Welcome to our dedicated page for Tempest Therapeutics news (Ticker: TPST), a resource for investors and traders seeking the latest updates and insights on Tempest Therapeutics stock.
Tempest Therapeutics, Inc. (TPST) is a biotechnology company focused on the development of small molecule therapeutics that modulate anti-tumor immunity pathways.
Tempest's mission is to pioneer novel treatments for cancer by leveraging a balanced and deep pipeline of small molecule therapeutics. These therapeutics are designed to modulate distinct immune response pathways that are crucial for mounting an effective anti-tumor response. Developed by Inception Sciences, a Versant Ventures-affiliated drug discovery engine, the company’s pipeline includes first-in-class and best-in-class molecules.
The company’s leading product candidates, TPST-1120 and TPST-1495, are in the clinical stage. TPST-1120 aims to inhibit its target to promote anti-tumor immunity, while TPST-1495 is designed to activate tumor-specific immune responses. These candidates are developed to address significant unmet medical needs across a range of cancers.
Tempest Therapeutics has assembled a highly experienced team of drug developers specializing in small molecules and immuno-oncology. This team is dedicated to advancing these programs through clinical trials and eventually to market. The company's robust research and development efforts are backed by a syndicate of leading venture capital firms based in the United States and China, providing strong financial support and strategic guidance.
Recent achievements for Tempest Therapeutics include the initiation and progress of randomized clinical trials, showcasing the company’s commitment to evidence-based development and regulatory approval. With a focus on innovation and patient outcomes, Tempest Therapeutics is well-positioned to make significant contributions to the field of oncology.
For more detailed information on the company’s latest updates, news, and financial performance, you can contact Sylvia Wheeler and Aljanae Reynolds at Wheelhouse Life Science Advisors.
Tempest Therapeutics (Nasdaq: TPST) announced the initiation of patient dosing with TPST-1495 in combination with pembrolizumab. This Phase 1a/1b study aims to optimize dosing schedules for patients with solid tumors. TPST-1495 targets the PGE2 pathway, which is linked to tumor growth and immune suppression. The study will evaluate safety, tolerability, and preliminary anti-tumor activity, focusing on prostaglandin-driven cancers. Tempest is exploring TPST-1495's potential to enhance treatment outcomes when combined with existing therapies.
Tempest Therapeutics (TPST) presented data at the 2021 Society for Immunotherapy of Cancer Annual Meeting, highlighting the dual mechanism of action of its small molecule TPST-1495. The data indicate that TPST-1495 effectively promotes anti-tumor activity in preclinical studies by inhibiting EP2 and EP4 receptors in the prostaglandin pathway. The company plans to initiate combination studies with pembrolizumab and conduct expansion studies focusing on specific cancer types in early 2022. This research underlines TPST-1495's potential in enhancing anti-tumor immunity and improving patient outcomes.
Tempest Therapeutics (TPST) announced the start of a Phase 1b/2 clinical trial for its TPST-1120 therapy in collaboration with Roche, aimed at treating hepatocellular carcinoma (HCC). The company reported a cash position of $59.8 million as of September 30, 2021, up from $18.8 million in December 2020, primarily due to a merger. However, net losses were $8.1 million for Q3 2021, increasing from $5.4 million in Q3 2020. Research and development expenses rose to $4.6 million, reflecting increased operational costs. Tempest anticipates sufficient resources to continue operations into Q2 2023.
Tempest Therapeutics (Nasdaq: TPST) announced participation in two investor conferences this November. The company will present at the Jefferies London Healthcare Conference on November 18, 2021, with an on-demand presentation available at 8:00 a.m. GMT. Additionally, they will engage in a fireside chat at the Piper Sandler 33rd Annual Virtual Healthcare Conference on November 22, 2021, available at 10:00 a.m. ET. Tempest is focused on developing innovative oncology therapeutics, including TPST-1495 and TPST-1120, which are currently in Phase 1 studies.
Tempest Therapeutics (Nasdaq: TPST) announced that the U.S. Patent Office has issued multiple patents for its therapeutic candidate TPST-1495, an orally available small molecule targeting EP2 and EP4 receptors in the PGE2 pathway. This dual antagonist shows enhanced potency in pre-clinical studies compared to single EP4 inhibitors and could address tumor progression and immune suppression linked to PGE2 signaling. The patent portfolio, now including U.S. Patent Numbers 10,968,201 and 11,066,405, strengthens Tempest's IP for TPST-1495's use, which is currently in Phase 1 clinical trials for advanced solid tumors.
Tempest Therapeutics (Nasdaq: TPST) announced the acceptance of a presentation for TPST-1495 at the Society for Immunotherapy of Cancer’s 36th Annual Meeting scheduled for November 10-14, 2021. The presentation, titled "Dual blockade of the EP2 and EP4 PGE2 receptors with TPST-1495 is an optimal approach for drugging the prostaglandin pathway", will highlight preclinical studies showing TPST-1495's enhanced efficacy over single antagonists against tumor progression and immune suppression. Tempest is currently advancing TPST-1495 in a Phase 1a/1b clinical trial targeting advanced solid tumors.
Tempest Therapeutics (TPST) has announced the start of a Phase 1b/2 clinical study for TPST-1120, a PPAR⍺ antagonist, in combination with atezolizumab and bevacizumab for advanced hepatocellular carcinoma (HCC). The trial, conducted in partnership with Roche, will assess the safety and anti-tumor activity of this combination in up to 60 patients across multiple sites. HCC presents significant treatment challenges, highlighting the need for new therapy options. Tempest retains global rights to TPST-1120, which has shown promise in preclinical studies.
Tempest Therapeutics (Nasdaq: TPST) announced on September 13, 2021, the appointment of Russell Vance, PhD, to its advisory board and an exclusive licensing agreement with the University of California at Berkeley. This license covers a new drug target identified in Dr. Vance's lab, which has potential implications for cancer treatment. Dr. Vance's research focuses on a pathway involved in immune response and tumor metastasis. The company continues to advance its clinical programs, including TPST-1495 and TPST-1120, both currently in Phase 1 studies.
Tempest Therapeutics, Inc. (Nasdaq: TPST) has announced its participation in two upcoming investor conferences in September 2021. The company will present at the H.C. Wainwright 23rd Annual Global Investment Conference on September 13 at 7:00 a.m. ET and at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on September 22 at 9:55 a.m. ET. Tempest is progressing its clinical-stage oncology programs, including TPST-1495 and TPST-1120, which target cancer treatment through innovative mechanisms. For more details, visit the Tempest investor website.
Science 37 has appointed Christine Pellizzari as the new Chief Legal Officer, bringing nearly 30 years of legal experience to enhance the company's mission of accelerating clinical trials. Previously serving at Insmed, Pellizzari's expertise will support Science 37's global expansion and improve access to clinical research for patients and providers. CEO David Coman emphasized her qualifications as instrumental in navigating the evolving decentralized clinical trial landscape.
FAQ
What is the current stock price of Tempest Therapeutics (TPST)?
What is the market cap of Tempest Therapeutics (TPST)?
What does Tempest Therapeutics, Inc. do?
What are Tempest Therapeutics' main product candidates?
Who developed Tempest Therapeutics' molecules?
What makes Tempest Therapeutics' pipeline unique?
Who are the key contacts for investor and media inquiries?
What type of cancers does Tempest Therapeutics target?
What is the core mission of Tempest Therapeutics?
What recent achievements has Tempest Therapeutics made?
Who supports Tempest Therapeutics financially?
How can I get the latest updates on Tempest Therapeutics?
