10x Genomics Launches 5,000-Plex Gene Panel for Xenium
10x Genomics announced the launch of its Xenium Prime 5K Pan-Tissue and Pathways panel, significantly enhancing single-cell and spatial biology research. The new panel boasts a tenfold increase in plex capacity, improved per-gene sensitivity, specificity, and spatial fidelity. Key features include rapid turnaround time, customizable options, and the capability to analyze extensive tissue areas efficiently. Optimized for human and mouse species, the panel is now available for preorder, with shipments expected next month. This innovation aims to advance the exploration of molecular pathways, biomarkers, and cell interactions in various diseases.
- Xenium Prime 5K increases plex capacity by tenfold, enhancing research capabilities.
- Improved per-gene sensitivity, specificity, and spatial fidelity ensures high-quality data.
- Rapid turnaround time with easy workflows boosts research efficiency.
- Industry-leading throughput allows analysis of up to 472 mm² of tissue in six days.
- Customizable with up to 100 additional genes to meet specific research needs.
- Optimized for performance in human and mouse species.
- High-plex assays may come with increased costs impacting research budgets.
- New technology's extensive data may require substantial storage and processing capabilities.
Insights
The launch of the Xenium Prime 5K Pan-Tissue and Pathways panel significantly enhances the capabilities available to researchers in the field of single cell and spatial biology. The primary advantage lies in its ability to handle a higher plex assay, allowing for a broader range of cell types and states to be profiled. This advancement is poised to facilitate the identification of molecular pathways and biomarkers across various tissue types and disease states. The integration with multimodal cell segmentation ensures high sensitivity and specificity, which are important for accurate data interpretation in complex biological systems. For researchers, the rapid turnaround time and customizable options add operational efficiency, enabling faster hypothesis testing and data-driven discoveries in both human and mouse models.
Given the significant improvements in throughput and data quality, the new panel can potentially expedite research and reduce costs, making it a valuable addition to the toolkit of laboratories focused on cutting-edge biomedical research.
The Xenium Prime 5K panel’s technological advancements are noteworthy. Increasing the plex by an order of magnitude while maintaining high sensitivity and specificity is a substantial achievement. This means researchers can process more data in a shorter amount of time, significantly boosting throughput. The integration of multimodal cell segmentation is a game-changer, allowing for a more comprehensive analysis of cell behaviors and interactions. This level of technological integration leads to more reliable and richer datasets, which is important for advancing our understanding of complex biological systems and diseases.
The customizable nature of the panel, allowing up to 100 additional genes, provides flexibility to tailor research to specific needs, potentially leading to more personalized and precise biomedical discoveries.
New Xenium Prime 5K Pan-Tissue and Pathways panel increases plex by an order of magnitude and delivers industry-leading speed and throughput
"Seeing the Xenium Prime 5K data reminded me of the excitement I experienced when I saw single cell RNA-seq data for the first time," said Dr. Kevin Wei, M.D., Ph.D., Assistant Professor of Medicine at Harvard Medical School. "Now, we can identify relevant molecular pathways in human diseases and explore new biological hypotheses, all from one glass slide."
The high-plex Xenium Prime 5K assay enables a new level of exploration for pathways, biomarkers, ligand-receptor pairings and cell-cell interactions. Key features include:
- Highest plex Xenium panel for comprehensive profiling of cell types and states and cell signaling pathways across multiple tissue and disease types.
- Excellent data quality to unlock mechanisms of disease, therapeutics and cell behavior. The Xenium Prime 5K assay is optimized for performance and paired with 10x Genomics' advanced multimodal cell segmentation, enabling high sensitivity, specificity and spatial fidelity.
- Rapid turnaround time with easy, tissue-agnostic workflows. 10x Genomics' industry-leading throughput enables researchers to analyze up to 472 mm² of tissue in six days or less.
- Easily customizable with up to 100 additional genes to capture customers' specific research needs.
- Rigorously designed and developed using single cell RNA-seq data from dozens of different organs and tissues, gene expression profiles from hundreds of cell types and a screen of more than 750,000 peer-reviewed publications to pinpoint highly cited biomarkers.
"We successfully launched Xenium with a broad menu of curated and highly customizable gene panels so customers could target specific biology important for their research," said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer at 10x Genomics. "With the launch of our 5K gene panel, researchers can now also use Xenium for spatial exploration, enabling more biology and more breakthroughs. This assay is yet another example of how we put our innovation engine to work for our customers and build best-in-class products that deliver best-in-class results."
The Xenium Prime 5K assay, optimized for human and mouse species, is now available for preorder and is expected to ship next month.
About 10x Genomics
10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter).
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