Welcome to our dedicated page for Verve Therapeutics news (Ticker: VERV), a resource for investors and traders seeking the latest updates and insights on Verve Therapeutics stock.
Verve Therapeutics, Inc. (VERV) is a clinical-stage biotechnology pioneer developing single-course gene editing treatments for cardiovascular disease. This news hub provides investors and healthcare professionals with essential updates on therapeutic advancements, clinical trial progress, and strategic developments.
Access comprehensive coverage of VERV's innovative pipeline including PCSK9, ANGPTL3, and LPA gene editing programs. Our curated news collection features regulatory milestones, partnership announcements, and scientific breakthroughs in base editing technology.
Stay informed about Verve's cutting-edge approach to permanently modifying cholesterol-related genes through precise liver-targeted therapies. The page aggregates official press releases, trial result analyses, and expert commentary while maintaining strict financial compliance standards.
Bookmark this page for real-time updates on Verve Therapeutics' mission to transform cardiovascular care through durable genetic medicines. Check regularly for new developments in this rapidly evolving sector of precision biotechnology.
Verve Therapeutics has announced positive initial data from the Heart-2 Phase 1b clinical trial of VERVE-102, a single-dose base editing treatment targeting PCSK9 for cardiovascular disease. The trial included 14 participants with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD).
Key findings across three dose cohorts (0.3, 0.45, and 0.6 mg/kg) showed:
- Mean LDL-C reduction of 53% and maximum reduction of 69% in the 0.6 mg/kg cohort
- Dose-dependent decreases in blood PCSK9 protein levels
- No treatment-related serious adverse events
- No clinically significant changes in ALT or platelets
The company plans to announce final dose escalation data in H2 2025, initiate Phase 2 trials, and receive Eli Lilly's decision on their PCSK9 program opt-in. Current funding is expected to last until mid-2027.
Verve Therapeutics has received FDA Fast Track designation for VERVE-102, an investigational base editing medicine targeting PCSK9 for treating hyperlipidemia patients with high cardiovascular risk. VERVE-102 is designed as a single-course treatment to permanently deactivate the PCSK9 gene in the liver and reduce LDL-C levels.
The treatment is currently in Phase 1b Heart-2 clinical trial, evaluating safety and tolerability in patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD). The company plans to announce initial safety and efficacy data from the first three dose cohorts (0.3, 0.45, and 0.6 mg/kg) in Q2 2025.
The Fast Track status may enable more frequent FDA communications and potential Priority Review. Verve plans to report final dose escalation data, deliver the opt-in package to Eli Lilly, and begin Phase 2 trials in H2 2025.
Verve Therapeutics, a clinical-stage cardiovascular genetic medicine company, has announced new equity awards granted to three employees on March 31, 2025. The inducement grants, made under the company's 2024 Inducement Stock Incentive Plan, include:
- Stock options to purchase 50,700 shares at $4.57 per share (closing price on grant date)
- 17,800 restricted stock units (RSUs)
The stock options have a 10-year term with a four-year vesting schedule: 25% vesting after one year, followed by monthly installments over three years. The RSUs will vest equally over three years, starting April 1, 2025. Both grants require continued employment for vesting.
Verve Therapeutics has received FDA clearance for its Investigational New Drug (IND) application for VERVE-102, a novel gene editing medicine targeting cardiovascular disease. The treatment is designed as a single-course therapy to inactivate the PCSK9 gene in the liver, aiming to permanently lower blood LDL cholesterol levels.
The ongoing Heart-2 Phase 1b clinical trial has shown promising interim results across three dose cohorts (0.3 mg/kg, 0.45 mg/kg, and 0.6 mg/kg), with no treatment-related serious adverse events reported as of January 10, 2025. The company plans to announce initial safety and efficacy data in Q2 2025, with final dose escalation data expected in H2 2025.
The treatment targets patients with heterozygous familial hypercholesterolemia (HeFH) and/or premature coronary artery disease (CAD). Verve will begin activating U.S. trial sites and plans to deliver an opt-in data package to Eli Lilly while initiating Phase 2 clinical trials in the second half of 2025.
