ProMIS Neurosciences Showcases Novel Vaccine Approach for Maximal Targeting of Toxic Amyloid-Beta Oligomers at the 2024 Alzheimer’s Association International Conference
ProMIS Neurosciences Inc. (Nasdaq: PMN) presented preclinical data at the 2024 Alzheimer's Association International Conference (AAIC) supporting their novel approach to optimizing an Alzheimer's disease (AD) vaccine. The company's proprietary computational platform identified four AβO-restricted conformational B cell epitopes as vaccine candidates. Vaccination with these epitopes produced strong antibody responses without measurable pro-inflammatory T cell responses against Aβ. Notably, immunization with epitope 301, the target of PMN310, alone was sufficient to produce maximal reactivity against brain AβO.
The study suggests that ProMIS' approach could potentially lead to an AD vaccine capable of inducing an effective antibody response against pathogenic Aβ. This vaccine could be administered as a preventative measure to at-risk individuals or given therapeutically to diagnosed patients to inhibit AD progression.
ProMIS Neurosciences Inc. (Nasdaq: PMN) ha presentato dati preclinici alla Conferenza Internazionale dell'Associazione Alzheimer 2024 (AAIC) a sostegno del loro approccio innovativo per ottimizzare un vaccino contro la malattia di Alzheimer (AD). La piattaforma computazionale proprietaria dell'azienda ha identificato quattro epitopi conformazionali B a restrizione AβO come candidati per il vaccino. La vaccinazione con questi epitopi ha prodotto forti risposte anticorpali senza risposte T cellulari pro-infiammatorie misurabili contro Aβ. È importante notare che l'immunizzazione con l'epitopo 301, il bersaglio di PMN310, da sola è stata sufficiente per produrre una reattività massima contro AβO cerebrale.
Lo studio suggerisce che l'approccio di ProMIS potrebbe potenzialmente portare a un vaccino AD in grado di indurre una risposta anticorpale efficace contro l'Aβ patogenico. Questo vaccino potrebbe essere somministrato come misura preventiva a individui a rischio o dato terapeuticamente a pazienti diagnosticati per inibire la progressione dell'AD.
ProMIS Neurosciences Inc. (Nasdaq: PMN) presentó datos preclínicos en la Conferencia Internacional de la Asociación de Alzheimer 2024 (AAIC) que apoyan su enfoque novedoso para optimizar una vacuna contra la enfermedad de Alzheimer (AD). La plataforma computacional patentada de la empresa identificó cuatro epitopos conformacionales restringidos a AβO como candidatos a vacuna. La vacunación con estos epitopos produjo fuertes respuestas de anticuerpos sin respuestas de células T pro-inflamatorias medibles contra Aβ. Cabe destacar que la inmunización con el epítopo 301, el objetivo de PMN310, fue suficiente por sí sola para producir una reactividad máxima contra AβO cerebral.
El estudio sugiere que el enfoque de ProMIS podría potencialmente llevar a una vacuna AD capaz de inducir una respuesta efectiva de anticuerpos contra Aβ patogénico. Esta vacuna podría administrarse como medida preventiva a individuos en riesgo o aplicarse terapéuticamente a pacientes diagnosticados para inhibir la progresión de la AD.
ProMIS Neurosciences Inc. (Nasdaq: PMN)는 2024년 알츠하이머 협회 국제 회의(AAIC)에서 알츠하이머병 (AD) 백신 최적화를 위한 새로운 접근 방식에 대한 전임상 데이터를 발표했습니다. 회사의 독점적인 컴퓨터 플랫폼은 네 가지 AβO 제한 구획 B 세포 에피토프를 백신 후보로 식별했습니다. 이 에피토프를 사용한 백신 접종은 Aβ에 대한 측정 가능한 염증성 T 세포 반응 없이 강한 항체 반응을 생성했습니다. 특히, PMN310의 표적 에피토프인 301로 면역화하는 것만으로도 뇌 AβO에 대한 최대 반응성을 얻는 데 충분했습니다.
이번 연구는 ProMIS의 접근 방식이 병원성 Aβ에 대한 효과적인 항체 반응을 유도할 수 있는 AD 백신으로 이어질 가능성이 있음을 시사합니다. 이 백신은 위험에 처한 개인에게 예방 조치로 투여하거나 진단된 환자에게 치료적으로 주어 AD 진행을 억제하는 데 사용할 수 있습니다.
