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SOPHiA GENETICS Reports Second Quarter 2024 Results

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SOPHiA GENETICS (Nasdaq: SOPH) reported Q2 2024 financial results, showing mixed performance. Revenue increased 5% year-over-year to $15.8 million, with constant currency revenue excluding COVID-19 up 7% to $16.0 million. Gross margins improved to 68.2% (reported) and 73.2% (adjusted), up from 66.7% and 70.0% respectively in the prior year.

The company saw strong growth in the U.S. market but faced challenges in BioPharma and EMEA regions. Operating loss improved by 25% to $15.0 million (reported) and 32% to $9.9 million (adjusted). For the full year 2024, SOPHiA GENETICS revised its revenue outlook to $65-$67 million, representing 4-7% growth, and expects adjusted gross margin between 72.0-72.5%.

SOPHiA GENETICS (Nasdaq: SOPH) ha riportato i risultati finanziari del secondo trimestre 2024, mostrando una performance mista. I ricavi sono aumentati del 5% rispetto all'anno precedente, raggiungendo 15,8 milioni di dollari, con i ricavi in valuta costante, escluse le entrate da COVID-19, in aumento del 7% a 16,0 milioni di dollari. I margini lordi sono migliorati al 68,2% (riportato) e al 73,2% (rettificato), rispetto al 66,7% e al 70,0% dell'anno precedente.

L'azienda ha registrato una crescita forte nel mercato statunitense, ma ha affrontato sfide nelle regioni BioPharma e EMEA. La perdita operativa è migliorata del 25% a 15,0 milioni di dollari (riportato) e del 32% a 9,9 milioni di dollari (rettificato). Per l'intero anno 2024, SOPHiA GENETICS ha rivisto le sue previsioni sui ricavi a 65-67 milioni di dollari, rappresentando una crescita del 4-7%, e si aspetta un margine lordo rettificato tra il 72,0 e il 72,5%.

SOPHiA GENETICS (Nasdaq: SOPH) reportó los resultados financieros del segundo trimestre de 2024, mostrando un desempeño mixto. Los ingresos aumentaron un 5% interanual hasta 15,8 millones de dólares, con ingresos en moneda constante excluyendo COVID-19 incrementados en un 7% a 16,0 millones de dólares. Los márgenes brutos mejoraron al 68,2% (reportado) y al 73,2% (ajustado), frente al 66,7% y al 70,0% del año anterior.

La compañía experimentó un fuerte crecimiento en el mercado estadounidense, pero enfrentó desafíos en las regiones de BioPharma y EMEA. La pérdida operativa mejoró en un 25% a 15,0 millones de dólares (reportado) y en un 32% a 9,9 millones de dólares (ajustado). Para el año completo 2024, SOPHiA GENETICS revisó su proyección de ingresos a 65-67 millones de dólares, lo que representa un crecimiento del 4-7%, y espera un margen bruto ajustado de entre el 72,0 y el 72,5%.

SOPHiA GENETICS (Nasdaq: SOPH)는 2024년 2분기 재무 결과를 발표하며 혼합된 실적을 보여주었습니다. 수익은 전년 대비 5% 증가하여 1580만 달러에 달했으며, COVID-19를 제외한 상수 환율 수익은 7% 증가하여 1600만 달러에 이르렀습니다. 총 마진은 68.2% (보고 기준) 및 73.2% (조정 기준)로 개선되었으며, 이는 각각 전년의 66.7% 및 70.0%에서 증가한 수치입니다.

회사는 미국 시장에서 강력한 성장을 보였지만 BioPharma 및 EMEA 지역에서는 도전에 직면했습니다. 영업 손실은 25% 개선된 1500만 달러 (보고 기준)와 32% 개선된 990만 달러 (조정 기준)로 보고되었습니다. 2024년 전체 연도에 대해, SOPHiA GENETICS는 수익 예상치를 6500만-6700만 달러로 수정했으며, 이는 4-7%의 성장을 나타내고, 조정된 총 마진은 72.0-72.5% 사이가 될 것으로 예상하고 있습니다.

SOPHiA GENETICS (Nasdaq: SOPH) a publié les résultats financiers du deuxième trimestre 2024, montrant des performances mitigées. Les revenus ont augmenté de 5 % par rapport à l'année précédente, atteignant 15,8 millions de dollars, avec des revenus en devises constantes hors COVID-19 en hausse de 7 % à 16,0 millions de dollars. Les marges brutes se sont améliorées à 68,2 % (reporté) et 73,2 % (ajusté), contre 66,7 % et 70,0 % respectivement l'année précédente.

