NanoString Launches nCounter Antibody Drug Conjugate Panel to Accelerate the Development of Oncology Treatments
NanoString Technologies, a leader in life science tools, has launched the nCounter® ADC Development Panel to facilitate research in Antibody Drug Conjugates (ADCs). This new gene expression tool, developed with input from pharmaceutical experts, aims to provide comprehensive molecular insights necessary for addressing critical questions in oncology therapies. The panel can profile 770 genes and aids in understanding ADC mechanisms, including tumor targeting and resistance. Currently, there are 10 approved ADCs and over 80 in clinical trials, indicating the growing importance of this technology in cancer treatment.
- Launch of the nCounter® ADC Development Panel enhances NanoString's product offerings in the ADC field.
- Panel allows profiling of 770 genes, addressing critical biological questions and enhancing research capabilities.
- Increased market relevance as ADCs gain traction in cancer therapies, with 10 approved drugs and over 80 in trials.
- None.
Image of an Antibody Drug Conjugates (ADCs) enabling the targeted delivery of highly potent cytotoxic compounds to treat cancer. (Photo: Business Wire)
ADCs are defined as a new class of highly potent therapeutics composed of an antibody attached via a chemical linker to a biologically active drug or cytotoxic compound. These targeted agents allow for sensitive discrimination between healthy and cancer tissues with the cell-killing ability of cytotoxic drugs. The field now has 10 approved drugs, over 80 investigational ADCs, and nearly 200 clinical trials and is gaining momentum as an effective approach for targeting cancer.
The new panel provides for customizable ADC content to address complex questions critical for the success of Antibody Drug Conjugates throughout discovery, pre-clinical and clinical development. The panel can be used to directly profile 770 genes addressing essential biological questions relevant to each step in the ADC development workflow, including tumor targeting and antigen expression; ADC internalization; payload release; drug mechanisms of action; target cell death; immunogenic cell death; and mechanisms of resistance.
"With this panel, researchers have a powerful, cutting-edge tool that addresses biological function with deep molecular characterization, expanding insights gained from traditional endpoint assays," said
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