ProMIS Neurosciences Inc. (Nasdaq: PMN) a présenté des données précliniques lors de la Conférence Internationale de l'Association Alzheimer 2024 (AAIC) soutenant leur approche novatrice pour optimiser un vaccin contre la maladie d'Alzheimer (MA). La plateforme computationnelle propriétaire de l'entreprise a identifié quatre épitopes B conformationalement restreints à AβO comme candidats vaccins. La vaccination avec ces épitopes a entraîné de fortes réponses anticorporelles sans réponses pro-inflammatoires des cellules T mesurables contre Aβ. Il convient de noter que l'immunisation avec l'épitop 301, la cible de PMN310, suffisait à elle seule à produire une réactivité maximale contre l'AβO cérébral.
Cette étude suggère que l'approche de ProMIS pourrait potentiellement aboutir à un vaccin MA capable d'induire une réponse anticorporelle efficace contre l'Aβ pathogène. Ce vaccin pourrait être administré comme mesure préventive aux personnes à risque ou donné de manière thérapeutique aux patients diagnostiqués afin d'inhiber la progression de la MA.
ProMIS Neurosciences Inc. (Nasdaq: PMN) präsentierte präklinische Daten auf der 2024 Alzheimer Association International Conference (AAIC), die ihren neuartigen Ansatz zur Optimierung eines Impfstoffs gegen Alzheimerkrankheit (AD) unterstützen. Die firmeneigene Computerplattform identifizierte vier AβO-restriktive konformale B-Zell-Epitopen als Impfstoffkandidaten. Die Impfung mit diesen Epitopen erzeugte starke Antikörperreaktionen ohne messbare proinflammatorische T-Zell-Reaktionen gegen Aβ. Bemerkenswert ist, dass die Immunisierung mit dem Epitop 301, dem Ziel von PMN310, allein ausreichte, um eine maximale Reaktivität gegen Gehirn-AβO zu erzeugen.
Die Studie legt nahe, dass der Ansatz von ProMIS potenziell zu einem AD-Impfstoff führen könnte, der in der Lage ist, eine effektive Antikörperreaktion gegen pathologisches Aβ auszulösen. Dieser Impfstoff könnte als Präventionsmaßnahme bei gefährdeten Personen verabreicht oder therapeutisch an diagnostizierten Patienten eingesetzt werden, um das Fortschreiten von AD zu hemmen.
- Preclinical data showed strong antibody responses against AβO without pro-inflammatory T cell responses
- Immunization with epitope 301 alone produced maximal reactivity against brain AβO
- Potential for developing a preventative or therapeutic AD vaccine
- None.
Insights
As a Medical Research Analyst, I find ProMIS Neurosciences' preclinical data on their novel Alzheimer's disease (AD) vaccine approach intriguing, yet it's important to maintain a measured perspective. The company's focus on targeting toxic amyloid-beta oligomers (AβO) aligns with current research trends in AD therapeutics. However, we must remember that many promising preclinical results in AD research have failed to translate into clinical success.
The key points that stand out are:
- The vaccine produced strong antibody responses without measurable pro-inflammatory T cell responses against Aβ, which could potentially reduce the risk of adverse effects seen in some previous AD vaccine attempts.
- Immunization with epitope 301, the target of PMN310, showed maximal reactivity against brain AβO, suggesting a focused approach that could enhance efficacy.
- The potential for preventative use in at-risk individuals is an interesting angle, though it would require extensive long-term studies to validate.
While these results are encouraging, it's important to note that this is still preclinical data. The path from preclinical success to an approved therapy is long and fraught with challenges, especially in AD research. Investors should be cautious about overinterpreting these early results and wait for human trial data to better assess the potential of this approach.
From a biotechnology industry perspective, ProMIS Neurosciences' approach to Alzheimer's disease (AD) treatment is noteworthy for several reasons:
- The company's proprietary computational platform for identifying AβO-restricted conformational B cell epitopes represents a unique technological advantage in the crowded AD research space.
- The focus on soluble toxic oligomers rather than insoluble fibrils aligns with emerging research trends, potentially positioning ProMIS ahead of competitors still targeting traditional amyloid plaques.
- The ex vivo approach for selecting optimal vaccine configuration could streamline the development process, potentially saving time and resources in future clinical trials.
However, it's important to contextualize this within the broader AD treatment landscape. Many companies have presented promising preclinical data only to face setbacks in human trials. The recent approval of Leqembi (lecanemab) has renewed interest in amyloid-targeting therapies, but the bar for success remains high.
For investors, while this news is positive, it's important to remember that ProMIS is still in the preclinical stage for this vaccine approach. The company's market position will depend heavily on how these results translate to human trials and how quickly they can progress through the clinical development stages. The potential for both therapeutic and preventative applications could expand the market opportunity, but also increases the complexity and duration of required clinical trials.
