Welcome to our dedicated page for Tempest Therapeutics news (Ticker: TPST), a resource for investors and traders seeking the latest updates and insights on Tempest Therapeutics stock.
Tempest Therapeutics, Inc. (TPST) is a biotechnology company focused on the development of small molecule therapeutics that modulate anti-tumor immunity pathways.
Tempest's mission is to pioneer novel treatments for cancer by leveraging a balanced and deep pipeline of small molecule therapeutics. These therapeutics are designed to modulate distinct immune response pathways that are crucial for mounting an effective anti-tumor response. Developed by Inception Sciences, a Versant Ventures-affiliated drug discovery engine, the company’s pipeline includes first-in-class and best-in-class molecules.
The company’s leading product candidates, TPST-1120 and TPST-1495, are in the clinical stage. TPST-1120 aims to inhibit its target to promote anti-tumor immunity, while TPST-1495 is designed to activate tumor-specific immune responses. These candidates are developed to address significant unmet medical needs across a range of cancers.
Tempest Therapeutics has assembled a highly experienced team of drug developers specializing in small molecules and immuno-oncology. This team is dedicated to advancing these programs through clinical trials and eventually to market. The company's robust research and development efforts are backed by a syndicate of leading venture capital firms based in the United States and China, providing strong financial support and strategic guidance.
Recent achievements for Tempest Therapeutics include the initiation and progress of randomized clinical trials, showcasing the company’s commitment to evidence-based development and regulatory approval. With a focus on innovation and patient outcomes, Tempest Therapeutics is well-positioned to make significant contributions to the field of oncology.
For more detailed information on the company’s latest updates, news, and financial performance, you can contact Sylvia Wheeler and Aljanae Reynolds at Wheelhouse Life Science Advisors.
Tempest Therapeutics (Nasdaq: TPST) announced participation in two investor conferences this November. The company will present at the Jefferies London Healthcare Conference on November 18, 2021, with an on-demand presentation available at 8:00 a.m. GMT. Additionally, they will engage in a fireside chat at the Piper Sandler 33rd Annual Virtual Healthcare Conference on November 22, 2021, available at 10:00 a.m. ET. Tempest is focused on developing innovative oncology therapeutics, including TPST-1495 and TPST-1120, which are currently in Phase 1 studies.
Tempest Therapeutics (Nasdaq: TPST) announced that the U.S. Patent Office has issued multiple patents for its therapeutic candidate TPST-1495, an orally available small molecule targeting EP2 and EP4 receptors in the PGE2 pathway. This dual antagonist shows enhanced potency in pre-clinical studies compared to single EP4 inhibitors and could address tumor progression and immune suppression linked to PGE2 signaling. The patent portfolio, now including U.S. Patent Numbers 10,968,201 and 11,066,405, strengthens Tempest's IP for TPST-1495's use, which is currently in Phase 1 clinical trials for advanced solid tumors.
Tempest Therapeutics (Nasdaq: TPST) announced the acceptance of a presentation for TPST-1495 at the Society for Immunotherapy of Cancer’s 36th Annual Meeting scheduled for November 10-14, 2021. The presentation, titled "Dual blockade of the EP2 and EP4 PGE2 receptors with TPST-1495 is an optimal approach for drugging the prostaglandin pathway", will highlight preclinical studies showing TPST-1495's enhanced efficacy over single antagonists against tumor progression and immune suppression. Tempest is currently advancing TPST-1495 in a Phase 1a/1b clinical trial targeting advanced solid tumors.
Tempest Therapeutics (TPST) has announced the start of a Phase 1b/2 clinical study for TPST-1120, a PPAR⍺ antagonist, in combination with atezolizumab and bevacizumab for advanced hepatocellular carcinoma (HCC). The trial, conducted in partnership with Roche, will assess the safety and anti-tumor activity of this combination in up to 60 patients across multiple sites. HCC presents significant treatment challenges, highlighting the need for new therapy options. Tempest retains global rights to TPST-1120, which has shown promise in preclinical studies.
Tempest Therapeutics (Nasdaq: TPST) announced on September 13, 2021, the appointment of Russell Vance, PhD, to its advisory board and an exclusive licensing agreement with the University of California at Berkeley. This license covers a new drug target identified in Dr. Vance's lab, which has potential implications for cancer treatment. Dr. Vance's research focuses on a pathway involved in immune response and tumor metastasis. The company continues to advance its clinical programs, including TPST-1495 and TPST-1120, both currently in Phase 1 studies.
Tempest Therapeutics, Inc. (Nasdaq: TPST) has announced its participation in two upcoming investor conferences in September 2021. The company will present at the H.C. Wainwright 23rd Annual Global Investment Conference on September 13 at 7:00 a.m. ET and at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on September 22 at 9:55 a.m. ET. Tempest is progressing its clinical-stage oncology programs, including TPST-1495 and TPST-1120, which target cancer treatment through innovative mechanisms. For more details, visit the Tempest investor website.
Science 37 has appointed Christine Pellizzari as the new Chief Legal Officer, bringing nearly 30 years of legal experience to enhance the company's mission of accelerating clinical trials. Previously serving at Insmed, Pellizzari's expertise will support Science 37's global expansion and improve access to clinical research for patients and providers. CEO David Coman emphasized her qualifications as instrumental in navigating the evolving decentralized clinical trial landscape.
Tempest Therapeutics (TPST) successfully completed a merger, raising $30M through a PIPE, boosting its cash reserves to $68.5M. The company advanced its clinical programs, including TPST-1495 and TPST-1120, showing promising results in patient trials. The net loss for Q2 2021 was $7.1M, higher than the previous year's $5.2M, mainly due to merger-related expenses. R&D expenses increased slightly to $4.2M. Looking forward, significant milestones are expected in 2022, including new studies for TPST-1495 and TPST-1120.
Tempest Therapeutics (Nasdaq: TPST) announced the appointment of Dr. Ronit Simantov to its board of directors, enhancing its leadership in oncology. Dr. Simantov brings over 20 years of experience from roles at Gamida Cell and Pfizer, where she led significant oncology programs. CEO Steve Brady expressed enthusiasm for her insights as Tempest advances its clinical programs, especially with its candidate therapies TPST-1495 and TPST-1120. This appointment aims to strengthen the company’s position in the competitive oncology landscape and expand its strategic oversight.
Tempest Therapeutics (Nasdaq: TPST) announced that Dr. Sam Whiting, the chief medical officer, will join a panel titled “Developing Therapies for the Next Immuno-Oncology Targets” at the William Blair 2021 Biotech Focus Conference on July 14, 2021, at 2:10 p.m. ET. Tempest is advancing clinical programs TPST-1495 and TPST-1120, which target EP2/EP4 and PPARα, respectively, through Phase 1 studies. The company aims to develop innovative therapies combining targeted and immune-mediated mechanisms to treat various tumors. More details are available on their investor website.
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