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Voyager Therapeutics Inc - VYGR STOCK NEWS

Welcome to our dedicated page for Voyager Therapeutics news (Ticker: VYGR), a resource for investors and traders seeking the latest updates and insights on Voyager Therapeutics stock.

Overview

Voyager Therapeutics Inc (VYGR) is a biotechnology company focused on developing innovative gene therapies for severe and debilitating diseases of the central nervous system (CNS). Using advanced AAV gene therapy techniques and its proprietary TRACER™ capsid discovery platform, Voyager is dedicated to overcoming traditional barriers in gene delivery and creating transformative solutions for neurological disorders.

Core Technology and Platform

The company leverages its TRACER™ (Tropism Redirection of AAV by Cell-type-specific Expression of RNA) platform to engineer and optimize novel AAV capsids that are designed to cross the blood-brain barrier with high efficiency. This RNA-based screening enables rapid identification of capsid variants with enhanced CNS tropism and controlled tissue targeting, ensuring robust genetic payload delivery to areas of the brain traditionally hard to reach. The platform underpins both its gene therapy and antibody development programs, reflecting a robust integration of genetic science and neuroscience.

Pipeline and Disease Focus

Voyager Therapeutics maintains an extensive pipeline of programs aimed at addressing several critical CNS diseases. The company is developing gene therapy candidates to target conditions such as Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), and Friedreich’s ataxia. Additionally, Voyager is advancing therapies aimed at modifying the pathological processes in Alzheimer’s disease through tau silencing and anti-tau antibodies. Each candidate is carefully designed to modulate protein expression in the CNS, aiming to slow disease progression and improve patient outcomes.

Research and Development Approach

Emphasizing rigorous process development and production scalability, Voyager invests heavily in vector optimization and sophisticated dosing techniques. The company conducts cross-species preclinical studies to ensure that its TRACER-generated capsids achieve widespread and efficient gene expression while minimizing off-target effects. Its commitment to scientific excellence is reflected in its strategic external collaborations, which not only validate its technology but also extend its reach within the neurogenetic medicines field.

Industry Significance and Competitive Position

Voyager Therapeutics distinguishes itself within the biotechnology landscape through its specialized focus on CNS diseases and its innovative AAV-based gene therapy solutions. By integrating cutting-edge gene editing methodologies with deep neuroscientific insights, the company fills a significant unmet need in neurological drug development. Its collaboration with established industry partners further underscores the scientific reliability, stringent development standards, and translational potential of its candidates. The company’s balanced portfolio and technology-driven approach position it as a critical contributor to the evolution of gene therapies for challenging neurological conditions.

Commitment to Innovation and Patient Impact

At the heart of Voyager Therapeutics’ mission is the goal of modifying the course of devastating neurological diseases. By focusing on durable gene expression attainable through a single administration, the company aims to provide long-lasting therapeutic benefits that can transform the quality of life for patients. Its efforts in process development and clinical standardization continue to set benchmarks within the field, reflecting a commitment to excellence that is both scientifically robust and patient-centered.

This comprehensive approach—encompassing advanced vector engineering, strategic collaborations, and meticulous clinical development—underscores Voyager Therapeutics’ prominence in the realm of neurogenetic medicines and offers a detailed perspective for investors and industry observers alike.

Rhea-AI Summary

Voyager Therapeutics (Nasdaq: VYGR), a biotech company specializing in neurogenetic medicines, will participate in two virtual investor conferences in June 2024.

The company will present at the TD Cowen Genetic Medicines & RNA Summit on June 20 at 1:35 p.m. ET and at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference on June 27 at 7:00 a.m. ET. Both presentations will be webcasted and available on Voyager’s investor website, with replays accessible for at least 30 days.

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Voyager Therapeutics (Nasdaq: VYGR) announced the appointment of Nathan Jorgensen, Ph.D., MBA, as Chief Financial Officer, effective July 8, 2024. Jorgensen, bringing extensive experience in investment banking, healthcare investing, and biotech operations, previously served as CFO at Vor Biopharma. He raised over $400 million in financings and managed various operational domains. Voyager's CEO, Alfred W. Sandrock, Jr., emphasized Jorgensen's blend of strategic leadership and neuroscience expertise as important for advancing their neurotherapeutics pipeline. Jorgensen expressed enthusiasm for Voyager's innovative platform and its potential to overcome neurology delivery challenges.

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Voyager Therapeutics announced the dosing of the first participants in a Phase 1a single ascending dose (SAD) trial of VY-TAU01, an investigational anti-tau antibody designed to inhibit the spread of pathological tau in Alzheimer's disease. This randomized, double-blind, placebo-controlled trial aims to assess the safety and pharmacokinetics of VY-TAU01 in healthy adults. Conducted at a single U.S. site, the trial plans to enroll around 48 patients. Data from this trial will inform a Phase 1b multiple ascending dose (MAD) trial in early Alzheimer's patients, expected to begin in 2025, with initial imaging data potentially available by late 2026. Chief Medical Officer Toby Ferguson highlighted this milestone as a testament to Voyager's neurology drug development capabilities.

