Welcome to our dedicated page for Shattuck Labs news (Ticker: STTK), a resource for investors and traders seeking the latest updates and insights on Shattuck Labs stock.
Introduction
Shattuck Labs, Inc. is a clinical-stage biotechnology company that is pioneering the development of dual-action fusion proteins, a new class of biologic medicines. Utilizing their proprietary Agonist Redirected Checkpoint (ARC®) platform, the company is dedicated to designing bi-functional fusion proteins capable of simultaneously inhibiting immune checkpoints and activating costimulatory pathways. This approach is instrumental in reactivating anti-tumor immune responses and modulating autoimmune mechanisms, addressing significant unmet needs in oncology and autoimmune disorders.
Innovative Technology and Platform
The core of Shattuck Labs’ innovation lies in its proprietary ARC® platform, which enables the rational design of fusion proteins with a dual mechanism of action. By targeting key immune checkpoints such as CD47 and PD-1 while concurrently stimulating costimulatory receptors like CD40 and OX40, the company is able to enhance the efficacy of immune-mediated treatments without the need for multiple separate therapies. This strategic integration of inhibitory and agonistic functions within a single molecule sets the company apart in the competitive biotechnology landscape.
Product Pipeline and Clinical Programs
Shattuck Labs is actively advancing several clinical programs with its innovative fusion protein candidates:
- SL-172154 (SIRPα-Fc-CD40L): Designed to block inhibitory checkpoints and stimulate immune activation, this candidate is undergoing early-phase clinical evaluation to address advanced cancer indications.
- SL-279252 (PD1-Fc-OX40L): Developed in collaboration with a major pharmaceutical partner, this compound exemplifies the company’s commitment to designing fusion proteins that combine checkpoint inhibition with costimulatory activation.
- Gamma Delta T Cell Engager Platform: Known as gadlen™, this innovative approach aims to bridge gamma delta T cells to tumor antigens, thereby enhancing the immune system’s ability to target and destroy cancer cells.
Throughout these programs, Shattuck Labs maintains a balanced focus on therapeutic innovation, clinical safety, and efficacy, which is thoroughly reflected in their robust preclinical data and ongoing Phase 1 clinical studies.
Market Position and Competitive Landscape
In the dynamic field of biotechnology, Shattuck Labs has carved out a unique niche by leveraging advanced protein engineering and novel therapeutic strategies. The company’s dual-action approach not only positions it as an innovator in the development of biologic medicines but also enables it to address complex diseases with limited treatment options. With clinical programs targeting both hematologic malignancies and autoimmune conditions, Shattuck Labs stands as a significant contributor in the realm of precision immunotherapy and therapeutic innovation.
Expertise, Experience, and Corporate Profile
With offices located in Austin, Texas and Durham, North Carolina, Shattuck Labs benefits from a strong foundation in regional biotech hubs known for their robust research and development ecosystems. The company’s leadership and scientific teams bring extensive expertise in protein engineering, immuno-oncology, and drug development. Their work not only reflects a deep understanding of molecular biology and immune regulation but also underscores a disciplined approach to clinical development that is critical for advancing novel therapeutics safely and effectively.
Understanding the Bi-Functional Fusion Protein Approach
At the heart of Shattuck Labs’ operations is the concept of a bi-functional fusion protein – a therapeutic designed to perform two critical functions within one molecule. This innovative approach allows for:
- Simultaneous inactivation of inhibitory checkpoints that normally prevent an effective immune response.
- Activation of costimulatory pathways that enhance the body's ability to combat cancer cells or manage autoimmune responses.
This dual mechanism is a testament to the company’s expertise in synthesizing complex biological data and leveraging cutting-edge protein design to create more potent therapies with a potentially improved safety profile.
Conclusion
Shattuck Labs, Inc. represents a forward-thinking force in the biotechnology industry. By integrating innovative dual-action fusion proteins with state-of-the-art research and a well-structured clinical development program, the company continues to bolster its position as an informed and experienced player in the field of biologic medicine. Investors and industry stakeholders will find that the company not only addresses pressing medical challenges but also exemplifies a commitment to scientific rigor and therapeutic innovation.
Shattuck Labs reported its Q2 2022 financial results, noting a net loss of $27.4 million, increasing from $23.6 million in Q2 2021. Cash and equivalents totaled $214.2 million, down from $268.8 million at the end of 2021. The company is advancing its SL-172154 clinical trials, with enrollment expected for a Phase 1B trial in ovarian cancer in Q3 2022, and initial data from these and other trials anticipated in 1H 2023. Shattuck maintains guidance that current cash resources will sustain operations into H2 2024 while progressing on its clinical programs.
