Phio Pharmaceuticals Corp. - PHIO STOCK NEWS

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced positive in vivo study results at the June 2021 ASCO Annual Meeting, showcasing its INTASYL™ RNAi therapy platform's efficacy in targeting BRD4 and PD-1 proteins. The dual-targeting approach led to complete tumor responses in 83% of tested mice, outperforming conventional treatments like JQ-1 and anti-PD-1 monoclonal antibodies. The study also indicated a superior safety profile for the INTASYL treatment. These findings emphasize INTASYL's potential in improving immuno-oncology therapies.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) reported financial results for Q1 2021, highlighting strong momentum in its pipeline. The company has significant data supporting its INTASYL compounds, showing potential to enhance CAR-T therapy efficacy. A clinical study for PH-762 in advanced melanoma is set to commence in Q4 2021, conducted at the Gustave Roussy Institute. Cash reserves reached $32.7 million, sufficient to fund operations into Q2 2023, despite a net loss of $3.4 million for the quarter. R&D expenses rose to $2.6 million, reflecting increased preclinical study costs.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced promising in vivo data on May 11, 2021, indicating that its compound PH-762 significantly boosts the antitumor efficacy of HER2-targeted CAR-T cells against solid tumors, particularly in a mouse model of ovarian cancer. The results show approximately 90% PD-1 silencing in HER2CART cells, enhancing their effectiveness without affecting cell viability. This breakthrough could improve T cell-based immunotherapies, addressing challenges faced by traditional CAR T-cell therapies in solid tumors.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced new data presentations at the upcoming 24th Annual Meeting of the ASGCT (May 11-14, 2021) and the ASCO Annual Meeting (June 4-8, 2021). At ASGCT, the poster titled "INTASYL PH-762 Self-Delivering RNAi Targeting PD-1 Enhances the Therapeutic Efficacy of HER2-Targeted CAR-T Cells" will be presented by Benjamin Cuiffo et al. Additionally, ASCO will feature a poster on INTASYL therapy targeting BRD4 and PD-1. Archived presentations will be available on the company's website.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced promising new in vivo data indicating that its INTASYL (mPH-762) therapy achieves significant tumor growth inhibition through intratumoral administration in both PD-1 responsive and refractory cancer models. This method shows potential for enhanced local immune checkpoint blockade without the systemic side effects of traditional therapies. The company plans to initiate a first-in-human clinical study for mPH-762 in advanced melanoma by Q4 2021, showcasing its commitment to advancing innovative cancer treatments.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) reported a net loss of $8.8 million for 2020, a slight improvement from $8.9 million in 2019. The company had cash of $14.2 million at year-end, up from $6.9 million in 2019, bolstered by $21.7 million raised in equity financing. Developmental progress includes new collaborations with AgonOx, Inc. and plans to initiate two clinical studies for PH-762 in 2021. R&D expenses rose to $4.4 million, while G&A expenses decreased to $4.4 million, reflecting reduced legal and hiring costs. Overall, the company maintains a solid financial outlook for the next two years.

Phio Pharmaceuticals Corp. announced new study data on its product candidate, PH-762, which targets PD-1 and shows promise in tumor control. This presentation will be part of the AACR Annual Meeting 2021, held virtually from April 10-15 and May 17-21. The poster titled "Intratumoral INTASYL™ self-delivering RNAi targeting PD-1" will explore the treatment's effects similar to systemic anti-PD-1 antibodies. Further details will be available on the Company’s website after the presentation.

Phio Pharmaceuticals Corp. has entered a clinical collaboration with AgonOx, Inc. to advance T cell-based cancer immunotherapies utilizing PH-762 and AgonOx's DP tumor-infiltrating lymphocyte (TIL) technology. The collaboration aims to enhance TIL therapeutic efficacy, with a clinical study expected to enroll patients later this year. Preclinical data suggests PH-762 significantly boosts the tumor-killing activity of CD8 DP TILs. AgonOx will receive financial support for the trial, while Phio stands to gain from future development milestones and royalties.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) announced its CEO, Dr. Gerrit Dispersyn, will present at the H.C. Wainwright Global Life Sciences Conference on March 9-10, 2021. The presentation will be available on-demand starting at 7 a.m. ET on March 9, and can be accessed through the company's website. Phio is focused on advancing its proprietary self-delivering RNAi therapeutic platform, INTASYL™, aimed at treating cancer by enhancing immune response against tumor cells.