Vyant Bio Announces Participation at the 2022 CDKL5 Forum Hosted by the Loulou Foundation on November 7-8, 2022

Rhea-AI Summary

Vyant Bio (Nasdaq: VYNT) showcased its advanced drug discovery platform at the 2022 CDKL5 Forum in Boston on November 7-8, 2022. The company highlighted its unique approach that leverages human-derived organoid models and machine learning to develop therapies for CDKL5 deficiency disorder (CDD). During the forum, Vyant will give a platform presentation titled High-throughput functional screening to develop novel therapies for CDKL5-deficiency disorder, and participate in a workshop discussing best practices for using induced pluripotent stem cell-derived brain organoids.

Positive

• Participation in significant industry events, such as the 2022 CDKL5 Forum, enhances visibility.
• Presentation of innovative approaches to drug discovery using human-derived organoid models.
• Focus on developing therapies for CDD, which currently lacks effective treatments.

Negative

• None.

Platform and Poster Presentations on Vyant Bio’s Human First Drug Discovery Platform and Progress on CDKL5 Deficiency Disorder (CDD)

CHERRY HILL, N.J., Oct. 27, 2022 (GLOBE NEWSWIRE) -- Vyant Bio, Inc. (“Vyant Bio” or “Company”) (Nasdaq: VYNT) is an innovative biotechnology company reinventing drug discovery for complex neurodevelopmental and neurodegenerative disorders. The Company’s proprietary central nervous system (“CNS”) drug discovery platform combines human-derived organoid models of brain disease, scaled biology, and machine learning to identify novel therapeutic candidates for neurodevelopmental and neurodegenerative disorders. Today, Vyant Bio announced their participation at the 2022 CDKL5 Forum Hosted by the Loulou Foundation on November 7^th and 8^th, 2022, in Boston, MA through platform and poster presentations. In addition, Vyant Bio will participate in a CDKL5 deficiency disorder scientific workshop on Monday October 31^st from 1-4 pm EDT and will present an industry perspective for the best practices for the use of human induced pluripotent stem cell (iPSC) derived brain organoids in drug discovery research.

Details for the platform talk and poster presentation include:

Title: High-throughput functional screening to develop novel therapies for CDKL5-deficiency disorder using human iPSC-derived cortical organoids
Authors: Matthew V. Green, Tori Alstat, Huda Ahmed, Kendra Prum, Cassiano Carromeu, Andrew LaCroix, Robert T. Fremeau, Jr.
Session: Molecular and Cellular Function
Session Date / Time: November 7, 11:35 am EDT

ABOUT CDKL5

CDKL5 stands for cyclin-dependent kinase-like 5, a protein whose gene is located on the X chromosome. The CDKL5 gene provides instructions for making a protein that is essential in forming the connections for normal brain development, with mutations causing a deficiency in the protein level. Mutations in the gene are usually spontaneous ‘de novo’ occurrences, rather than inherited. About 90% of patients with CDKL5 deficiency disorder (CDD) are girls. CDD patients suffer from seizures that usually begin within the first few months of life, as well as from profound neurodevelopmental delay. Estimates suggest that one in 40,000-60,000 live births develop the disorder, making it difficult to study when compared to common diseases like cancer and heart disease.

ABOUT THE LOULOU FOUNDATION

The Loulou Foundation is a private non-profit organization founded in 2015 to support the development of effective therapeutics and eventual cures for CDD. Through robust grant and directed research programs, the Foundation provides tools and resources to basic and clinical scientists to enable the development of disease-modifying therapeutics for CDD. These programs include support for pre-clinical, translational, and clinical research into basic CDKL5 biology, CDD disease mechanisms, and the proof-of-concept studies for gene therapy and genome modifying therapeutics. Visit www.louloufoundation.org for more information.

ABOUT VYANT BIO, INC.

Vyant Bio, Inc. (“Vyant Bio” or the “Company”) (Nasdaq: VYNT) is an innovative biotechnology company focused on identifying unique biological targets and novel and repurposed therapeutics for treating the debilitating neurodevelopmental and neurodegenerative disorders for which there are no current therapies.. Vyant Bio has built a platform of therapeutics seeking to treat neurodevelopmental and neurodegenerative diseases, with current programs targeting Rett Syndrome (“Rett”), CDKL5 Deficiency Disorders (“CDD”), and Parkinson’s Disease. The Company’s approach to drug discovery integrates human-derived biology with artificial intelligence and machine learning technologies to de-risk candidate selection, with the goal of improving the potential effectiveness of drugs discovered earlier in the development cycle. Vyant Bio’s management believes that drug discovery needs to progressively shift to more efficient methods as the widely used models for predicting safe and effective drugs have under-performed, as evidenced by the significant time and cost of bringing novel drugs to patients. By combining sophisticated data science capabilities with highly functional human cell derived disease models, Vyant Bio seeks to leverage its current ability to screen and test therapeutic candidates, and create a unique approach to assimilating data that supports decision making iteratively throughout the discovery phase of drug development to identify both novel and repurposed CNS therapeutic candidates.

For more information, please visit or follow Vyant Bio at:
Internet: www.vyantbio.com
LinkedIn: https://www.linkedin.com/company/vyant-bio
Twitter: @VyantBio

Forward Looking Statements:

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements pertaining to Vyant Bio, Inc.’s expectations regarding future financial and/or operating results, the efficacy of our drug screening and discovery process, and potential for our services, future revenue or growth in this press release constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to, statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” and “estimates”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in our attempts to discover drug candidates, partner with pharmaceutical and other biotechnology companies, achieve profitability, adapt to the global coronavirus pandemic, raise capital to meet our liquidity needs, and other risks discussed in the Vyant Bio, Inc. Form 10-K for the year ended December 31, 2021, and any subsequent filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. Vyant Bio disclaims any obligation to update these forward-looking statements.

Investor Contact:
Skyline Corporate Communications Group, LLC
Scott Powell, President
One Rockefeller Plaza, 10th Floor
New York, NY 10020 USA
Office: (646) 893-5835 x2
Email: info@skylineccg.com

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FAQ

What is Vyant Bio's focus in drug discovery?

Vyant Bio focuses on drug discovery for complex neurodevelopmental and neurodegenerative disorders using human-derived organoid models and machine learning.

When is Vyant Bio presenting at the CDKL5 Forum?

Vyant Bio will present at the CDKL5 Forum on November 7, 2022.

What is the significance of CDKL5 deficiency disorder?

CDKL5 deficiency disorder is a rare neurodevelopmental disorder affecting mainly girls, characterized by seizures and significant developmental delays.

What are the key components of Vyant Bio's drug discovery platform?

The platform combines human-derived organoid models, scaled biology, and machine learning to identify therapeutic candidates.

What are Vyant Bio’s future plans regarding drug discovery?

Vyant Bio plans to continue developing innovative therapies for disorders like CDKL5 deficiency by leveraging its advanced drug discovery platform.