Shattuck Labs reported Q1 2022 results with a net loss of $24.5 million, equating to $0.58 per share, a significant increase from a loss of $11.8 million in Q1 2021. The company is advancing its clinical trials, including SL-172154 for platinum-resistant ovarian cancer and acute myeloid leukemia, with initial data expected in H1 2023. R&D expenses rose to $19.2 million, driven by process development and trial-related costs. As of March 31, 2022, cash and equivalents stood at $239.2 million, sufficient to support operations into H2 2024, excluding additional funding.
Shattuck Labs (NASDAQ: STTK) announced promising preclinical data at the 2022 AACR Annual Meeting for its innovative cancer therapies. The SL-9258 (TIGIT-Fc-LIGHT) compound showed enhanced anti-tumor effects, particularly in CPI-resistant tumors. Notably, it modulates immune responses and was well tolerated in non-human primates. The company also highlighted the potential of its GADLEN platform in targeting CD19 and CD20 antigens, showing substantial tumor cell killing in preclinical models. Shattuck aims to nominate its next clinical candidate in 2022.
Shattuck Labs, Inc. (NASDAQ: STTK), a clinical-stage biotechnology firm, will be participating in the 21st Annual Needham Virtual Healthcare Conference from April 11-14, 2022. The presentation, featuring CEO Taylor Schreiber and CFO Andrew Neill, will take place on April 11 at 1:30 p.m. ET. This virtual conference aims to highlight Shattuck's innovative bi-functional fusion proteins designed to treat cancer and autoimmune diseases, with ongoing Phase 1 clinical trials for products like SL-172154 and SL-279252. A live webcast will be available on the company's website.
Shattuck Labs reported promising initial clinical data for its bi-functional fusion proteins SL-172154 and SL-279252 in heavily pretreated cancer patients. The data, presented at the Society for the Immunotherapy of Cancer meeting, highlighted favorable safety profiles, dose-dependent immune activation, and evidence of anti-tumor activity. The company also disclosed a significant increase in collaboration revenue from $1.3 million in Q4 2020 to $30.1 million in Q4 2021. Shattuck's cash position stood at $268.8 million, sufficient to support operations into the second half of 2024.
Shattuck Labs, Inc. (NASDAQ: STTK) announced the acceptance of two posters for presentation at the American Association for Cancer Research (AACR) Annual Meeting, April 8-13, 2022, in New Orleans. The posters will feature preclinical data from their GADLEN™ and ARC® platforms, focusing on cancer treatment advancements. Dr. Anne Lai will present on bispecific gamma delta T cell engagers on April 12, while Dr. George Fromm and Kyung Jin Yoo will discuss LIGHT costimulation with TIGIT blockade on April 13. More details and poster access will be available on their website post-event.
Shattuck Labs, Inc. (NASDAQ: STTK), a clinical-stage biotechnology firm, announced participation in two virtual investor conferences in March 2022. The first conference is the 42nd Annual Cowen Healthcare Conference on March 9, featuring a panel discussion on ovarian cancer, presented by Chief Medical Officer Lini Pandite. The second is Oppenheimer's 32nd Annual Healthcare Conference on March 15, with a corporate presentation by Conor Richardson, Senior Director of Finance. Both presentations will be available via live webcast and archived for 90 days.
Shattuck Labs, a clinical-stage biotechnology company (NASDAQ: STTK), will participate in the 11th Annual SVB Leerink Global Healthcare Conference from February 14-18, 2022. CEO Taylor Schreiber will present on February 18 at 10:40 a.m. EST. The company focuses on developing bi-functional fusion proteins for treating cancer and autoimmune diseases, currently conducting three Phase 1 clinical trials, including its SL-172154 and SL-279252 programs. A live webcast of the presentation will be available on their website, with a replay accessible for 90 days.
Shattuck Labs, Inc. (NASDAQ: STTK), a clinical-stage biotechnology firm, announced its participation in two virtual investor conferences this January 2022. CEO Taylor Schreiber will present at the H.C. Wainwright BioConnect 2022 Conference on January 10 at 7:00 a.m. EST and the 40th Annual J.P. Morgan Healthcare Conference on January 13 at 11:15 a.m. EST. The company is advancing bi-functional fusion proteins targeting cancer and autoimmune diseases, with three ongoing Phase 1 clinical trials. Webcasts will be available live and archived for 90 days on their website.
Shattuck Labs, a clinical-stage biotechnology company (NASDAQ: STTK), is set to present at the TIGIT Therapies Digital Summit 2021 from December 7-9. CEO Taylor Schreiber will present on December 9 at 9:30 a.m. EST, discussing TIGIT blockade in refractory tumors. Shattuck is advancing bi-functional fusion proteins targeting cancer and autoimmune diseases, with three ongoing Phase 1 trials. The presentation will be available for download on the company's website and to registered participants of the summit.
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