L'entreprise a connu une forte croissance sur le marché américain, mais a dû faire face à des défis dans les régions BioPharma et EMEA. La perte opérationnelle s'est améliorée de 25 % pour atteindre 15,0 millions de dollars (reporté) et de 32 % pour s'établir à 9,9 millions de dollars (ajusté). Pour l'ensemble de l'année 2024, SOPHiA GENETICS a révisé ses prévisions de revenus à 65-67 millions de dollars, représentant une croissance de 4 à 7 %, et s'attend à une marge brute ajustée comprise entre 72,0 et 72,5 %.

SOPHiA GENETICS (Nasdaq: SOPH) hat die finanziellen Ergebnisse des zweiten Quartals 2024 veröffentlicht, die eine gemischte Leistung zeigen. Der Umsatz stieg im Jahresvergleich um 5% auf 15,8 Millionen Dollar, wobei der Umsatz in konstanter Währung, exklusive COVID-19, um 7% auf 16,0 Millionen Dollar zulegte. Die Bruttomargen verbesserten sich auf 68,2% (berichtet) und 73,2% (bereinigt), gegenüber 66,7% und 70,0% im Vorjahr.

Das Unternehmen verzeichnete starkes Wachstum im US-Markt, hatte jedoch Herausforderungen in den Regionen BioPharma und EMEA. Der Betriebsverlust verbesserte sich um 25% auf 15,0 Millionen Dollar (berichtet) und um 32% auf 9,9 Millionen Dollar (bereinigt). Für das Gesamtjahr 2024 überarbeitete SOPHiA GENETICS die Umsatzprognose auf 65-67 Millionen Dollar, was einem Wachstum von 4-7% entspricht, und erwartet eine bereinigte Bruttomarge von 72,0-72,5%.

Positive
  • Revenue increased 5% year-over-year to $15.8 million
  • Constant currency revenue excluding COVID-19 grew 7% to $16.0 million
  • Gross margins improved to 68.2% (reported) and 73.2% (adjusted)
  • Operating loss decreased by 25% (reported) and 32% (adjusted)
  • Strong growth in the U.S. market
Negative
  • Challenges faced in BioPharma and EMEA regions
  • Revised full-year revenue outlook to $65-$67 million, lower than previous expectations
  • Company still operating at a loss despite improvements

Insights

SOPHiA GENETICS' Q2 2024 results present a mixed picture. While revenue growth of 5% year-over-year to $15.8 million shows some progress, it's below industry averages for high-growth biotech companies. The adjusted gross margin improvement to 73.2% is a positive sign, indicating better operational efficiency.

However, the lowered full-year revenue guidance of $65-67 million is concerning, suggesting challenges in scaling. The maintained adjusted operating loss guidance of $45-50 million demonstrates strong cost management, but also highlights the company's struggle to achieve profitability.

Investors should closely monitor the company's ability to accelerate growth, particularly in BioPharma and EMEA regions, while maintaining its cost discipline. The balance between growth and profitability will be important for SOPHiA GENETICS' long-term success in the competitive data-driven medicine market.

SOPHiA GENETICS' performance in Q2 2024 reflects the evolving landscape of data-driven medicine. The company's cloud-native software approach positions it well in the growing field of precision medicine, but challenges in BioPharma and EMEA markets indicate potential hurdles in adoption or competition.

The strength in U.S. growth is encouraging, suggesting increasing acceptance of SOPHiA's platform in a key market. However, the overall modest growth rate raises questions about the scalability of their technology across different healthcare systems and regions.

For the medical research community, SOPHiA's progress is important as it could accelerate the integration of genomic data into clinical decision-making. The company's ability to improve gross margins while investing in R&D will be important for advancing their platform's capabilities and maintaining a competitive edge in this rapidly evolving field.

SOPHiA GENETICS' Q2 results highlight the complex dynamics of the data-driven medicine market. The company's modest growth and regional disparities reflect the varying adoption rates of AI-driven healthcare solutions across different markets.

The strong performance in the U.S. suggests a growing acceptance of SOPHiA's platform in a mature healthcare market. However, challenges in BioPharma and EMEA indicate potential regulatory hurdles, competition, or market-specific barriers that need to be addressed.