Verve Therapeutics, a clinical-stage cardiovascular genetic medicine company, has granted equity awards to four new employees on February 28, 2025. The compensation package includes:
- 14,300 stock options with an exercise price of $6.33 per share (matching closing price)
- 20,100 restricted stock units (RSUs)
The stock options have a 10-year term with a 4-year vesting schedule: 25% vests after one year, with remaining shares vesting monthly over three years. RSUs will vest equally over three years starting April 1, 2025. These grants were made under the company's 2024 Inducement Stock Incentive Plan, complying with Nasdaq Listing Rule 5635(c)(4).
Verve Therapeutics reported key pipeline progress and financial results for Q4 and full year 2024. The company expects initial data from the Heart-2 Phase 1b trial of VERVE-102 (PCSK9 targeting) in Q2 2025, with final dose escalation data in H2 2025. VERVE-102 has shown positive safety profile with no serious adverse events.
The company maintains a strong financial position with $524.3 million in cash and equivalents, providing runway into mid-2027. Q4 2024 saw collaboration revenue of $13.1 million and a net loss of $50.0 million ($0.58 per share). For full year 2024, collaboration revenue was $32.3 million with a net loss of $198.7 million ($2.35 per share).
Key developments include ongoing enrollment in Pulse-1 Phase 1b trial of VERVE-201 targeting ANGPTL3, and the nomination of VERVE-301 targeting LPA gene. The company expects an opt-in decision from Eli Lilly in H2 2025.
Verve Therapeutics, a clinical-stage cardiovascular genetic medicine company, has granted equity awards to eight new employees on January 31, 2025. The compensation package includes:
- Stock options for 34,320 shares at $7.61 per share (closing price on grant date)
- 48,540 restricted stock units (RSUs)
The stock options have a 10-year term with a four-year vesting schedule: 25% vests after one year, with the remainder vesting monthly over three years. The RSUs will vest equally over three years, starting April 1, 2025. Both are subject to continued employment. These grants were made under the company's 2024 Inducement Stock Incentive Plan, complying with Nasdaq Listing Rule 5635(c)(4).
Verve Therapeutics, a clinical-stage biotechnology company focused on developing genetic medicines for cardiovascular disease, has announced its participation in the upcoming Guggenheim Securities SMID Cap Biotech Conference. The company's co-founder and CEO, Sekar Kathiresan, M.D., will engage in a fireside chat on Wednesday, February 5, 2025 at 9 a.m. ET in New York.
The event will be accessible via a live webcast through the investor section of Verve's website at www.vervetx.com. For those unable to attend live, the presentation will remain archived on the website for 90 days following the event.
Verve Therapeutics, focused on genetic medicines for cardiovascular disease, announced significant updates and anticipated milestones for 2025.
Pipeline Progress: Initial data from the Heart-2 Phase 1b trial for VERVE-102 targeting PCSK9 is expected in Q2 2025. Dosing has progressed to the 0.6 mg/kg cohort. VERVE-301, targeting the LPA gene, has been nominated as a development candidate, with associated milestone payments from Eli Lilly.
Financial Outlook: The company is well-capitalized with a cash runway extending into mid-2027.
Collaborations: Eli Lilly holds an opt-in right for the PCSK9 program and will fund Phase 1 of the LPA program, with Verve eligible for up to $465 million in milestones and royalties.
Upcoming Events: Verve will present at the 43rd Annual J.P. Morgan Healthcare Conference on January 15, 2025.
Verve Therapeutics (VERV), a clinical-stage biotechnology company focused on developing genetic medicines for cardiovascular disease, has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference. Dr. Sekar Kathiresan, the company's co-founder and CEO, will deliver a presentation on Wednesday, January 15, 2025, at 11:15 a.m. PT in San Francisco.
The presentation will be accessible through a live webcast on the investor section of Verve's website at www.vervetx.com. Interested parties can access the archived version of the webcast for 30 days following the presentation.
