Stoke Therapeutics, Inc. - STOK STOCK NEWS

Acadia Pharmaceuticals and Stoke Therapeutics have formed a collaboration to co-develop RNA-based therapies for severe neurodevelopmental diseases, including SYNGAP1 syndrome and Rett syndrome. Acadia gains exclusive licenses for two additional preclinical programs. Stoke receives a $60 million upfront payment, with potential milestone payments reaching $907 million, along with royalties. The partnership combines Stoke’s TANGO research platform with Acadia’s development expertise, aiming to enhance treatment options for patients with these debilitating conditions.

Stoke Therapeutics, Inc. (NASDAQ: STOK) announced its participation in the 40th Annual J.P. Morgan Healthcare Conference on January 10, 2022, at 4:30 p.m. ET. The conference will feature a live audio webcast available on the company's investor relations website, along with a replay accessible for 30 days post-event. Stoke focuses on developing RNA-based medicines to address severe diseases by upregulating protein expression, with its lead compound STK-001 currently in clinical testing for Dravet syndrome.

Stoke Therapeutics (NASDAQ: STOK) presented promising data regarding its investigational therapy STK-001 for Dravet syndrome at the American Epilepsy Society 2021 Annual Meeting. Single doses of STK-001 (up to 30 mg) and multiple doses (20 mg) were well tolerated. Notably, 70.6% of patients displayed reduced convulsive seizure frequency within 84 days post-treatment. All patients aged 2-12 experienced a reduction in seizure frequency, and further data on pharmacokinetics and safety will be released. Stoke aims to target the underlying genetic causes of Dravet syndrome, representing a potential breakthrough in treatment.

Stoke Therapeutics (NASDAQ: STOK) announced that five abstracts regarding STK-001 for treating Dravet syndrome will be presented at the American Epilepsy Society annual meeting from December 3-7, 2021 in Chicago. The presentations include interim data on safety, pharmacokinetics, and exposure from the Phase 1/2a MONARCH study. Stoke aims to develop the first disease-modifying therapy for Dravet syndrome, a severe genetic epilepsy with no approved therapies. Updates from the ongoing studies will provide insights into treatment efficacy and safety.

Stoke Therapeutics, Inc. (Nasdaq: STOK) has nominated STK-002 as a clinical candidate targeting autosomal dominant optic atrophy (ADOA), an inherited optic nerve disorder. The company reported financial results for Q3 2021, showing a net loss of $22.6 million, or $0.61 per share, compared to $13.7 million, or $0.41 per share in 2020. Research and development expenses rose to $14.4 million from $8.1 million year-over-year. With $236.9 million in cash as of September 30, 2021, Stoke expects to fund operations through 2023. Positive interim data from the MONARCH study of STK-001 was also highlighted.

Stoke Therapeutics, Inc. (NASDAQ: STOK), a biotechnology firm focused on RNA-based therapies, has announced participation in two investor conferences this November. The Credit Suisse 30th Annual Healthcare Conference will take place on November 10, 2021, at 10:30 a.m. ET, followed by the Stifel 2021 Virtual Healthcare Conference on November 15, 2021, at 3:20 p.m. ET. Live webcasts of the presentations will be available on Stoke's website, with replays accessible for 30 days afterwards. Stoke is advancing therapies for severe diseases via its proprietary TANGO approach.

Stoke Therapeutics (Nasdaq: STOK) is set to present at the Cantor Global Healthcare Virtual Conference on September 28, 2021, at 4:00 p.m. ET. Chief Medical Officer Barry Ticho, M.D., Ph.D., will lead the session in a fireside chat format, which will be accessible via live audio webcast on the company's website. Stoke is a biotechnology firm focused on RNA-based medicines to treat severe diseases caused by protein expression deficiencies, including its lead candidate, STK-001, for Dravet syndrome and potential therapies for autosomal dominant optic atrophy.

Stoke Therapeutics announced positive interim results for STK-001, an investigational medicine for treating Dravet syndrome. The Phase 1/2a MONARCH study indicated that single doses up to 30mg were well-tolerated, showing no safety concerns. A trend toward reduced convulsive seizures was noted, especially in younger patients. Over 95% of subjects could achieve pharmacologically active levels with three doses of 30mg. The FDA has allowed the evaluation of a higher 45mg dose in the study. Ongoing studies aim to establish effective dosing and long-term treatment strategies.

Stoke Therapeutics, Inc. (Nasdaq: STOK) announced its Q2 2021 financial results, reporting a net loss of $22.0 million or $0.60 per share, up from $13.0 million or $0.39 per share in Q2 2020. Research and development expenses increased to $14.1 million from $8.0 million. The company completed dosing in the MONARCH study of STK-001 for Dravet syndrome and expects interim analysis results in Q3 2021. Stoke plans to identify a clinical candidate for autosomal dominant optic atrophy (ADOA) by year-end 2021, and as of June 30, 2021, had around $251.4 million available to fund operations into 2024.