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Oculis Reports Q2 2024 Financial Results and Provides Recent Company Update

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Oculis Holding AG (Nasdaq: OCS; XICE: OCS) reported Q2 2024 financial results and provided a company update. Key highlights include:

1. Positive topline results from Phase 2b RELIEF trial of OCS-02 for Dry Eye Disease

2. Phase 2 ACUITY trial of OCS-05 for acute optic neuritis on track for Q4 2024 readout

3. Pre-NDA meeting completed for OCS-01 in post-operative inflammation and pain, with NDA submission planned for Q1 2025

4. Cash position of $131.2 million as of June 30, 2024, providing runway into 2H 2026

5. Q2 net loss of $23.0 million, primarily due to increased clinical development expenses

6. Continued progress in Phase 3 DIAMOND trials for OCS-01 in diabetic macular edema

Oculis Holding AG (Nasdaq: OCS; XICE: OCS) ha riportato i risultati finanziari del secondo trimestre 2024 e fornito un aggiornamento aziendale. I punti salienti includono:

1. Risultati positivi dalla fase 2b dello studio RELIEF di OCS-02 per la malattia dell'occhio secco

2. Lo studio di fase 2 ACUITY di OCS-05 per la neurite ottica acuta è in programma per la lettura nel quarto trimestre 2024

3. Incontro pre-NDA completato per OCS-01 nell'infiammazione post-operatoria e nel dolore, con invio dell'NDA previsto per il primo trimestre 2025

4. Posizione di liquidità di 131,2 milioni di dollari al 30 giugno 2024, garantendo risorse fino al secondo semestre 2026

5. Perdita netta nel secondo trimestre di 23,0 milioni di dollari, principalmente a causa di maggiori spese di sviluppo clinico

6. Continuo progresso negli studi di fase 3 DIAMOND per OCS-01 nell'edema maculare diabetico

Oculis Holding AG (Nasdaq: OCS; XICE: OCS) informó los resultados financieros del segundo trimestre de 2024 y presentó una actualización de la empresa. Los aspectos destacados incluyen:

1. Resultados positivos del ensayo RELIEF de fase 2b de OCS-02 para la enfermedad del ojo seco

2. El ensayo ACUITY de fase 2 de OCS-05 para neuritis óptica aguda está previsto para su lectura en el cuarto trimestre de 2024

3. Se completó la reunión previa al NDA para OCS-01 en inflamación y dolor posoperatorio, con presentación del NDA planificada para el primer trimestre de 2025

4. Posición de efectivo de 131,2 millones de dólares a fecha del 30 de junio de 2024, lo que proporciona margen hasta el segundo semestre de 2026

5. Pérdida neta en el segundo trimestre de 23,0 millones de dólares, principalmente debido a mayores gastos en desarrollo clínico

6. Progreso continuo en los ensayos DIAMOND de fase 3 para OCS-01 en edema macular diabético

Oculis Holding AG (Nasdaq: OCS; XICE: OCS)가 2024년 2분기 재무 결과를 보고하고 회사 업데이트를 제공했습니다. 주요 내용은 다음과 같습니다:

1. Positive topline results from Phase 2b RELIEF trial of OCS-02 for Dry Eye Disease

2. 2024년 4분기 OCS-05에 대한 급성 시신경염의 2단계 ACUITY 시험이 예정되어 있습니다

3. OCS-01의 수술 후 염증 및 통증을 위한 NDA 사전 회의가 완료되었으며, 2025년 1분기 NDA 제출 계획입니다

4. 2024년 6월 30일 기준 1억 3120만 달러의 현금 위치로, 2026년 하반기까지 여유를 제공합니다

5. 2분기 순손실 2300만 달러로, 주로 증가한 임상 개발 비용 때문입니다

6. 당뇨병성 황반 부종에 대한 OCS-01의 3단계 DIAMOND 시험에서 지속적인 진전이 있습니다

Oculis Holding AG (Nasdaq: OCS; XICE: OCS) a annoncé les résultats financiers du deuxième trimestre 2024 et a fourni une mise à jour de l'entreprise. Les points clés incluent :

1. Résultats positifs de l'essai RELIEF de phase 2b d'OCS-02 pour la maladie de l'œil sec

2. L'essai ACUITY de phase 2 d'OCS-05 pour la névrite optique aiguë est prévu pour un aperçu au quatrième trimestre 2024

3. Réunion pré-NDA complétée pour OCS-01 dans l'inflammation et la douleur postopératoires, avec dépôt du NDA prévu pour le premier trimestre 2025

