Voyager Therapeutics Inc Stock Price, News & Analysis

Voyager Therapeutics (Nasdaq: VYGR) announced promising preclinical data on its GBA1 gene replacement therapy, showing sustained correction of GCase enzyme activity across multiple brain regions in mice after a single intravenous dose. Results from the virtual Congress of the European Society of Gene and Cell Therapy indicated a 300% to 660% increase in GCase levels, potentially enabling effective treatment for neurological diseases like Gaucher disease and Parkinson’s. The therapy was well-tolerated, showcasing the advantages of blood-brain barrier-penetrant AAV capsids over traditional delivery methods.

Voyager Therapeutics (Nasdaq: VYGR) has entered a partnership with Pfizer, receiving $30 million upfront. The collaboration allows Pfizer to access Voyager's advanced AAV capsids, enhancing drug delivery for gene therapies targeting neurological and cardiovascular diseases. The agreement includes potential exercise fees and milestone payments up to $600 million, along with royalties based on product sales. Voyager retains rights for other applications of its TRACER technology, expected to boost the development of gene therapies and address unmet medical needs.

Voyager Therapeutics (Nasdaq: VYGR) announced its participation in three upcoming virtual investor conferences on September 9, 14, and 15, 2021. These conferences will feature a fireside chat at the Wells Fargo Securities Healthcare Conference, a fireside chat at the Morgan Stanley Global Healthcare Conference, and a company presentation at the Baird Global Healthcare Conference, respectively. Investors can access these sessions via the Investors & Media section of Voyager's website, where replays will also be archived for at least 30 days.

Voyager Therapeutics (Nasdaq: VYGR) announced its participation in two upcoming virtual investor conferences. The first is the Wedbush PacGrow Healthcare Conference, featuring a panel discussion on August 11, 2021, at 8:35 AM ET. The second is the Canaccord Genuity Growth Conference, which includes a fireside chat on August 12, 2021, from 10:30 to 10:55 AM ET. Investors can access these sessions via the Investors & Media section of Voyager’s website. The company focuses on advancing AAV gene therapy to treat serious diseases using its TRACER™ screening platform.

Voyager Therapeutics (VYGR) announced significant updates in its pipeline, focusing on second-generation programs for Huntington’s disease, ALS, spinal muscular atrophy, and GBA1 mutation-related diseases, utilizing proprietary AAV capsids. The TRACER platform aims to discover targeted AAV capsids for various tissues. Financially, collaboration revenue dropped to $1.4 million in Q2 2021 from $28.7 million in Q2 2020, while net loss increased to $30.1 million. The company maintains a cash position of $143 million, sufficient for operations into early 2023.

Voyager Therapeutics (NASDAQ: VYGR) announces a strategic shift towards enhancing its gene therapy pipeline, particularly focusing on VY-HTT01 for Huntington's disease. Michael Higgins steps in as interim CEO following Andre Turenne's resignation, while Glenn Pierce assumes the role of interim CSO. The company aims to maximize its TRACER gene therapy platform, which has shown promising transgene expression in non-human primates. Upcoming milestones include the initiation of a Phase 1/2 clinical trial for VY-HTT01 in Q4 2021, emphasizing the potential of its next-generation AAV capsids.

Voyager Therapeutics (NASDAQ: VYGR) presented new preclinical data on a vectorized anti-tau antibody at the 24th Annual Meeting of the American Society of Gene and Cell Therapy. The data indicates durable expression within the central nervous system, which may provide a novel single-dose strategy for treating tauopathies like Alzheimer's. Key findings include a 59% reduction in tau pathology after intravenous administration in rodent models and lasting expression for at least 28 days. A virtual investor event is planned for July 2021 to discuss further developments.

Voyager Therapeutics (NASDAQ: VYGR) presented preclinical data at the 24th Annual Meeting of the American Society of Gene and Cell Therapy, showing significant advancements in gene therapy for neurological diseases. Their novel AAV capsids demonstrated up to 1000-fold higher transgene expression in the brain compared to traditional AAV therapy after intravenous administration. The lead candidate, TRACER 9P801, exhibited a favorable tolerability profile with no observed toxicity. This breakthrough underscores the potential for treating CNS disorders with lower doses than current AAV serotypes.

Voyager Therapeutics (VYGR) reported Q1 2021 financial results, highlighting progress in its Huntington's disease program, VY-HTT01. The FDA cleared its IND application, with plans to initiate a Phase 1/2 trial by Q4 2021. The company also developed novel AAV capsids that improve gene delivery. However, collaboration revenues dropped to $6.5 million from $18.1 million a year prior, with a net loss of $21.6 million. The company has $153.1 million in cash as of March 31, 2021, positioning itself for upcoming trials and innovations.