinic: Spotlight on RNA Editing for AATD', will provide insights from AATD expert Dr. D. Kyle Hogarth and the Wave management team. WVE-006 aims to correct mutations in the SERPINA1 gene, addressing both lung and liver disease. Registration is available on Wave's website.

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Wave Life Sciences (WVE) announced the selection of WVE-006 as its first RNA editing candidate for treating alpha-1 antitrypsin deficiency (AATD), with clinical trial applications expected in 2023. The company reported a net loss of $41.3 million for Q2 2022, down from $38.8 million a year earlier, with revenue declining to $0.4 million. Research and development expenses were $29.7 million, while general and administrative expenses increased to $12.8 million. A successful financing round in June 2022 raised $70 million, strengthening the balance sheet and providing cash runway until the end of 2023.

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Wave Life Sciences (Nasdaq: WVE) will host a live webcast and conference call on August 11, 2022, at 8:30 a.m. ET to review its Q2 2022 financial results and provide a business update. Investors can access the webcast through the company's investor relations website. Analysts are encouraged to register in advance for the Q&A session. Wave Life Sciences focuses on developing genetic medicines for severe diseases, using its proprietary PRISM platform to create stereopure oligonucleotides.

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Wave Life Sciences (Nasdaq: WVE) announced an underwritten offering of 25,464,483 ordinary shares at $2.15 each, representing a 7.5% premium over the June 13 closing price. Additionally, when issuing pre-funded warrants to buy 7,093,656 shares at $2.1499, they aim to raise approximately $70 million. The offering will close around June 16, 2022, subject to customary conditions. RA Capital Management is a notable participant, with SVB Securities acting as the bookrunning manager. The offering is made under a previously approved SEC registration statement.

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Wave Life Sciences (Nasdaq: WVE) announced that its CEO, Paul Bolno, will participate in an analyst-led fireside chat at the 2022 Jefferies Healthcare Conference in New York City on June 8, 2022, at 3:00 p.m. ET. A live webcast will be available on Wave's Investor Relations page, with a replay accessible for a limited time after the event. Wave Life Sciences is focused on developing genetic medicines for serious diseases using its proprietary PRISM platform.

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Wave Life Sciences (WVE) announced first clinical data from the FOCUS-C9 trial, showcasing effective target engagement of WVE-004 for C9-ALS and C9-FTD. The company reported a net loss of $37.8 million for Q1 2022, with revenues of $1.8 million, primarily from a collaboration with Takeda. R&D expenses decreased to $27.5 million, while G&A expenses rose to $12.4 million. Wave has $111.7 million in cash as of March 31, 2022, sufficient to fund operations into Q2 2023. Key clinical data updates are anticipated later this year for Huntington’s disease and Duchenne muscular dystrophy.

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Wave Life Sciences (Nasdaq: WVE), a clinical-stage genetic medicines company, announced that Paul Bolno, MD, CEO, will participate in two investor conferences in May 2022. The first is at the RBC Capital Markets 2022 Global Healthcare Conference on May 17, 2022, from 2:05 p.m. to 2:30 p.m. ET in New York. The second is at the H.C. Wainwright Global Investment Conference on May 24, 2022, from 3:30 p.m. to 4:00 p.m. ET in Miami. Live webcasts will be available on their Investor Relations page.

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Wave Life Sciences Ltd. (Nasdaq: WVE) has announced a live webcast and conference call scheduled for May 12, 2022, at 8:30 a.m. ET to discuss its first quarter 2022 financial results and provide a business update. The event will be accessible via the company's investor relations website, with teleconference options available for domestic and international participants. Wave Life Sciences focuses on developing life-changing genetic medicines using its proprietary PRISM platform to target genetically defined diseases.

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Wave Life Sciences announced the publication of preclinical data for WVE-004, targeting C9orf72-associated ALS and frontotemporal dementia. The study, published in Molecular Therapy Nucleic Acids, demonstrated significant reductions in pathogenic RNA transcripts and poly(GP) proteins over six months in mice, highlighting its potential efficacy. Initial clinical data from the ongoing FOCUS-C9 trial suggests that these preclinical results are translating into human applications, with effective target engagement and sustained reductions in poly(GP) levels.

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Wave Life Sciences Ltd. (Nasdaq: WVE) will participate in Chardan’s 6th Annual Genetic Medicines & Cell Therapy Manufacturing Summit on April 26, 2022, at 2:30 p.m. ET. CEO Paul Bolno and SVP Sri Vaddeboina will join an analyst-led fireside chat, which will be streamed live on their Investor Relations page. Wave Life Sciences focuses on delivering innovative genetic medicines for devastating diseases using its PRISM platform for the precise design and production of stereopure oligonucleotides. A replay will be available shortly after the event on their website.

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FAQ

What is the current stock price of Wave Life Sciences Ltd. Ordinary Shares (WVE)?

The current stock price of Wave Life Sciences Ltd. Ordinary Shares (WVE) is $14.27 as of November 22, 2024.

What is the market cap of Wave Life Sciences Ltd. Ordinary Shares (WVE)?

The market cap of Wave Life Sciences Ltd. Ordinary Shares (WVE) is approximately 2.2B.

What is Wave Life Sciences Ltd.?

Wave Life Sciences Ltd. (Nasdaq: WVE) is a biotechnology company focused on developing stereopure nucleic acid therapeutics for genetic diseases using its proprietary PRISMTM platform.

What diseases is Wave targeting?

Wave Life Sciences is developing treatments for diseases such as alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.

What is the PRISMTM platform?

PRISMTM is Wave's proprietary platform that combines multiple RNA modalities, chemistry innovation, and genetic insights to create RNA-targeting therapies.

What is the FORWARD-53 trial?

FORWARD-53 is a Phase 2 trial evaluating WVE-N531 for boys with Duchenne muscular dystrophy amenable to exon 53 skipping. It aims to assess dystrophin protein levels and safety.

What recent achievements has Wave Life Sciences made?

Wave has initiated dosing in the FORWARD-53 trial, advanced its WVE-006 program, and received significant milestone payments through its partnership with GSK.

How is Wave Life Sciences funded?

Wave Life Sciences is well-capitalized with substantial cash inflows, including $142 million in Q4 2023 and additional payments under existing collaborations.

What is WVE-006?

WVE-006 is Wave's RNA editing candidate for alpha-1 antitrypsin deficiency, designed to restore functional M-AAT protein and expected to provide proof-of-mechanism data in 2024.

What is the significance of the partnership with GSK?

The partnership with GSK allows Wave to advance multiple RNA-targeting programs, providing substantial milestone payments and leveraging Wave's PRISMTM platform.

What is Wave's approach to RNA medicines?

Wave Life Sciences employs a multimodal approach, utilizing RNA editing, splicing, RNA interference, and antisense silencing to design precise, effective therapies.

Where is Wave Life Sciences headquartered?

Wave Life Sciences is headquartered in Cambridge, Massachusetts.

Wave Life Sciences Ltd. Ordinary Shares

Nasdaq:WVE

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2.16B
129.41M
15.04%
78.49%
4.48%
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