4. Position de trésorerie de 131,2 millions de dollars au 30 juin 2024, ce qui permet un avantage jusqu'au second semestre 2026

5. Perte nette de 23,0 millions de dollars au deuxième trimestre, principalement en raison de l'augmentation des dépenses de développement clinique

6. Progrès continu dans les essais DIAMOND de phase 3 pour OCS-01 dans l'œdème maculaire diabétique

Oculis Holding AG (Nasdaq: OCS; XICE: OCS) hat die finanziellen Ergebnisse des zweiten Quartals 2024 berichtet und ein Unternehmensupdate bereitgestellt. Die wichtigsten Punkte sind:

1. Positive Ergebnisse aus der Phase 2b RELIEF-Studie von OCS-02 für die Krankheit des trockenen Auges

2. Die Phase 2 ACUITY-Studie von OCS-05 zur akuten Optikusneuritis ist auf Kurs für die Auswertung im vierten Quartal 2024

3. Vorbesprechung für die NDA von OCS-01 bei postoperativen Entzündungen und Schmerzen abgeschlossen, NDA-Einreichung für das erste Quartal 2025 geplant

4. Bargeldposition von 131,2 Millionen USD zum 30. Juni 2024, was einen finanziellen Spielraum bis in die zweite Hälfte 2026 gibt

5. Nettoverlust im zweiten Quartal von 23,0 Millionen USD, hauptsächlich aufgrund gestiegener klinischer Entwicklungskosten

6. Fortlaufender Fortschritt in den Phase 3 DIAMOND-Studien für OCS-01 bei diabetischen Makulödem

Positive
  • Positive topline results from Phase 2b RELIEF trial of OCS-02 for Dry Eye Disease
  • Pre-NDA meeting completed for OCS-01, with clear path for NDA submission in Q1 2025
  • Strong cash position of $131.2 million, providing runway into 2H 2026
  • Successful $59 million registered direct offering completed
  • Patient enrollment in DIAMOND-1 and DIAMOND-2 trials exceeding expectations
Negative
  • Increased net loss of $23.0 million in Q2 2024 compared to $14.3 million in Q2 2023
  • Closure of Phase 3 OPTIMIZE-2 trial due to third-party administrative error
  • Increased research and development expenses to $18.2 million in Q2 2024 from $6.9 million in Q2 2023

Oculis' Q2 2024 results demonstrate strong financial positioning with $131.2 million in cash, providing runway into 2H 2026. This robust cash position, bolstered by a $59 million registered direct offering, supports ongoing clinical trials and potential commercialization efforts.

R&D expenses increased to $18.2 million, reflecting intensified clinical activities. While this escalates short-term costs, it's a positive indicator of pipeline progression. The 35% and 23% enrollment rates in DIAMOND-1 and DIAMOND-2 trials, respectively, surpassing expectations, suggest potential for accelerated development timelines.

The widened net loss of $23 million for Q2 is primarily attributed to increased R&D spending, a necessary investment for future growth. However, investors should monitor cash burn rate closely as clinical trials advance.

Oculis' clinical progress is impressive, particularly the positive Phase 2b RELIEF trial results for OCS-02 in Dry Eye Disease (DED). The potential for precision medicine in DED, based on the TNFR1 genetic biomarker, could be a game-changer in this heterogeneous condition.

The advancement of OCS-01 for DME is noteworthy, with Phase 3 trials progressing well. If successful, this could be the first eye drop treatment for DME, offering a less invasive alternative to current therapies.

The upcoming Q4 2024 readout for the Phase 2 ACUITY trial of OCS-05 in acute optic neuritis (AON) is another critical milestone. Given the lack of approved therapies for AON, positive results could open up a new market opportunity and potentially extend to other neuro-ophthalmic diseases.

Oculis is positioning itself as a pioneer in ophthalmology, targeting multiple high-unmet-need areas. The potential first-in-class treatments for DME (OCS-01) and precision medicine approach for DED (OCS-02) could disrupt current treatment paradigms and capture significant market share.

The company's diverse pipeline mitigates risk and offers multiple shots on goal. The planned NDA submission for OCS-01 in post-ocular surgery in Q1 2025 presents a near-term commercialization opportunity.

