Seagen to Present New Clinical and Preclinical Data From Broad Portfolio of Targeted Cancer Therapeutics at the 2023 AACR Annual Meeting

Rhea-AI Summary

Seagen Inc. (NASDAQ: SGEN) will present 17 abstracts at the upcoming AACR Annual Meeting from April 14-19, 2023, in Orlando, highlighting clinical and preclinical data. Key presentations include interim results from the innovaTV 207 Phase 2 trial of tisotumab vedotin for squamous cell carcinoma in head and neck cancer and initial Phase 1 data for SEA-TGT monotherapy in advanced malignancies. Seagen emphasizes its commitment to enhancing cancer treatment through innovative antibody-drug conjugate technologies.

Positive

• Presentation of 17 abstracts at AACR demonstrates active research and development.
• Interim results from the Phase 2 innovaTV 207 trial show progress for tisotumab vedotin in treating head and neck cancer.
• Initial Phase 1 data for SEA-TGT monotherapy may indicate potential in advanced malignancies.

Negative

• None.

- Interim results from Phase 2 innovaTV 207 trial of tisotumab vedotin in head and neck cancer to be presented -

- Initial Phase 1 dose-escalation data for SEA-TGT monotherapy in advanced malignancies to be disclosed -

- Preclinical data and discovery research underscore Seagen’s mission to innovate through next-generation ADC technologies -

BOTHELL, Wash.--(BUSINESS WIRE)-- Seagen Inc. (Nasdaq: SGEN) today announced the presentation of 17 abstracts featuring new clinical and preclinical data at the upcoming American Association for Cancer Research (AACR) Annual Meeting taking place in Orlando from April 14-19, 2023. The broad range of data being presented at this year’s meeting includes research from Seagen’s approved medicines, as well as data from early-stage clinical, preclinical, and discovery research programs.

“Seagen’s robust presence at AACR this year, highlighting progress across our diverse pipeline, underscores our commitment to improving and extending the lives of people living with cancer,” said Roger Dansey, M.D., President of Research and Development and Chief Medical Officer at Seagen. “As a pioneer in antibody-drug conjugates, we strive to optimize and expand the potential of our core technology, while also progressing innovative, targeted cancer approaches.”

Highlights include an interim analysis from the innovaTV 207 Phase 2 study of tisotumab vedotin (TV) given every 2 weeks in patients with recurrent or metastatic squamous cell carcinoma of the head and neck who have progressed after prior platinum combination, immunotherapy, and targeted therapy, if eligible. TV, which is being developed in partnership with Genmab, is a tissue factor (TF)-directed antibody-drug conjugate (ADC). The innovaTV 207 study is currently ongoing and evaluating alternative dosing regimens of TV across multiple advanced solid tumors.

Other notable clinical data include initial results from a Phase 1 dose-escalation study of SEA-TGT monotherapy in patients with advanced malignancies. SEA-TGT is a novel investigational nonfucosylated human IgG1 antibody directed against TIGIT, an inhibitory immune checkpoint receptor that has emerged as a clinically relevant immuno-oncology target. SEA-TGT continues to be evaluated both as monotherapy and in combination with an anti-PD1 agent.

Seagen will also present new preclinical findings on the antitumor activity of disitamab vedotin, an ADC that targets cancers expressing HER2, as a monotherapy and in combination with tucatinib in breast and gastric cancer models, and on SGN-B6A, a wholly-owned, first-in-class vedotin ADC that targets integrin beta-6, which is highly expressed in a range of solid tumors.

Seagen and Sanofi will also unveil the first preclinical data from a novel topoisomerase I inhibitor ADC targeting CEACAM5, showing potent antitumor activity in patient-derived colorectal cancer models. These are the first data disclosed from the companies’ 2022 collaboration to develop and commercialize multiple novel ADCs.

Additional preclinical data disclosures are planned, highlighting vedotin programs and novel ADC and tumor targeting technologies, including payloads with immune stimulatory properties.

