Novocure Announces Review Article of Anti-Cancer Mechanisms of Action of Tumor Treating Fields Published in Journal of Molecular Cell Biology

Rhea-AI Summary

Novocure (NASDAQ: NVCR) has released a review article highlighting the mechanisms of action of Tumor Treating Fields (TTFields) in cancer treatment, published in the Journal of Molecular Cell Biology. The article discusses various ways TTFields impact cancer cells, including interference with cell division, motility, and activation of anti-tumor immunity. TTFields therapy can be combined with treatments like chemotherapy and radiotherapy, enhancing effectiveness across various solid tumors. The study aims to further understanding of TTFields for improving patient outcomes.

Positive

• Publication of a peer-reviewed article on TTFields mechanisms, enhancing scientific credibility.
• TTFields show multiple mechanisms for targeting cancer cells, potentially increasing treatment options.
• Research indicates positive effects when combined with other cancer therapies.

Negative

• None.

A fast-growing body of research, both in vitro and in vivo, is converging to demonstrate the multiple inhibitory effects of Tumor Treating Fields on cancer growth

The review article summarizes the known mechanisms of action of Tumor Treating Fields that have been reported by in vitro and in vivo studies of cancer

ROOT, Switzerland--(BUSINESS WIRE)-- Novocure (NASDAQ: NVCR) today announced a review article of anti-cancer mechanisms of action of Tumor Treating Fields (TTFields) has been published in the Journal of Molecular Cell Biology (JMCB).

The review article, written by Shadi Shams of Rowan University School of Osteopathic Medicine and Chirag B. Patel, MD, PhD, Assistant Professor and McNair Scholar, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center in Houston, summarizes the known mechanisms of action of TTFields that have been reported by in vitro and in vivo studies of cancer. TTFields are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology and electrical properties) than cancer cells.

The review article cites that many studies to date have focused on TTFields’ effect on cancer cell division. More recently, research has demonstrated the effects of TTFields expand beyond preventing cancer cell division. The multiple, distinct mechanisms of TTFields therapy work together to selectively target and kill cancer cells. Along with disruption of mitosis, the review article states that preclinical research has also shown interference with cancer cell motility and migration, activation of downstream anti-tumor immunity, downregulation of genes important for DNA damage repair, and other potential mechanisms. Due to its multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or PARP inhibition in preclinical models.

“A fast-growing body of research, both in vitro and in vivo, is converging to demonstrate the multiple inhibitory effects of TTFields on cancer growth,” the article states.

Shams and Patel state in the review article that further investigation and understanding of how TTFields work “will guide strategies focused on the timing and combination of TTFields with other therapies, to further improve survival outcomes in patients with solid organ cancers.”

“This publication of peer-reviewed research on Tumor Treating Fields’ mechanisms of action encapsulates a thorough, scientific history of our therapy in the preclinical setting,” said Novocure’s Chief Science Officer Uri Weinberg, MD, PhD. “We are very proud of the research that has been conducted to date and are energized by the interest in Tumor Treating Fields among our peers in the scientific community. TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors.”

About Tumor Treating Fields
Tumor Treating Fields (TTFields) are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology, and electrical properties) than cancer cells. The multiple, distinct mechanisms of TTFields therapy work together to selectively target and kill cancer cells. Due to its multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or PARP inhibition in preclinical models. TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors. To learn more about Tumor Treating Fields therapy and its multifaceted effect on cancer cells, visit tumortreatingfieldstherapy.com.

About Novocure
Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma and malignant pleural mesothelioma. Novocure has ongoing or completed clinical studies investigating Tumor Treating Fields in brain metastases, gastric cancer, glioblastoma, liver cancer, non-small cell lung cancer, pancreatic cancer and ovarian cancer. Headquartered in Root, Switzerland and with a growing global footprint, Novocure has regional operating centers in Portsmouth, New Hampshire and Tokyo, as well as a research center in Haifa, Israel. For additional information about the company, please visit Novocure.com and follow @Novocure on LinkedIn and Twitter.

Forward-Looking Statements
In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure’s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical study progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe” or other words and terms of similar meaning. Novocure’s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, environmental, regulatory and political conditions as well as issues arising from the COVID-19 pandemic and other more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 24, 2022, as amended to date, with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.

View source version on businesswire.com: https://www.businesswire.com/news/home/20221020005705/en/

Investors:

Ingrid Goldberg

investorinfo@novocure.com

610-723-7427

Media:

Leigh Labrie

media@novocure.com

610-723-7428

Source: Novocure

FAQ

What is the significance of the recent review article published by Novocure?

The review article highlights the mechanisms of Tumor Treating Fields in cancer therapy, enhancing understanding of its effectiveness.

How do Tumor Treating Fields affect cancer cells?

TTFields interfere with cancer cell division, motility, and activate anti-tumor immunity, selectively targeting cancer cells.

What types of cancer can benefit from Tumor Treating Fields therapy?

TTFields therapy is being investigated for various cancers, including glioblastoma, non-small cell lung cancer, and pancreatic cancer.

What was the publication date of the review article on Tumor Treating Fields?

The review article was published on October 20, 2022.

What are the potential benefits of combining Tumor Treating Fields with other therapies?

Combining TTFields with therapies like chemotherapy may enhance treatment effectiveness across solid tumors.