Oculis' dual listing on Nasdaq Global Market and Nasdaq Iceland Main Market enhances its visibility and access to capital. The recent oversubscribed offering demonstrates strong investor interest. However, as with any biotech company, future success hinges on clinical trial outcomes and regulatory approvals. Investors should closely monitor upcoming milestones, particularly the Q4 2024 ACUITY trial readout and the planned FDA consultation for OCS-02 in Q1 2025.

  • Reported positive topline results for the Phase 2b RELIEF trial of OCS-02 (licaminlimab) paving the way for potentially the first precision medicine in Dry Eye Disease (DED)
  • Phase 2 ACUITY trial of OCS-05 in acute optic neuritis (AON) is on track for topline readout in Q4 2024
  • Pre-NDA meeting with U.S. Food and Drug Administration (FDA) completed in August for once daily OCS-01 for the treatment of post-operative inflammation and pain following ocular surgery; Providing a clear path forward for NDA submission in Q1 2025, while randomization in Phase 3 DIAMOND-1 and DIAMOND-2 trials in diabetic macular edema (DME) is on track
  • Cash, cash equivalents and short-term investments of $131.2 million as of June 30, 2024 provides cash runway into the 2H 2026.

ZUG, Switzerland, Aug. 27, 2024 (GLOBE NEWSWIRE) -- Oculis Holding AG (Nasdaq: OCS; XICE: OCS) (“Oculis” or the “Company”), a global biopharmaceutical company purposefully driven to save sight and improve eye care, today announced results for the quarter ended June 30, 2024, and provided an overview of the Company’s progress.

Riad Sherif M.D., Chief Executive Officer of Oculis: “We made significant strides in advancing our innovative clinical programs this past quarter, demonstrating strong momentum and exceptional execution in our DIAMOND-1 and DIAMOND-2 trials with Oculis’ lead asset, OCS-01, the first eye drop in Phase 3 for DME. Additionally, we were excited to announce the positive results from the Phase 2b RELIEF trial of OCS-02 (licaminlimab) in dry eye, which showed improvements in multiple regulatory sign endpoints and materially more profound results in patients with the TNFR1 genetic biomarker. These results are potentially paving the way for the first precision medicine in dry eye disease for this heterogeneous condition, where the current treatment approach mainly consists of “trial and error”. We look forward also to the upcoming topline readout from the Phase 2 ACUITY trial in AON with OCS-05 in the fourth quarter of 2024, and to our anticipated first NDA submission with OCS-01 in post-ocular surgery in the first quarter of 2025.”

Q2 2024 and Recent Highlights

Clinical Highlights

  • OCS-01 for DME: Continued positive momentum in the randomization of patients for both Phase 3 DIAMOND trials with OCS-01 eye drop in DME. Patient enrollment through the end of June exceeded the Company’s expectations and was at 35% and 23% for DIAMOND-1 and DIAMOND-2, respectively.
  • OCS-02 (licaminlimab) in DED: Announced positive topline results of Phase 2b RELIEF trial evaluating OCS-02 (licaminlimab) for the treatment of signs in DED. Improvements in multiple regulatory efficacy sign endpoints were observed in full population and with rapid and materially more pronounced effects in the TNFR1 genetic biomarker population as identified in the prior successful Phase 2 symptoms trial. OCS-02 (licaminlimab)’s tolerability was excellent with drop comfort level reported similar to artificial tears. If approved, OCS-02 (licaminlimab) has the potential to transform the treatment paradigm in DED with a precision medicine approach.
  • OCS-05 in AON: Completed enrollment in the Phase 2 ACUITY trial with OCS-05 in AON, and on-track for topline readout in Q4 2024 for its novel neuroprotective candidate with potential for neuro-ophthalmic diseases.

Corporate Highlights

  • Raised gross proceeds of $59 million in an oversubscribed registered direct offering, with participation from new Icelandic institutional and existing investors. Concurrently, the Company listed on the Nasdaq Iceland Main Market in addition to Nasdaq Global Market in the U.S.
  • Snehal Shah, Pharm. D., was appointed as President of Research & Development strengthening the Company’s R&D capabilities.
  • Robert K. Warner, M.B.A. and Arshad M. Khanani, M.D., M.A., FASRS elected as members of the Board of Directors, bolstering its development and commercial expertise.
  • Baruch D. Kuppermann, M.D., Ph.D. and Frank G. Holz, M.D., Ph.D. appointed as members of the Scientific Advisory Board, and working closely with senior management team as the Company advances both Phase 3 DIAMOND trials with OCS-01 eye drops in DME.

