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Wave Life Sciences Ltd. (Nasdaq: WVE) is a clinical-stage biotechnology company harnessing its groundbreaking synthetic chemistry platform to create stereopure nucleic acid therapeutics. Focused on rare genetic diseases, Wave's pipeline addresses conditions such as alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy (DMD), and Huntington's disease. Wave's proprietary PRISMTM platform integrates various RNA modalities, including RNA editing, antisense, exon-skipping, and RNA interference, enabling scientific breakthroughs that address both rare and common disorders.
Recently, Wave has made significant progress with its Phase 2 FORWARD-53 trial for DMD, showing promising results with WVE-N531. This trial, which began dosing in December 2023, aims to evaluate dystrophin protein generation in boys amenable to exon 53 skipping, with critical data expected in 2024. The company also anticipates delivering first-of-its-kind RNA editing proof-of-mechanism data in 2024 for its WVE-006 program, targeting alpha-1 antitrypsin deficiency.
Financially, Wave is well-capitalized, with substantial cash inflows and strategic partnerships, including a notable collaboration with GSK. This partnership has led to significant milestone payments and the initiation of development programs utilizing Wave's advanced GalNAc-siRNA format.
Wave Life Sciences is at the forefront of RNA medicine, driven by a commitment to transform human health and provide life-changing treatments for devastating diseases.
Wave Life Sciences (WVE), a clinical-stage biotechnology company specializing in RNA medicines, has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference. The company's President and CEO, Paul Bolno, MD, MBA, will deliver a presentation on Monday, January 13, 2025, at 9:45 a.m. PT / 12:45 p.m. ET in San Francisco, CA.
Investors and interested parties can access a live webcast of the presentation through the company's Investor Relations website under the 'Investor Events' section. A replay will be available for a time after the event.
Wave Life Sciences (Nasdaq: WVE) has announced its participation in two major investor conferences this December. Paul Bolno, MD, MBA, President and CEO, will represent the company at both events. The first appearance will be an analyst-led fireside chat at the 7th Annual Evercore HealthCONx Conference on December 3, 2024, at 3:00 p.m. ET. The following day, December 4, he will participate in a Neuromuscular Disorders panel at the Citi 2024 Global Healthcare Conference at 1:00 p.m. ET. Both presentations will be available via webcast on the company's investor relations website, with replays accessible for a time.
Wave Life Sciences (Nasdaq: WVE) has announced its participation in the Jefferies London Healthcare Conference. The company's President and CEO, Paul Bolno, MD, MBA, will engage in an analyst-led fireside chat on Wednesday, November 20, 2024, at 4:30 p.m. GMT / 11:30 a.m. ET.
The presentation will be accessible through a live webcast in the 'Investor Events' section of Wave Life Sciences' website. A replay will be available for a time after the event.
Wave Life Sciences reported its Q3 2024 financial results, highlighting several key achievements. The company demonstrated first-ever RNA editing in humans through its WVE-006 trial for alpha-1 antitrypsin deficiency. Cash position stands at $310.9 million as of September 30, 2024, plus additional $28 million from greenshoe option, extending runway into 2027. The company received supportive FDA feedback on WVE-003 for Huntington's disease and reported positive interim data from FORWARD-53 study of WVE-N531. Wave also announced three new GalNAc-AIMer preclinical programs for cardiometabolic diseases and plans to initiate WVE-007 clinical trial for obesity in Q1 2025.
Wave Life Sciences (Nasdaq: WVE) has announced it will host a live webcast and conference call on Tuesday, November 12, 2024, at 8:30 a.m. ET to discuss its third quarter 2024 financial results and provide business updates. The event will be accessible through the company's investor relations website, with analysts able to participate in the Q&A session through a provided audio conferencing link. An archived version of the webcast will be available on the company's website following the live event.
Wave Life Sciences announced updates on its pipeline during a virtual Research Day. The company's WVE-007, a GalNAc-siRNA targeting INHBE for obesity treatment, is set to begin clinical trials in Q1 2025. New preclinical data shows WVE-007's potential as a monotherapy, in combination with GLP-1s, and for maintenance after GLP-1 discontinuation. The company also introduced three new RNA editing programs targeting PNPLA3, LDLR, and APOB for cardiometabolic diseases, with candidate selection planned for 2025. Wave aims to have five GalNAc-RNA editing or GalNAc-siRNA programs in clinical trials by 2026.
Wave Life Sciences (Nasdaq: WVE) has announced a virtual Research Day on October 30, 2024, from 10:00 a.m. to 11:30 a.m. ET. The event will showcase the company's progress in RNA medicines, including:
- Updates on their wholly owned pipeline
- Introduction of new GalNAc-conjugated RNA editing and siRNA programs
- Discussion of their clinically validated discovery and drug development platform
The company will highlight WVE-006, their RNA editing oligonucleotide for alpha-1 antitrypsin deficiency (AATD), and WVE-007, a GalNAc-siRNA INHBE candidate for obesity treatment. Dr. Mehmet Furkan Burak, an obesity specialist from Harvard Medical School, will provide insights on the current obesity treatment landscape. The event will be accessible via webcast on Wave Life Sciences' investor relations website.
Wave Life Sciences (Nasdaq: WVE) has successfully closed its previously announced public offering, raising approximately $230 million in gross proceeds. The offering included 26,875,001 ordinary shares at $8.00 per share and pre-funded warrants to purchase 1,875,023 ordinary shares. The underwriters fully exercised their option to purchase an additional 3,750,000 ordinary shares at the same price. J.P. Morgan and Leerink Partners served as joint book-running managers, with Truist Securities and Mizuho as book-runners. The offering was made through a shelf registration statement filed with the SEC, with the final prospectus supplement and accompanying base prospectus available on the SEC's website.
Wave Life Sciences (Nasdaq: WVE), a clinical-stage biotechnology company focusing on RNA medicines, has announced its participation in the Chardan 8th Annual Genetic Medicines Conference in New York City. Paul Bolno, MD, MBA, the company's President and CEO, is scheduled for an analyst-led fireside chat on Tuesday, October 1, 2024, at 1:00 p.m. ET.
The presentation will be accessible via a live webcast on the Investor Relations page of Wave Life Sciences' website. A replay will be available for a time after the event. This conference appearance underscores Wave Life Sciences' commitment to advancing RNA medicines and engaging with the investment community.
Wave Life Sciences (Nasdaq: WVE) has announced the pricing of its upsized public offering of ordinary shares and pre-funded warrants, aiming to raise approximately $200 million in gross proceeds. The offering includes 23,125,001 ordinary shares at $8.00 per share and pre-funded warrants to purchase up to 1,875,023 ordinary shares at $7.9999 per warrant. The company has also granted underwriters a 30-day option to purchase up to an additional 3,750,000 ordinary shares. The offering is expected to close around September 27, 2024. J.P. Morgan and Leerink Partners are acting as joint book-running managers, with Truist Securities and Mizuho as book-runners. The offering is being made through a prospectus and related supplement, with details available on the SEC's website.
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