ReNeuron Group (RENE): Differentiating in Exosome Drug Delivery
ReNeuron Group presented preclinical data revealing its CustomEx exosome platform's superior drug delivery capabilities compared to conventional HEK-derived exosomes. Key findings include a minimum 10-fold increase in cellular uptake across three cell types, with an 18-fold increase in endothelial cells. Notably, siRNA-loaded CustomEx exosomes achieved a 600% improvement in delivery to target cells. This technology positions ReNeuron favorably for potential partnerships and aligns with growth in the RNA therapeutic market.
- 10-fold increase in cellular uptake across multiple cell types.
- 600% improvement in siRNA delivery compared to HEK exosomes.
- Potential competitive advantage in the RNA therapeutic market.
- None.
LONDON, UK / ACCESSWIRE / October 10, 2022 / ReNeuron Group, a stem cell-derived exosome technology company, has presented encouraging preclinical data highlighting the enhanced drug delivery capability of its customisable exosome platform (CustomEx) over conventional human embryonic kidney-derived (HEK) exosomes. The company's CustomEx exosomes displayed a minimum 10-fold increase in cellular uptake across three cell types (endothelial, neural and epithelial) compared to HEK-derived exosomes, with an 18-fold increase observed in endothelial cells. Additionally, when loaded with a therapeutic payload (small interfering RNA, siRNA), a
Notably, the study was able to demonstrate the effective delivery of siRNA, a new class of complex drug modality, in which targeted drug delivery remains a significant challenge. The RNA therapeutic pipeline is poised to deliver further drug candidates, so we view this market as a potential opportunity for ReNeuron to target. While therapeutic exosomes may still be in the early stages of clinical development, demonstrating positive preclinical data has led to the signing of significant licensing deals within the market. This latest data will therefore further promote ReNeuron's technology platform and may garner heightened interest from potential partners, in our view.
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