Presentations and Awards Highlights

  • Presented the Phase 3 OPTIMIZE-1 positive results with OCS-01 for treating inflammation and pain following cataract surgery at the 2024 American Society of Cataract and Refractive Surgery (ASCRS) Annual Meeting.
  • Established the Ramin Tadayoni Award together with EURETINA in memory of the Company’s late Chief Scientific Officer and a world-renowned retina expert.

Recent Updates and Upcoming Milestones

  • Pre-NDA meeting conducted as planned in August 2024 to seek alignment with the FDA on the regulatory submission for once daily OCS-01 for the treatment of post-operative inflammation and pain following ocular surgery. FDA confirmed that the completed Phase 3 OPTIMIZE-1 trial, along with the completed Phase 2 SKYGGN trial and safety data from completed trials in ocular surgery and diabetic macular edema, are sufficient to support an NDA submission in Q1 2025. The Company will close the Phase 3 OPTIMIZE-2 trial due to a third-party administrative error which affected the conduct of the trial and prevents analysis of trial results. If approved, OCS-01 with its OPTIREACH® formulation would become the first once-daily, preservative-free steroid for treating inflammation and pain following ocular surgery.
  • Topline readout for the Phase 2 ACUITY trial with OCS-05 is anticipated in the fourth quarter of 2024. The ACUITY trial is a randomized, double-blind, placebo-controlled, multi-center trial in France designed to evaluate the safety and tolerability of OCS-05, a novel serum glucocorticoid kinase-2 (SGK-2) activator and potentially neuroprotective candidate in AON. Enrollment is completed with 36 patients randomized. In addition to safety, an objective measurement of retinal thickness, as assessed by optical coherence tomography (OCT), will be evaluated as an exploratory efficacy endpoint. OCS-05 was granted orphan drug designation by FDA in the U.S. and by the European Medicine Agency (EMA) in Europe for AON, a disease characterized by acute inflammation and demyelination of the optic nerve, often affecting young adults, in which retinal thinning is directly associated with vision loss and permanent visual impairment. This study seeks to explore the potential neuroprotective benefits of OCS-05 on preserving retinal thickness in AON patients. To date there is no specific therapy approved for AON and unmet needs remain for therapies that can prevent vision loss after an acute episode of optic neuritis. In addition to AON, a neuroprotective treatment could have wide applicability in neuro-ophthalmic diseases where protecting neural retina is key to preserving patients’ sight such as glaucoma, geographic atrophy, diabetic retinopathy and also for other ophthalmic indications where other nerves are impacted like neurotrophic keratitis. Additionally, the Company is on track to complete an IND submission for OCS-05 in the U.S. by fall 2024.
  • The Company is planning to consult with the FDA in Q1 2025 to discuss next steps for the OCS-02 (licaminlimab) program in DED.

Q2 2024 Financial Highlights

  • Cash position: As of June 30, 2024, the Company had total cash, cash equivalents and short-term investments of CHF 117.9 million or $131.2 million, compared to CHF 91.7 million or $109.0 million as of December 31, 2023. The increase in cash position from December 31, 2023 reflects proceeds from the registered direct offering in the second quarter of 2024. Based on its current development plans, the Company’s cash balances are expected to fund operations into the second half of 2026.
  • Research and development expenses were CHF 16.5 million or $18.2 million for the three-month ended June 30, 2024, compared to CHF 6.2 million or $6.9 million in the same period in 2023. The increase was primarily due to increases in clinical trial expenses related to the ongoing OCS-01, OCS-02 (licaminlimab) and OCS-05 clinical trials, including positive advancements in DIAMOND-1 and DIAMOND-2 Phase 3 DME trials.
  • General and administrative expenses were CHF 6.3 million or $6.9 million for the three-month ended June 30, 2024, compared to CHF 4.8 million or $5.3 million in the same period in 2023. The increase was primarily due to increases in personnel costs as well as certain non-recurring non-capitalized transaction costs associated with the registered direct offering in April 2024.
  • Q2 Net loss was CHF 20.8 million or $23.0 million for the second quarter ended June 30, 2024, compared to CHF 12.9 or $14.3 million in the second quarter of 2023. The increase was primarily driven by increases in clinical development expenses.
  • Q2 Year to date net loss was CHF 36.9 million or $41.5 million for the six months ended June 30, 2024, compared to CHF 58.9 or $64.6 million for the same period in 2023. The decrease was primarily due to a non-recurring and non-cash merger and listing expense recorded in 2023, partially offset by increases clinical development costs and costs incurred to operate as a public company.
  • Q2 Year to date non-IFRS net loss was CHF 36.9 million or $41.5 million, or CHF 0.96 or $1.08 per share, for the six months ended June 30, 2024, compared to CHF 24.0 million or $26.3 million, or CHF 1.03 or $1.13 per share, for the same period in 2023. The increase in non-IFRS net loss was primarily driven by increases in development expenses.