The revised revenue guidance implies a cautious outlook for the remainder of 2024. This could be due to longer sales cycles, budget constraints in healthcare systems, or increased competition. SOPHiA's ability to navigate these challenges while maintaining its technological edge will be important for its market position. Investors should watch for strategic initiatives to overcome regional challenges and accelerate adoption in key markets.

Strength in U.S. Growth Offset by Challenges in BioPharma and EMEA; Strong Cost Management Buffers Loss

BOSTON and ROLLE, Switzerland, Aug. 6, 2024 /PRNewswire/ -- SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native software company and leader in data-driven medicine, today reported financial results for the second quarter ended June 30, 2024.

Second Quarter 2024 Financial Update

  • Revenue was $15.8 million, up 5% year-over-year; Constant currency revenue excluding COVID-19 revenue was $16.0 million, up 7% year-over-year
  • Gross margins were 68.2% on a reported basis and 73.2% on an adjusted basis, up from 66.7% and 70.0% in the prior year period, respectively
  • Operating loss was $15.0 million on a reported basis and $9.9 million on an adjusted basis, representing year-over-year improvements of 25% and 32%, respectively

2024 Financial Outlook

  • Full-year revenue is now expected to be between $65 million and $67 million, representing growth of 4% to 7% compared to FY 2023
  • Adjusted gross margin is now expected to be between 72.0% to 72.5%, compared to 72.2% in FY 2023
  • Adjusted operating loss guidance remains unchanged and is expected to be between $45M and $50M, compared to $55.9 million in FY 2023

"We delivered another quarter of strong forward-looking indicators and continued bottom-line improvements in Q2, despite facing macro-related headwinds in BioPharma and EMEA which offset outsized performance in the U.S.," said Jurgi Camblong, PhD., Chief Executive Officer and Co-founder. "We believe the headwinds we are facing are temporary in nature and remain encouraged by positive new business momentum, such as bookings and new customers signed, which will materialize as revenue later this year and into 2025. Despite the headwinds, I'm proud that we delivered a 32% year-over-year improvement to adjusted operating loss during the quarter and that disciplined spending has kept our path to profitability on track."

Camblong added, "Looking ahead, we remain confident in our long-term growth and in the growth prospects of our end markets. Exciting catalysts such as the continued success of MSK-ACCESS® powered with SOPHiA DDM™, a suite of new applications launching this year, and refreshed momentum in our BioPharma business offer meaningful upside and give us conviction in a medium-term growth recovery."

Business Highlights

Expanding usage of SOPHiA DDM™ worldwide

  • Reached 457 core genomics customers as of June 30, 2024, who used SOPHiA DDM™ over the past 12 months to analyze patients with cancer or rare diseases, up from 434 customers at the end of Q2 2023
  • Performed approximately 87,000 analyses on SOPHiA DDM™ in Q2 2024, representing 12% year-over-year analysis volume growth or 14% growth when excluding COVID-related analyses
  • Delivered strong growth in the U.S. and Canada with over 40% year-over-year analysis volume growth in NORAM

Accelerating adoption of SOPHiA DDM™ by landing new Clinical customers

  • Landed 20 new core genomic customers in Q2 2024 who will implement SOPHiA DDM™ and begin generating revenue over the next twelve months, continuing the positive trend of solid bookings momentum
  • Signed major new customers across geographies including Detroit Medical Center in the U.S. who is adopting SOPHiA DDM™ for Hematology Oncology and the NHS's North Bristol Trust in the U.K. who is adopting both the Homologous Recombination Deficiency ("HRD") application on SOPHiA DDM™ and MSK-ACCESS® powered with SOPHiA DDM™

Building strong business momentum with new product launches

  • Launched a new SOPHiA DDM™ application for measuring Minimal Residual Disease ("MRD") for Acute Myeloid Leukemia during the quarter
  • Announced a Q4 2024 launch for MSK-IMPACT® powered with SOPHiA DDM™, the decentralized, Solid Tumor profiling counterpart to MSK-ACCESS®; Signed two customers to the application, several months ahead of launch
  • Announced a collaboration with Microsoft and NVIDIA to launch a scalable Whole Genome Sequencing ("WGS") application on SOPHiA DDM™ by the end of the year

Growing sustainably by maintaining an obsession with operational excellence

  • Remained laser-focused on operational excellence by improving adjusted operating loss 32% year-over-year in Q2 2024
  • Delivered adjusted gross margin of 73.2% as we continue to optimize compute and leverage the scale of the cloud-native SOPHiA DDM™ platform
  • Reaffirmed commitment to achieve adjusted operating profitability within the next 2 years; Current cash and existing capital resources are expected to be sufficient to reach adjusted operating profitability

