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Poseida Therapeutics, Inc. (Nasdaq: PSTX) is a clinical-stage biopharmaceutical company that specializes in developing innovative cell and gene therapies aimed at curing certain cancers and rare diseases. The company's core focus is on leveraging non-viral gene engineering technologies to create life-saving therapeutics for patients with unmet medical needs. Poseida's pipeline includes autologous and allogeneic chimeric antigen receptor T cell (CAR-T) product candidates, initially targeting hematological malignancies and solid tumors.
Poseida boasts best-in-class genome engineering capabilities, utilizing proprietary tools like the piggyBac™ DNA modification system, nextGEN™ CRISPR, XTN™ TALEN, and the footprint-free™ gene editing system. These tools are virus-free and offer surgical precision in gene editing, enabling the development of highly effective therapies.
Recent achievements include significant advancements in the company's lead program, P-BCMA-ALLO1, a novel BCMA-targeted allogeneic CAR-T therapy for treating relapsed/refractory multiple myeloma (RRMM). The FDA recently granted Orphan Drug Designation for P-BCMA-ALLO1, underscoring its potential to meet high unmet medical needs. Poseida is investigating this therapy in collaboration with Roche, with promising preliminary data presented at major scientific conferences.
In addition to its focus on cancer, Poseida is also advancing genetic medicines for rare diseases. The company has highlighted progress in its gene therapy pipeline, especially for conditions like Hereditary Angioedema and Hemophilia A. These programs employ fully non-viral approaches, leveraging Poseida's advanced genetic engineering and delivery platforms.
Poseida has formed strategic collaborations with industry giants like Janssen and Roche, enhancing its capacity to bring innovative therapies to market. The company also recently entered into a research collaboration with Xyphos Biosciences, a subsidiary of Astellas, to develop novel convertibleCAR® programs targeting solid tumors.
Financially, Poseida reported revenues of $28.1 million for Q1 2024, a substantial increase from the previous year, primarily driven by collaborations with Astellas and Roche. With a strong cash position and additional funding from strategic partnerships, Poseida is well-positioned to advance its pipeline and achieve key milestones in 2024 and beyond.
Learn more about Poseida Therapeutics and its groundbreaking work by visiting www.poseida.com and connecting with the company on X and LinkedIn.
Poseida Therapeutics (PSTX) hosted a virtual R&D Day showcasing its allogeneic CAR-T therapy pipeline across hematologic malignancies, solid tumors, and autoimmune diseases. The company highlighted recent Phase 1 data for P-BCMA-ALLO1 and new preclinical findings for multiple programs. Key updates include P-CD19CD20-ALLO1's progress in B-cell malignancies, P-CD70-ALLO1's potential in AML, and P-BCMACD19-ALLO1's promising results in both autoimmune diseases and oncology. The company also presented innovative strategies for solid tumors through programs like P-MUC1C-ALLO1 and P-PSMA-ALLO1, leveraging their proprietary non-viral technology platform and TSCM-rich CAR-T approach.
Poseida Therapeutics (Nasdaq: PSTX), a clinical-stage company focused on allogeneic cell therapy and genetic medicines, has announced its participation in two major healthcare investor conferences. The company will present at the Stifel 2024 Healthcare Conference on Monday, November 18, 2024, at 10:20am ET, and the Piper Sandler 36th Annual Healthcare Conference on Wednesday, December 4, 2024, at 12:00pm ET.
Webcasts of both presentations will be accessible through Poseida's website and will remain available for approximately 90 days after the events.
Poseida Therapeutics (PSTX) reported strong Q3 2024 results, generating $71.7 million in revenue and achieving $20.2 million in net income. The company has been cash flow positive for the first nine months of 2024, securing $130 million in milestone and upfront payments. Their lead candidate P-BCMA-ALLO1 showed a 91% overall response rate in Phase 1 trials for multiple myeloma. The company expanded collaborations with Roche and Astellas, with cash runway extended into early 2026. Their cash position stands at $230.9 million as of September 30, 2024.
Poseida Therapeutics (PSTX) announced upcoming presentations of new data at two major conferences. At SITC 2024, the company will present preclinical data on allogeneic CAR+TCR-T cells rich in stem cell memory T cells (TSCM) with enhanced potency for solid tumors. At ASH 2024, they will showcase additional patient response data from the P-BCMA-ALLO1 Phase 1 trial's Arm C and preclinical data from P-CD19CD20-ALLO1 for B-cell malignancies. Both therapies are being developed in collaboration with Roche. P-BCMA-ALLO1 has received RMAT designation for relapsed/refractory multiple myeloma patients.
