Tango Therapeutics Announces Presentation of TNG908 Preclinical Combination Data at 2022 ESMO Targeted Anticancer Therapies Congress

Rhea-AI Summary

Tango Therapeutics, Inc. (NASDAQ: TNGX) announced the presentation of an e-Poster at the 2022 ESMO Targeted Anticancer Therapies Congress, scheduled for March 7-8, 2022. The poster titled 'Evidence for synergy between TNG908, an MTAP-null selective PRMT5 inhibitor, and sotorasib in an MTAP-null/KRAS^G12C xenograft model' will be presented on March 4 at 12:00 CET. Tango focuses on developing precision cancer medicines based on synthetic lethality, targeting crucial cancer pathways.

Positive

• Presentation of e-Poster at a prominent cancer congress highlights ongoing research and development efforts.
• TNG908 shows potential synergy with sotorasib, indicating promising therapeutic avenues.

Negative

• No revenue generated to date from drug sales, indicating financial vulnerability.
• Dependence on third-party evaluations for combination therapies poses risks to commercialization.

CAMBRIDGE, Mass., March 03, 2022 (GLOBE NEWSWIRE) -- Tango Therapeutics, Inc. (NASDAQ: TNGX), a biotechnology company committed to discovering and delivering the next generation of precision cancer medicines, today announced the presentation of an e-Poster at the 2022 European Society for Medical Oncology (ESMO) Targeted Anticancer Therapies Congress, which is being held virtually from March 7 – 8, 2022.

Details on Tango’s presentation at the 2022 ESMO Targeted Anticancer Therapies Congress are as follows:

Poster Title: Evidence for synergy between TNG908, an MTAP^null-selective PRMT5 inhibitor, and sotorasib in an MTAP^null/KRAS^G12C xenograft model
Abstract #: 24P
Date and Time: Friday, March 4, 12:00 CET

About Tango Therapeutics

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. For more information, please visit www.tangotx.com.

Forward-Looking Statements

Certain statements in this press release and the poster referenced herein may be considered forward-looking statements. Forward-looking statements generally relate to future events, Tango’s future operating performance, goals, the anticipated benefits of combination therapies (that include a Tango pipeline product) expectations, beliefs and development objectives for Tango’s product pipeline. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “intend”, “will”, “goal”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. For example, statements concerning the following include or constitute forward-looking statements: that treatment of KRAS^G12C-mutant lung adenocarcinoma with TNG908 and a KRAS^G12C inhibitor may be of clinical benefit for certain patients; Tango’s ability to identify, develop and commercialize drug candidates; the future anticipated benefits of product candidates (including TNG908) and combination therapies; and the expected timing of: (i) development candidate declaration for certain targets, (ii) initiating IND-enabling studies; (iii) filing INDs and (iv) clinical trial initiation. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Tango and its management are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: the benefits of Tango pipeline products and potential combination therapies that are seen in pre-clinical experiments may not be present in clinical trials or in use commercially or may not be safe and/or effective in humans (and Tango or a third-party may not be able to obtain approval or commercial sales of any combination therapies); Tango may be unable to reach an agreement with any third-party to evaluate and/or commercialize a Tango product as a combination therapy with such third-party’s product; Tango has a limited operating history and has not generated any revenue to date from drug sales, and may never become profitable; Tango will need to raise capital in the future and if we are unable to raise capital when needed or on attractive terms, we would be forced to delay, scale back or discontinue some of our development programs or future commercialization efforts; we may be unable to advance our preclinical development programs into and through the clinic for safety or efficacy reasons or commercialize our product candidates or we may experience significant delays in doing so as a result of factors beyond Tango’s control; Tango’s approach to the discovery and development of product candidates is novel and unproven, which makes it difficult to predict the time, cost of development, and likelihood of successfully developing any products; Tango may not identify or discover additional product candidates or may expend limited resources to pursue a particular product candidate or indication and fail to capitalize on product candidates or indications that may be more profitable or for which there is a greater likelihood of success; our products candidates, as a stand alone therapy or in combination with other therapies, may cause adverse or other undesirable side effects that could, among other things, delay or prevent regulatory approval; our dependence on third parties for conducting clinical trials and producing drug product; our ability to obtain and maintain patent and other intellectual property protection for our technology and product candidates or the scope of intellectual property protection obtained is not sufficiently broad; and delays and other impacts on product development and clinical trials from the COVID-19 pandemic. Additional information concerning risks, uncertainties and assumptions can be found in Tango’s filings with the SEC, including the risk factors referenced in Tango’s Quarterly Report on Form 10-Q filed with the SEC on November 9, 2021. You should not place undue reliance on forward-looking statements in this presentation, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Tango specifically disclaims any duty to update these forward-looking statements.

Investor Contact:
Sam Martin/Michael Barron
Argot Partners
tango@argotpartners.com

Media Contact:
Joshua R. Mansbach
Argot Partners
tango@argotpartners.com

FAQ

What is Tango Therapeutics presenting at ESMO 2022?

Tango Therapeutics is presenting an e-Poster titled 'Evidence for synergy between TNG908 and sotorasib'.

When is Tango's poster presentation scheduled?

The poster presentation is scheduled for March 4, 2022, at 12:00 CET.

What does TNG908 aim to treat?

TNG908 is designed to target MTAP-null/KRAS^G12C cancer models.

What is the significance of the ESMO Congress for Tango?

The ESMO Congress is a prominent platform to showcase Tango's research advancements in precision cancer therapies.

What risks does Tango Therapeutics face?

Tango faces financial vulnerability due to lack of revenue and reliance on third-party evaluations for therapy efficacy.