Accelerated planned growth initiatives to offset headwinds in BioPharma and EMEA

  • Restructured the BioPharma business by separating Data and Diagnostics offerings; Refocused BioPharma sales efforts to target smaller, more repeatable business in higher volumes to expedite sales cycles
  • Reallocated Clinical sales resources from established EMEA markets to higher-growth markets such as the U.S., the U.K., Germany, and the Middle East; Implemented a more strategic approach to winning key, high-volume accounts, including investments in certain, strategic accounts to displace competition and win market share

Earnings Call and Webcast Information

SOPHiA GENETICS will host a conference call and live webcast to discuss the second quarter 2024 results on Tuesday, August 6, 2024, at 8:00 a.m. (08:00) Eastern Time / 2:00 p.m. (14:00) Central European Time. The call will be webcast live on the SOPHiA GENETICS Investor Relations website, ir.sophiagenetics.com. Additionally, an audio replay of the conference call will be available on the SOPHiA GENETICS website after its completion.

Non-IFRS Financial Measures

Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted operating loss (non-IFRS measure) to operating loss (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses and intangible assets, share-based compensation expenses, and non-cash portion of pensions paid in excess of actual contributions, that are necessary for such reconciliation.

To provide investors with additional information regarding the company's financial results, SOPHiA GENETICS has disclosed here and elsewhere in this earnings release the following non-IFRS measures:

  • Adjusted gross profit, which the company calculates as revenue minus cost of revenue adjusted to exclude amortization of capitalized research and development expenses;
  • Adjusted gross profit margin, which the company calculates as adjusted gross profit as a percentage of revenue;
  • Adjusted operating loss, which the company calculates as operating loss adjusted to exclude amortization of capitalized research and development expenses, amortization of intangible assets, share-based compensation expense, and non-cash portion of pensions expense paid in excess of actual contributions to match the actuarial expense.

These non-IFRS measures are key measures used by SOPHiA GENETICS management and board of directors to evaluate its operating performance and generate future operating plans. The exclusion of certain expenses facilitates operating performance comparability across reporting periods by removing the effect of non-cash expenses and certain variable charges. Accordingly, the company believes that these non-IFRS measures provide useful information to investors and others in understanding and evaluating its operating results in the same manner as its management and board of directors.

These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS' results as reported under IFRS. Some of these limitations are:

  • These non-IFRS measures exclude the impact of amortization of capitalized research and development expenses and intangible assets. Although amortization is a non-cash charge, the assets being amortized may need to be replaced in the future and these non-IFRS measures do not reflect capital expenditure requirements for such replacements or for new capital expenditures;
  • These non-IFRS measures exclude the impact of share-based compensation expenses. Share-based compensation has been, and will continue to be for the foreseeable future, a recurring expense in the company's business and an important part of its compensation strategy;
  • These non-IFRS measures exclude the impact of the non-cash portion of pensions paid in excess of actual contributions to match actuarial expenses. Pension expenses have been, and will continue to be for the foreseeable future, a recurring expense in the business; and
  • Other companies, including companies in the company's industry, may calculate these non-IFRS measures differently, which reduces their usefulness as comparative measures.

Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.

The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.

Presentation of Constant Currency Revenue and Excluding COVID-19-Related Revenue

SOPHiA GENETICS operates internationally, and its revenues are generated primarily in the U.S. dollar, the euro and Swiss franc and, to a lesser extent, British pound, Australian dollar, Brazilian real, Turkish lira and Canadian dollar depending on the company's customers' geographic locations. Changes in revenue include the impact of changes in foreign currency exchange rates. We present the non-IFRS financial measure "constant currency revenue" (or similar terms such as constant currency revenue growth) to show changes in revenue without giving effect to period-to-period currency fluctuations. Under IFRS, revenues received in local (non-U.S. dollar) currencies are translated into U.S. dollars at the average monthly exchange rate for the month in which the transaction occurred. When the company uses the term "constant currency", it means that it has translated local currency revenues for the current reporting period into U.S. dollars using the same average foreign currency exchange rates for the conversion of revenues into U.S. dollars that we used to translate local currency revenues for the comparable reporting period of the prior year. The company then calculates the difference between the IFRS revenue and the constant currency revenue to yield the "constant currency impact" for the current period.

