ProQR Announces Second Quarter 2024 Operating and Financial Results
ProQR Therapeutics NV (Nasdaq: PRQR) reported its Q2 2024 financial and operating results. Key highlights include:
- AX-0810 (for cholestatic diseases) and AX-1412 (for cardiovascular diseases) programs advancing to clinic in late 2024/early 2025
- $4.5 million in milestones achieved in H1 from Lilly partnership
- €96.2 million cash position as of Q2 end, providing runway into mid-2026
- Net loss of €2.7 million (€0.03 per diluted share) for Q2 2024
- R&D costs increased to €7.1 million in Q2 2024 from €5.9 million in Q2 2023
- General and administrative costs decreased to €3.0 million in Q2 2024 from €4.1 million in Q2 2023
ProQR plans to announce translational data and clinical trial designs for AX-0810 and AX-1412 in H2 2024.
ProQR Therapeutics NV (Nasdaq: PRQR) ha riportato i risultati finanziari e operativi del secondo trimestre del 2024. I punti salienti includono:
- I programmi AX-0810 (per le malattie colestatiche) e AX-1412 (per le malattie cardiovascolari) progrediranno verso la clinica alla fine del 2024/primi del 2025
- Raggiunti 4,5 milioni di dollari in obiettivi nel primo semestre grazie alla partnership con Lilly
- Posizione di cassa di 96,2 milioni di euro alla fine del secondo trimestre, garantendo fondi fino a metà del 2026
- Perdita netta di 2,7 milioni di euro (0,03 euro per azione diluita) per il secondo trimestre del 2024
- I costi di R&S sono aumentati a 7,1 milioni di euro nel secondo trimestre del 2024 rispetto ai 5,9 milioni del secondo trimestre del 2023
- I costi generali e amministrativi sono diminuiti a 3,0 milioni di euro nel secondo trimestre del 2024 rispetto ai 4,1 milioni del secondo trimestre del 2023
ProQR prevede di annunciare dati traslazionali e design di studi clinici per AX-0810 e AX-1412 nella seconda metà del 2024.
ProQR Therapeutics NV (Nasdaq: PRQR) informó sus resultados financieros y operativos del segundo trimestre de 2024. Los aspectos destacados incluyen:
- Los programas AX-0810 (para enfermedades colestáticas) y AX-1412 (para enfermedades cardiovasculares) avanzarán a la clínica a finales de 2024/principios de 2025
- Se lograron 4,5 millones de dólares en hitos en el primer semestre gracias a la asociación con Lilly
- Posición de efectivo de 96,2 millones de euros a finales del segundo trimestre, proporcionando financiamiento hasta mediados de 2026
- Pérdida neta de 2,7 millones de euros (0,03 euros por acción diluida) para el segundo trimestre de 2024
- Los costos de I+D aumentaron a 7,1 millones de euros en el segundo trimestre de 2024 desde 5,9 millones en el segundo trimestre de 2023
- Los costos generales y administrativos disminuyeron a 3,0 millones de euros en el segundo trimestre de 2024 desde 4,1 millones en el segundo trimestre de 2023
ProQR planea anunciar datos traslacionales y diseños de ensayos clínicos para AX-0810 y AX-1412 en la segunda mitad de 2024.
ProQR Therapeutics NV(Nasdaq: PRQR)는 2024년 2분기 재무 및 운영 결과를 보고했습니다. 주요 사항은 다음과 같습니다:
- AX-0810(콜레스테롤성 질환 치료제)와 AX-1412(심혈관 질환 치료제) 프로그램이 2024년 말/2025년 초에 임상 단계로 진입 예정
- Lilly와의 파트너십을 통해 상반기에 450만 달러의 이정표를 달성
- 2024년 2분기 말 기준 현금 보유액 9,620만 유로로, 2026년 중반까지 자금 확보
- 2024년 2분기 순손실 270만 유로(희석주당 0.03 유로)
- R&D 비용이 2023년 2분기 590만 유로에서 2024년 2분기 710만 유로로 증가
- 일반 및 관리 비용이 2023년 2분기 410만 유로에서 2024년 2분기 300만 유로로 감소
ProQR은 2024년 하반기에 AX-0810 및 AX-1412에 대한 전환 데이터 및 임상 시험 설계를 발표할 계획입니다.
