Pharvaris Announces Data Highlighting Deucrictibant for the Treatment of HAE to be Presented at Upcoming Scientific Meetings

Rhea-AI Summary

Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company, announced the acceptance of multiple abstracts for presentation at upcoming scientific meetings. The presentations will focus on deucrictibant, an oral bradykinin B2 receptor antagonist for treating hereditary angioedema (HAE) attacks.

Key events include:

• Seven e-Poster presentations at the American College of Allergy, Asthma, & Immunology's Annual Scientific Meeting in Boston, October 24-28, 2024
• Three poster presentations at the Canadian Society of Allergy and Clinical Immunology in Banff, Alberta, November 6-9, 2024
• One oral presentation at the Japanese Society of Allergology in Kyoto, October 18-20, 2024

The presentations will cover various aspects of deucrictibant, including long-term safety and efficacy, biomarker assays, and results from clinical trials such as CHAPTER-1 and RAPIDe-2.

ZUG, Switzerland, Oct. 16, 2024 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat hereditary angioedema (HAE) attacks, today announced the acceptance of multiple abstracts at several upcoming scientific meetings. Presentation details are as follows:

American College of Allergy, Asthma, & Immunology’s Annual Scientific Meeting (ACAAI), Boston, October 24-28, 2024. Seven abstracts have been accepted for e-Poster presentation:

• Poster: Long-Term Safety and Efficacy of Oral Deucrictibant for Hereditary Angioedema Prophylaxis: CHAPTER-1 Open-Label Extension Study
  Speaker: John Anderson, M.D.
  Format: e-Poster (R102)
  Date, Time: Friday, Oct. 25, 2:00-2:15 p.m. EDT
  Location: Monitor 21, Exhibit Hall A

• Poster: Long-Term Treatment of Hereditary Angioedema Attacks With Oral Deucrictibant: RAPIDe-2 Extension Study Results
  Speaker: John Anderson, M.D.
  Format: e-Poster (R103)
  Date, Time: Friday, Oct. 25, 2:15-2:30 p.m. EDT
  Location: Monitor 21, Exhibit Hall A

• Poster: Development Of A Novel Kinin Biomarker Assay For Characterization Of Bradykinin-Mediated Disorders
  Speaker: Evangelia Pardali, Ph.D.
  Format: e-Poster (R088)
  Date, Time: Friday, Oct. 25, 2:30-2:45 p.m. EDT
  Location: Monitor 20, Exhibit Hall A

• Poster: Development of a HMWK Capillary Immunoblotting Assay for Characterization of Bradykinin-Mediated Disorders
  Speaker: Evangelia Pardali, Ph.D.
  Format: e-Poster (R090)
  Date, Time: Friday, Oct. 25, 3:00-3:15 p.m. EDT
  Location: Monitor 20, Exhibit Hall A

• Poster: The Bradykinin Challenge Model In Non-Human Primates Successfully Predicted Efficacious Doses of Deucrictibant in Humans
  Speaker: Juan Bravo, Ph.D.
  Format: e-Poster (R112)
  Date, Time: Friday, Oct. 25, 4:30-4:45 p.m. EDT
  Location: Monitor 21, Exhibit Hall A

• Poster: CHAPTER-1 Phase 2 Trial of Oral Bradykinin B2 Receptor Antagonist Deucrictibant for Hereditary Angioedema Prophylaxis
  Speaker: H. James Wedner, M.D.
  Format: e-Poster (R100)
  Date, time: Friday, Oct. 25, 5:30-5:45 p.m. EDT
  Location: Monitor 20, Exhibit Hall A

• Poster: Prophylactic Treatment With Oral Deucrictibant Improves Hereditary Angioedema Disease Control and Health-Related Quality of Life
  Speaker: H. James Wedner, M.D.
  Format: e-Poster (R101)
  Date, Time: Friday, Oct. 25, 5:45-6:00 p.m. EDT
  Location: Monitor 20, Exhibit Hall A
  

Canadian Society of Allergy and Clinical Immunology (CSACI), Banff, Alberta, Canada, November 6-9, 2024. Three abstracts have been accepted for poster presentation.