The company's management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

In addition to constant currency revenue, the company presents constant currency revenue excluding COVID-19-related revenue to further remove the effects of revenues that are derived from sales of COVID-19-related offerings, including a NGS assay for COVID-19 that leverages the SOPHiA DDM™ Platform and related products and solutions analytical capabilities and COVID-19 bundled access products. SOPHiA GENETICS do not believe that these revenues reflect its core business of commercializing its platform because the company's COVID-19 solution was offered to address specific market demand by its customers for analytical capabilities to assist with their testing operations. The company does not anticipate additional development of its COVID-19-related solution as the pandemic transitions into a more endemic phase and as customer demand continues to decline. Further, COVID-19-related revenues did not constitute, and the company does not expect COVID-19-related revenues to constitute in the future, a significant part of its revenue. Accordingly, the company believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating its revenue growth. However, this non-IFRS measure has limitations, including that COVID-19-related revenues contributed to the company's cash position, and other companies may define COVID-19-related revenues differently. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period.

About SOPHiA GENETICS

SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of SOPHiA DDM™, a platform that analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

Forward-Looking Statements

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding SOPHiA GENETICS future results of operations and financial position, business strategy, products and technology, partnerships and collaborations, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on SOPHiA GENETICS' management's beliefs and assumptions and on information currently available to the company's management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in the company's filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of its date. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in the company's expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

SOPHiA GENETICS SA

Interim Condensed Consolidated Statements of Loss

(Amounts in USD thousands, except per share data)

(Unaudited)




Three months ended June 30,


Six months ended June 30,



2024


2023


2024


2023

Revenue


$   15,808


$   15,054


$   31,587


$   29,020

Cost of revenue


(5,032)


(5,007)


(10,406)


(9,279)

Gross profit


10,776


10,047


21,181


19,741

Research and development costs


(7,958)


(8,891)


(17,349)


(18,225)

Selling and marketing costs


(7,258)


(7,203)


(14,209)


(13,627)

General and administrative costs


(10,583)


(14,041)


(23,408)


(27,283)

Other operating income, net


18


41


24


60

Operating loss


(15,005)


(20,047)


(33,761)


(39,334)

Interest income, net


450


1,134


1,208


1,996

Fair value adjustments on warrant obligations


84



84


Foreign exchange (losses) gains, net


(561)


(2,410)


4,049


(3,578)

Loss before income taxes


(15,032)


(21,323)


(28,420)


(40,916)

Income tax expense


(161)


(73)


(477)


(180)

Loss for the period


(15,193)


(21,396)


(28,897)


(41,096)

Attributable to the owners of the parent


(15,193)


(21,396)


(28,897)


(41,096)










Basic and diluted loss per share


$     (0.23)


$     (0.33)


$     (0.44)


$     (0.64)

 

SOPHiA GENETICS SA

Interim Condensed Consolidated Statements of Comprehensive Loss

(Amounts in USD thousands)

(Unaudited)




Three months ended June 30,


Six months ended June 30,



2024


2023


2024


2023

Loss for the period


$ (15,193)


$ (21,396)


$ (28,897)


$ (41,096)

Other comprehensive (loss) income:









Items that may be reclassified to statement of loss (net of tax)









Currency translation adjustments


252


3,680


(9,139)


5,651

Total items that may be reclassified to statement of loss


252


3,680


(9,139)


5,651

Items that will not be reclassified to statement of loss (net of tax)









Remeasurement of defined benefit plans


(41)


(226)


(58)


(296)

Total items that will not be reclassified to statement of loss


(41)


(226)


(58)


(296)

Other comprehensive (loss) income for the period


$       211


$     3,454


$   (9,197)


$     5,355

Total comprehensive loss for the period


$ (14,982)


$ (17,942)


$ (38,094)


$ (35,741)

Attributable to owners of the parent


$ (14,982)


$ (17,942)


$ (38,094)


$ (35,741)

 

SOPHiA GENETICS SA

Interim Condensed Consolidated Balance Sheets

(Amounts in USD thousands)

 (Unaudited)