Non-IFRS Financial Information
This press release contains financial measures that do not comply with International Financial Reporting Standards (IFRS) including non-IFRS loss, and non-IFRS loss attributable to equity holders per common share. These non-IFRS financial measures exclude the impact of items that the Company’s management believes affect comparability or underlying business trends. These measures supplement the Company’s financial results prepared in accordance with IFRS. The Company’s management uses these measures to better analyze its financial results and better estimate its financial outlook. In management’s opinion, these non-IFRS measures are useful to investors and other users of the Company's financial statements by providing greater transparency into the ongoing operating performance of the Company and its future outlook. Such measures should not be deemed to be an alternative to IFRS requirements.

The non-IFRS measures for the reported periods reflect adjustments made to exclude merger and listing expense, which was a one-time non-cash expense CHF 34.9 million or $38.2 million in the six months ended June 30, 2023 total operating expenses.

Condensed Consolidated Statements of Financial Position (Unaudited)

 

(Amounts in CHF thousands)As of June 30, As of December 31,
 2024 2023
ASSETS   
    
Non-current assets   
Property and equipment, net249 288
Intangible assets12,206 12,206
Right-of-use assets1,465 755
Other non-current assets178 89
Total non-current assets14,098 13,338
    
Current assets   
Other current assets5,329 8,488
Accrued income1,383 876
Short-term financial assets74,070 53,324
Cash and cash equivalents43,852 38,327
Total current assets124,634 101,015
    
TOTAL ASSETS138,732 114,353
    
EQUITY AND LIABILITIES   
    
Shareholders' equity   
Share capital427 366
Share premium340,046 288,162
Reserve for share-based payment10,819 6,379
Actuarial loss on post-employment benefit obligations (1,447)  (1,072)
Treasury shares (10) -
Cumulative translation adjustments (297)  (327)
Accumulated losses (236,712)  (199,780)
Total equity112,826 93,728
    
Non-current liabilities   
Long-term lease liabilities1,011 431
Long-term payables- 378
Defined benefit pension liabilities1,261 728
Total non-current liabilities2,272 1,537
    
Current liabilities   
Trade payables3,181 7,596
Accrued expenses and other payables12,763 5,948
Short-term lease liabilities327 174
Warrant liabilities7,363 5,370
Total current liabilities23,634 19,088
    
Total liabilities25,906 20,625
    
TOTAL EQUITY AND LIABILITIES138,732 114,353
    

 

Condensed Consolidated Statements of Loss (Unaudited)

(Amounts in CHF thousands, except per share data) For the three months ended
June 30,
 For the six months ended
June 30,
  2024 2023 2024 2023
Grant income 245 250 467 479
Operating income 245 250 467 479
Research and development expenses  (16,465)  (6,198)  (27,321)  (12,346)
General and administrative expenses  (6,265)  (4,797)  (10,959)  (8,840)
Merger and listing expense - - -  (34,863)
Operating expenses  (22,730)  (10,995)  (38,280)  (56,049)
         
Operating loss  (22,485)  (10,745)  (37,813)  (55,570)
         
Finance income 660 216 1,241 253
Finance expense  (87)  (17)  (128)  (1,297)
Fair value adjustment on warrant liabilities 1,370  (2,625)  (1,699)  (2,203)
Foreign currency exchange gain (loss), net  (267) 408 1,527 161
Finance result, net 1,676  (2,018) 941  (3,086)
         
Loss before tax for the period  (20,809)  (12,763)  (36,872)  (58,656)
         
Income tax expense  (30)  (114)  (60)  (236)
         
Loss for the period  (20,839)  (12,877)  (36,932)  (58,892)
         
Loss per share:        
Basic and diluted loss attributable to equity holders                       (0.51)                       (0.38)                       (0.96)                       (2.53)
         

Reconciliation of Non-IFRS Measures (Unaudited)

