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About Shuttle Pharmaceuticals Holdings Inc
Shuttle Pharmaceuticals Holdings Inc is a clinical-stage biopharmaceutical company focused on the development of innovative radiation sensitizers and selective HDAC inhibitors. Founded by faculty members of a renowned medical center, the company is deeply rooted in cutting-edge research and clinical innovation, strategically positioned to address unmet needs in the treatment of cancer.
Utilizing its proprietary technology, Shuttle Pharmaceuticals is dedicated to enhancing the efficacy of radiation therapy (RT) by integrating its novel therapeutic candidates with standard treatment modalities. This includes not only the adjunctive use with surgery, chemotherapy, and immunotherapy but also optimizing outcomes in patients undergoing radiation treatment. Through its pioneering work, the company is developing products that aim to sensitize tumors to radiation while protecting surrounding healthy tissues from adverse effects.
Therapeutic Focus and Pipeline
The company’s robust pipeline is centered on two major therapeutic programs:
- Radiation Sensitization: Shuttle Pharmaceuticals is advancing its lead candidate, Ropidoxuridine (IPdR), designed to enhance the cytotoxic effects of radiation on brain tumors, specifically targeting glioblastoma—a challenging malignancy where current treatment options are limited.
- Selective HDAC Inhibitors: The company’s portfolio includes novel HDAC inhibitors, such as SP-1-303, which exploits the potential of inhibiting class I HDACs and modulating ATM activity. This dual-target approach not only sensitizes cancer cells to radiation but also activates immune responses, providing a multifaceted strategy against cancers like estrogen receptor-positive breast cancer.
Clinical Development and Research Excellence
Shuttle Pharmaceuticals is recognized for its methodical approach to clinical research, with its Phase 2 clinical trial for Ropidoxuridine already underway at several nationally recognized cancer centers. The trial is designed to evaluate optimal dosing regimens in patients with aggressive glioblastoma, showcasing the company’s commitment to rigorous clinical standards and robust data-driven decision making. Its research extends beyond immediate clinical application, delving into diagnostics and theranostic approaches that could further refine treatment paradigms in oncology.
Innovative Technology and Industry Impact
At the core of Shuttle Pharmaceuticals' operations is a blend of advanced molecular pharmacology and clinical insight. The company leverages its proprietary HDAC platform to identify and develop drug candidates that selectively modulate gene expression involved in cancer progression and the immune response. This strategic use of technology not only advances cancer therapy but also contributes to broader biomedical research in areas such as autoimmune and inflammatory diseases.
Competitive Position and Market Context
Operating in the competitive and dynamic oncology sector, Shuttle Pharmaceuticals distinguishes itself through its singular focus on radiation sensitization—a critical component in improving the outcomes of radiation therapy. Despite challenges such as rigorous regulatory requirements and the high costs associated with clinical trials, its deep scientific expertise and academic backing provide a strong foundation for overcoming these hurdles. The company is a significant entity in its niche, strategically differentiating its offerings by combining novel drug candidates with advanced delivery protocols aimed at enhancing the precision and safety of cancer treatments.
Commitment to Scientific Rigor and Patient Outcomes
Every aspect of Shuttle Pharmaceuticals’ operations echoes a commitment to improving patient outcomes without compromising safety. By maintaining stringent research protocols and engaging with collaborative research institutions, the company not only educates the scientific community but also ensures that every advancement is thoroughly validated and transparently reported. This approach builds trust among clinical peers, investors, and regulatory bodies, reinforcing its reputation as a credible and reliable innovator in the field of oncology.
In summary, Shuttle Pharmaceuticals Holdings Inc epitomizes a blend of scientific innovation and applied clinical research. Its focus on maximizing the effectiveness of traditional radiation therapy through novel sensitizers and targeted inhibitors positions it as a resourceful player within the oncology sector—driving forward research that may one day transform the treatment landscape for some of the most challenging cancers.
Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) announced a private placement of a $4.3 million senior secured convertible note and warrant. The company will receive $4.0 million initially, with a potential for an additional $2.4 million if warrants are exercised at $2.35 per share. Monthly amortizations can be settled in cash or stock and the deal has a 5% annual interest rate.
This initiative aims to support Shuttle's mission to enhance cancer treatment outcomes while minimizing radiation side effects.
