Shuttle Pharmaceuticals Holdings, Inc. - SHPH STOCK NEWS

Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) announced a private placement of a $4.3 million senior secured convertible note and warrant. The company will receive $4.0 million initially, with a potential for an additional $2.4 million if warrants are exercised at $2.35 per share. Monthly amortizations can be settled in cash or stock and the deal has a 5% annual interest rate.

This initiative aims to support Shuttle's mission to enhance cancer treatment outcomes while minimizing radiation side effects.

Shuttle Pharmaceuticals Holdings (Nasdaq: SHPH) announced the publication of a manuscript that discusses immune responses in cancer patients post-radiation therapy. The study, authored by Dr. Amrita K Cheema, reveals how radiation therapy induces innate immune responses in patients with prostate cancer. Key findings include an increase in DNA Damage Response (DDR) shortly after treatment, and sustained immune signaling for up to three months. The research may inform the development of biomarkers and therapeutic strategies for better cancer treatment outcomes. The publication is available in Clinical Cancer Research.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) has published research detailing novel prostate cancer cell lines derived from African American men aimed at enhancing precision medicine. This work, part of a NIH-funded 'Moonshot' project, addresses significant health disparities in prostate cancer within this demographic. The research is expected to facilitate studies on cancer biology and drug effectiveness. The initiative underscores the company's commitment to improving cancer treatment outcomes for African American patients.

Shuttle Pharmaceuticals Holdings, Inc. (NASDAQ: SHPH) provided a corporate update following its quarterly report for Q3 2022. Highlights include an IPO raising $10 million, along with an additional $1.5 million from an overallotment option. The company announced an agreement with TCG GreenChem to manufacture its lead drug candidate, Ropidoxuridine, aimed at enhancing cancer treatment outcomes through radiation therapy. Shuttle Pharma also engaged Theradex Oncology for clinical study preparations and received patents in the U.S. and Hong Kong for its HDAC inhibitor technology.

Shuttle Pharmaceuticals Holdings (SHPH) announced its collaboration with Theradex Oncology to prepare for a Phase II clinical study of Ropidoxuridine, an innovative cancer treatment aimed at enhancing the efficacy of radiation therapy (RT). The IND application is expected to be submitted to the FDA by Q2 2023. Ropidoxuridine, designed to improve patient outcomes in glioblastoma treatment, has received orphan-drug designation from the FDA. The market for radiation sensitizers is projected to exceed $4 billion, with expected growth in patient numbers and treatment effectiveness.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced the appointment of Dr. Bette Jacobs to its Board of Directors on November 1, 2022. Dr. Jacobs will serve on the Audit and Nominating Committees, bringing extensive experience in healthcare system design, equity, and diversity. She is a professor at Georgetown University and has held various leadership positions, including dean and vice president at Honda of America Manufacturing. Dr. Jacobs expressed her commitment to enhancing the company's mission of improving cancer treatment outcomes.

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) announced a partnership with TCG GreenChem, Inc. to manufacture Ropidoxuridine, its lead clinical sensitizer drug candidate. This agreement aims to facilitate the formulation of Ropidoxuridine for clinical trials targeting brain tumors, sarcomas, and pancreatic cancers. The FDA has granted orphan-drug designation for Ropidoxuridine in glioblastoma treatment. The agreement also includes process research and optimization to enhance drug development. The market for radiation sensitizers is projected to exceed $4.0 billion due to a growing patient base.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) has received patents in the U.S. and Hong Kong for its HDAC inhibitor technology, aimed at enhancing radiation therapy outcomes for cancer patients. This innovation targets over 800,000 U.S. patients undergoing radiation, with a projected market exceeding $4 billion annually. The company is focused on building its drug candidate portfolio to improve patient quality of life and treatment efficacy.

CEO Anatoly Dritschilo emphasized the goal of being at the forefront of cancer treatment advancements with selective HDAC6 inhibitors.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) announced the successful closing of its initial public offering (IPO) on September 6, 2022. The company sold 1,225,888 units at a public offering price of $8.125 per unit, raising approximately $9,960,340 before expenses. Each unit comprises one share of common stock and a warrant for one additional share, exercised at $0.01 each. The stock began trading on the Nasdaq on August 31, 2022. Boustead Securities, LLC acted as lead underwriter for the offering.