Welcome to our dedicated page for Vaccinex news (Ticker: VCNX), a resource for investors and traders seeking the latest updates and insights on Vaccinex stock.
Vaccinex, Inc. (VCNX) is a clinical-stage biotechnology company headquartered in Rochester, NY. Specializing in the discovery and development of human therapeutic monoclonal antibodies, therapeutic vaccines, and other biologic products, Vaccinex is dedicated to addressing serious diseases with unmet medical needs, including cancer, multiple sclerosis, and other autoimmune diseases.
The company is pioneering a unique approach to treating cancer and neurodegenerative diseases through the inhibition of semaphorin 4D (SEMA4D). Vaccinex's leading drug candidate, pepinemab, is designed to block SEMA4D, a potent agent believed to prevent immune infiltration into tumors and reduce inflammation in chronic brain diseases. Currently, pepinemab is undergoing evaluation in a Phase 1b/2 study for recurrent or metastatic head and neck cancer and in a Phase 1/2a study for Alzheimer’s Disease. Additionally, there is ongoing exploration for potential Phase 3 development in Huntington's disease.
Vaccinex conducts research both in-house and through collaborations with prominent academic institutions and biotechnology firms. The company's proprietary drug discovery platform, ActivMAb, plays a significant role in its innovative drug development approach. The development team at Vaccinex comprises experienced industry veterans skilled in therapeutic biologics research, manufacturing, quality control, toxicology, pharmacology, regulatory affairs, and clinical affairs.
Recently, Vaccinex has achieved notable milestones, including a 1-for-15 reverse stock split to regain compliance with Nasdaq listing standards and the advancement of its clinical trials. The company continues to secure funding for its research, with significant investments from the Alzheimer’s Drug Discovery Foundation and grants from the Alzheimer’s Association.
Vaccinex remains committed to advancing its clinical programs and expanding its pipeline of innovative therapies to improve patient outcomes in challenging diseases.
Vaccinex, Inc. (Nasdaq: VCNX) announced promising results from its Phase 2 SIGNAL trial of pepinemab for Huntington's disease (HD), presented during the Huntington Study Group conference. The data indicate significant cognitive benefits and reduced brain atrophy in HD patients treated with pepinemab. Key findings include strong improvements in the HD-Cognitive Assessment Battery and clinical assessments. The company aims to further develop pepinemab for HD and other neurodegenerative diseases. Safety data show good tolerability and low dropout rates, supporting its potential for combination therapies.
Vaccinex, Inc. (Nasdaq: VCNX) has announced a live moderated video webcast featuring management and KOL Eric Siemers, MD on October 27, 2020, at 10:00 AM EDT. The discussion will cover insights from the SIGNAL phase 2 study in Huntington’s disease, its implications for Alzheimer’s disease, and a review of the combination treatment of pepinemab with Keytruda® for Head & Neck Cancer. The event will be accessible via the Investors section of Vaccinex’s website, with a replay available two hours after the live session.
Vaccinex, Inc. (Nasdaq: VCNX) announced topline results from its Phase 2 SIGNAL trial of pepinemab in Huntington's disease patients. Although the study did not meet its co-primary endpoints, cognitive assessments showed a trend towards improvement. Pepinemab was well-tolerated, with low discontinuation rates. The company plans to initiate a new study for Alzheimer's disease and expects to balance its budget to support ongoing research. The results indicate that patients with greater cognitive deficits may benefit more from pepinemab treatment.
Vaccinex (Nasdaq: VCNX) announced a clinical collaboration with Merck to assess the combination of its SEMA4D inhibitor, pepinemab, and Merck's KEYTRUDA® for treating advanced head and neck squamous cell carcinoma (HNSCC). The study will include a dose escalation phase and an expansion phase with up to 65 patients, focusing on enhancing immunotherapy efficacy. Key endpoints will encompass objective response, progression-free survival, and overall survival. Pepinemab has shown promise in preclinical studies for enhancing immune responses in tumors.
Vaccinex, Inc. (Nasdaq: VCNX) announced the appointment of Robert Scala as Chief Commercial Officer, effective immediately. Scala will oversee all commercial functions and strategic operations for the company, starting with pepinemab, a potential treatment for Huntington’s disease. With over 30 years of experience in neurology, oncology, and immunology, Scala previously held leadership roles at biotechnology firms and major pharmaceutical companies. This appointment signifies a pivotal growth phase for Vaccinex, enhancing its commercial capabilities in addressing the unmet needs in Huntington’s disease.
Vaccinex reported its financial results for Q2 2020, raising $19.8 million in funding since June 30. The company anticipates topline data from its SIGNAL trial for Huntington's disease by early October 2020. A Phase 1/2 trial for pepinemab in Alzheimer’s is expected to begin enrolling patients in September. R&D expenses decreased to $4.6 million from $7.3 million in 2019, while general and administrative expenses increased to $1.9 million. Cash and equivalents fell to $0.5 million from $2.8 million at year-end 2019.
Vaccinex, Inc. (VCNX) remains on schedule to complete its pivotal SIGNAL trial for Huntington's disease despite COVID-19 challenges. The trial includes 265 subjects, with data collection almost complete; only two subjects are pending due to pandemic delays. Database lock is expected by September, with topline results anticipated in October. The FDA has approved primary and secondary endpoints for the trial, and initial results show potential cognitive improvements linked to pepinemab treatment. The company aims to advance therapies for Huntington’s and other neurodegenerative diseases.
Vaccinex, a clinical-stage biotechnology firm, will host a Virtual Investor Fireside Chat featuring CEO Maurice Zauderer, Ph.D., on June 16, 2020, at 10:00 AM ET. The event will include a live webcast and an interactive Q&A session for attendees. Vaccinex focuses on developing antibody therapies for Huntington's disease and cancer, with ongoing clinical trials. Investors can access the webcast via the company’s website, where a replay will also be available for one year.
Vaccinex, Inc. (Nasdaq: VCNX) reported its Q1 2020 financial results, showcasing significant developments in its ongoing clinical trials. The company continues its CLASSICAL-Lung study for non-small cell lung cancer (NSCLC) and a SIGNAL trial for Huntington’s disease, with upcoming topline data expected in May 2020. Vaccinex's lead candidate, pepinemab, is also being evaluated for Alzheimer’s disease, though enrollment has been delayed due to COVID-19. Financially, R&D expenses decreased to $5.5 million from $7.4 million year-over-year, with cash and equivalents at $2.5 million.
Vaccinex (Nasdaq: VCNX) announced interim results from the CLASSICAL-Lung Phase 1b/2 study of pepinemab combined with avelumab for non-small cell lung cancer (NSCLC) at the ASCO 2020 Annual Meeting. Key findings show that 59% of patients previously treated with anti-PD-1/PD-L1 therapies exhibited anti-tumor activity after switching to the combination therapy. Additionally, 81% of immunotherapy-naïve patients experienced disease control. The study aims to evaluate the safety and efficacy of this combination treatment, potentially expanding the patient population benefiting from immunotherapy.
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