Details of Seagen Presentations at AACR Annual Meeting 2023

Abstract Title	Abstract #	Presentation Time	Lead Author
ADCETRIS® (brentuximab vedotin)
CD30 is a marker of activated effector regulatory T cells in solid tumors providing clinical rationale for the combination of brentuximab vedotin and PD-1 inhibitors	3253	Poster Presentation   Clinical Research Excluding Trials / Combination Immunotherapies 1 Mon., April 17 1:30 - 5:00 p.m. ET	B. Grogan
Exposure-response and age subgroup analyses to support body-weight (BW) dosing of brentuximab vedotin (BV) in newly diagnosed high-risk classical Hodgkin lymphoma (cHL) in children and young adults (aged 2-21 years [y]): A randomized Children’s Oncology Group phase 3 trial (AHOD1331)	6737	Poster Presentation   Clinical Research Excluding Trials / Preclinical Therapies and Clinical Observations in Pediatric Oncology Wed., April 19 9:00 a.m. - 12:30 p.m. ET	Z. Zhang
PADCEV® (enfortumab vedotin)
Enfortumab vedotin, a Nectin-4-directed antibody-drug conjugate, demonstrates compelling antitumor activity in non-muscle invasive bladder cancer models and accurately predicts minimal systemic exposure when administered by intravesical instillation in patients	LB246	Poster Presentation   Late-Breaking Research: Experimental and Molecular Therapeutics 2 Tues., April 18 1:30 - 5:00 p.m. ET	D. Olson
TIDVAK® (tisotumab vedotin)
Tisotumab vedotin (TV) in squamous cell carcinoma of head and neck (SCCHN): interim analysis from innovaTV 207	CT164	Poster Presentation   Phase II Clinical Trials 1 Mon., April 17 1:30 - 5:00 p.m. ET	B. Cirauqui
TUKYSA® (tucatinib)
Phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for HER2+ metastatic breast cancer (HER2CLIMB-05, trial-in-progress)	CT065	Poster Presentation   Phase II and Phase III Clinical Trials in Progress Mon., April 17 9:00 a.m. - 12:30 p.m. ET	E. Hamilton
Tucatinib does not alter oxaliplatin PK or associated renal function: An OCT2/MATE transport inhibition study	5060	Poster Presentation   Experimental and Molecular Therapeutics - Theranostics and Radionuclides / Pharmacologic Approaches Tues., April 18 1:30 - 5:00 p.m. ET	A. Topletz-Erickson
Disitamab Vedotin
Disitamab vedotin, an investigational HER2-directed antibody-drug conjugate, shows potent antitumor activity as a monotherapy and in combination with tucatinib in preclinical cancer models	560	Poster Presentation   Experimental and Molecular Therapeutics / Oncogenes and Tumor Suppressor Genes as Targets for Therapy 1 Sun., April 16 1:30 - 5:00 p.m. ET	K. Willis
Early-Stage Programs
SGN-BB228, a CD228-directed costimulatory antibody anticalin bispecific provides potent and conditional 4-1BB costimulation to T cells in vivo and in an in vitro model of T-cell exhaustion	5676	Poster Presentation   Clinical Research Excluding Trials / Therapeutic Antibodies, Including Engineered Antibodies Tues., April 18 1:30 - 5:00 p.m. ET	B. Updegraff
SGN-B6A induces immunogenic cell death as an additional mechanism of action	1522	Poster Presentation   Experimental and Molecular Therapeutics / Antibody-Drug Conjugates Mon., April 17 9:00 a.m. - 12:30 p.m. ET	V. Trang
Generation of an antibody-drug conjugate-optimized TLR7/8 agonist payload	1542	Poster Presentation   Experimental and Molecular Therapeutics / Antibody-Drug Conjugates Mon., April 17 9:00 a.m. - 12:30 p.m. ET	K.P. Wang
Phase 1 dose-escalation study of SEA-TGT monotherapy in patients with advanced malignancies	CT265	Poster Presentation   Phase I Clinical Trials 2 Tues., April 18 1:30 - 5:00 p.m. ET	E. Garralda Cabanas
Using a clinical utility index (CUI) to determine the optimal biological dose of a nonfucosylated anti-TIGIT antibody: A proposed alternative to maximum tolerated dose (MTD)	5668	Poster Presentation   Clinical Research Excluding Trials / Therapeutic Antibodies, Including Engineered Antibodies Tues., April 18 1:30 - 5:00 p.m. ET	G. Patilea-Vrana
A preclinical model of acquired anti-PD-1 resistance is responsive to SEA-TGT, an effector-function enhanced anti-TIGIT monoclonal antibody	6361	Poster Presentation   Immunology / Immune Checkpoints Wed., April 19 9:00 a.m. - 12:30 p.m. ET	D. Gruber
A novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5 has potent antitumor activity in colorectal cancer models	4890	Poster Presentation   Experimental and Molecular Therapeutics / Anticancer Approaches: Antibody-Drug Conjugates, Epigenetics, and Tumor Environment Tues., April 18 1:30 - 5:00 p.m. ET	Y. Baudat
Discovery Research
Oxidized anthracycline payloads induce antitumor immunogenic cell death and show linker-dependent tolerability when delivered as ADCs	2013	Poster Presentation   Chemistry / Drug Delivery Mon., April 17 9:00 a.m. - 12:30 p.m. ET	J. Hamilton
Reversible chemical modification of antibodies: A complementary approach to tuning FcγR binding that maintains antitumor activity while mitigating peripheral immune activation	2656	Poster Presentation   Experimental and Molecular Therapeutics / Antibody Technologies Mon., April 17 9:00 a.m. - 12:30 p.m. ET	P. Moquist
MMAE drives immunomodulatory changes in a preclinical xenograft model that are distinct from other clinical-stage ADC payloads	4892	Poster Presentation   Experimental and Molecular Therapeutics / Anticancer Approaches: Antibody-Drug Conjugates, Epigenetics, and Tumor Environment Tues., April 18 1:30 - 5:00 p.m. ET	M. Ulrich

