Welcome to our dedicated page for Tango Therapeutics news (Ticker: TNGX), a resource for investors and traders seeking the latest updates and insights on Tango Therapeutics stock.
Tango Therapeutics, Inc. (NASDAQ: TNGX) is a pioneering biotechnology company focused on discovering and developing novel medicines aimed at targeting cancer vulnerabilities. Founded in 2017 with an initial $55 million Series A investment from Third Rock Ventures, Tango leverages the latest advancements in DNA sequencing and CRISPR-based target discovery. Their goal is to create breakthrough medicines that offer deeper and more sustained benefits than current targeted therapies and to extend the effectiveness of available immuno-oncology agents.
Tango Therapeutics concentrates on three core areas of drug development, each addressing well-defined patient populations with limited treatment options. These areas include:
- Loss of tumor suppressor gene function
- Multiple oncogenic drivers
- Immune evasion
The company’s robust product pipeline includes several promising candidates:
- TNG908 - An MTA-cooperative inhibitor of PRMT5 designed to selectively target cancer cells with MTAP deletions.
- TNG462 - Another advanced preclinical candidate aimed at targeting different cancer types.
- TNG348 - Recently entered Phase 1/2 clinical trials for advanced ovarian, breast, and other cancers with DNA damage repair pathway defects.
- Other discovery programs such as TNG260 and TNG348, focusing on different cancer types with limited current treatment options.
In recent developments, Tango announced dosing the first patient in the TNG348 Phase 1/2 trial, a significant milestone for the company. The trial will assess the safety, pharmacokinetics, pharmacodynamics, and efficacy of TNG348 both as a single agent and in combination with olaparib, a PARP inhibitor.
Tango has established partnerships with several key players in the pharmaceutical industry. These collaborations have significantly bolstered their drug development pipeline. However, recent news highlights the termination of the TNG348 Phase 1/2 clinical trial due to observed toxicity, underscoring the inherent risks in drug development.
For more information, visit www.tangotx.com.
Tango Therapeutics announced the preclinical development of TNG260, a novel CoREST deacetylase inhibitor targeting STK11-mutant cancers. Presenting three abstracts at the 37th Annual Meeting of the Society for Immunotherapy of Cancer from November 8-12, 2022, the company aims to demonstrate how TNG260 potentially overcomes immune evasion associated with STK11 mutations, common in non-small cell lung cancers. Plans include submitting an IND application in H1 2023, highlighting the innovative approach to cancer treatment.
Tango Therapeutics, Inc. (NASDAQ: TNGX), a biotechnology company focused on precision cancer medicines, announced that its CEO, Barbara Weber, M.D., will participate in the H.C. Wainwright 24th Annual Global Investment Conference. The presentation will be available on-demand starting September 12, 2022, at 7:00 AM ET. An archived replay will be accessible on the company’s website for approximately 90 days post-event. Tango Therapeutics specializes in discovering novel drug targets, emphasizing precision oncology for cancer treatment.
Tango Therapeutics reported its Q2 2022 financial results, holding $416.4 million in cash. The company is advancing TNG908, an MTA-cooperative PRMT5 inhibitor, in a Phase 1/2 trial for treating MTAP-deleted solid tumors, having received Orphan Drug Designation from the FDA for malignant peripheral nerve sheath tumors. Collaboration revenue decreased to $5.8 million, while research and development expenses rose to $23.7 million. The net loss for Q2 2022 increased to $24.9 million, or $0.28 per share, compared to a loss of $4.5 million, or $0.09 per share, in Q2 2021.
Tango Therapeutics, Inc. (NASDAQ: TNGX) announced that its CEO, Barbara Weber, M.D., will participate in a virtual panel on synthetic lethality in cancer therapeutics at the 13th Annual Wedbush PacGrow Healthcare Conference on August 9 at 12:00 PM ET. The event will be accessible via a live webcast on the company's website and will remain available for replay for 30 days after the presentation. Tango is focused on advancing precision cancer therapies through innovative drug targets and leveraging synthetic lethality.
Tango Therapeutics (TNGX) announced its inclusion in the Russell 2000, Russell 3000, and Russell Microcap Indexes, effective June 24, 2022. This addition reflects increasing investor interest as the company progresses its lead asset, TNG908, into clinical trials and expands its pipeline with new candidates. According to CEO Barbara Weber, this visibility could attract new investors, enhancing the company's market position and potential growth opportunities.
Tango Therapeutics, a biotechnology firm focused on precision cancer medicines, will participate in a fireside chat at the Goldman Sachs 43rd Annual Global Healthcare Conference on June 15, 2022, at 11:20 AM PT in Rancho Palos Verdes, CA. Investors can access a live webcast on the company's website under the 'Events & Presentations' section, with a replay available for 30 days afterward. Tango applies the principle of synthetic lethality to explore cancer therapies, targeting critical areas, including tumor suppressor gene loss.
Tango Therapeutics (TNGX) announced significant advancements in cancer treatments, including the start of a Phase 1/2 trial for TNG908, a PRMT5 inhibitor, now open for enrollment targeting MTAP-deleted tumors. The company also declared TNG462 and TNG260 as development candidates for similar applications. With a robust cash position of $450 million, Tango aims to progress its pipeline into late 2024. Financially, Tango reported a net loss of $25.2 million for Q1 2022, with research and development expenses rising to $24.3 million compared to $15 million a year prior.
Tango Therapeutics (NASDAQ: TNGX) announced its management team will participate in a fireside chat at Guggenheim Synthetic Lethality Day 2022 on May 16 at 10:00 AM ET. The event will be accessible via a live webcast found on the company's website under the 'Events & Presentations' section. Additionally, a replay will be available for 30 days post-event. The company focuses on developing precision cancer medicines by leveraging synthetic lethality, targeting tumor suppressor gene loss, and enhancing cancer treatments.
Tango Therapeutics (TNGX) announced significant developments, including the Fast Track Designation for its lead candidate, TNG908, an inhibitor targeting MTAP-deleted cancers. The company plans to start a Phase 1/2 clinical trial in Q2 2022, with preliminary data expected in H1 2023. Tango also reported financial results for 2021, revealing a net loss of $58.2 million and a revenue of $37 million. A strong cash position of $485 million is anticipated to support operations through the second half of 2024.
Tango Therapeutics (NASDAQ: TNGX) announced three abstracts selected for presentation at the AACR 2022 Annual Meeting, highlighting innovative cancer therapies. The presentations will cover:
- TNG908: an MTAP-null selective PRMT5 inhibitor showing tumor regressions in various cancer models.
- USP1 inhibitor: exploring synthetic lethality in BRCA1-mutant cancer via PCNA ubiquitination.
- UMIBB: introducing a Bayesian method enhancing CRISPR-Cas9 screen analysis.
These advancements aim to strengthen precision oncology and enrich Tango's therapeutic pipeline.
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