Preclinical data showed strong antibody responses with no measurable pro-inflammatory T cell responses against AßO and support novel approach for potential Alzheimer’s disease vaccine
CAMBRIDGE, Massachusetts and TORONTO, Ontario, July 30, 2024 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (Nasdaq: PMN), a biotechnology company focused on the generation and development of antibody therapeutics targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), presented preclinical data at the 2024 Alzheimer’s Association International Conference (AAIC) that further supports the potential therapeutic advantage of the Company’s novel approach to optimization of an Alzheimer’s disease (AD) vaccine for maximum targeting of toxic amyloid-beta oligomers (AβO).
A large body of evidence indicates that the most pathogenic species of amyloid-beta (Aß) in AD consist of soluble toxic oligomers as opposed to insoluble fibrils and monomers. ProMIS’ proprietary computational platform identified four different AßO-restricted conformational B cell epitopes as vaccine candidates. Additionally, the Company’s novel ex vivo approach selected an optimal vaccine configuration to provide maximal binding to a toxic oligomer-enriched low molecular weight fraction of soluble AD brain extracts.
The results from the study showed that vaccination with AßO-restricted conformational B cell epitopes produced strong antibody responses with no measurable pro-inflammatory T cell responses against Aß. Importantly, immunization with epitope 301, the target of PMN310, alone was sufficient to produce maximal reactivity against brain AßO.
“The new data presented at the AAIC conference and the increasingly recognized benefit of targeting oligomers of Aβ underscores the potential advantage of our PMN310 antibody and AβO vaccine candidates,” stated Neil R. Cashman, M.D., Chief Scientific Officer and Co-Founder of ProMIS Neurosciences and an author on the paper. “These data are particularly encouraging as an AD vaccine capable of inducing an effective antibody response against pathogenic Aβ, as seen in these preclinical data, could potentially be administered as a preventative measure to at-risk individuals to prevent the development of symptomatic disease or given therapeutically to diagnosed patients to inhibit the progression of AD.”
Details of the poster presentation are as follows:
Poster Title: Novel approach to optimization of Alzheimer’s vaccine configuration for maximal targeting of toxic amyloid-beta oligomers
Poster Number: 86601
Date and Time of Presentation: Monday, July 29, 2024 from 7:30 am – 4:15 pm EDT
Session: Drug Development
Authors: Johanne Kaplan, Ebrima Gibbs, Scott Napper, Erin Scruten, Juliane Coutts, Neil R. Cashman
The poster presentation is available on the Posters and Publications page of the Company’s website at www.promisneurosciences.com.
About ProMIS Neurosciences Inc.
ProMIS Neurosciences Inc. is a clinical stage biotechnology company focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). The Company’s proprietary target discovery engine applies a thermodynamic, computational discovery platform - ProMIS™ and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. ProMIS has offices in Toronto, Ontario and Cambridge, Massachusetts.
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Certain information in this news release constitutes forward-looking statements and forward-looking information (collectively, “forward-looking information”) within the meaning of applicable securities laws. In some cases, but not necessarily in all cases, forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “excited to”, “targets”, “expects” or “does not expect”, “is expected”, “an opportunity exists”, “is positioned”, “estimates”, “intends”, “assumes”, “anticipates” or “does not anticipate” or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might”, “will” or “will be taken”, “occur” or “be achieved”. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances contain forward-looking information. Specifically, this news release contains forward-looking information relating to the Company’s novel vaccine approach for maximal targeting of toxic amyloid-beta oligomers and the potential implications thereof, the Company's expectations regarding its clinical development of its lead product, PMN310, for AD, and the Company’s plans to advance into a Phase 1b multiple ascending dose study in AD patients. Statements containing forward-looking information are not historical facts but instead represent management's current expectations, estimates and projections regarding the future of our business, future plans, strategies, projections, anticipated events and trends, the economy and other future conditions. Forward-looking information is necessarily based on a number of opinions, assumptions and estimates that, while considered reasonable by the Company as of the date of this news release, are subject to known and unknown risks, uncertainties and assumptions and other factors that may cause the actual results, level of activity, performance or achievements to be materially different from those expressed or implied by such forward-looking information, including, but not limited to, the risk that the results of nonclinical studies and early clinical trials are not necessarily predictive of future results with PMN310, the Company’s ability to fund its operations and continue as a going concern, its accumulated deficit and the expectation for continued losses and future financial results. Important factors that could cause actual results to differ materially from those indicated in the forward-looking information include, among others, the factors discussed throughout the “Risk Factors” section of the Company's most recently filed Annual Report on Form 10-K for the year ended December 31, 2023 and in its subsequent filings filed with the United States Securities and Exchange Commission. Except as required by applicable securities laws, the Company undertakes no obligation to publicly update any forward-looking information, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
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