ProQR Therapeutics NV (Nasdaq: PRQR) a rapporté ses résultats financiers et opérationnels pour le deuxième trimestre 2024. Les points clés incluent :
- Les programmes AX-0810 (pour les maladies cholestatiques) et AX-1412 (pour les maladies cardiovasculaires) passeront en clinique à la fin de 2024/début 2025
- 4,5 millions de dollars de jalons atteints au premier semestre grâce au partenariat avec Lilly
- Position de trésorerie de 96,2 millions d'euros à la fin du deuxième trimestre, offrant des ressources jusqu'à mi-2026
- Perte nette de 2,7 millions d'euros (0,03 € par action diluée) pour le deuxième trimestre 2024
- Les coûts de R&D ont augmenté à 7,1 millions d'euros au deuxième trimestre 2024 contre 5,9 millions d'euros au deuxième trimestre 2023
- Les coûts généraux et administratifs ont diminué à 3,0 millions d'euros au deuxième trimestre 2024 contre 4,1 millions d'euros au deuxième trimestre 2023
ProQR prévoit d'annoncer des données translationnelles et des conceptions d'essais cliniques pour AX-0810 et AX-1412 dans la seconde moitié de 2024.
ProQR Therapeutics NV (Nasdaq: PRQR) berichtete über die finanziellen und betrieblichen Ergebnisse des zweiten Quartals 2024. Die wichtigsten Highlights sind:
- Die Programme AX-0810 (für cholestatische Krankheiten) und AX-1412 (für Herz-Kreislauf-Erkrankungen) schreiten Ende 2024/Anfang 2025 in die klinische Phase voran
- 4,5 Millionen Dollar an Meilensteinen wurden im ersten Halbjahr durch die Partnerschaft mit Lilly erreicht
- Cash-Position von 96,2 Millionen Euro zum Ende des zweiten Quartals, was bis Mitte 2026 Spielraum gibt
- Nettoverlust von 2,7 Millionen Euro (0,03 Euro pro verwässerter Aktie) für das zweite Quartal 2024
- F&E-Kosten stiegen im zweiten Quartal 2024 auf 7,1 Millionen Euro von 5,9 Millionen Euro im zweiten Quartal 2023
- Allgemeine und Verwaltungskosten sanken im zweiten Quartal 2024 auf 3,0 Millionen Euro von 4,1 Millionen Euro im zweiten Quartal 2023
ProQR plant, in der zweiten Jahreshälfte 2024 translational Daten und klinische Studien für AX-0810 und AX-1412 anzukündigen.
- Achieved $4.5 million in milestones from Lilly partnership in H1 2024
- Strong cash position of €96.2 million, providing runway into mid-2026
- Reduced net loss to €2.7 million in Q2 2024 from €8.0 million in Q2 2023
- Decreased general and administrative costs to €3.0 million in Q2 2024 from €4.1 million in Q2 2023
- Potential for additional milestone income and $50 million opt-in payment from Lilly partnership
- Increased R&D costs to €7.1 million in Q2 2024 from €5.9 million in Q2 2023
- Cash and cash equivalents decreased to €96.2 million from €118.9 million at end of 2023
Insights
ProQR's Q2 2024 results show a mixed financial picture. The company's cash position of
ProQR's pipeline progress is noteworthy, with two lead candidates, AX-0810 and AX-1412, advancing to clinical trials in late 2024/early 2025. The in vivo proof of target engagement for AX-0810 in non-human primates is particularly significant, as it demonstrates the potential of their Axiomer™ RNA editing technology. However, it's important to note that these are still early-stage developments. The focus on cholestatic diseases and cardiovascular diseases targets large markets with unmet needs, which could be lucrative if successful. The partnership with Lilly adds credibility to ProQR's platform, but investors should remain cautious until human clinical data is available to truly assess the technology's potential.
ProQR's strategic focus on RNA editing technology positions it in a cutting-edge area of biotechnology. The Axiomer™ platform's potential to address multiple diseases could be a significant advantage. The Lilly partnership validates the technology's promise and provides important financial support. However, the RNA editing field is highly competitive, with several players vying for dominance. ProQR's success will depend on translating preclinical results into clinical efficacy. The company's IP portfolio strength is a key asset, but the timeline to market remains long. Investors should closely monitor upcoming clinical trial initiations and data readouts as critical inflection points for assessing ProQR's long-term potential in this rapidly evolving sector.