June 30, 2024


December 31, 2023

Assets





Current assets





Cash and cash equivalents


$                 105,396


$                 123,251

Accounts receivable


9,924


13,557

Inventory


6,545


6,482

Prepaids and other current assets


3,887


4,757

Total current assets


125,752


148,047

Non-current assets





Property and equipment


6,134


7,469

Intangible assets


27,428


27,185

Right-of-use assets


14,067


15,635

Deferred tax assets


1,717


1,720

Other non-current assets


5,998


6,100

Total non-current assets


55,344


58,109

Total assets


$                 181,096


$                 206,156

Liabilities and equity





Current liabilities





Accounts payable


$                     5,321


$                     5,391

Accrued expenses


12,229


17,808

Deferred contract revenue


7,918


9,494

Lease liabilities, current portion


2,569


2,928

Warrant obligations


572


Total current liabilities


28,609


35,621

Non-current liabilities





Borrowings


13,344


Lease liabilities, net of current portion


14,157


15,673

Defined benefit pension liabilities


3,123


3,086

Other non-current liabilities


420


334

Total non-current liabilities


31,044


19,093

Total liabilities


59,653


54,714

Equity





Share capital


4,048


4,048

Share premium


472,140


471,846

Treasury share


(590)


(646)

Other reserves


52,526


53,978

Accumulated deficit


(406,681)


(377,784)

Total equity


121,443


151,442

Total liabilities and equity


$                 181,096


$                 206,156

 

SOPHiA GENETICS SA

Interim Condensed Consolidated Statements of Cash Flows

(Amounts in USD thousands)

(Unaudited)




Six months ended June 30,



2024


2023

Operating activities





Loss before tax


$                  (28,420)


$                  (40,916)

Adjustments for non-monetary items





Depreciation


2,287


2,873

Amortization


1,809


1,281

Finance (income) expense, net


(5,747)


1,394

Interest expense from borrowings



Fair value adjustments on warrant obligations


(84)


Expected credit loss allowance


(34)


123

Share-based compensation


7,797


7,106

Movements in provisions and pensions


410


478

Research tax credit


(283)


(600)

Working capital changes





Decrease (Increase) in accounts receivable


3,042


(834)

Decrease (increase) in prepaids and other assets


934


(1,061)

Increase in inventory


(655)


(268)

(Decrease) Increase in accounts payables, accrued expenses,
deferred contract revenue, and other liabilities


(6,100)


3,749

Cash used in operating activities


(25,044)


(26,675)

Income tax paid


(18)


(676)

Interest paid


(572)


(5)

Interest received


1,795


2,243

Net cash flows used in operating activities


(23,839)


(25,113)

Investing activities





Purchase of property and equipment


(111)


(1,246)

Acquisition of intangible assets


(167)


(788)

Capitalized development costs


(3,637)


(2,842)

Proceeds upon maturity of term deposits



17,546

Net cash flow (used in) provided from investing activities


(3,915)


12,670

Financing activities





Proceeds from exercise of share options


298


207

Proceeds from borrowings, net of transaction costs


13,930


Payments of principal portion of lease liabilities


(1,477)


(1,761)

Net cash flow provided from (used in) financing activities


12,751


(1,554)

Decrease in cash and cash equivalents


(15,003)


(13,997)

Effect of exchange differences on cash balances


(2,852)


1,244

Cash and cash equivalents at beginning of the year


123,251


161,305

Cash and cash equivalents at end of the period


$                 105,396


$                 148,552

 

SOPHiA GENETICS SA

Reconciliation of IFRS Revenue Growth to Constant Currency Revenue Growth

and Constant Currency Revenue Growth Excluding COVID-19-Related Revenue

(Amounts in USD thousands, except for %)

(Unaudited)




Three months ended June 30,


Six months ended June 30,



2024


2023


Growth


2024


2023


Growth

IFRS revenue


$   15,808


$   15,054


5 %


$   31,587


$   29,020


9 %

Current period constant currency impact


179





(5)




Constant currency revenue


$   15,987


$   15,054


6 %


$   31,582


$   29,020


9 %

COVID-19-related revenue


(4)


(72)




(39)


(197)



Constant currency impact on COVID-19-related revenue






1




Constant currency revenue excluding COVID-19-related revenue


$   15,983


$   14,982


7 %


$   31,544


$   28,823


9 %

 

SOPHiA GENETICS SA

Reconciliation of IFRS to Adjusted Gross Profit and Gross Profit Margin

(Amounts in USD thousands, except percentages)

(Unaudited)




Three months ended
June 30,


Six months ended
June 30,



2024


2023


2024


2023

Revenue


$ 15,808


$ 15,054


$ 31,587


$ 29,020

Cost of revenue


(5,032)