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Voyager Therapeutics reported its first quarter 2024 financial and operating results, highlighting several milestones and future expectations. The company received IND clearance for its anti-tau antibody VY-TAU01 for Alzheimer's disease and plans to start a trial soon. Development candidates were chosen for the GBA1 and Friedreich’s Ataxia gene therapy programs, with potential clinical entries in 2025. Voyager appointed Dr. Toby Ferguson as Chief Medical Officer. The company completed a $100 million public offering and announced a strategic collaboration with Novartis, which included an $80 million upfront payment and $20 million in newly issued equity. Voyager’s cash position is strong at approximately $400 million, providing financial runway into 2027. However, collaboration revenue dropped from $150.5 million in Q1 2023 to $19.5 million in Q1 2024, leading to a net loss of $11.3 million compared to a net income of $124 million in the same period last year. R&D expenses increased due to program-related spending.

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Voyager Therapeutics, Inc. presented data on second-generation TRACER™-Generated Capsids and CNS Gene Therapy Programs at the ASGCT 27th Annual Meeting. The data showed enhanced blood-brain barrier penetrance, broad CNS biodistribution, and robust transduction of key cell types, supporting the high translational potential of TRACER capsids for gene therapy in the CNS. The company aims to file INDs for three development candidates in neurologic diseases by 2025.

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Voyager Therapeutics, Inc. (Nasdaq: VYGR) will report its first quarter 2024 financial and operating results on May 13, 2024. The company will host a conference call and webcast to review the results. Participants can join via telephone or live webcast. Registration is required.

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Voyager Therapeutics will showcase translational data supporting IV-delivered, CNS gene therapy programs at the ASGCT 27th Annual Meeting. The company will present findings on TRACER capsid discovery platform, second-generation AAV capsids, and activity against therapeutic targets in Alzheimer's disease and ALS. Voyager's progress includes 13 partnered programs and three wholly-owned programs with development candidates selected, aiming for clinical trials next year.
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Voyager Therapeutics, in collaboration with Neurocrine Biosciences, selects a lead development candidate for the GBA1 gene therapy program to treat Parkinson's disease and other GBA1-mediated diseases. The candidate combines a GBA1 gene replacement payload with a novel capsid. Voyager expects a $3 million milestone payment and potential future payments based on program advancement.
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Voyager Therapeutics, Inc. grants non-qualified stock options and restricted stock units to Dr. Toby Ferguson as an inducement for his employment. The stock option allows the purchase of 210,000 shares at $9.26 per share, while the restricted stock unit represents 105,000 shares. Both awards vest over several years, contingent on Dr. Ferguson's continued employment.
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Voyager Therapeutics, Inc. appoints Toby Ferguson, M.D., Ph.D., as Chief Medical Officer, bringing valuable expertise in advancing clinical programs for neurological diseases. Ferguson's track record includes successful IND filings and proof-of-concept clinical trials, enhancing Voyager's prospects for developing neurogenetic medicines.
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FAQ

What is the current stock price of Voyager Therapeutics (VYGR)?

The current stock price of Voyager Therapeutics (VYGR) is $3.41 as of April 2, 2025.

What is the market cap of Voyager Therapeutics (VYGR)?

The market cap of Voyager Therapeutics (VYGR) is approximately 185.2M.

What is the primary focus of Voyager Therapeutics?

Voyager Therapeutics is dedicated to developing gene therapies for severe neurological diseases using innovative AAV platforms and advanced vector engineering.

What is the TRACER™ platform?

The TRACER™ platform is an RNA-based screening technology that enables rapid discovery and optimization of AAV capsids for improved blood-brain barrier penetration and targeted CNS delivery.

Which central nervous system diseases does Voyager address?

Voyager’s pipeline includes therapies for Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, and Alzheimer’s disease, among other CNS conditions.

How does Voyager’s technology enhance gene delivery to the brain?

Their engineered AAV capsids are designed to cross the blood-brain barrier efficiently, target specific cell types, and achieve robust gene expression while limiting off-target transduction.

What distinguishes Voyager Therapeutics from other biotech companies?

Voyager is distinguished by its specialized focus on CNS diseases, its proprietary TRACER™ capsid discovery platform, and its commitment to integrating advanced gene therapy approaches with deep neuroscientific expertise.

Does Voyager collaborate with other organizations?

Yes, Voyager has strategic collaborations with established biotech firms, enhancing the scientific rigor and translational impact of its gene therapy candidates.

How do Voyager's therapies aim to impact patient treatment?

Their gene therapy candidates are designed to modify the underlying disease mechanisms by regulating protein expression, potentially slowing disease progression and improving patient quality of life.

What research methods support Voyager's development approach?

Voyager employs cross-species preclinical studies, advanced vector optimization, and robust process development to validate the safety and efficacy of its therapies.
Voyager Therapeutics Inc

Nasdaq:VYGR

VYGR Rankings

VYGR Stock Data

185.22M
45.58M
17%
63.9%
4.95%
Biotechnology
Biological Products, (no Disgnostic Substances)
Link
United States
LEXINGTON