- AX-0810 program targeting NTCP for cholestatic diseases and AX-1412 program targeting B4GALT1 for cardiovascular diseases advancing to the clinic in late 2024/early 2025 with translational data and trial design details to be announced in H2 2024
$4.5 million in milestones achieved in H1 related to progress in the Lilly partnership€96.2 million cash position as of end of Q2 providing runway into mid-2026, plus additional potential milestones from Lilly partnership
LEIDEN, Netherlands & CAMBRIDGE, Mass., Aug. 08, 2024 (GLOBE NEWSWIRE) -- ProQR Therapeutics NV. (Nasdaq: PRQR) (ProQR), a company dedicated to changing lives through transformative RNA therapies based on its proprietary Axiomer™ RNA editing technology platform, today reported its financial and operating results for the second quarter ended June 30, 2024, and provided a business update.
“In the second quarter, we took important steps toward advancing our first editing oligonucleotide programs to clinical stage, with AX-0810 targeting NTCP for cholestatic diseases and AX-1412 targeting B4GALT1 for cardiovascular diseases on track to enter the clinic in late 2024/early 2025,” said Daniel A. de Boer, Founder and CEO of ProQR. “We were excited to share data at ASGCT in May, demonstrating in vivo proof of target engagement with meaningful changes in disease-relevant biomarkers in non-human primates for our NTCP program. As we progress our CTA/IND-enabling studies, we plan to announce translational data and more about our clinical plans for AX-0810 in the second half of the year, as well as preclinical proof of concept and translational data for AX-1412.”
de Boer continued, “Beyond our own pipeline programs, we are pleased with the progress we are making in our partnership with Lilly and highlight the achievement of multiple milestones in the first half of the year. With the benefits of a productive partnership, a differentiated pipeline strategy rooted in human genetics, our leading IP portfolio, and a strong cash balance with runway into mid-2026, we look forward to continued execution as we advance our science and pipeline programs.”
Recent Progress and Anticipated Upcoming Events
- In June, ProQR presented at the RNA Editing Summit in Boston, highlighting its Axiomer technology platform and AX-0810, the Company’s program targeting NTCP for cholestatic diseases.
- In May at the American Society of Cell and Gene Therapy (ASGCT) Annual Meeting, ProQR presented preclinical proof of concept in vitro and in vivo data for AX-0810 for Cholestatic Diseases targeting NTCP (poster P-705). ProQR scientists showed for the first time in the ADAR RNA editing field in vivo proof of target engagement (RNA editing) with meaningful changes in biomarkers in NHPs using Axiomer RNA Editing Oligonucleotides. At ASGCT, ProQR and partner Eli Lilly presented preclinical data related to Axiomer in poster P-726 titled “Complex Metabolism and Prolonged PK/PD of a GalNAc-Conjugated Editing Oligonucleotide (EON) in Mice”.
- Anticipated Upcoming Events:
- AX-0810 targeting NTCP for cholestatic diseases: clinical development candidate translational data to be reported, and design for the clinical trial to be shared in H2 2024 with program to advance to the clinic in late 2024/early 2025.
- AX-1412 targeting B4GALT1 for cardiovascular diseases: preclinical proof of concept data and translational data to be reported in H2 2024 with program to advance to the clinic in late 2024/early 2025.
- Potential additional new pipeline target announcements in 2024.
- Continue to execute on partnership with Eli Lilly and Company (Lilly), with potential additional data updates to come in 2024, along with potential additional milestone income from existing partnership, and potential option to exercise for expansion of deal to 15 targets, which would result in a
$50 million opt-in payment to ProQR. - ProQR may selectively form new partnerships, which could include multi-target discovery alliances, or product alliances on specific programs.
Financial Highlights
At June 30, 2024, ProQR held cash and cash equivalents and short term financial assets of
Research and development (R&D) costs were
General and administrative costs were
Net loss for the three-month period ended June 30, 2024 was
About Axiomer™
ProQR is pioneering a next-generation RNA base editing technology called Axiomer™, which could potentially yield a new class of medicines for diverse types of diseases. Axiomer™ “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way using molecular machinery that is present in human cells called ADAR (Adenosine Deaminase Acting on RNA). Axiomer™ EONs are designed to recruit and direct endogenously expressed ADARs to change an Adenosine (A) to an Inosine (I) in the RNA – an Inosine is translated as a Guanosine (G) – correcting an RNA with a disease-causing mutation back to a normal (wild type) RNA, modulating protein expression, or altering a protein so that it will have a new function that helps prevent or treat disease.
About Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC)
Cholestatic disorders refer to a group of diseases presenting excessive and toxic buildup of bile acids in the liver due to bile ducts dysfunction. This leads to liver damage and a range of debilitating symptoms. Without treatment, liver damage can progress through various stages, ultimately leading to liver failure and elevated risk of liver malignancy, affecting life expectancy. Cholestatic diseases remain leading causes of liver transplantation. There are no approved therapies for primary sclerosing cholangitis (PSC) for adults and biliary atresia (BA) for pediatrics It is estimated that 80,000 and 20,000 individuals have PSC and BA, respectively, in North America and in Europe.
About AX-0810 targeting NTCP
The majority of the bile acids present in the liver cells originate from the enterohepatic reuptake cycle. The key transporter responsible for hepatic uptake of bile acids from portal circulation is the sodium (Na+)-taurocholate cotransporting polypeptide (NTCP, SLC10A1 gene) expressed in the liver. AX-0810 is designed to introduce a loss of function variant in SLC10A1 RNA that has been found in human genetics to prevent re-uptake of bile acids in liver via NTCP. Based on its mechanism of action, AX-0810 has the potential to become a disease modifying treatment for PSC and BA primarily among other cholestatic diseases.
About Cardiovascular Diseases
Cardiovascular diseases (CVDs) are a group of health conditions that affect the heart and blood vessels, such as atherosclerosis which can lead to severe problems like heart attacks, heart failure, and stroke. CVDs represent the leading cause of disability and death in the world. Approximately 18 million people die every year from CVDs representing one third of all the global deaths. Despite available lipid lowering therapies and hypertension medications, the risk of CVDs is still projected to increase rapidly over the coming years.
About AX-1412 targeting B4GALT1
Gene–based analysis of rare beta-1,4-galactosyltransferase 1 (B4GALT1) missense variant (p.Asn352Ser) is known to lead to B4GALT1 protein loss of function and showed an association with decreased coronary artery disease. These beneficial effects are mediated by hypo-galactosylation of the apolipoprotein B100 and fibrinogen, known – independent – drivers of increased risk of CVDs. AX-1412 introduces a protective variant into B4GALT1 RNA to address the remaining residual risk of developing cardiovascular diseases. ProQR intends to advance AX-1412 targeting B4GALT1 to early clinical proof of concept stage, then would seek to partner this program.
About ProQR
ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer™, which uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unmet need. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.
Learn more about ProQR at www.proqr.com.
Forward Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “continue,” "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding our business, technology, strategy, preclinical model data, our initial pipeline targets and the upcoming strategic priorities and milestones related thereto, our Axiomer™ platform, including the continued development and advancement of our Axiomer platform, the therapeutic potential of our Axiomer RNA editing oligonucleotides and our ability to expand preclinical in vivo and in vitro data, the timing, progress and results of our preclinical studies and other development activities, including the release of data related thereto, our patent estate, including our anticipated strength and our continued investment in it, as well as the timing of our clinical development, the potential of our technologies and product candidates, the collaboration with Lilly and the intended and potential benefits thereof, including the receipt of milestone and royalty payments from commercial product sales, if any, from the products covered by the collaboration, our ability to selectively form new partnerships and enter into future collaborations, and our financial position and cash-runway. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those expressed or implied by these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings made with the Securities and Exchange Commission, including certain sections of our annual report filed on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and clinical trials and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted shortage and pressure on supply and logistics on the global market; the likelihood of our preclinical and clinical programs being initiated and executed on timelines provided and reliance on our contract research organizations and predictability of timely enrollment of subjects and patients to advance our clinical trials and maintain their own operations; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption from a contract manufacturer; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of applications or clearances that are necessary to initiate and continue to advance and progress our clinical programs; the ability to secure, maintain and realize the intended benefits of collaborations with partners, including the collaboration with Lilly; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; general business, operational, financial and accounting risks, and risks related to litigation and disputes with third parties; and risks related to macroeconomic conditions and market volatility resulting from global economic developments, geopolitical instability and conflicts. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.
ProQR Therapeutics N.V.
Investor contact:
Sarah Kiely
ProQR Therapeutics N.V.