• Poster: Efficacy and Safety of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, in Prophylaxis of HAE Attacks: Results of CHAPTER-1 Phase 2 Trial
  Speaker: William H. Yang, M.D., FRCPC, FAAAAI
  Format: Poster
  Date, Time: Thursday, Nov. 7, 12:30-1:00 p.m. MST (2:30-3:00 p.m. EST) and Friday, Nov. 8, 1:30-2:00 p.m. MST (3:30-4:00 p.m. EST)

• Poster: Long-term safety and efficacy of oral deucrictibant, a bradykinin B2 receptor antagonist, for prophylaxis in HAE: CHAPTER-1 extension study results
  Speaker: William H. Yang, M.D., FRCPC, FAAAAI
  Format: Poster
  Date, Time: Thursday, Nov. 7, 12:30-1:00 p.m. MST (2:30-3:00 p.m. EST) and Friday, Nov. 8, 1:30-2:00 p.m. MST (3:30-4:00 p.m. EST)

• Poster: Long-term efficacy and safety of oral bradykinin B2 receptor antagonist deucrictibant in treatment of HAE attacks: RAPIDe-2 extension study results 
  Speaker: Hugo Chapdelaine, M.D., FRCPC
  Format: Poster
  Date, Time: Thursday, Nov. 7, 12:30-1:00 p.m. MST (2:30-3:00 p.m. EST) and Friday, Nov. 8, 1:30-2:00 p.m. MST (3:30-4:00 p.m. EST)

Japanese Society of Allergology (JSA), Kyoto, Japan, October 18-20, 2024. One abstract has been accepted for oral presentation.

• Presentation: Efficacy and safety of oral deucrictibant IR capsule in HAE: RAPIDe-3 phase 3 trial design
  Speaker: Prof. Michihiro Hide, M.D., Ph.D.
  Format: Oral Presentation
  Date, Time: Sunday, Oct. 20, 13:30-14:45 JST (12:30 -1:45 a.m. EDT)

The presentation slides and posters will be available on the Investors section of the Pharvaris website at: https://ir.pharvaris.com/news-events/events-presentations.

About Pharvaris

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat HAE attacks. By directly pursuing this clinically proven therapeutic target with novel small molecules, the Pharvaris team aspires to offer people with all types of bradykinin-mediated angioedema effective, well-tolerated, and easy-to-administer alternatives to treat attacks, both prophylactically and on-demand. With positive data in both Phase 2 prophylaxis and on-demand studies in HAE, Pharvaris is encouraged to further develop deucrictibant. Pharvaris is currently enrolling a pivotal Phase 3 study for the on-demand treatment of HAE attacks and plans to initiate a pivotal Phase 3 study of deucrictibant for the prevention of HAE attacks in the coming months. For more information, visit https://pharvaris.com/.

FAQ

What is the main focus of Pharvaris' presentations at upcoming scientific meetings?

Pharvaris will present data on deucrictibant, an oral bradykinin B2 receptor antagonist, for the treatment and prevention of hereditary angioedema (HAE) attacks at several scientific meetings in October and November 2024.

How many abstracts will Pharvaris present at the ACAAI Annual Scientific Meeting in 2024?

Pharvaris will present seven abstracts as e-Posters at the American College of Allergy, Asthma, & Immunology's Annual Scientific Meeting in Boston, October 24-28, 2024.

What are the key clinical trials of deucrictibant (PHVS) that will be discussed in the presentations?

The presentations will discuss results from key clinical trials including CHAPTER-1 (long-term safety and efficacy for HAE prophylaxis), RAPIDe-2 (long-term treatment of HAE attacks), and the design of RAPIDe-3 (phase 3 trial for HAE treatment).

Where can investors find the presentation slides and posters for Pharvaris (PHVS)?

The presentation slides and posters will be available on the Investors section of the Pharvaris website at: https://ir.pharvaris.com/news-events/events-presentations.