Poseida Therapeutics (PSTX) announced new preclinical data for P-KLKB1-101, a liver-directed gene editing therapy for hereditary angioedema (HAE). The data demonstrated high-fidelity KLKB1 gene editing with off-target edits below 0.1%. In a humanized mouse model, a single dose achieved 58% reduction in kallikrein levels at 0.125 mg/kg, with effects lasting at least 180 days. Non-human primate studies showed favorable tolerability with liver editing approaching therapeutic range, and optimization yielded 29% increased potency. The company's proprietary lipid nanoparticle delivery system enabled controlled dose response.
Poseida Therapeutics (Nasdaq: PSTX) has announced the nomination of a new development candidate under its collaboration with Roche, triggering a $15 million milestone payment. The candidate is an allogeneic, dual CAR-T therapy targeting hematologic malignancies, including multiple myeloma. This nomination builds on their collaboration with Roche, showcasing Poseida's non-viral genetic engineering toolkit to create TSCM-rich allogeneic CAR-T therapies.
The company now has three programs under their collaboration with Roche, including P-BCMA-ALLO1 and P-CD19CD20-ALLO1. Poseida plans to host a Cell Therapy R&D Day on November 14th, 2024, to highlight progress across its pipeline. With this milestone payment, Poseida expects its cash position to be sufficient to fund operations into early 2026.
Poseida Therapeutics has been named to Newsweek's List of the Top 200 America's Most Loved Workplaces for 2024, ranking #140. This recognition highlights the company's commitment to employee satisfaction and strong workplace culture. The list, developed by Most Loved Workplace®, a division of Best Practice Institute (BPI), surveyed over 2.6 million employees from various-sized businesses.
The evaluation focused on five critical areas: employees' positive feelings about their future at the company, career achievement, alignment of employer and employee values, respect at all levels, and collaboration. Additional factors like inclusion, diversity, equity, and career development were also considered.
Poseida's president and CEO, Kristin Yarema, Ph.D., emphasized the importance of employees in achieving the company's mission to develop new cell and gene therapies. The recognition reflects Poseida's strong culture, values, and commitment to both employees and patients.
Poseida Therapeutics reported positive interim Phase 1 results for its allogeneic CAR-T therapy P-BCMA-ALLO1 in relapsed/refractory multiple myeloma patients. The study showed a 91% overall response rate (ORR) in the optimized lymphodepletion arm, including a 100% ORR in BCMA-naïve patients. Key findings include:
- High efficacy in heavily pretreated patients
- Differentiated safety profile with no dose-limiting toxicities
- Low rates of CRS and ICANS (all Grade 2 or less)
- No graft vs. host disease or Parkinsonism observed
P-BCMA-ALLO1 received Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA. The therapy is being developed in collaboration with Roche for blood cancers using Poseida's TSCM-rich CAR-T platform.
Poseida Therapeutics (Nasdaq: PSTX) has received Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA for P-BCMA-ALLO1, their investigational allogeneic CAR-T cell therapy for relapsed/refractory multiple myeloma. This designation, based on positive Phase 1 clinical data, offers benefits like Fast Track and Breakthrough Therapy designations, enabling increased FDA interaction. P-BCMA-ALLO1 has shown promising efficacy, safety, and rapid 'off-the-shelf' access. New clinical data will be presented at the 21st International Myeloma Society Annual Meeting. The therapy has demonstrated responses in refractory patients, including those previously treated with BCMA-targeted therapies. Poseida plans additional clinical updates in the second half of 2024, in coordination with their strategic partner Roche.
Poseida Therapeutics (Nasdaq: PSTX) will present new clinical data from its ongoing Phase 1 study of P-BCMA-ALLO1, an investigational off-the-shelf allogeneic CAR-T cell therapy for relapsed/refractory multiple myeloma, at the 21st International Myeloma Society Annual Meeting. The presentation will take place on September 27, 2024, in Rio de Janeiro. Poseida has also initiated the Phase 1b portion of the clinical trial, triggering a $20 million payment from partner Roche. The company will host a conference call on September 28, 2024, to review the data. P-BCMA-ALLO1 is based on Poseida's unique stem cell memory T cell (TSCM) platform and is being developed in partnership with Roche to address the need for patient-focused, off-the-shelf therapies in multiple myeloma treatment.
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