T: +1 617 599 6228
skiely@proqr.com
or
Peter Kelleher
LifeSci Advisors
T: +1 617 430 7579
pkelleher@lifesciadvisors.com
Media contact:
Robert Stanislaro
FTI Consulting
T: +1 212 850 5657
robert.stanislaro@fticonsulting.com
Financial Tables
PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Financial Position
| June 30, | December 31, | |||
| 2024 | 2023 | |||
| | | |||
| Assets | ||||
| Current assets | ||||
| Cash and cash equivalents | 78,970 | 118,925 | ||
| Financial asset - current | 17,183 | — | ||
| Prepayments and other receivables | 5,116 | 1,538 | ||
| Other taxes | 497 | 523 | ||
| Total current assets | 101,766 | 120,986 | ||
| Property, plant and equipment | 16,285 | 16,897 | ||
| Investments in financial assets | — | — | ||
| Total assets | 118,051 | 137,883 | ||
| Equity and liabilities | ||||
| Equity | ||||
| Equity attributable to owners of the Company | 32,854 | 41,390 | ||
| Total equity | 32,854 | 41,390 | ||
| Current liabilities | ||||
| Borrowings | 4,437 | — | ||
| Lease liabilities | 1,675 | 1,614 | ||
| Derivative financial instruments | 184 | 311 | ||
| Trade payables | 33 | 1,541 | ||
| Social securities and other taxes | 1,448 | 1,659 | ||
| Deferred income | 23,827 | 20,569 | ||
| Other current liabilities | 5,675 | 8,509 | ||
| Total current liabilities | 37,279 | 34,203 | ||
| Borrowings | — | 4,292 | ||
| Lease liabilities | 13,078 | 13,828 | ||
| Deferred income | 34,840 | 44,170 | ||
| Total liabilities | 85,197 | 96,493 | ||
| Total equity and liabilities | 118,051 | 137,883 |
PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Profit or Loss and OCI
(€ in thousands, except share and per share data)
| Three month period | Six month period | |||||||
| ended June 30, | ended June 30, | |||||||
| 2024 | 2023 | 2024 | 2023 | |||||
| | | | | |||||
| Revenue | 6,305 | 1,205 | 10,755 | 1,860 | ||||
| Other income | 156 | 38 | 366 | 80 | ||||
| Research and development costs | (7,048) | (5,909) | (16,331) | (11,969) | ||||
| General and administrative costs | (3,013) | (4,145) | (6,465) | (8,171) | ||||
| Total operating costs | (10,061) | (10,054) | (22,796) | (20,140) | ||||
| Operating result | (3,600) | (8,811) | (11,675) | (18,200) | ||||
| Finance income and expense | 513 | 470 | 1,001 | (74) | ||||
| Results related to associates and financial assets | — | — | — | — | ||||
| Results related to financial liabilities measured at fair value through profit or loss | 195 | 221 | 127 | 891 | ||||
| Results on derecognition of financial liabilities | — | 101 | — | 509 | ||||
| Result before corporate income taxes | (2,892) | (8,019) | (10,547) | (16,874) | ||||
| Income taxes | 200 | 42 | 197 | 42 | ||||
| Result for the period | (2,692) | (7,977) | (10,350) | (16,832) | ||||
| Other comprehensive income (foreign exchange differences on foreign operation) | 85 | 7 | 276 | (212) | ||||
| Total comprehensive income | (2,607) | (7,970) | (10,074) | (17,044) | ||||
| Result attributable to | ||||||||
| Owners of the Company | (2,692) | (7,993) | (10,350) | (16,926) | ||||
| Non-controlling interests | — | 16 | — | 94 | ||||
| (2,692) | (7,977) | (10,350) | (16,832) | |||||
| Total comprehensive income attributable to | ||||||||
| Owners of the Company | (2,607) | (7,986) | (10,074) | (17,138) | ||||
| Non-controlling interests | — | 16 | — | 94 | ||||
| (2,607) | (7,970) | (10,074) | (17,044) | |||||
| Share information | ||||||||
| Weighted average number of shares outstanding1 | 81,665,565 | 80,939,392 | 81,618,038 | 80,913,751 | ||||
| Earnings per share attributable to owners of the Company (Euro per share) | ||||||||
| Basic loss per share1 | (0.03) | (0.10) | (0.13) | (0.21) | ||||
| Diluted loss per share1 | (0.03) | (0.10) | (0.13) | (0.21) | ||||
- For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.
PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Changes in Equity
| Attributable to owners of the Company | ||||||||||||||||||
| Number of shares | Share Capital | Share Premium | Equity settled Employee Benefit Reserve | Translation Reserve | Accumulated Deficit | Total | Non- controlling interests | Total Equity | ||||||||||
| | | | | | | | | |||||||||||
| Balance at January 1, 2023 | 84,246,967 | 3,370 | 412,540 | 29,052 | 1,212 | (379,110) | 67,064 | (384) | 66,680 | |||||||||
| Result for the period | — | — | — | — | — | (16,926) | (16,926) | 94 | (16,832) | |||||||||
| Other comprehensive income | — | — | — | — | (212) | — | (212) | — | (212) | |||||||||
| Recognition of share-based payments | — | — | — | 1,860 | — | — | 1,860 | — | 1,860 | |||||||||
| Treasury shares transferred | (122,584) | — | — | — | — | — | — | — | — | |||||||||
| Share options lapsed | — | — | — | (3,873) | — | 3,873 | — | — | — | |||||||||
| Share options exercised | 122,584 | — | 4 | (231) | — | 231 | 4 | — | 4 | |||||||||
| Balance at June 30, 2023 | 84,246,967 | 3,370 | 412,544 | 26,808 | 1,000 | (391,932) | 51,790 | (290) | 51,500 | |||||||||
| Balance at January 1, 2024 | 84,248,384 | 3,370 | 412,894 | 25,159 | 817 | (400,850) | 41,390 | — | 41,390 | |||||||||
| Result for the period | — | — | — | — | — | (10,350) | (10,350) | — | (10,350) | |||||||||
| Other comprehensive income | — | — | — | — | 276 | — | 276 | — | 276 | |||||||||
| Recognition of share-based payments | — | — | — | 1,364 | — | — | 1,364 | — | 1,364 | |||||||||
| Treasury shares transferred | (326,455) | — | — | — | — | — | — | — | — | |||||||||
| Share options lapsed | — | — | — | (359) | — | 359 | — | — | — | |||||||||
| Share options exercised / RSUs vested | 326,455 | — | 174 | (288) | — | 288 | 174 | — | 174 | |||||||||
| Balance at June 30, 2024 | 84,248,384 | 3,370 | 413,068 | 25,876 | 1,093 | (410,553) | 32,854 | — | 32,854 | |||||||||
PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Cash Flows
| Three month period | Six month period | |||||||
| ended June 30, | ended June 30, | |||||||
| 2024 | 2023 | 2024 | 2023 | |||||
| | | | | |||||
| Cash flows from operating activities | ||||||||
| Net result | (2,692) | (7,977) | (10,350) | (16,832) | ||||
| Adjustments for: | ||||||||
| — Depreciation | 711 | 594 | 1,402 | 1,143 | ||||
| — Share-based compensation | 628 | 765 | 1,364 | 1,860 | ||||
| — Financial income and expenses | (513) | (470) | (1,001) | 74 | ||||
| — Results related to associates and financial assets | — | — | — | — | ||||
| — Results related to financial liabilities measured at fair value through profit or loss | (195) | (221) | (127) | (891) | ||||
| — Results on derecognition of financial liabilities | — | (101) | — | (509) | ||||
| — Income tax expenses | (200) | — | (197) | — | ||||
| Changes in working capital | (4,614) | (3,622) | (13,838) | 48,668 | ||||
| Cash (used in)/generated from operations | (6,875) | (11,032) | (22,747) | 33,513 | ||||
| Corporate income tax received/(paid) | 199 | — | 196 | — | ||||
| Interest received | 610 | 685 | 1,542 | 865 | ||||
| Interest paid | (190) | — | (379) | — | ||||
| Net cash (used in)/generated from operating activities | (6,256) | (10,347) | (21,388) | 34,378 | ||||
| Cash flow from investing activities | ||||||||
| Increase in financial asset - current | — | — | (17,000) | — | ||||
| Purchases of property, plant and equipment | (267) | (294) | (999) | (430) | ||||
| Sales of property, plant and equipment | — | — | — | 47 | ||||
| Net cash used in investing activities | (267) | (294) | (17,999) | (383) | ||||
| Cash flow from financing activities | ||||||||
| Proceeds from exercise of share options | 12 | 4 | 174 | 4 | ||||
| Repayment of lease liability | (294) | (647) | (875) | (906) | ||||
| Net cash used in financing activities | (282) | (643) | (701) | (902) | ||||
| Net (decrease)/increase in cash and cash equivalents | (6,805) | (11,284) | (40,088) | 33,093 | ||||
| Currency effect cash and cash equivalents | 62 | 860 | 133 | 694 | ||||
| Cash and cash equivalents, at beginning of the period | 85,713 | 138,986 | 118,925 | 94,775 | ||||
| Cash and cash equivalents at the end of the period | 78,970 | 128,562 | 78,970 | 128,562 | ||||
FAQ
What are ProQR's key pipeline programs advancing to the clinic?
How much cash does ProQR (PRQR) have as of Q2 2024?
What was ProQR's (PRQR) net loss for Q2 2024?
How much did ProQR (PRQR) earn in milestones from its Lilly partnership in H1 2024?
