Welcome to our dedicated page for Tango Therapeutics news (Ticker: TNGX), a resource for investors and traders seeking the latest updates and insights on Tango Therapeutics stock.
Tango Therapeutics, Inc. (NASDAQ: TNGX) is a pioneering biotechnology company focused on discovering and developing novel medicines aimed at targeting cancer vulnerabilities. Founded in 2017 with an initial $55 million Series A investment from Third Rock Ventures, Tango leverages the latest advancements in DNA sequencing and CRISPR-based target discovery. Their goal is to create breakthrough medicines that offer deeper and more sustained benefits than current targeted therapies and to extend the effectiveness of available immuno-oncology agents.
Tango Therapeutics concentrates on three core areas of drug development, each addressing well-defined patient populations with limited treatment options. These areas include:
- Loss of tumor suppressor gene function
- Multiple oncogenic drivers
- Immune evasion
The company’s robust product pipeline includes several promising candidates:
- TNG908 - An MTA-cooperative inhibitor of PRMT5 designed to selectively target cancer cells with MTAP deletions.
- TNG462 - Another advanced preclinical candidate aimed at targeting different cancer types.
- TNG348 - Recently entered Phase 1/2 clinical trials for advanced ovarian, breast, and other cancers with DNA damage repair pathway defects.
- Other discovery programs such as TNG260 and TNG348, focusing on different cancer types with limited current treatment options.
In recent developments, Tango announced dosing the first patient in the TNG348 Phase 1/2 trial, a significant milestone for the company. The trial will assess the safety, pharmacokinetics, pharmacodynamics, and efficacy of TNG348 both as a single agent and in combination with olaparib, a PARP inhibitor.
Tango has established partnerships with several key players in the pharmaceutical industry. These collaborations have significantly bolstered their drug development pipeline. However, recent news highlights the termination of the TNG348 Phase 1/2 clinical trial due to observed toxicity, underscoring the inherent risks in drug development.
For more information, visit www.tangotx.com.
Tango Therapeutics (NASDAQ: TNGX) recently announced significant developments in its clinical pipeline. The U.S. FDA has granted Orphan Drug Designation to TNG908 for treating malignant glioma, enhancing its market exclusivity and providing potential financial incentives. Additionally, the FDA cleared an Investigational New Drug (IND) application for TNG462, a next-generation inhibitor targeting MTAP-deleted cancers, with a clinical trial expected to start in mid-2023. These advancements may broaden the company's strategic options and opportunity to address unmet medical needs in oncology.
Tango Therapeutics (NASDAQ: TNGX) announced the approval of a Clinical Trial Application for TNG908, a PRMT5 inhibitor, by France's ANSM. The company introduced TNG260, targeting STK11-mutant cancers, and TNG348 as a USP1 inhibitor for BRCA1/2-mutant cancers. Aaron Weitzman, M.D., was appointed Chief Medical Officer. Financially, Tango reported Q3 2022 results: collaboration revenue of $6.9 million, a net loss of $29.1 million, and $393.3 million in cash, expected to fund operations into 2025, despite increased R&D and G&A expenses.
Tango Therapeutics (NASDAQ: TNGX), a clinical-stage biotechnology company, announced that its CEO, Barbara Weber, will participate in two investor conferences this November. The first event is the H.C. Wainwright 3rd Annual Precision Oncology Conference on November 14 at 11:00 AM ET, followed by the Jefferies London Healthcare Conference on November 15 at 10:20 AM GMT. Both presentations will be available via live webcast on the company’s website, with replays accessible for 90 days.
Tango Therapeutics (NASDAQ: TNGX) announced the selection of three abstracts for poster presentations at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, scheduled from October 26-28, 2022. The posters will cover the characterization and potential of TNG908 and TNG462, both designed to target MTAP-deleted cancers. Notably, TNG908 is highlighted as a brain-penetrant inhibitor, while TNG462 aims to be a best-in-class option. These presentations showcase Tango's focus on precision cancer therapies.
Tango Therapeutics announced the preclinical development of TNG260, a novel CoREST deacetylase inhibitor targeting STK11-mutant cancers. Presenting three abstracts at the 37th Annual Meeting of the Society for Immunotherapy of Cancer from November 8-12, 2022, the company aims to demonstrate how TNG260 potentially overcomes immune evasion associated with STK11 mutations, common in non-small cell lung cancers. Plans include submitting an IND application in H1 2023, highlighting the innovative approach to cancer treatment.
Tango Therapeutics, Inc. (NASDAQ: TNGX), a biotechnology company focused on precision cancer medicines, announced that its CEO, Barbara Weber, M.D., will participate in the H.C. Wainwright 24th Annual Global Investment Conference. The presentation will be available on-demand starting September 12, 2022, at 7:00 AM ET. An archived replay will be accessible on the company’s website for approximately 90 days post-event. Tango Therapeutics specializes in discovering novel drug targets, emphasizing precision oncology for cancer treatment.
Tango Therapeutics reported its Q2 2022 financial results, holding $416.4 million in cash. The company is advancing TNG908, an MTA-cooperative PRMT5 inhibitor, in a Phase 1/2 trial for treating MTAP-deleted solid tumors, having received Orphan Drug Designation from the FDA for malignant peripheral nerve sheath tumors. Collaboration revenue decreased to $5.8 million, while research and development expenses rose to $23.7 million. The net loss for Q2 2022 increased to $24.9 million, or $0.28 per share, compared to a loss of $4.5 million, or $0.09 per share, in Q2 2021.
Tango Therapeutics, Inc. (NASDAQ: TNGX) announced that its CEO, Barbara Weber, M.D., will participate in a virtual panel on synthetic lethality in cancer therapeutics at the 13th Annual Wedbush PacGrow Healthcare Conference on August 9 at 12:00 PM ET. The event will be accessible via a live webcast on the company's website and will remain available for replay for 30 days after the presentation. Tango is focused on advancing precision cancer therapies through innovative drug targets and leveraging synthetic lethality.
Tango Therapeutics (TNGX) announced its inclusion in the Russell 2000, Russell 3000, and Russell Microcap Indexes, effective June 24, 2022. This addition reflects increasing investor interest as the company progresses its lead asset, TNG908, into clinical trials and expands its pipeline with new candidates. According to CEO Barbara Weber, this visibility could attract new investors, enhancing the company's market position and potential growth opportunities.
Tango Therapeutics, a biotechnology firm focused on precision cancer medicines, will participate in a fireside chat at the Goldman Sachs 43rd Annual Global Healthcare Conference on June 15, 2022, at 11:20 AM PT in Rancho Palos Verdes, CA. Investors can access a live webcast on the company's website under the 'Events & Presentations' section, with a replay available for 30 days afterward. Tango applies the principle of synthetic lethality to explore cancer therapies, targeting critical areas, including tumor suppressor gene loss.
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