(Amounts in CHF thousands, except per share data)       
 For the three months ended June 30,For the six months ended June 30,
 2024 2023 2024 2023
IFRS loss for the period (20,839)  (12,877)  (36,932)  (58,892)
Non-IFRS adjustments:       
Merger and listing expense (i)- - - 34,863
Non-IFRS loss for the period (20,839)  (12,877)  (36,932)  (24,029)
        
IFRS basic and diluted loss attributable to equity holders                     (0.51)                       (0.38)                      (0.96)                       (2.53)
Non-IFRS basic and diluted loss attributable to equity holders                     (0.51)                       (0.38)                      (0.96)                       (1.03)
        
IFRS weighted-average number of shares used to compute loss per share basic and diluted40,535,173 33,565,542 38,567,675 23,274,136
        
(i) Merger and listing expense is the difference between the fair value of the shares transferred and the fair value of the EBAC net assets per the Business Combination Agreement. This merger and listing expense is non-recurring in nature and represented a share-based payment made in exchange for a listing service and does not lead to any cash outflows.

About Oculis

Oculis is a global biopharmaceutical company (Nasdaq: OCS; XICE: OCS) purposefully driven to save sight and improve eye care. Oculis’ highly differentiated pipeline comprises multiple innovative product candidates in development. It includes OCS-01, a topical eye drop candidate for diabetic macular edema (DME) and for the treatment of inflammation and pain following cataract surgery; OCS-02 (licaminlimab), a topical biologic anti-TNFα eye drop candidate for dry eye disease (DED) and for non-infectious anterior uveitis; and OCS-05, a neuroprotective candidate for acute optic neuritis (AON). Headquartered in Switzerland and with operations in the U.S. and Iceland, Oculis’ goal is to improve the health and quality of life of patients worldwide. The company is led by an experienced management team with a successful track record and is supported by leading international healthcare investors.

For more information, please visit: www.oculis.com

Oculis Contacts

Ms. Sylvia Cheung, CFO
sylvia.cheung@oculis.com

Investor & Media Relations

LifeSci Advisors
Corey Davis, Ph.D.
cdavis@lifesciadvisors.com
1-212-915-2577

Cautionary Statement Regarding Forward Looking Statements

This press release contains forward-looking statements and information. For example, statements regarding the potential benefits of the Company’s product candidates, including patient impact and market opportunity; expected future milestones and catalysts; the initiation, timing, progress and results of Oculis’ clinical and preclinical studies; Oculis’ research and development programs, regulatory and business strategy, future development plans, and management; Oculis’ ability to advance product candidates into, and successfully complete, clinical trials; the timing or likelihood of regulatory filings and approvals; and the Company’s expected cash runway are forward-looking. Certain clinical trial results presented in this press release are topline and preliminary and subject to change, as analysis is ongoing. These topline results may not be reproduced in subsequent patients and clinical trials. All forward-looking statements are based on estimates and assumptions that, while considered reasonable by Oculis and its management, are inherently uncertain and are inherently subject to risks, variability, and contingencies, many of which are beyond Oculis’ control. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, assurance, prediction or definitive statement of a fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. All forward-looking statements are subject to risks, uncertainties and other factors that may cause actual results to differ materially from those that we expected and/or those expressed or implied by such forward-looking statements. Forward-looking statements are subject to numerous conditions, many of which are beyond the control of Oculis, including those set forth in the Risk Factors section of Oculis’ annual report on Form 20-F and any other documents filed with the U.S. Securities and Exchange Commission (the “SEC”). Copies of these documents are available on the SEC’s website, www.sec.gov. Oculis undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law.


FAQ

What were Oculis' (OCS) Q2 2024 financial results?

Oculis reported a Q2 2024 net loss of $23.0 million, with cash, cash equivalents, and short-term investments of $131.2 million as of June 30, 2024.

When does Oculis (OCS) plan to submit its NDA for OCS-01?

Oculis plans to submit the NDA for OCS-01 in post-operative inflammation and pain following ocular surgery in Q1 2025.

What are the key clinical trial updates for Oculis (OCS) in Q2 2024?

Oculis reported positive topline results from the Phase 2b RELIEF trial of OCS-02 for Dry Eye Disease and continued progress in Phase 3 DIAMOND trials for OCS-01 in diabetic macular edema.

How long is Oculis' (OCS) current cash runway?

Oculis' current cash position is expected to fund operations into the second half of 2026.

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