Novocure Announces 15 Presentations at the American Society for Radiation Oncology 2021 Annual Meeting

Rhea-AI Summary

Novocure (NASDAQ: NVCR) announced 15 presentations on Tumor Treating Fields (TTFields) at the ASTRO 2021 Annual Meeting, occurring from Oct. 24-27 in Chicago. Five presentations include new data on the combination of TTFields and chemoradiation for glioblastoma patients. The research underscores the growing interest in TTFields within radiation oncology. The company aims to establish TTFields as a vital treatment for solid tumors, reflecting its ongoing commitment to cancer care innovation.

Positive

• 15 presentations on Tumor Treating Fields (TTFields) at ASTRO 2021 highlight company research.
• Three presentations feature new data, indicating strong interest in TTFields in radiation oncology.
• Investigational data will be presented on TTFields combined with chemoradiation for glioblastoma.

Negative

• Concurrent TTFields with chemoradiation may increase distant recurrence rates in glioblastoma patients.

Highlights include presentations by external authors studying the effects of concurrent Tumor Treating Fields and chemoradiation for patients with newly diagnosed glioblastoma

ST. HELIER, Jersey--(BUSINESS WIRE)-- Novocure (NASDAQ: NVCR) today announced 15 presentations on Tumor Treating Fields (TTFields) will be featured at the American Society for Radiation Oncology (ASTRO) 2021 Annual Meeting from Oct. 24 to Oct. 27 in Chicago. External authors prepared five of the presentations, three of which include new data, reflecting continued interest in Novocure’s proprietary TTFields platform within the radiation oncology community.

Two presentations will feature new data on the investigational use of concurrent TTFields and chemoradiation for patients with newly diagnosed glioblastoma (GBM). Another presentation will highlight new data on the effects of TTFields in combination with irradiation on human GBM cells.

“We and our partners are excited to present and see a variety of research on Tumor Treating Fields at ASTRO’s 2021 Annual Meeting,” said Dr. Ely Benaim, Novocure’s Chief Medical Officer. “We appreciate the opportunity to continue our partnership with the radiation oncology community in working to establish Tumor Treating Fields as an important treatment for solid tumors. We look forward to participating in the exchange of scientific information at one of the premier meetings for radiation oncologists.”

The following will be presented at the ASTRO 2021 Annual Meeting:

Poster Presentations

(2045) Mechanism of action of Tumor Treating Fields (TTFields) in combination with sorafenib for treatment of hepatocellular carcinoma. Lead author: S. Davidi. Presenter: E. Dor-On. 1:30 p.m. to 2:45 p.m. CDT Sunday, Oct. 24.

(2250) Comprehensive approaches to enhancing Tumor Treating Fields dose at the tumor. Lead author and presenter: Z. Bomzon. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2251) Framework for dosimetry and treatment planning of TTFields. Lead author and presenter: Z. Bomzon. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2252) Tumor Treating Fields (TTFields) treatment planning for a patient with astrocytoma in the spinal cord. Lead author and presenter: J. De Los Santos. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2253) Creating computational models for planning TTFields treatment for tumors in the infratentorial brain. Lead author: Y. Glozman. Presenter: B. Berger. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2257) Impact of model inaccuracy on dose estimation in TTFields therapy. Lead author and presenter: T. Marciano. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2258) Treating spinal-cord tumors with TTFields – a simulation study. Lead author and presenter: A. Naveh. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2259) Segmentation of the upper torso for lung cancer TTFields treatment planning. Lead author: O. Peles. Presenter: B. Berger. 4:45 p.m. to 6 p.m. CDT Sunday, Oct. 24.

(2454) Tumor Treating Fields synergistically enhances cell death in non-small cell lung and pancreatic cancer cells treated with the combination of radiation and chemo agents that interfere with DNA replication fork stability. Lead author: N. Karanam. Presenter: M. Story. 11 a.m. to 12:15 p.m. CDT Monday, Oct. 25.

(2504) Activated phosphoinositide 3-kinase/AKT/mTOR signaling confers resistance to Tumor Treating Fields (TTFields). Lead author: A. Klein-Goldberg. Presenter: M. Giladi. 11 a.m. to 12:15 p.m. CDT Monday, Oct. 25.

(2960) Impact of Tumor Treating Fields on DNA damage repair in mesothelioma. Lead author: H. Mumblat. Presenter: E. Dor-On. 3:30 p.m. to 4:45 p.m. CDT Tuesday, Oct. 26.

(3252) SPARE trial: Scalp sparing radiation with concurrent temozolomide and Tumor Treating Fields (200 kHz) for patients with newly diagnosed glioblastoma. Lead author and presenter: R.C. Miller. 1 p.m. to 2:15 p.m. CDT Wednesday, Oct. 27.

(3255) Concurrent chemoradiation and Tumor Treating Fields (TTFields, 200 kHz) for patients with newly diagnosed glioblastoma may increase the rate of distant recurrence. Lead author: A. Ali. Presenter: M. Z. K. Niazi. 1 p.m. to 2:15 p.m. CDT Wednesday, Oct. 27.

(3264) Combination treatment of Irradiation and Tumor Treating Fields for human glioblastoma cells. Lead author and presenter: M. Stein. 1 p.m. to 2:15 p.m. CDT Wednesday, Oct. 27.

(3268) Concurrent TTFields (200 kHz) with chemoradiation for patients with newly diagnosed glioblastoma may increase the rate of pseudoprogression: analysis of a pilot clinical trial. Lead author and presenter: J. Taylor. 1 p.m. to 2:15 p.m. CDT Wednesday, Oct. 27.

All poster presentations will be held outside Room W375 in McCormick Place West.

About Novocure

Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma and in the U.S. for the treatment of adult patients with malignant pleural mesothelioma. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in brain metastases, gastric cancer, glioblastoma, liver cancer, non-small cell lung cancer, pancreatic cancer and ovarian cancer.

Headquartered in Jersey, Novocure has U.S. operations in Portsmouth, New Hampshire, Malvern, Pennsylvania and New York City. Additionally, the company has offices in Germany, Switzerland, Japan and Israel. For additional information about the company, please visit Novocure.com and follow @Novocure on LinkedIn and Twitter.

Forward-Looking Statements

In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure’s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical trial progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe” or other words and terms of similar meaning. Novocure’s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, environmental, regulatory and political conditions as well as issues arising from the COVID-19 pandemic and other more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 25, 2021 with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.

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Investors:

Ingrid Goldberg

investorinfo@novocure.com

610-723-7427

Media:

Leigh Labrie

media@novocure.com

610-723-7428

Source: Novocure

FAQ

What presentations will Novocure showcase at the ASTRO 2021 Annual Meeting?

Novocure will present 15 studies on Tumor Treating Fields, including new data on its use with chemoradiation for glioblastoma.

When is the ASTRO 2021 Annual Meeting?

The ASTRO 2021 Annual Meeting will take place from October 24 to October 27, 2021.

What is the significance of the new data presented by Novocure?

The new data highlights the potential of TTFields in combination with chemoradiation for glioblastoma, which could impact treatment strategies.

What could be the implications of concurrent TTFields and chemoradiation?

Data suggests that using concurrent TTFields with chemoradiation may increase the rate of distant recurrence in glioblastoma patients.