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Arcus Biosciences, Inc. (NASDAQ: RCUS) is a cutting-edge, clinical-stage biopharmaceutical company dedicated to developing innovative immunotherapies for cancer treatment. Founded in 2015 by experienced researchers from the biotechnology and pharmaceutical sectors, Arcus is based in the San Francisco Bay Area, a hub for biotechnological innovation.
Arcus Biosciences focuses on leveraging insights in immunology to create new cancer therapeutics. The company is particularly known for its work on the ATP-adenosine pathway, a significant driver of immunosuppression in the tumor microenvironment. Their aim is to optimize small-molecule immuno-oncology product candidates that could revolutionize cancer treatment.
Arcus has a robust product pipeline that includes several promising candidates such as Domvanalimab, Etrumadenant, AB598, and Casdatifan. These drugs target different aspects of the immune system to either modulate cellular processes in cancer or directly combat tumor growth.
Significant achievements include successful clinical trials for treating various types of cancers, including lung, colorectal, and pancreatic cancers. The company operates through a single segment focused on the development and commercialization of its immunotherapies.
Arcus prides itself on maintaining an internal team of highly skilled professionals rather than outsourcing its research and development efforts. This approach ensures the highest quality and innovation in their drug discovery process.
With ongoing partnerships and collaborations, notably with Gilead Sciences, Arcus is well-positioned to bring its innovative therapies to market, providing new hope for patients with cancer.
Arcus Biosciences (NYSE:RCUS) announced the granting of stock options for 31,600 shares to three new employees, priced at $30.83 each, reflecting the company's closing share price on January 8, 2021. This initiative is part of the Company’s 2020 Inducement Plan, approved in January 2020. Arcus is focused on developing innovative cancer therapies, with four clinical candidates under evaluation for various cancer types, including the dual A2a/A2b antagonist, Etrumadenant, currently in multiple Phase 2 and 1b studies.
Arcus Biosciences (NYSE:RCUS) announced promising preliminary data from its ongoing Phase 1/1b trial, ARC-8, evaluating AB680 combined with zimberelimab and chemotherapy for front-line treatment of metastatic pancreatic cancer. The data shows favorable safety and clinical activity, indicating it is well-tolerated with side effects similar to established therapies. The company plans to present detailed results at the ASCO GI symposium on January 15, 2021, and advance to the Phase 1b expansion of the study.
Arcus Biosciences (NYSE:RCUS) announced the appointment of Andrew Perlman, M.D., Ph.D. and Michael Quigley, Ph.D. to its Board of Directors, focusing on strengthening its leadership as it approaches a pivotal year with key clinical trials. Dr. Perlman, an experienced biotechnology leader, has played significant roles at Genentech and Tularik, while Dr. Quigley has a strong background in oncology drug discovery from Gilead and Bristol-Myers Squibb. Their expertise aims to enhance Arcus's strategy to maximize long-term value for patients and shareholders.
Arcus Biosciences (NYSE:RCUS) announced that its Compensation Committee granted stock options to 20 new employees, totaling 310,500 shares at an exercise price of $29.93. This grant adheres to the 2020 Inducement Plan, approved by the Board of Directors in January 2020, in compliance with NYSE rules. The company is focused on developing advanced therapies for cancer, with four clinical candidates currently under investigation. Etrumadenant, AB680, Domvanalimab, and Zimberelimab represent their innovative approach to addressing unmet medical needs in oncology.
Arcus Biosciences (RCUS) and WuXi Biologics have expanded their strategic partnership to discover anti-CD39 antibodies using WuXi's proprietary technology. This collaboration marks the fourth antibody development program between the two companies. Arcus has exclusive global rights to these antibodies and will handle further development and commercialization. The CD39 axis is critical for tumor immunosuppression, and preclinical data suggest that inhibiting CD39 may enhance anti-tumor immunity. Financial details of the agreement were not disclosed, and no material impact on Arcus’s financial position is anticipated.
Arcus Biosciences (NYSE:RCUS) announced its participation in the Evercore ISI 3rd Annual HealthCONx Virtual Conference on December 2, 2020, at 10:30 a.m. Eastern Time. The event will feature a live audio webcast accessible via the Arcus website, with a replay available for two weeks post-event.
The company focuses on oncology and is advancing four clinical candidates: Etrumadenant (AB928), AB680, Domvanalimab (AB154), and Zimberelimab (AB122), targeting significant unmet needs in various cancers.
Arcus Biosciences (NYSE:RCUS) announced that its Compensation Committee granted stock options to ten new employees, totaling 343,000 shares at an exercise price of $21.53, the closing price on November 9, 2020. This grant was made under the 2020 Inducement Plan, approved by the Board of Directors in January 2020, in line with NYSE rules. Arcus is focused on developing innovative cancer therapies and currently has four clinical candidates: Etrumadenant, AB680, Domvanalimab, and Zimberelimab, addressing significant cancer treatment gaps.
Arcus Biosciences (NYSE:RCUS) reported Q3 2020 financial results, revealing revenues of $64.5 million, a substantial increase from $1.8 million in Q3 2019, driven by collaboration with Gilead. The company holds $785 million in cash, expected to fund operations into 2023. R&D expenses grew to $51.8 million from $17.2 million due to increased clinical trial activities. Arcus anticipates significant clinical readouts in 2021, aiming for pivotal trials for its cancer therapies, including zimberelimab and domvanalimab.
Arcus Biosciences (NYSE:RCUS) has partnered with AstraZeneca to evaluate the investigational anti-TIGIT antibody, domvanalimab, in a Phase 3 clinical trial for unresectable Stage III non-small cell lung cancer (NSCLC), using Imfinzi as a combination therapy. The collaboration aims to enhance efficacy and long-term survival rates in NSCLC patients, building on promising data from previous trials. AstraZeneca will lead the trial while both companies share costs and maintain rights to their respective therapies.
Arcus Biosciences, Inc. (NYSE:RCUS) has granted stock options to 17 new employees to purchase a total of 559,000 shares at an exercise price of $19.20, reflecting the closing price on October 8, 2020. This issuance falls under the 2020 Inducement Plan, which was approved by the Board of Directors. The company focuses on developing innovative cancer therapies, with four molecules in clinical trials targeting various cancers, including Etrumadenant and AB680.