Shuttle Pharmaceuticals Holdings (Nasdaq: SHPH) announced the publication of a manuscript that discusses immune responses in cancer patients post-radiation therapy. The study, authored by Dr. Amrita K Cheema, reveals how radiation therapy induces innate immune responses in patients with prostate cancer. Key findings include an increase in DNA Damage Response (DDR) shortly after treatment, and sustained immune signaling for up to three months. The research may inform the development of biomarkers and therapeutic strategies for better cancer treatment outcomes. The publication is available in Clinical Cancer Research.
Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) has published research detailing novel prostate cancer cell lines derived from African American men aimed at enhancing precision medicine. This work, part of a NIH-funded 'Moonshot' project, addresses significant health disparities in prostate cancer within this demographic. The research is expected to facilitate studies on cancer biology and drug effectiveness. The initiative underscores the company's commitment to improving cancer treatment outcomes for African American patients.
Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) provided a corporate update following its quarterly report for Q3 2022. Highlights include an IPO raising $10 million, along with an additional $1.5 million from an overallotment option. The company announced an agreement with TCG GreenChem to manufacture its lead drug candidate, Ropidoxuridine, aimed at enhancing cancer treatment outcomes through radiation therapy. Shuttle Pharma also engaged Theradex Oncology for clinical study preparations and received patents in the U.S. and Hong Kong for its HDAC inhibitor technology.
Shuttle Pharmaceuticals Holdings (SHPH) announced its collaboration with Theradex Oncology to prepare for a Phase II clinical study of Ropidoxuridine, an innovative cancer treatment aimed at enhancing the efficacy of radiation therapy (RT). The IND application is expected to be submitted to the FDA by Q2 2023. Ropidoxuridine, designed to improve patient outcomes in glioblastoma treatment, has received orphan-drug designation from the FDA. The market for radiation sensitizers is projected to exceed $4 billion, with expected growth in patient numbers and treatment effectiveness.
Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced the appointment of Dr. Bette Jacobs to its Board of Directors on November 1, 2022. Dr. Jacobs will serve on the Audit and Nominating Committees, bringing extensive experience in healthcare system design, equity, and diversity. She is a professor at Georgetown University and has held various leadership positions, including dean and vice president at Honda of America Manufacturing. Dr. Jacobs expressed her commitment to enhancing the company's mission of improving cancer treatment outcomes.
Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced a partnership with TCG GreenChem, Inc. to manufacture Ropidoxuridine, its lead clinical sensitizer drug candidate. This agreement aims to facilitate the formulation of Ropidoxuridine for clinical trials targeting brain tumors, sarcomas, and pancreatic cancers. The FDA has granted orphan-drug designation for Ropidoxuridine in glioblastoma treatment. The agreement also includes process research and optimization to enhance drug development. The market for radiation sensitizers is projected to exceed $4.0 billion due to a growing patient base.
Shuttle Pharmaceuticals Holdings, Inc. (SHPH) has received patents in the U.S. and Hong Kong for its HDAC inhibitor technology, aimed at enhancing radiation therapy outcomes for cancer patients. This innovation targets over 800,000 U.S. patients undergoing radiation, with a projected market exceeding $4 billion annually. The company is focused on building its drug candidate portfolio to improve patient quality of life and treatment efficacy.
CEO Anatoly Dritschilo emphasized the goal of being at the forefront of cancer treatment advancements with selective HDAC6 inhibitors.
Shuttle Pharmaceuticals Holdings, Inc. (SHPH) announced the successful closing of its initial public offering (IPO) on September 6, 2022. The company sold 1,225,888 units at a public offering price of $8.125 per unit, raising approximately $9,960,340 before expenses. Each unit comprises one share of common stock and a warrant for one additional share, exercised at $0.01 each. The stock began trading on the Nasdaq on August 31, 2022. Boustead Securities, LLC acted as lead underwriter for the offering.
Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) has commenced trading on The Nasdaq Capital Market. The company focuses on developing sensitizers to enhance the efficacy of radiation therapy for cancer patients while minimizing side effects. Their lead product candidate, Ropidoxuridine, has completed a Phase I clinical trial. Shuttle Pharma aims to address serious needs in treating brain tumors, sarcomas, and pancreatic cancers. The company is positioned to progress its innovative therapy pipeline and deliver new treatments for patients lacking effective options.
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