Novocure Highlights Use of Tumor Treating Fields Therapy in Treatment of Non-Small Cell Lung Cancer at 2023 World Conference on Lung Cancer
- Novocure's participation in the conference and positive results from the LUNAR trial could generate investor interest and potentially lead to a rise in stock price.
- The post-hoc analysis showing improved survival outcomes based on PD-L1 expression could be seen as a positive indication for the use of TTFields therapy in lung cancer treatment.
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Presentations include new post-hoc analysis of data from phase 3 LUNAR trial in metastatic non-small cell lung cancer
ROOT,
The LUNAR trial was designed to evaluate the use of TTFields therapy together with standard systemic therapies for the treatment of metastatic non-small cell lung cancer, following progression on or after platinum-based therapy. The trial met its primary endpoint, demonstrating a statistically significant and clinically meaningful extension in overall survival (OS) for patients treated with TTFields and standard systemic therapies, as well as a pronounced extension in OS for patients randomized to receive physician’s choice immune checkpoint inhibitor (ICI) together with TTFields.
In a new post-hoc analysis of data from the LUNAR trial, researchers reviewed survival patterns of patients with known Tumor Proportion Scores (TPS) randomized to receive ICI together with or without TTFields. Among patients with TPS >
Further analysis shows evidence of a relationship between increasing PD-L1 expression and improved survival outcomes. In patients with TPS 1–
These data will be presented on September 12, 2023 at 2:30 p.m. UTC+8 by primary investigator Ticiana Leal, M.D., a researcher and medical oncologist at Winship Cancer Institute of Emory University and associate professor and director of the Thoracic Medical Oncology Program in the Department of Hematology and Medical Oncology at Emory University School of Medicine in
“This analysis further elucidates the promising results from the LUNAR trial and the potential benefit of utilizing TTFields therapy for the treatment of metastatic non-small cell lung cancer,” Dr. Leal said. “I look forward to sharing these data with the global thoracic oncology community and continuing to analyze the data from this impactful study.”
Novocure’s presence at the 2023 WCLC will also include:
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An Industry Sponsored Symposium: A Spotlight on Tumor Treating Fields in Thoracic Oncology, on September 10 at 6:30 p.m. UTC+8
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A poster displayed in the Exhibit Hall on September 10 from 5:30-7:30 p.m. UTC+8: P1.12-10 – Sensitization of Cancer Cells to Tumor Treating Fields (TTFields) via Inhibition of the PI3K/AKT Signaling Pathway
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Three ePosters on demand:
- EP02.02-02 – Transcriptomic Response to Tumor Treating Fields (TTFields) Across Tumor Types
- EP09.02-06 – Long-term Efficacy of Tumor Treating Fields (TTFields 150 kHz) in metastatic NSCLC: A Case Report
- EP17.03-02 – Utilities Used in HTAs in mNSCLC Following Progression on or After Platinum-Based Chemotherapy
In addition, Novocure is partnering with the IASLC, host of the WCLC, to provide research opportunities to investigators worldwide who are conducting innovative research on TTFields in the treatment of non-small cell lung cancer and other thoracic malignancies. These grants offer
“We are honored to partner with the IASLC in their mission to study and eradicate lung cancer and other thoracic malignancies,” said Moshe Giladi, Ph.D., Novocure’s Chief Science Officer. “We look forward to supporting researchers and together expanding understanding of how TTFields therapy can be beneficial in the treatment of these diseases.”
To learn more about these grants, please visit https://iaslc.secure-platform.com/researchgrants/page/Grant_Guidelines/Partner_Grants/IASLC_Novocure_Grants.The application deadline is noon MDT on October 9, 2023.
About LUNAR
LUNAR was a phase 3 trial testing the safety and effectiveness of TTFields therapy when used together with ICI or docetaxel versus ICI or docetaxel alone for patients with metastatic NSCLC who progressed during or after platinum-based therapy. The trial met its primary endpoint, exhibiting a statistically significant and clinically meaningful improvement in median OS when TTFields therapy was added to standard therapies. Patients randomized to receive TTFields therapy together with standard therapies (n=137) demonstrated median OS of 13.2 months compared to 9.9 months in patients treated with standard therapies alone (n=139; HR: 0.74, P=0.035).
The trial also demonstrated a statistically significant and clinically meaningful improvement in median OS when TTFields therapy was added to ICI. Patients randomized to receive TTFields therapy and physician’s choice ICI (n=66) demonstrated a median OS of 18.5 months versus a median OS of 10.8 months in patients treated with ICIs alone (n=68; HR=0.63; P=0.03). Patients randomized to receive TTFields therapy and docetaxel (n=71) had a positive survival trend with a median OS of 11.1 months vs 8.7 months in patients treated with docetaxel alone (n=71). TTFields therapy was well-tolerated with no added systemic toxicities and few grade 3 (no grade 4 or 5) device-related adverse events.
TTFields therapy is intended principally for use with other concomitant standard therapies, and LUNAR was designed to generate data that contemplates multiple outcomes, all of which Novocure believes will be clinically meaningful.
About NSCLC
Lung cancer is the most common cause of cancer-related death worldwide, and NSCLC accounts for approximately
About Novocure
Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, malignant pleural mesothelioma and pleural mesothelioma. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in brain metastases, gastric cancer, glioblastoma, liver cancer, non-small cell lung cancer, pancreatic cancer and ovarian cancer.
Headquartered in Root,
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