Verona Pharma to Announce Top-line Data from Phase 3 ENHANCE-2 Trial of Nebulized Ensifentrine for COPD

Rhea-AI Summary

Verona Pharma announces the reporting of top-line Phase 3 data from its ENHANCE-2 trial on August 9, 2022. This trial evaluates the efficacy of nebulized ensifentrine for the treatment of COPD. The company will also disclose its financial results for Q2 2022 during an investment community webcast at 8:30 a.m. EDT. Notably, the ENHANCE program includes two studies focused on lung function improvements over 24 weeks, with primary endpoints measuring FEV₁. Verona Pharma seeks to address significant unmet needs in respiratory diseases.

Positive

• Upcoming Phase 3 data from ENHANCE-2 trial expected to show efficacy of nebulized ensifentrine.
• Potential for ensifentrine to be the first dual-action therapy for respiratory diseases.

Negative

• None.

Second quarter 2022 financial results and corporate update

LONDON and RALEIGH, N.C., Aug. 08, 2022 (GLOBE NEWSWIRE) -- Verona Pharma plc (Nasdaq: VRNA) (“Verona Pharma” or the "Company"), a clinical-stage biopharmaceutical company focused on respiratory diseases, announces that it will report top-line Phase 3 data from its ENHANCE-2 (“Ensifentrine as a Novel inHAled Nebulized COPD thErapy”) trial of nebulized ensifentrine and its financial results for the second quarter ended June 30, 2022 on August 9, 2022. The Company will host an investment community webcast and conference call at 8:30 a.m. EDT / 1:30 p.m. BST to discuss these data and financial results and to provide a corporate update.

Antonio Anzueto, MD, Professor of Medicine and Section Chief of Pulmonary at South Texas Veterans Healthcare System, will join Verona Pharma’s management team on the call to provide his perspective on the trial results and answer questions related to the ENHANCE-2 data.

The Company previously announced it would hold an investment community conference call on August 15, 2022, to discuss the Company’s second quarter financial results and provide a corporate update. This press release updates the date, time and call-in information for such call.

To participate, please dial one of the following numbers and reference conference ID 2165062:

• Link to ENHANCE-2 and second quarter 2022 results call
• +1-888-317-6003 for callers in the United States
• +1-412-317-6061 for international callers
  

A live webcast will be available on the Events and Presentations link on the Investors page of the Company’s website, www.veronapharma.com, and the audio replay will be available for 90 days.

For further information please contact:

Verona Pharma plc	US Tel: +1-833-417-0262 UK Tel: +44 (0)203 283 4200
Victoria Stewart, Director of Investor Relations and Communications	info@veronapharma.com
Argot Partners (US Investor Enquiries)	Tel: +1-212-600-1902 verona@argotpartners.com
Kimberly Minarovich / Michael Barron
Optimum Strategic Communications (International Media and European Investor Enquiries)	Tel: +44 (0)203 882 9621 verona@optimumcomms.com
Mary Clark / Rebecca Noonan / Zoe Bolt

About the ENHANCE program

The two randomized, double-blind, placebo-controlled studies (ENHANCE-1 and ENHANCE-2) evaluate the efficacy and safety of nebulized ensifentrine in subjects with COPD over 24 weeks. The primary endpoint of both studies is improvement in lung function, as measured by average forced expiratory volume in one second (“FEV₁”) area under the curve (“AUC”) 0-12 hours post dose at week 12. Key secondary endpoints comprise measurements of COPD symptoms and health-related quality of life measures. ENHANCE-1 will also evaluate longer-term safety over 48 weeks. Further information about the program can be found at www.clinicaltrials.gov, NCT04535986 (ENHANCE-1) and NCT04542057 (ENHANCE-2).

About Verona Pharma

Verona Pharma is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative therapies for the treatment of respiratory diseases with significant unmet medical needs. If successfully developed and approved, Verona Pharma’s product candidate, ensifentrine, has the potential to be the first therapy for the treatment of respiratory diseases that combines bronchodilator and anti-inflammatory activities in one compound. The Company is evaluating nebulized ensifentrine in its Phase 3 clinical program ENHANCE (“Ensifentrine as a Novel inHAled Nebulized COPD thErapy”) for COPD maintenance treatment. Two additional formulations of ensifentrine are in Phase 2 development for the treatment of COPD: dry powder inhaler (“DPI”) and pressurized metered-dose inhaler (“pMDI”). Ensifentrine has potential applications in cystic fibrosis, asthma and other respiratory diseases. For more information, please visit www.veronapharma.com. 

FAQ

What is the ENHANCE-2 trial for Verona Pharma (VRNA)?

The ENHANCE-2 trial focuses on evaluating the efficacy and safety of nebulized ensifentrine for treating COPD over 24 weeks.

When will Verona Pharma (VRNA) release its financial results?

Verona Pharma will release its second quarter financial results on August 9, 2022.

What are the primary endpoints of the ENHANCE program?

The primary endpoint is improvement in lung function, specifically measuring FEV₁ at week 12.

Who will discuss the ENHANCE-2 trial results during the call?

Antonio Anzueto, MD, will join the call to provide insights on the trial results.

What potential market impact does ensifentrine have for Verona Pharma (VRNA)?

If successful, ensifentrine could be the first therapy combining bronchodilator and anti-inflammatory effects, addressing significant unmet needs in COPD treatment.