(5,007)


(10,406)


(9,279)

Gross profit


$ 10,776


$ 10,047


$ 21,181


$ 19,741

Amortization of capitalized research and development expenses(1)


794


496


1,521


928

Adjusted gross profit


$ 11,570


$ 10,543


$ 22,702


$ 20,669










Gross profit margin


68.2 %


66.7 %


67.1 %


68.0 %

Amortization of capitalized research and development expenses(1)


5.0 %


3.3 %


4.8 %


3.2 %

Adjusted gross profit margin


73.2 %


70.0 %


71.9 %


71.2 %

 

SOPHiA GENETICS SA

Reconciliation of IFRS to Adjusted Operating Loss for the Period

(Amounts in USD thousands)

(Unaudited)




Three months ended
June 30,


Six months ended
June 30,



2024


2023


2024


2023

Operating loss


$ (15,005)


$ (20,047)


$ (33,761)


$ (39,334)

Amortization of capitalized research & development expenses(1)


794


496


1,521


928

Amortization of intangible assets(2)


114


179


288


352

Share-based compensation expense(3)


4,084


4,676


7,797


7,106

Non-cash pension expense(4)


96


84


173


162

Adjusted operating loss


$   (9,917)


$ (14,612)


$ (23,982)


$ (30,786)

 

SOPHiA GENETICS SA

Reconciliation of IFRS to Adjusted Operating Loss

for the fourth quarter and fiscal year 2023

(Amounts in USD thousands)

(Unaudited)




Three months ended


Year ended



December 31, 2023

Operating loss


$          (18,946)


$          (74,826)

Amortization of capitalized research & development expenses (1)


619


2,099

Amortization of intangible assets(2)


193


729

Share-based compensation expense(3)


4,211


15,247

Non-cash pension expense(4)


(625)


(394)

Costs associated with restructuring(5)


1,232


1,232

Adjusted operating loss


$          (13,316)


$          (55,913)

 

Notes to the Reconciliation of IFRS to Adjusted Financial Measures Tables

(1)

Amortization of capitalized research and development expenses consists of software development costs amortized using the straight-line method over an estimated life of five years. These expenses do not have a cash impact but remain a recurring expense generated over the course of our research and development initiatives.

(2)

Amortization of intangible assets consists of costs related to intangible assets amortized over the course of their useful lives. These expenses do not have a cash impact, but we could continue to generate such expenses through future capital investments.

(3)

Share-based compensation expense represents the cost of equity awards issued to our directors, officers, and employees. The fair value of awards is computed at the time the award is granted and is recognized over the vesting period of the award by a charge to the income statement and a corresponding increase in other reserves within equity. These expenses do not have a cash impact but remain a recurring expense for our business and represent an important part of our overall compensation strategy.

(4)

Non-cash pension expense consists of the amount recognized in excess of actual contributions made to our defined pension plans to match actuarial expenses calculated for IFRS purposes. The difference represents a non-cash expense but remains a recurring expense for our business as we continue to make contributions to our plans for the foreseeable future.

(5)

Costs associated with restructuring consists of compensation paid to employees during their garden leave period, severance, and any other amounts legally owed to the employees resulting from their termination as part of a planned workforce reduction, which we undertook to optimize our operations. Additionally, it includes any legal fees incurred as part of the restructuring process. While such actions are not planned going forward as part of our regular operations, we expect such expenses could still be incurred from time to time based on corporate needs.

 

 

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SOURCE SOPHiA GENETICS

FAQ

What was SOPHiA GENETICS (SOPH) revenue for Q2 2024?

SOPHiA GENETICS reported revenue of $15.8 million for Q2 2024, representing a 5% increase year-over-year.

How did SOPHiA GENETICS (SOPH) gross margins change in Q2 2024?

Gross margins improved to 68.2% on a reported basis and 73.2% on an adjusted basis, up from 66.7% and 70.0% in the prior year period, respectively.

What is SOPHiA GENETICS (SOPH) revenue outlook for full-year 2024?

SOPHiA GENETICS revised its full-year 2024 revenue outlook to between $65 million and $67 million, representing growth of 4% to 7% compared to FY 2023.

Did SOPHiA GENETICS (SOPH) reduce its operating loss in Q2 2024?

Yes, SOPHiA GENETICS improved its operating loss by 25% to $15.0 million on a reported basis and by 32% to $9.9 million on an adjusted basis compared to the prior year.

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