Welcome to our dedicated page for Vaccinex news (Ticker: VCNX), a resource for investors and traders seeking the latest updates and insights on Vaccinex stock.
Vaccinex, Inc. (VCNX) is a clinical-stage biotechnology company headquartered in Rochester, NY. Specializing in the discovery and development of human therapeutic monoclonal antibodies, therapeutic vaccines, and other biologic products, Vaccinex is dedicated to addressing serious diseases with unmet medical needs, including cancer, multiple sclerosis, and other autoimmune diseases.
The company is pioneering a unique approach to treating cancer and neurodegenerative diseases through the inhibition of semaphorin 4D (SEMA4D). Vaccinex's leading drug candidate, pepinemab, is designed to block SEMA4D, a potent agent believed to prevent immune infiltration into tumors and reduce inflammation in chronic brain diseases. Currently, pepinemab is undergoing evaluation in a Phase 1b/2 study for recurrent or metastatic head and neck cancer and in a Phase 1/2a study for Alzheimer’s Disease. Additionally, there is ongoing exploration for potential Phase 3 development in Huntington's disease.
Vaccinex conducts research both in-house and through collaborations with prominent academic institutions and biotechnology firms. The company's proprietary drug discovery platform, ActivMAb, plays a significant role in its innovative drug development approach. The development team at Vaccinex comprises experienced industry veterans skilled in therapeutic biologics research, manufacturing, quality control, toxicology, pharmacology, regulatory affairs, and clinical affairs.
Recently, Vaccinex has achieved notable milestones, including a 1-for-15 reverse stock split to regain compliance with Nasdaq listing standards and the advancement of its clinical trials. The company continues to secure funding for its research, with significant investments from the Alzheimer’s Drug Discovery Foundation and grants from the Alzheimer’s Association.
Vaccinex remains committed to advancing its clinical programs and expanding its pipeline of innovative therapies to improve patient outcomes in challenging diseases.
Vaccinex, Inc. (Nasdaq: VCNX) reported positive developments in its ongoing clinical trials for pepinemab in oncology and neurodegenerative diseases. The Phase 1b segment of the KEYNOTE-B84 study in head and neck cancer showed two complete responses among three initial patients. Enrollment is ongoing for both the KEYNOTE-B84 and SIGNAL-AD trials, with topline data expected in 2023. Financially, Vaccinex ended 2021 with $8.6 million in cash, reflecting a decrease from $10.6 million in 2020. The comprehensive loss for 2021 was $22.4 million, an improvement from $28.9 million in the previous year.
Vaccinex, Inc. (Nasdaq: VCNX) announced its selection for a poster presentation at the 2022 American Association for Cancer Research Meetings, showcasing the phase 1b segment of the KEYNOTE-B84 study. This study evaluates pepinemab in combination with KEYTRUDA for patients with recurrent or metastatic head and neck cancer. The presentation is scheduled for April 11, 2022, featuring abstract CT111 by VP Clinical Science Terrence Fisher. Vaccinex holds global rights to pepinemab, which aims to improve tumor immunity and shows promise in ongoing clinical trials.
Vaccinex, Inc. (Nasdaq: VCNX) announced a poster presentation for its research on combination immunotherapy and HTT-lowering in humanized HD mice at the 17th Annual HD Therapeutics Conference on March 2, 2022. The presentation, led by Dr. Amber Southwell, will explore the efficacy of pepinemab in treating Huntington's disease by inhibiting semaphorin 4D (SEMA4D). The conference serves as a platform for advancing research in neurodegenerative diseases. Detailed presentation information and links are available on the company’s website.
Vaccinex announces a stock purchase agreement on January 27, 2022, with existing and new investors for a private placement of 5,945,943 shares at $1.11 per share, yielding approximately $6.6 million. This funding is part of a total of $10.1 million in new equity financing for January 2022. The proceeds will support the development of pepinemab, its lead drug candidate for cancer and neurodegenerative diseases. The placement is expected to close by January 31, 2022, and includes a registration rights agreement with investors.
Vaccinex, a clinical-stage biotechnology firm, announced positive interim results from the Phase Ib segment of the KEYNOTE-B84 study, featuring its drug pepinemab combined with Merck's KEYTRUDA for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC).
Of three patients, two achieved a complete response (CR), despite low PD-L1 biomarker levels. The recommended dose of pepinemab was well tolerated, allowing the continuation of treatment.
Vaccinex plans to expand the trial, enrolling up to an additional 62 patients, and aims to share further findings at a medical conference in 2022.
Vaccinex, Inc. (Nasdaq: VCNX) announced positive interim safety data from the Phase 1b segment of the KEYNOTE B84 study, evaluating the combination of pepinemab and Keytruda in advanced head and neck cancer patients. The safety run-in phase confirmed that pepinemab (20 mg/kg) and Keytruda (200 mg Q3W) were well tolerated, paving the way for the Phase 2 expansion segment, which will enroll up to 62 subjects. This study aims to assess the Objective Response Rate (ORR) and other key metrics, with interim results expected in the second half of 2022.
Vaccinex, Inc. (Nasdaq: VCNX) has announced that Dr. Elizabeth Evans will present a Phase 1/2 study on pepinemab in combination with pembrolizumab for advanced head and neck cancer at the SITC Annual Meeting from November 12-14, 2021. The presentation, Poster #434, will highlight the potential of pepinemab in enhancing treatment efficacy. The poster will be showcased in-person and virtually, with virtual access available until January 9, 2022. Vaccinex aims to leverage its unique drug discovery platform to expand its therapeutic pipeline, particularly in cancer and neurodegenerative diseases.
Vaccinex, Inc. (Nasdaq: VCNX) announces a live presentation by Terrence Fisher, Ph.D., at the Clinical Trials on Alzheimer's Disease Meeting in Boston on November 11, 2021. The presentation will focus on the potential of pepinemab, a SEMA4D-blocking antibody, as a novel treatment for neurodegenerative diseases, supported by clinical proof of concept in Huntington's Disease. Vaccinex aims to leverage its proprietary ActivMAb® platform for future drug development. Further details about the presentation can be found on the company’s website.
Vaccinex, Inc. (Nasdaq: VCNX) has launched clinical trials for its drug pepinemab, targeting advanced recurrent head and neck cancer and Alzheimer’s disease. The Phase 1b/2 trial in head and neck cancer will assess the combination with KEYTRUDA® and aims to enroll 65 subjects, with results expected in H2 2022. The Alzheimer’s study has begun enrollment for 40 subjects, with topline data anticipated in late 2022 or early 2023. Financially, R&D expenses decreased significantly to $3.6 million from $7.3 million year-over-year, while cash reserves increased to $13.8 million.
Vaccinex (Nasdaq: VCNX) announced a virtual presentation by CEO Dr. Maurice Zauderer at the 12th Annual Jefferies London Healthcare Conference on November 18-19, 2021. Investors are invited for one-on-one meetings during this period. The presentation will be accessible from 8:00 am GMT on November 18 until 5:00 pm GMT on November 19. Additionally, the presentation and a replay will be available on Vaccinex's website post-event. The company is focused on treating cancer and neurodegenerative diseases through SEMA4D inhibition, with its lead candidate, pepinemab, currently in clinical evaluation.
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