About Seagen

Seagen Inc. is a global biotechnology company that discovers, develops and commercializes transformative cancer medicines to make a meaningful difference in people’s lives. Seagen is headquartered in the Seattle, Washington area, and has locations in California, Canada, Switzerland and the European Union. For more information on our marketed products and robust pipeline, visit www.seagen.com and follow @SeagenGlobal on Twitter.

Forward-Looking Statements

Certain statements made in this press release are forward-looking, such as those, among others, relating to the therapeutic potential of Seagen’s products and product candidates, including their potential efficacy, safety and therapeutic uses, as well as the company’s pipeline, technologies, collaborations and planned or ongoing clinical trials. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include without limitation the difficulty and uncertainty of pharmaceutical product development, including the risks that the company may experience delays in its clinical trials or otherwise experience failures or setbacks in its clinical development programs due to lack of efficacy, adverse events or other factors, and that adverse regulatory actions may occur. More information about the risks and uncertainties faced by Seagen is contained under the caption “Risk Factors” included in the company’s Annual Report on Form 10-K for the year ended December 31, 2022, filed with the Securities and Exchange Commission. Seagen disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230314005811/en/

For Media

David Caouette

(310) 430-3476

dcaouette@seagen.com

For Investors

Douglas Maffei, Ph.D.

(425) 527-4160

dmaffei@seagen.com

Source: Seagen Inc.

FAQ

What are the key findings from the innovaTV 207 trial presented by SGEN?

The innovaTV 207 trial reported interim results for tisotumab vedotin, indicating its efficacy in treating recurrent or metastatic squamous cell carcinoma of the head and neck.

What does the Phase 1 SEA-TGT trial mean for SGEN investors?

Initial data from the SEA-TGT trial suggests promising outcomes in advanced malignancies, potentially expanding SGEN's treatment options.

When will the AACR Annual Meeting take place?

The AACR Annual Meeting is scheduled for April 14-19, 2023, in Orlando.

How many abstracts will SGEN present at AACR?

Seagen will present 17 abstracts at the upcoming AACR Annual Meeting.

What is the significance of the preclinical data presented by SGEN?

Preclinical data highlights advancements in Seagen's next-generation antibody-drug conjugate technologies, indicating ongoing innovation in cancer treatment.