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Tempest Therapeutics, Inc. (TPST) is a biotechnology company focused on the development of small molecule therapeutics that modulate anti-tumor immunity pathways.
Tempest's mission is to pioneer novel treatments for cancer by leveraging a balanced and deep pipeline of small molecule therapeutics. These therapeutics are designed to modulate distinct immune response pathways that are crucial for mounting an effective anti-tumor response. Developed by Inception Sciences, a Versant Ventures-affiliated drug discovery engine, the company’s pipeline includes first-in-class and best-in-class molecules.
The company’s leading product candidates, TPST-1120 and TPST-1495, are in the clinical stage. TPST-1120 aims to inhibit its target to promote anti-tumor immunity, while TPST-1495 is designed to activate tumor-specific immune responses. These candidates are developed to address significant unmet medical needs across a range of cancers.
Tempest Therapeutics has assembled a highly experienced team of drug developers specializing in small molecules and immuno-oncology. This team is dedicated to advancing these programs through clinical trials and eventually to market. The company's robust research and development efforts are backed by a syndicate of leading venture capital firms based in the United States and China, providing strong financial support and strategic guidance.
Recent achievements for Tempest Therapeutics include the initiation and progress of randomized clinical trials, showcasing the company’s commitment to evidence-based development and regulatory approval. With a focus on innovation and patient outcomes, Tempest Therapeutics is well-positioned to make significant contributions to the field of oncology.
For more detailed information on the company’s latest updates, news, and financial performance, you can contact Sylvia Wheeler and Aljanae Reynolds at Wheelhouse Life Science Advisors.
Tempest Therapeutics, a clinical-stage oncology company, announced participation in the Emerging Technologies for IO Targeting and Discovery Summit on October 13-14, 2022. Dara Burdette, Ph.D., will chair a session on 'New Approaches to Solid Tumor Targeting' and present on the TREX1 pipeline asset. Additionally, Nicholas DeVito, M.D., will share preclinical data on TPST-1495, a dual inhibitor targeting EP2 and EP4 receptors. Both presentations aim to enhance understanding of tumor-targeted therapies and immune response.
Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage oncology company, announced that CEO Stephen R. Brady will present at the H.C. Wainwright 24th Annual Global Investment Conference. The presentation will be available on-demand starting September 12, 2022, at 7:00 a.m. ET on the Tempest investor website. The company is focused on developing innovative therapeutics, including its lead candidates, TPST-1120 and TPST-1495, which target various tumor mechanisms. More details can be found on the company's website.
Tempest Therapeutics (Nasdaq: TPST) reported its Q2 2022 financial results, showing a net loss of $9.2 million and a net loss per share of $0.79, compared to a net loss of $7.1 million and $7.63 per share in Q2 2021. Cash and cash equivalents stood at $51.6 million, slightly down from $51.8 million at the end of 2021. The company successfully closed a $15 million PIPE financing, extending its financial runway into 2024. Key developments included progress on clinical studies for TPST-1120 and TPST-1495, with expected data releases by early 2023.
Tempest Therapeutics (Nasdaq: TPST) announced that President Tom Dubensky, Ph.D. will participate in a panel on Next Generation Immuno-Oncology Targets at the 2022 William Blair Biotech Focus Conference on July 12, 2022, at 4:10 p.m. ET. The company, based in South San Francisco, focuses on developing first-in-class therapeutics that integrate targeted and immune-mediated mechanisms for treating various tumors. Key clinical programs include TPST-1120 and TPST-1495, advancing through trials as monotherapies and in combination treatments.
Tempest Therapeutics (TPST) presented promising results from its TPST-1120 clinical program at the 2022 ASCO Annual Meeting. The drug demonstrated clinical benefits in patients with late-line advanced cancers, showing a 53% clinical benefit rate when used as monotherapy. In combination with anti-PD-1 therapy, it provided objective responses in patients previously resistant to such treatments. A potential biomarker for patient responsiveness was identified. Additionally, the company expects sufficient cash runway into the first quarter of 2024 to support ongoing studies.
Tempest Therapeutics (Nasdaq: TPST) announced its participation at the Jefferies Healthcare Conference on June 8, 2022, at 10:30 a.m. ET. The company, focused on innovative oncology therapeutics, is advancing clinical programs TPST-1120 and TPST-1495 that target tumors through both targeted and immune-mediated mechanisms. TPST-1120 is undergoing a Phase 1b/2 study in collaboration with Roche for treating advanced hepatocellular carcinoma. For access to the presentation, visit Tempest's investor section online.
Tempest Therapeutics, Inc. (TPST) reported promising Phase 1 clinical trial results for its novel therapy, TPST-1120, both as a monotherapy and in combination with nivolumab. The data highlighted a 30% Objective Response Rate (ORR) at higher doses of TPST-1120 combined with nivolumab and a 53% Disease Control Rate (DCR) for patients on TPST-1120 alone. Notably, patients with advanced renal cell carcinoma showed a 50% ORR. The product displayed a favorable safety profile, with no severe toxicities reported. Continued development is expected, with results to be shared at the upcoming ASCO Annual Meeting.
Tempest Therapeutics, Inc. (TPST) recently announced the completion of enrollment in Phase 1 trials for TPST-1120, a PPARα antagonist, and presented promising preclinical data for TPST-1495 at the AACR Annual Meeting. The company reported a net loss of $8.5 million for Q1 2022, with cash reserves decreasing to $45.8 million, attributed to operational cash usage of $7.1 million. Amidst these financials, the company remains focused on upcoming clinical data presentations and has secured $15 million in PIPE financing to support ongoing development.
Tempest Therapeutics (Nasdaq: TPST) announced the acceptance of two abstracts for presentation at the 2022 ASCO Annual Meeting. An oral presentation will detail Phase 1 trial results for TPST-1120, a PPARα antagonist, while a poster presentation will cover the ongoing TPST-1495 trial. CEO Stephen Brady emphasized the significance of these presentations, marking Tempest's first clinical data release. The abstracts will be available on ASCO's website on May 26, 2022. Key presentation details include dates and titles relevant to ongoing clinical investigations.
Tempest Therapeutics, Inc. (Nasdaq: TPST) announced a $15 million PIPE financing, selling 3,149,912 shares at $2.36 each and pre-funded warrants at $2.359 to EcoR1 Capital and Versant Venture Capital. The financing aims to enhance the development of targeted cancer therapies. The transaction, expected to close by April 29, 2022, signifies trust from significant investors amidst current market conditions. The company plans to file a registration statement for the resale of shares involved in this placement.
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